THE USE OF ULTRASONIC TECHNIQUES FOR THE MEASUREMENT OF FLOW RATES IN GAS-LIQUID SLUG FLOW

Goncalves M. A. L.,Franca F. A. 대한기계학회 1992 International Conference on Fluid Machinery Vol.1 No.1

Experimental investigation of the large amplitude vibrations of a thin-walled column under self-weight

Goncalves, Paulo B.,Jurjo, Daniel Leonardo B.R.,Magluta, Carlos,Roitman, Ney Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.46 No.6

This work presents an experimental methodology specially developed for the nonlinear large-amplitude free vibration analysis of a clamped-free thin-walled metal column under self-weight. The main contribution of this paper is related to the developed experimental methodology which is based on a remote sensing technique using a computer vision system that integrates, on-line, the digital image acquisition and its treatment through special image processing routines. The main importance of this methodology is that it performs large deflections measurements without making contact with the structure and thus, not introducing undesirable changes in its behavior, for instance, appreciable changes in mass and stiffness properties. This structure presents, in most cases, highly non-linear responses, which cannot be reproduced by conventional finite-element softwares due, mainly, to the simultaneous influence of geometric and inertial non-linearities. To capture the non-linearities associated with large amplitude vibration and be able to describe the buckling process, the structure is discretized as a sequence of jointed coupled elastic pendulums. The obtained numerical results are favorably compared with the experimental ones, in the pre- and post-buckling regimes.

Large deflection behavior and stability of slender bars under self weight

Goncalves, Paulo B.,Jurjo, Daniel Leonardo B.R.,Magluta, Carlos,Roitman, Ney,Pamplona, Djenane Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.24 No.6

In this paper the buckling and post-buckling behavior of slender bars under self-weight are studied. In order to study the post-buckling behavior of the bar, a geometrically exact formulation for the non-linear analysis of uni-directional structural elements is presented, considering arbitrary load distribution and boundary conditions. From this formulation one obtains a set of first-order coupled nonlinear equations which, together with the boundary conditions at the bar ends, form a two-point boundary value problem. This problem is solved by the simultaneous use of the Runge-Kutta integration scheme and the Newton-Raphson method. By virtue of a continuation algorithm, accurate solutions can be obtained for a variety of stability problems exhibiting either limit point or bifurcational-type buckling. Using this formulation, a detailed parametric analysis is conducted in order to study the buckling and post-buckling behavior of slender bars under self-weight, including the influence of boundary conditions on the stability and large deflection behavior of the bar. In order to evaluate the quality and accuracy of the results, an experimental analysis was conducted considering a clamped-free thin-walled metal bar. As this kind of structure presents a high index of slenderness, its answers could be affected by the introduction of conventional sensors. In this paper, an experimental methodology was developed, allowing the measurement of static or dynamic displacements without making contact with the structure, using digital image processing techniques. The proposed experimental procedure can be used to a wide class of problems involving large deflections and deformations. The experimental buckling and post-buckling behavior compared favorably with the theoretical and numerical results.

The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate

Goncalves, Joao,Pelletier, Laurence Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.4

Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for embryonic development and adult tissue homeostasis. Importantly, a multitude of human diseases is caused by abnormal cilia biogenesis and functions which rely on the compartmentalization of the cilium and the maintenance of its protein composition. The transition zone (TZ) is a specialized ciliary domain present at the base of the cilium and is part of a gate that controls protein entry and exit from this organelle. The relevance of the TZ is highlighted by the fact that several of its components are coded by ciliopathy genes. Here we review recent developments in the study of TZ proteomes, the mapping of individual components to the TZ structure and the establishment of the TZ as a lipid gate.

COINCIDENCE OF MAPS BETWEEN SURFACES

Goncalves, Daciberg L. Korean Mathematical Society 1999 대한수학회지 Vol.36 No.2

We will consider f,g : S1longrightarrowS2 a pair of maps between two orientable compact surfaces. The purpose of this paper is to decide when the pair can be deformed to a pair (f', g') such that

REVIEW : Pichia pastoris: A Recombinant Microfactory for Antibodies and Human Membrane Proteins

( Goncalves A M ),( A Q Pedro ),( C Maia F Sousa ),( J A Queiroz ),( L A Passarinha ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.5

