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RISS 인기검색어
- 검색키워드
- 저자 : Geng-Ping ZHU (검색결과 4 건)
- 무료
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Physiological oxygen level is critical for modeling neuronal metabolism in vitro
Zhu, Jing,Aja, Susan,Kim, Eun‐,Kyoung,Park, Min Jung,Ramamurthy, Santosh,Jia, Junling,Hu, Xueying,Geng, Ping,Ronnett, Gabriele V. Wiley Subscription Services, Inc., A Wiley Company 2012 Journal of neuroscience research Vol.90 No.2
<P><B>Abstract</B></P><P>In vitro models are important tools for studying the mechanisms that govern neuronal responses to injury. Most neuronal culture methods employ nonphysiological conditions with regard to metabolic parameters. Standard neuronal cell culture is performed at ambient (21%) oxygen levels, whereas actual tissue oxygen levels in the mammalian brain range from 1% to 5%. In this study, we examined the consequences of oxygen level on the viability and metabolism of primary cultures of cortical neurons. Our results indicate that physiological oxygen level (5% O<SUB>2</SUB>) has a beneficial effect on cortical neuronal survival and mitochondrial function in vitro. Moreover, oxygen level affects metabolic fluxes: glucose uptake and glycolysis was enhanced at physiological oxygen level, whereas glucose oxidation and fatty acid oxidation were reduced. Adenosine monophosphate‐activated protein kinase (AMPK) was more activated in 5% O<SUB>2</SUB> and appears to play a role in these metabolic effects. Inhibiting AMPK activity with compound C decreased glucose uptake, intracellular ATP level, and viability in neurons cultured in 5% O<SUB>2</SUB>. These data indicate that oxygen level is an important parameter to consider when modeling neuronal responses to stress in vitro. © 2011 Wiley Periodicals, Inc.</P>
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Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report
Zhi-Yu Zhu,Yu Chen,Zhi-Gang Chu,Wei-Ping Zhang,Di Lv,Ning Geng,Ming-Zhong Yang 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.5
Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.
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Song, Bo,Choi, Ji Il,Zhu, Yuntong,Geng, Zhishuai,Zhang, Le,Lin, Ziyin,Tuan, Chia-chi,Moon, Kyoung-sik,Wong, Ching-ping American Chemical Society 2016 Chemistry of materials Vol.28 No.24
<P>Three phenylenediamine (PD) monomers, o-phenylenediamine (OPD), m-phenylenediamine (MPD), and p-phenylenediamine (PPD), were used to prepare the functionalized graphene (PD/rGO) networks. The results obtained from a series of chemical, thermal, and rheological analyses elucidated the mechanism of the covalent bonding and the existence of cross-linked graphene networks. The measured XRD patterns and molecular dynamic calculations discovered that those PPD and MPD molecules could enlarge graphene interlayer spacing to 1.41 and 1.30 nm, respectively, while OPD molecules were disorderly bonded or nonbonded to the basal planes of graphene layers, resulting in small and variable inter layer distances. The loadings of PD monomers were optimized to achieve superior supercapacitor performance. Electrochemical study showed that PPD/rGO exhibited the largest specific capacitance of 422 F/g with excellent cycling stability and low charge transfer resistance. The large variations in the capacitance values among PD/rGO networks with different PD monomers were explained by the difference in the graphene nanostructures, reversible redox transitions, and charge transfer characteristics. Particularly, density function theory calculations were adopted to compare electronic properties of the PD/rGO composites, including formation energy, electron density distribution, HOMO energy levels, and electron density of states near the Fermi level.</P>
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Li‐Na Pan,Feng-ZhuWANG,Xin-Yue ZHANG,Yan-Ni ZHAO,Geng-Ping ZHU,Min LI 한국곤충학회 2018 Entomological Research Vol.48 No.3
Heat shock proteins (HSPs) are known to be induced in response to various stress factors. Although HSPs have been studied in a number of insects, not much is known about HSPs in the natural enemies of insects, especially parasitoids. In this study, we identified and characterized five full‐length HSP genes (Cchsp40, Cchsp60, Cchsp70, Cchsp83, and Cchsp90) from an endoparasitic chalcid wasp, Chouioia cunea, which parasitizes the fall webworm, Hyphantria cunea pupae, a worldwide pest. The expression of Cchsps in response to temperature, pesticide stresses and UV radiation were also investigated by quantitative real‐time polymerase chain reaction (RT‐qPCR). The results showed that all five Cchsps were induced in response to hot and cold temperatures. Four pesticides induced the abundant expression of Cchsp70, Cchsp83 and Cchsp90 while ultraviolet radiation up‐regulated Cchsp40, Cchsp70, Cchsp83 and Cchsp90. These results indicate the different transcriptional profiles of the five different Cchsps in response to various abiotic stresses. The findings of this study provide insights into the response of C. cunea to abiotic stresses and insight into the use of this parasitoid in biological control strategies.
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