http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Federico Sinche (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
박광식,George Tuttle,Federico Sinche,Stacey L. Harper 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.1
The stability of citrate-capped silver nanoparticles(AgNPs) and the embryonic developmental toxicitywere evaluated in the fish test water. Serious aggregation ofAgNPs was observed in undiluted fish water (DM-100) inwhich high concentration of ionic salts exist. However,AgNPs were found to be stable for 7 days in DM-10,prepared by diluting the original fish water (DM-100) withdeionized water to 10 %. The normal physiology of zebrafishembryos were evaluated in DM-10 to see if DM-10can be used as a control vehicle for the embryonic fishtoxicity test. As results, DM-10 without AgNPs did notinduce any significant adverse effects on embryonicdevelopment of zebrafish determined by mortality, hatching,malformations and heart rate. When embryonic toxicityof AgNPs was tested in both DM-10 and in DM-100,AgNPs showed higher toxicity in DM-10 than in DM-100. This means that the big-sized aggregates of AgNPs werelow toxic compared to the nano-sized AgNPs. AgNPsinduced delayed hatching, decreased heart rate, pericardialedema, and embryo death. Accumulation of AgNPs in theembryo bodies was also observed. Based on this study,citrate-capped AgNPs are not aggregated in DM-10 and itcan be used as a control vehicle in the toxicity test of fishembryonic development.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
