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      • SCOPUSSCIEKCI등재

        Relationship between Class III malocclusion and hyoid bone displacement during swallowing: a cine-magnetic resonance imaging study

        Gokce,,Sila,Mermut,Gokce,,Hasan,Suat,Gorgulu,,Serkan,Karacay,,Seniz,Akca,,Eralp,Olmez,,Huseyin The Korean Association Of Orthodontists 2012 대한치과교정학회지 Vol.42 No.4

        Objective: The displacement of the hyoid bone (HB) is a critical biomechanical component of the swallowing function. The aim of this study was to evaluate the swallowing-induced vertical and horizontal displacements of the HB in subjects with 2 different magnitudes of skeletal Class III malocclusion, by means of real-time, balanced turbo-field-echo (B-TFE) cine-magnetic resonance imaging. Methods: The study population comprised 19 patients with mild skeletal Class III malocclusion, 16 with severe skeletal Class III malocclusion, and 20 with a skeletal Class I relationship. Before the commencement of the study, all subjects underwent cephalometric analysis to identify the nature of skeletal malformations. B-TFE images were obtained for the 4 consecutive stages of deglutition as each patient swallowed 10 mL of water, and the vertical and horizontal displacements of the HB were measured at each stage. Results: At all stages of swallowing, the vertical position of the HB in the severe Class III malocclusion group was significantly lower than those in the mild Class III and Class I malocclusion groups. Similarly, the horizontal displacement of the HB was found to be significantly associated with the severity of malocclusion, i.e., the degree of Class III malocclusion, while the amount of anterior displacement of the HB decreased with an increase in the severity of the Class III deformity. Conclusions: Our findings indicate the existence of a relationship between the magnitude of Class III malocclusion and HB displacement during swallowing.

      • KCI등재SCIESCOPUS

        Control of the Oxidation Kinetics of H-terminated (111)Si by Using the Carrier Concentration and the Strain: a Second-harmonic-generation Investigation

        B.,Gokce,K.,Gundogdu,데이비드에스프네스 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.10

        We discuss recent results regarding the effects of strain, carrier type and concentration on the oxidation of H-terminated (111)Si. Second-harmonic-generation data show that this is a two-stage process where the H of the “up” bonds of the outermost Si layer is replaced by OH, followed by O insertion into the “back” bonds. These data provide additional detailed information about both stages. In particular, directional control of the in-plane surface chemistry by using the applied uniaxial stress provides new opportunities for interface control.

      • SCOPUSKCI등재

        A CLASS OF MÖBIUS ITERATED FUNCTION SYSTEMS

        Cakmak,,Gokce,Deniz,,Ali,Kocak,,Sahin Korean Mathematical Society 2020 대한수학회논문집 Vol.35 No.3

        We characterize Möbius functions mapping the unit disc of the complex plane contractively into itself. We then give a procedure to produce Möbius iterated function systems on the unit disc.

      • KCI등재SCIE

        Relationship between Class III malocclusion and hyoid bone displacement during swallowing

        Sila,Mermut,Gokce,Hasan,Suat,Gokce,Serkan,Gorgulu,Seniz,Karacay,Eralp,Akca,Huseyin,Olmez 대한치과교정학회 2012 대한치과교정학회지 Vol.42 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Objective: The displacement of the hyoid bone (HB) is a critical biomechanical component of the swallowing function. The aim of this study was to evaluate the swallowing-induced vertical and horizontal displacements of the HB in subjects with 2 different magnitudes of skeletal Class III malocclusion, by means of realtime, balanced turbo-field-echo (B-TFE) cine-magnetic resonance imaging. Methods: The study population comprised 19 patients with mild skeletal Class III malocclusion, 16 with severe skeletal Class III malocclusion, and 20 with a skeletal Class I relationship. Before the commencement of the study, all subjects underwent cephalometric analysis to identify the nature of skeletal malformations. B-TFE images were obtained for the 4 consecutive stages of deglutition as each patient swallowed 10 mL of water, and the vertical and horizontal displacements of the HB were measured at each stage. Results: At all stages of swallowing, the vertical position of the HB in the severe Class III malocclusion group was significantly lower than those in the mild Class III and Class I malocclusion groups. Similarly, the horizontal displacement of the HB was found to be significantly associated with the severity of malocclusion, i.e., the degree of Class III malocclusion, while the amount of anterior displacement of the HB decreased with an increase in the severity of the Class III deformity. Conclusions: Our findings indicate the existence of a relationship between the magnitude of Class III malocclusion and HB displacement during swallowing.

