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Gonhyung Kim , Ji-Hye Kim, Bibek Sutradhar, Seok Hwa Choi 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.2
Peripheral nerve injuries are very common in clinics and often result in severe functional deficits. The aim of this study was to evaluate the effect of treadmill running and electro-acupuncture on nerve regeneration and functional recovery of muscle activity following sciatic nerve crush injury in a rat model. A comparative study was conducted over 30 days on 60 adult male Sprague-Dawley rats grouped into sham control (C), electro-acupuncture (EA), treadmill (T), and treadmill plus electro-acupuncture (TEA). The left sciatic nerve was crushed for 30 sec using a hemostatic forceps and functional activity was evaluated with sciatic functional tests, nerve conduct velocity, muscle weight, and histology at 10, 20, and 30 days after injury. Muscle weight was significantly (P<0.05) increased between days 10 and 30 in the TEA group. In histology, the degree of damage was scored as C > TEA > T > EA, although necrosis and fibrosis of muscle was observed only in the TEA group. The EA and TEA groups showed rapid recovery with better myelinated axons on day 10. These results suggest that application of the TEA method with balanced exercise is a useful treatment option for peripheral nerve injury regeneration and muscle activity.
Male pseudohermaphroditism in a Maltese/poodle mixed dog
Seok-jin Jang, Young-jae Kim, Gonhyung Kim, Seok Hwa Choi 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.1
Male pseudohermaphroditism is not commonly reported in veterinary medicine. Here, a 3-year-old Maltese/poodle mixed dog presented with malformed external genitalia and episodic hematuria. Inspection and palpation of the external genitals showed a malformed penis, shortened prepuce, external urethral orifice, and cryptorchidism. There was no urethral meatus at the tip of the penis. The urethral opening was situated between the prepuce and the penis. The anterior half of the prepuce was absent, and the penis was free and exposed to both trauma and licking. Plain radiographic examination showed absence of an os penis in the penis. A double-contrast cystograph showed the suspected uterus as well as the cystic calculi. A hypoechoic space was seen at the dorsal portion of the urinary bladder. The space was suspected to be the uterus. A sagital ultrasonograph showed cystic calculi in the urinary bladder. During surgery to remove cystic calculi, hypoplastic testes as well as the uterus were observed. Histological examination of the testes showed the seminiferous tubules and interstitial cells. The sertoli cells and spermatogonia were adjacent to the basement membrane. No evidence of spermatogenesis was found. Striated squamous epithelial cells and smooth muscle cells were found in the uterus. This dog had vestigial oviducts as well as a uterus with male-appearing external genitals.
Effect of Feed Restriction in Modeling of Dietary Obesity
Yeoung Mi Cho,Sunhee Shin,Dongsun Park,Jeong Hee Jeon,Min-Jung Jang,Jwa Jin Kim,Jae Wook Kim,Hyeong-Jin Ji,Chang Hwan Kim,Seongjin Baek,Seok-Yeon Hwang,Gonhyung Kim,Yun-Bae Kim 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.4
Ad libitum feeding of normal diet to rats usually leads to overweight, showing higher body-mass index than 25, while the supplementation of high (20-40%) content of lard or beef tallow in the diet to make a high-fat diet (HFD)-induced obesity rather decreases body weights partially due to decrease in feed intake of HFD or occurrence of diarrhea. In our study, for modeling dietary obesity, rats were subjected to feed restriction by 20 and 40% with normal diet or HFD supplemented with 25% of lard for 6 weeks. Ad libitum (100%) feeding of HFD decreased body weight gain and body fat in rats, resulting from a lower feed intake and transient diarrhea, compared to that of animals fed normal diet. In comparison with ad libitum-feeding groups, HFD restricted to 60 and 80% resulted in higher body weight gain and body fat compared with the normal diet with corresponding restriction to 60% or 80%. The changes in body and fat weights exhibited a good relationship with blood lipids profiles and leptin level in feed restricted groups. In addition, body fat and lipid profiles were confirmed to be parallel with the lipid accumulation in the liver and blood parameters associated with liver function. Based on the results, it is suggested that an appropriate degree (80%) of dietary restriction could be a candidate of modeling HFD-induced obesity for the screening of antiobesity substances.
Retrospective study on fractures in dogs
Gonhyung Kim*, Maruf Minar, Yawon Hwang, Minhyeok Park, Somin Kim, Cheongjin Oh, Seokhwa Choi 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.3
Patients referred to the Veterinary Medical Center at Chungbuk National University were analyzed. This study aimed to provide information to clinicians in Korea on the factors affecting fracture incidence in patients adapted to Korean companion animal culture. Eighty cases showingbone fractures were investigated from January, 2005 to December, 2011. Fractures were mainly observed in miniature dogs such as Yorkshire terrier (12%), Poodle (12%), and Maltese (9%). Almost 50% of all cases were less than 1 year old. Total bone fractures in summer and fall constituted 62%. Fracture incidence was higher in male dogs (54%) than female dogs (46%). Hindlimb fracture (37%) was the most common. Distribution of limb fractures was higher in the femur (19), followed by the tibia/fibula (15), radius/ulna (13), humerus (11), and mandible (8). Pelvic fracture was observed in 19 cases. Simple fracture (84%) was the most common fracture type, followed by comminuted fracture (16%). Distal portion was the most common fracture site in long bones (67%), followed by middle (26%) and proximal bones (7%). Fractures were mainly caused by traffic accidents (43%), whereas 28.5% of fractures were due to falling down. Plate & screw (26%) was the most common method of fracture repair, followed by intramedullary pin (24%), wire (11%), external skeletal fixation (10%), screw (9%), amputation (7%), cross pin (6%), IM pin and wire (5%), and rush pin (1%). Among 80 patients, 79%of patients showed a good prognosis after surgery, whereas 13% patients did not experience a good result. This study shows that miniature dogs are prone to falling and fractures, especially in the distal part of long bones.
