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- 검색키워드
- 저자 : Ganai, Bashir (검색결과 5 건)
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Shabir Ahmad Ganai 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
Histone deacetylases (HDACs) regulate geneexpression by creating the closed state of chromatin viahistone hypoacetylation. Histone acetylation deregulationcaused by aberrant expression of classical HDACs leads toimprecise gene regulation culminating in various diseasesincluding cancer. Histone deacetylase inhibitors (HDACi),the small-molecules modulating the biological function ofHDACs have shown promising results in inducing cellcycle arrest, differentiation and apoptosis in tumour models. HDACi do not show desired cytotoxic effect whenused in monotherapy due to triggering of various resistancemechanisms in cancer cells emphasizing the desperate needof novel strategies that can be used to overcome suchchallenges. The present article provides intricate detailsabout the novel HDACi dacinostat (LAQ-824) againstmultiple myeloma and acute myeloid leukaemia. The distinctmolecular mechanisms modulated by dacinostat inexerting cytotoxic effect against the defined malignancieshave also been detailed. The article also explains thestrategy that can be used to circumvent the conventionaltherapy resistant cases and for enhancing the therapeuticefficacy of dacinostat for effective anticancer therapy.
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Macroeconomic Response to Oil and Food Price Shocks: A Structural VAR Approach to the Indian Economy
Javed Ahmad Bhat,Aadil Ahmad ganaie,Naresh Kumar Sharma 한국국제경제학회 2018 International Economic Journal Vol.32 No.1
The study analyzed the dynamic impact of oil and food price shocks on the macroeconomy of India, using the monthly time series data from April 1994 to May 2016 in a structural vector autoregression (SVAR) framework. Being a net food exporter and net oil importer, the economy is found to face deleterious impacts of global oil and food price shocks on its macroeconomic performance. Output responds negatively to oil and food price hikes along with their volatility and positively to the fall in these prices. Inflation responds positively to all the three transformations of shocks with no signs of coming down, highlighting the price downward inflexibility in India. The study could not establish any evidence of negative demand shocks in face of oil and food price volatility. Central bank responds with a contractionary policy stance to negate the influences of external shocks. Forecast error variance decomposition points out the dominance of external shocks in influencing the domestic variables after their own shocks. Finally, the inflation downward rigidity is observed even in the long run.
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Free Radical Scavenging Activity of Elsholtzia densa
Misba Khan,Rabia Hamid,Showkat Ahmad Ganie,Ishfak Hussain Wani,Bashir Ahmad Ganai,Akbar Masood,Mohmmad Afzal Zargar,Akhter Hussain Malik 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.3
Medicinal plants have been used traditionally to cure variety of diseases from times immemorial. Elsholtzia densa, a rare annual herb of Kashmir valley was assessed for its antioxidant efficacy. Antioxidant activity of the crude extracts was evaluated using DPPH, DNA sugar damage, lipid peroxidation, FTC and hydrogen peroxide scavenging assays. The percentage decrease of 1, 1-diphenyl-2-picryl hydrazyl radical (DPPH) standard solution was recorded maximum for the 50% ethanolic extract (90.48%). The extracts were further evaluated using the thiobarbituric acid-reactive species (TBARS) assay. The methanolic extract showed the highest activity (32.02%) in reducing oxidative damage to DNA. The antioxidant activity of the extracts were also determined using linoleic acid system and the highest antioxidant activity of 49.64% was found in 50% ethanolic extract. In case of FTC assay, the 50% ethanolic extract showed the highest activity (70.14%) which was comparable to that of α-tocopherol. Moreover, total phenolics concentration was found to be 62.5mg% and 77.5mg% in case of absolute ethanolic and 50% ethanolic extracts, respectively. These findings indicate promising antioxidant activity of crude extracts of the plant and need further exploration for its effective use in both modern and traditional system of medicines.
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Bhat, Gulzar,Bhat, Ashaqullah,Wani, Aadil,Sadiq, Nida,Jeelani, Samoon,Kaur, Rajinder,Masood, Akbar,Ganai, Bashir Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Cancer is a complex disease and the genetic susceptibility to it could be an outcome of the inherited difference in the capacity of xenobiotic metabolizing enzymes. Glutathione-S-transferases (GSTs) are phase II metabolizing enzymes whose various genotypes have been associated with increased risk of different types of cancer. Null mutations caused by the deletion of the entire gene result in the absence of the enzymatic activity and increase in the risk of developing cancer including chronic myeloid leukaemia (CML). In the present case-control study we evaluated the effect of null mutations in GSTM1 and GSTT1 genes on the risk of developing CML. The study included 75 CML patients (43 males and 32 females; age (mean ${\pm}$ S.D) $42.3{\pm}13.4$ years) and unrelated non-malignant controls (76 male and 48 females; age (mean ${\pm}$ S.D) $41.5{\pm}12.9$). The distribution of GSTM1 and GSTT1 genotypes in CML patients and controls was assessed by multiplex-PCR method. Logistic regression was used to assess the relationship between GSTM1 and GSTT1 genotypes and risk of CML. Chi-square test was used to evaluate the trend in modulating the risk to CML by one or more potential high risk genotype. Although GSTM1 null genotype frequency was higher in CML patients (41%) than in the controls (35%), it did not reached a statistical significance (OD = 1.32, 95% CI: 0.73-2.40; P value = 0.4295). The frequency of GSTT1 null genotypes was higher in the CML patients (36%) than in the controls (21%) and the difference was found to be statistically significant (OD = 2.12, 95% CI: 1.12-4.02; P value = 0.0308). This suggests that the presence of GSTT1genotype may have protective role against the CML. We found a statistically significant (OD = 3.09, 95% CI: 1.122-8.528; P value = 0.0472) interaction between the GSTM1 and GSTT1 null genotypes and thus individuals carrying null genotypes of both GSTM1 and GSTT1 genes are at elevated risk of CML.
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Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir
Rasool, Sabha,Kadla, Showkat Ahmad,Khan, Tanzeela,Qazi, Falak,Shah, Nisar Ahmad,Basu, Javed,Khan, Bilal Ahmad,Ahktar, Qulsum,Sameer, Aga Syed,Ganai, Bashir Ahmad Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir.
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