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Francisco J. Ortega,Francisco J. Navarro,Moisés García-Morales,Tony McNally 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-
Polymer modified bitumens (PMBs) have largely been utilized as a construction material. However, lackof affinity between bitumen and polymer leads to phase separation, and eventually, performancedepletion. In this paper, alternative formulations of bitumen with an organically-modified montmorillonite(OMMT) Cloisite 20A1 and polymeric methylene diphenyl diisocyanate (MDI) were prepared bymelt blending. Their comprehensive rheological characterisation evidenced improved linear viscoelasticproperties when OMMT is added, revealing a noticeable structural reinforcement and thermal stability. Rheological data also showed that MDI-involved reactions control the composite end properties, beinggreatly influenced by the shear conditions applied
A Fixed Start Scheduling Approach for Repetitive Construction Projects
Francisco Moreno,Francisco Orozco,Omar Rojas,Bolivar Senior,Mani Poshdar,Eric Forcael 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.6
In the face of the high variability in the completion of construction projects, the following research is generated. In the literature we can find several proposals to program projects, however, the variability of the activities causes high variability in the completion date of the projects. We hope that the proposed method, by controlling the start of activities, will ensure the completion date of the projects, by fixing the start of every activity with a high level of probabilistic confidence for the planned project duration. The proposed fixed start method (FSM) was tested in two case studies by using discrete event simulation. Project completion duration results were compared with the critical path method (CPM) and the program evaluation and review technique (PERT). Project completion was evaluated in the case studies by the coefficient of variance (COV), mean, and variance. The new method decreased the scheduled duration variability while meeting project completion times.
Nonlinear bending vibration of a prestressed thick plate
Francisco J. Nieves,Ana Bayón,Francisco Gascón,Rafael Medina,Félix Salazar 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.4
In this paper, the flexural vibration frequency in the antisymmetric mode of a thick plate as a function of the amplitude of the vibration and the axial force applied is investigated. With this aim, the theory of geometrically nonlinear deformation of second order and an optimized three-dimensional Ritz method are used. The plate is homogeneous, elastically linear, free from any constraints, and subjected to axial forces uniformly distributed on two of its opposite sides. Several approaches are discussed. First, the problem based on finite stress and infinitesimal strains is solved. Second, the deformation energy is assumed as the energy in the initial state plus the vibration energy of small or large amplitude. Third, without assumptions about the size of the deformation and of the vibration amplitude, the theory of nonlinear deformation is employed. Finally, numerical calculations for free vibration are compared with experimental results, including their systematic uncertainties.
del Toro, Francisco,Fern?ndez, F?tima Tena,Tilsner, Jens,Wright, Kathryn M,Tenllado, Francisco,Chung, Bong Nam,Praveen, Shelly,Canto, Tomas APS Press 2014 Molecular plant-microbe interactions Vol.27 No.12
<P>Potyvirus HCPro is a multifunctional protein that, among other functions, interferes with antiviral defenses in plants and mediates viral transmission by aphid vectors. We have visualized in vivo the subcellular distribution and dynamics of HCPro from Potato virus Y and its homodimers, using green, yellow, and red fluorescent protein tags or their split parts, while assessing their biological activities. Confocal microscopy revealed a pattern of even distribution of fluorescence throughout the cytoplasm, common to all these modified HCPros, when transiently expressed in Nicotiana benthamiana epidermal cells in virus-free systems. However, in some cells, distinct additional patterns, specific to some constructs and influenced by environmental conditions, were observed: i) a small number of large, amorphous cytoplasm inclusions that contained α-tubulin; ii) a pattern of numerous small, similarly sized, dot-like inclusions distributing regularly throughout the cytoplasm and associated or anchored to the cortical endoplasmic reticulum and the microtubule (MT) cytoskeleton; and iii) a pattern that smoothly coated the MT. Furthermore, mixed and intermediate forms from the last two patterns were observed, suggesting dynamic transports between them. HCPro did not colocalize with actin filaments or the Golgi apparatus. Despite its association with MT, this network integrity was required neither for HCPro suppression of silencing in agropatch assays nor for its mediation of virus transmission by aphids.</P>
Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study
Elena Maria Yubero-Serrano,Javier Delgado-Lista,Patricia Pena-Orihuela,Pablo Perez-Martine,Francisco Fuentes,Carmen Marin,Isaac Tunez,Francisco Jose Tinahones,Francisco Perez-Jimenez,Helen M Roche,Jos 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.6
Previous evidence supports the important role that oxidative stress (OxS) plays in metabolic syndrome (MetS)-related manifestations. We determined the relationship between the number of MetS components and the degree of OxS in MetS patients. In this comparative cross-sectional study from the LIPGENE cohort, a total of 91 MetS patients (43 men and 48women; aged between 45 and 68 years) were divided into four groups based on the number of MetS components: subjects with 2, 3, 4 and 5 MetS components (n¼20, 31, 28 and 12, respectively). We measured ischemic reactive hyperemia (IRH),plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), total nitrite, lipid peroxidation products (LPO), hydrogen peroxide (H2O2), superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities. sVCAM-1, H2O2 and LPO levels were lower in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. IRH and total nitrite levels were higher in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. SOD and GPx activities were lower in subjects with 2 MetS components than subjects with 4 or 5 MetS components. Waist circumference,weight, age, homeostatic model assessment-b, triglycerides (TGs), high-density lipoprotein and sVCAM-1 levels were significantly correlated with SOD activity. MetS subjects with more MetS components may have a higher OxS level. Furthermore, association between SOD activity and MetS components may indicate that this variable could be the most relevant OxS biomarker in patients suffering from MetS and could be used as a predictive tool to determine the degree of the underlying OxS in MetS.
BEAM T-JUNCTION MODEL ACCURACY IMPROVEMENT BASED ON EXPERIMENTAL MODAL ANALYSIS
Francisco Badea,JesusAngel Pere,JoseLuis Olazagoitia 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.6
For structural analysis of bus and coach tubular structures, finite element analysis with beam type elements is widely approved and utilized. These elements have an infinitely rigid behavior at the joint level, which represents an unrealistic stiffer estimation of the modeled structures. This cannot be neglected since it introduces stiffness variations when analyzing complex structures. To overcome this limitation, in this article an alternative beam T-junction model, in which 6 elastic elements are included at the joint level in order to improve the local stiffness behavior, is utilized. A new methodology to determine these 6 elastic constants is proposed, based on the analysis of the modal response differences between the beam model and the real prototype T-junctions. In this way, a completely new methodology for the determination of the rigidity of the elastic elements based on the analysis of the modal characteristics of these structures is presented. The methodology is validated against experimental modal analysis. The results show that using this methodology with the alternative beam T-junction model is possible to obtain a more accurate T-junction model with an average deviation from real models of less than 1.5%, and a maximum deviation among the studied modes of less than 4.