Evaluation of Hypertriglyceridemia as a Mediator Between Endocrine Diseases and Pancreatitis in Dogs
Kim, Hakhyun,Kang, Ji-Houn,Heo, Tae-Young,Kang, Byeong-Teck,Kim, Gonhyung,Chang, Dongwoo,Na, Ki-Jeong,Yang, Mhan-Pyo American Animal Hospital Association 2019 The Journal of the American Animal Hospital Associ Vol.55 No.2
Kim, Jong Min,Son, Jun Sik,Kang, Seong Soo,Kim, Gonhyung,Choi, Seok Hwa Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>The aim of this study was to evaluate the bone regeneration of hydroxyapatite (HA)/alumina bilayered scaffold with a 3 mm passage-like medullary canal in a beagle tibia model. A porous HA/alumina scaffold was fabricated using a polymeric template-coating technique. HA/alumina scaffold dimensions were 10 mm in outer diameter, 20 mm in length, and with either a 3 mm passage or no passage. A 20 mm segmental defect was induced using an oscillating saw through the diaphysis of the beagle tibia. The defects of six beagles were filled with HA/alumina bilayered scaffolds with a 3 mm passage or without. The segmental defect was fixated using one bone plate and six screws. Bone regeneration within the HA/alumina scaffolds was observed at eight weeks after implantation. The evaluation of bone regeneration within the scaffolds after implantation in a beagle tibia was performed using radiography, computerized tomography (CT), micro-CT, and fluorescence microscopy. New bone successfully formed in the tibia defects treated with 3 mm passage HA/alumina scaffolds compared to without-passage HA/alumina scaffolds. It was concluded that the HA/alumina bilayered scaffold with 3 mm passage-like medullary canal was instrumental in inducing host-scaffold engraftment of the defect as well as distributing the newly formed bone throughout the scaffold at 8 weeks after implantation.</P>
Kim, Jong Min,Han, Tae Sung,Park, Jinuk,Sutradhar, Bibek Chandra,Kim, Gonhyung,Kang, Seong Soo,Choi, Seok Hwa [s.n 2010 IN VIVO -ATHENS- Vol.24 No.6
<P>The rat model that is commonly used to study femoral head osteonecrosis involves the induction of osteonecrosis by surgery employing a lateral approach to the hip joint. However, this approach induces hip joint luxation, which means it is difficult to determine whether the osteonecrosis arises because of the vascular deprivation or because of the hip joint luxation. Whether or not femoral head osteonecrosis can be induced by the medial approach to the hip joint, which does not generate hip joint luxation, was assessed.</P>
Surgical Animal Models for Bone and Cartilage Regeneration
Gonhyung Kim(김근형) 한국실험동물학회 2008 한국실험동물학회 학술발표대회 논문집 Vol.2008 No.-
Tissue engineering for bone and cartilage which fail to treat effectively by severe damage and degeneration is still in the experimental stage. Stem cells, growth factors and scaffolds have been suggested as candidate therapeutic methods to develop neo-tissue during the last decade. A number of experimental surgical animal models are studied on different species of animals to treat the bone and cartilage defects. Rat, rabbit, dog, sheep and pig are frequently used for animal models. Partial or segmental defects are created in long bones such as femur, tibia, humerus, radius and ulna. However, orthopaedic experimental studies are more sensitive to infection and painful to the animals. It is therefore essential for accurate results to find suitable and successful surgical method in animal models.
Treatment of hydrocephalus with high-pressure valve ventriculoperitoneal shunt in a dog.
Kim, Jong Min,Park, Jinuk,Kim, Ji-Hye,Han, Tae Sung,Chang, Dongwoo,Na, Ki-Jeong,Choi, Seok Hwa,Kim, Gonhyung Faculty of Veterinary Medicine, Hokkaido Universit 2010 The Japanese journal of veterinary research Vol.58 No.2
<P>A 5-month-old male Maltese with right-sided circling, deafness, and blindness was presented. A diagnosis of communicating hydrocephalus was made. A ventriculoperitoneal shunt was implanted and the cerebrospinal fluid was drained by using an adjustable valve type (Medtronic Strata). The valve was set at 2.5 (135-155 mmH2O). This was done to prevent the possibility of an overdrainage-induced collapse of the brain parenchyma, which can occur rarely when canine hydrocephalus is treated by using a low-pressure valve. Computed tomography performed 6 weeks and 1 year after surgery revealed the ventricles had decreased in size. Thus, a high-pressure valve used during the treatment of hydrocephalus was able to maintain normal intracranial pressure.</P>