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      • KCI등재

        Clinical characteristics and treatment outcomes of primary autoimmune hemolytic anemia: a single center study from South India

        Raghuveer Prabhu,Renjitha Bhaskaran,Veena Shenoy,Rema G,Neeraj Sidharthan 대한혈액학회 2016 Blood Research Vol.51 No.2

        BackgroundAutoimmune hemolytic anemia (AIHA) is a less recognized, potentially fatal condition. There is a scarcity of data on clinicoserological characteristics and response to therapy concerning this disease from South India.MethodsData for 33 patients with primary AIHA recorded from July 2009 to June 2015 were retro-spectively analyzed for clinical presentation, response to frontline therapy, durability of response, time to next treatment (TTNT), and response to second-line agents.ResultsThe median follow-up period was 50 months. Among 33 patients, 48% of the cases were warm autoimmune hemolytic anemia (WAIHA), 46% were cold agglutinin disease (CAD), and 6% were atypical. Three-fourth of patients had severe anemia (<8 g/dL hemoglobin [Hb]) at onset; younger patients (age <40 yr) had more severe anemia. All of the patients who required treatment received oral prednisolone at 1.5 mg/kg/d as a frontline therapy, and the response rate was 90% (62% complete response [CR] and 28% partial response [PR]). The overall response to corticosteroids in WAIHA and CAD was 87% and 92%, respectively. The median corticosteroid duration was 14 months, and 50% of the patients required second-line agents. Fourteen patients received azathioprine as a second-line agent, and 11 of these patients responded well, with half of them not requiring a third agent. Four patients developed severe infections (pneumonia, sepsis, and soft tissue ab-scess) and two had life-threatening venous thrombosis. One case of death was recorded.ConclusionAIHA is a heterogeneous disease that requires care by physicians experienced in treating these patients.

      • KCI등재

        Ventricular Tachycardia Ablation in Non-ischemic Cardiomyopathy

        Ashwin Bhaskaran,Kasun De Silva,Karan Rao,Timothy Campbell,Ivana Trivic,Richard G. Bennett,Eddy Kizana,Saurabh Kumar 대한심장학회 2020 Korean Circulation Journal Vol.50 No.3

        Non-ischemic cardiomyopathies are a heterogeneous group of diseases of the myocardium that have a distinct proclivity to ventricular arrhythmias. Of these, ventricular tachycardias pose significant management challenges with the risk of sudden cardiac death and morbidity from multiple causes. Catheter ablation of ventricular tachycardias is becoming an increasingly utilised intervention that has been found to have significant benefits with improving symptoms, reducing anti-arrhythmic drug burden and debilitating device therapies, thereby improving quality of life. Nonetheless, the approach to the ablation of ventricular tachycardias in non-ischemic cardiomyopathies is governed heavily by the disease process, with several distinct differences from ischemic cardiomyopathy including a preponderance to epicardial and deep intramural substrate. This contemporary review aims to present the various disease processes within non-ischemic cardiomyopathies, catheter ablation techniques which have been developed to target ventricular tachycardia and more novel adjunctive therapeutic measures.

      • KCI등재

        Letter : Site Suitability Assessment for Joint Forest Management (JFM)-a Geospatial Approach

        S. Jayakumar,A. Ramachandran,G. Bhaskaran,Joon Heo,Woo Sun Kim 大韓遠隔探査學會 2007 大韓遠隔探査學會誌 Vol.23 No.5

        Joint Forest Management (JFM) is a concept of developing partnerships between fringe forest user groups and the Forest Department (FD) on the basis of mutual trust and jointly defined roles and responsibilities with regard to forest protection and development. In India, JFM was started during 1992 and it was implemented in many states. However success rate of JFM activity was not promising. Though there are many factors attributed to the failures, one of the main factors is the JFM site. This paper deals with the significant ground works to be done before planning for JFM using recent technologies such as remote sensing (RS) and Geographic Information System (GIS). Also it deals with the advantages of weighted overlay analysis in selecting suitable sites for JFM taking into consideration the various criteria. As a result of weighted overlay analysis, there were four types of suitability classes viz., less, moderate, highly and un-suitable. The moderately suitable class occupied maximum area (13209.64 ha) than less and highly suitable classes. If JFM is implemented on the suitability area, then the failure could be avoided in the future.

      • KCI등재후보

        Forest Cover Change Detection Analysis in the Eastern Ghats of Tamil Nadu, India - a Remote Sensing and GIS Approach

        Jayakumar S.,Ramachandran A.,Bhaskaran G.,Lee Jung Bin 대한공간정보학회 2007 대한공간정보학회지 Vol.15 No.4

        대축척(1:50,000)지도의 산림 정보는 산림지역 보호에 중요한 자료로 이용된다. 그러나 대상지역인 인도 Tamil Nadu의 Eastern Ghats(EG) 지역에는 대축척 지도를 사용할 수 없기 때문에 위성 데이터를 이용한 산림의 변화 탐지를 적용하여 분석하였다. 대상지역의 1990년과 2003년의 산림의 변화에 대한 연구 결과 약 10가지의 산림 종류가 관측되었으며 가장 변화가 큰 지역은 상록수와 낙엽수지역에서 관측되었다. Information on forest type and cover density status of the present and past on large scale (1:50,000) is very much needed for conservation of any forest region. Such large-scale maps are not available for the Eastern Ghats (EG) of Tamil Nadu. This study deals with the preparation of forest type and cover density map of EG of Tamil Nadu during 2003 and the changes it has undergone between 1990 and 2003 using appropriate satellite data. About 10 forest types have been identified and mapped. Major changes have been observed in the forest types such as evergreen, and deciduous.

      • KCI등재

        Site Suitability Assessment for Joint Forest Management(JFM) - a Geospatial Approach

        Jayakumar, S.,Ramachandran, A.,Bhaskaran, G.,Heo, Joon,Kim, Woo-Sun The Korean Society of Remote Sensing 2007 大韓遠隔探査學會誌 Vol.23 No.5

        Joint Forest Management(JFM) is a concept of developing partnerships between fringe forest user groups and the Forest Department(FD) on the basis of mutual trust and jointly defined roles and responsibilities with regard to forest protection and development. In India, JFM was started during 1992 and it was implemented in many states. However success rate of JFM activity was not promising. Though there are many factors attributed to the failures, one of the main factors is the JFM site. This paper deals with the significant ground works to be done before planning for JFM using recent technologies such as remote sensing(RS) and Geographic Information System(GIS). Also it deals with the advantages of weighted overlay analysis in selecting suitable sites for JFM taking into consideration the various criteria. As a result of weighted overlay analysis, there were four types of suitability classes viz., less, moderate, highly and un-suitable. The moderately suitable class occupied maximum area(13209.64 ha) than less and highly suitable classes. If JFM is implemented on the suitability area, then the failure could be avoided in the future.

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