During the last few decades, it has become evident that the compatibility of the yeast biochemical environment with the ability to process and translate the RNA transcript, along with its capacity to modify a translated protein, are relevant requirements for selecting this host cell for protein expression in several pharmaceutical and clinical applications. In particular, Pichia pastoris is used as an industrial host for recombinant protein and metabolite production, showing a powerful capacity to meet required biomolecular target production levels in high-throughput assays for functional genomics and drug screening. In addition, there is a great advantage to using P. pastoris for protein secretion, even at high molecular weights, since the recovery and purification steps are simplified owing to relatively low levels of endogenous proteins in the extracellular medium. Clearly, no single microexpression system can provide all of the desired properties for human protein production. Moreover, chemical and physical bioprocess parameters, including culture medium formulation, temperature, pH, agitation, aeration rates, induction, and feeding strategies, can highly influence product yield and quality. In order to benefit from the currently available wide range of biosynthesis strategies using P. pastoris, this mini review focuses on the developments and technological fermentation achievements, providing both a comparative and an overall integration analysis. The main aim is to highlight the relevance and versatility of the P. pastoris biosystem to the design of more cost-effective microfactories to meet the increasing demands for recombinant membrane proteins and clinical antibodies for several therapeutic applications.

Experimental characterization of timber framed masonry walls cyclic behaviour

Goncalves, Ana Maria,Ferreira, Joao Gomes,Guerreiro, Luis,Branco, Fernando Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.53 No.2

After the large destruction of Lisbon due to the 1755 earthquake, the city had to be almost completely rebuilt. In this context, an innovative structural solution was implemented in new buildings, comprising internal timber framed walls which, together with the floors timber elements, constituted a 3-D framing system, known as "cage", providing resistance and deformation capacity for seismic loading. The internal timber framed masonry walls, in elevated floors, are constituted by a timber frame with vertical and horizontal elements, braced with diagonal elements, known as Saint Andrew's crosses, with masonry infill. This paper describes an experimental campaign to assess the in-plane cyclic behaviour of those so called "frontal" walls. A total series of 4 tests were conducted in 4 real size walls. Two models consist of the simple timber frames without masonry infill, and the other two specimens have identical timber frames but present masonry infill. Experimental characterization of the in-plane behaviour was carried out by static cyclic shear testing with controlled displacements. The loading protocol used was the CUREE for ordinary ground motions. The hysteretic behaviour main parameters of such walls subjected to cyclic loading were computed namely the initial stiffness, ductility and energy dissipation capacity.

Scrutinizing the Method of Evaluating Overheating Risks in Passive Houses

Vitor Goncalves,Yewande Ogunjimi,Yeonsook Heo 대한설비공학회 2020 대한설비공학회 학술발표대회논문집 Vol.2020 No.6

This paper scrutinizes the method of evaluating overheating risks in passive houses. Particularly, this research investigates the effect of: (1) the choice of overheating criterion, (2) simplifications commonly made in airflow modelling techniques, and (3) uncertainty in the building simulation on the overheating risk of residential buildings. Analysis results from the case study suggested that overheating assessment results are highly dependent on the choice of thermal comfort criterion and modelling approaches. Furthermore, the results highlighted the necessity of properly modelling airflow phenomena by coupling the thermal model with the airflow network model for overheating analysis. In addition, the sensitivity analysis results indicated that although the most dominant uncertain parameters are in the thermal model, uncertain parameters in the airflow network model such as effective leakage areas and wind pressure coefficients also showed a relatively high ranking.

Automatic Generation of a Simulated Robot from an Ontology-Based Semantic Description

Yuri Goncalves Rocha,Sung-Hyeon Joo,Eun-Jin Kim,Tae-Yong Kuc 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10

Humans are capable of generating simulated mental worlds based on their past experiences and use such an environment for prospecting, planning, and learning. Such capabilities could enhance current robotic systems, allowing them to plan ahead based on predicted outputs, and even compare their performance with a different agent. In this work, we propose a semantic robot modeling framework, which is able to express intrinsic semantic knowledge in order to better represent the robot and its surrounding environment. We also show that such data can be used to automatically generate a simulated model, allowing robots to simulate themselves and other modeled agents.

Anticancer Properties of Psidium guajava - a Mini-Review

Correa, Mariana Goncalves,Couto, Jessica Soldani,Teodoro, Anderson Junger Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Cancer is a complex disease caused by a progressive accumulation of multiple genetic mutations. Consumption of fruits is associated with lower risk of several cancers, which is mainly associated to their phytochemical content. The use of functional foods and chemopreventive compounds seems to contribute in this process, acting by mechanisms of antioxidant, anti-inflammatory, anti-angiogenic and hormonal. The Psidium Guajava has high potential functional related to pigments who are involved in the process of cancer prevention by having antioxidant activity. The aim of the present review is to expose some chemical compounds from P. Guajava fractions and their association with anti-carcinogenic function. The evidences supports the theory of anticancer properties of P. Guajava, although the mechanisms are still not fully elucidated, but may include scavenging free radicals, regulation of gene expression, modulation of cellular signalling pathways including those involved in DNA damage repair, cell proliferation and apoptosis.