      • Perspectives of Women during Reproductive Years for Cervical Cancer Scans and Influencing Factors

        Acar,,Gokce,Banu,Pinar,,Gul Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

        Background: This descriptive study was performed in order to assess health perspectives of women, who applied to Yildirim Beyazit University Ataturk Education and Research Hospital, Outpatient Clinic of Obstetrics and Gynecology for cervical cancer scans and were in the reproductive years. Factors influencing their perspectives were also assessed. Materials and Methods: In this study, a simple random sampling formula was adopted to calculate the volume (300) of the targeted sample. Results of the research were obtained through individual diagnosis form and cervical cancer and the Pap smear test health belief model scale (HBMS). Results: It was found that 75.0% of the women heard of the Pap smear test before, and 48.7% had undertaken one. Some 51.4% of the women who had Pap smear test expressed that they had the test at irregular periods. Most of the women stated that they heard about the smear test from the health staff (51.7%). Lack of any health complaints (28.3%) and not having adequate information about the test (21.0%) were among the reasons for not undergoing a Pap smear test. It was found that lower dimension average scores of the women obtained from the cervical cancer and Pap smear test HBMS varied from $7.7{\pm}2.3$ to $33.5{\pm}9.3$. When the lower dimension average scores of women from the HBMS were examined, the perception of usefulness was high but the susceptibility and health motivations were low. Conclusions: In this study, it was determined that the awareness of women about cervical cancer and the Pap smear test was insufficient, and susceptibility and motivation perception towards having a Pap smear test were low.

      • KCI등재SCIESCOPUS

        Back-reflection Second-harmonic Generation of (111)Si: Theory and Experiment

        B.,Gokce,K.,Gundogdu,E.,J.,Adles,데이비드에스프네스 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.51

        We consider second-harmonic generation (SHG) from a (111) surface of a tetrahedrally bonded semiconductor illuminated at normal incidence by a focused pump beam of Gaussian cross section as a model of SHG by focused beams. Calculations are done in the anisotropic bond model (ABM) and the results are applied to Si. The unit-cell configuration is simple enough for the calculations to be done analytically, so the results can be compared directly to similar calculations done for amorphous material. Although the differences in unit-cell symmetry occur on the atomic scale, they lead to large differences in the spatial distribution of the emerging radiation. Lateral focusing, which might be expected to increase the bulk contribution to SHG by increasing the lateral field gradient, has little effect; the spatial-dispersion contribution remains dominated by the phase term. Focusing does not inhibit backscattered SHG from the bulk, although our data on the oxidation of H-terminated (111)Si clearly show that in some cases the interface contribution dominates by a wide margin.

      • Effect of Pulsed Electromagnetic Field on MMP-9 and TIMP-1 Levels in Chondrosarcoma Cells Stimulated with IL-1β

        Caliskan,,Serife,Gokce,Bilgin,,Mehmet,Dincer,Kozaci,,Leyla,Didem Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

        Chondrosarcoma, the second most common type of bone malignancy, is characterized by distant metastasis and local invasion. Previous studies have shown that treatment by pulsed electromagnetic field (PEMF) has beneficial effects on various cancer cells. In this study, we investigated the effects of PEMF applied for 3 and 7 days on the matrix metalloproteinase (MMP) levels in chondrosarcoma SW1353 cells stimulated with two different doses of $IL-1{\beta}$. SW1353 cells were treated with (0.5 and 5 ng/ml) $IL-1{\beta}$ and PEMF exposure was applied either 3 or 7 days. MMP-9 and TIMP-1 levels were measured in conditioned media by enzyme-linked immunosorbent assay. The results were relative to protein levels. Statistical analyses were performed using one-way analysis of variance (ANOVA). P<0.05 was considered significant. PEMF treatment significantly decreased MMP-9 protein levels in human chondrosarcoma cells stimulated with 0.5 ng/ml $IL-1{\beta}$ at day 7, whereas it did not show any effect on cells stimulated with 5 ng/ml $IL-1{\beta}$. There was no significant change in TIMP-1 protein levels either by $IL-1{\beta}$ stimulation or by PEMF treatment. The results of this study showed that PEMF treatment suppressed $IL-1{\beta}$-mediated upregulation of MMP-9 protein levels in a dual effect manner. This finding may offer new perspectives in the therapy of bone cancer.

      • KCI등재

        Aged Garlic Extract Attenuates Neuronal Injury in a Rat Model of Spinal Cord Ischemia/Reperfusion Injury

        Berker,Cemil,Emre,Cemal,Gokce,Ramazan,Kahveci,Aysun,Gokce,Nurkan,Aksoy,Mustafa,Fevzi,Sargon,Bulent,Erdogan,Bahadir,Kosem 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.6

        Garlic has been used as a food as well as a component of traditional medicine. Aged garlic extract (AGE) is claimed to promote human health through antioxidant/anti-inflammatory activities with neuroprotective effects. We evaluated the possible beneficial effect of AGE neurologically, pathologically, ultrastructurally, and biochemically in a spinal cord ischemia–reperfusion (I/R) model of rats. Twenty-four Sprague-Dawley rats were divided into three groups: sham (no I/R), I/R, and AGE (I/R+AGE); each group consisted of eight animals. Animals were evaluated neurologically with the Basso, Beattie, and Bresnahan (BBB) scoring system. The spinal cord tissue samples were harvested for pathological and ultrastructural examinations. Oxidative products (Malondialdehyde, nitric oxide), antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), inflammatory cytokines (tissue tumor necrosis factor alpha, interleukin-1), and caspase-3 activity were analyzed. The AGE group had significantly higher BBB scores than the I/R group. Pathologically, AGE group revealed reduced degree of ischemia and spinal cord edema. Ultrastructural results also showed preservation of tissue structure in the AGE group. Oxidative product levels of the I/R group were significantly higher than both the other groups, and antioxidant enzyme levels of AGE group were significantly higher than the I/R group. There was also significant difference between the sham and AGE groups in terms of total antioxidant enzyme levels. Furthermore, AGE treatment significantly reduced the inflammatory cytokines and caspase-3 activity than the I/R group. This study demonstrates the considerable neuroprotective effect of AGE on the neurological, pathological, ultrastructural, and biochemical status of rats with I/R-induced spinal cord injury.

      • KCI등재SCOPUS

        APPLICATION OF IMPULSIVE DETERMINISTIC SIMULATION OF BIOCHEMICAL NETWORKS VIA SIMULATION TOOLS

        GOKCE,TUNCER,VILDA,PURUTCUOGLU 장전수학회 2017 Proceedings of the Jangjeon mathematical society Vol.20 No.1

        In order to understand the possible behaviour of biochemi- cal networks, deterministic and stochastic simulation methods have been developed. However in some cases, these methods should be broaden. For example, if the biochemical system is subjected to the unexpected effects causing abrupt changes in the network, the ordinary simulation algorithms cannot capture these impulsive expressions. In this study, we select the simulations tools, specifically, COPASI and Systems Biology Toolbox for MATLAB among alternatives that en- able us to represent the impulsive changes in the system via impulsive or adaptive deterministic simulation algorithms. Accordingly, we com- pare these tools by applying the two major impulsive scenarios, namely, impulses for fixed times and fixed states, based on their accuracies and computational demands. We evaluate our results for small and large systems, respectively.

      • KCI등재SCOPUS

        Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety

        Gokce,Isıl,Kurmus,Muzeyyen,Gonul,Filiz,Canpolat,Demet,Yılmazer,Eylem,Sahin,Cankurtaran 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

        Background: Psychological factors such as stress, depression, and anxiety have been documented to contribute to the development of lesions in lichen planus (LP). Objective: To evaluate the relationship between serotonin expression in LP lesions and depression/anxiety. Methods: Forty patients (22 females, 18 males) with LP and 20 healthy control subjects were included in this study. The severity of LP was assessed with the palmar method (using the measurement of affected body surface area [BSA]). The depression and anxiety scores were measured with Beck's depression inventory (BDI) and Beck's anxiety inventory (BAI). The expression of serotonin was determined via immunohistochemistry in LP lesions and in the control group skin using a monoclonal antibody to serotonin. Results: The skin biopsies of the LP patients had significantly higher levels of serotonin than those of the control subjects (p<0.001). In the LP patients, and there was a positive correlation between serotonin expression and LP severity (p=0.022). Based on the results from the BDI and BAI, there was a significant relationship between the severity of depression/anxiety and intensity of serotonin expression (p <0.001). Conclusion: Data from this study suggest that serotonin may have a possible role in the pathogenesis of LP. Further, the relationship between serotonin expression in acute cutaneous lesions and the depression/anxiety scores indicates that serotonin may be a mediator for the association of LP and depression/anxiety simultaneously. There is a need for more specific studies showing the expression of serotonin in the lichen planus to demonstrate the cause or effect.

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