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Faiyaz K. Shaikh,Prafull P. Gadge,Ashok A. Shinde,Manohar V. Padul,Manvendra S. Kachole 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.3
Here, we report multiple molecular forms of Albizia lebbeck trypsin inhibitors (AlTIs) by using a simple and sensitivegel X-ray film contact print technique. About 17 AlTIs were detected in the seed extracts of A. lebbeck. Twogroups of AlTIs—1 major (10 AlTIs; slow migration on the gel) and 1 minor (7 AlTIs; fast migration on the gel)were identified. The formerwas specific only toward trypsin. However, the latter was specific toward both trypsinand Helicoverpa armigera gut proteinases (HaGPs). The most potent AlTI (AlTI13) was purified to assess itsin vivo bioefficacy toward HaGPs. Purification was achieved using (NH4)2SO4 fractionation, Sephadex G-100 columnchromatography, and preparative native-polyacrylamide gel electrophoresis (PAGE). The dose dependentbioefficacies of AlTIs in the (NH4)2SO4 F3 fractions (0.1%, 0.5%, and 1%) were approximately 79%, 83%, and 90%,respectively, resulting in reductions in the average larval weight of H. armigera. Artificial diet containing a singledose of AlTI13 (5 μg/g diet) reduced the larval weight by about 76%, with 60% mortality. The half-maximal inhibitoryconcentrations (IC50) of AlTI13 for trypsin and HaGPs were 0.14 and 0.17 μmol/ml, respectively. The optimumconditions for AlTI13 were pH 8 and temperatures ranging from 35 to 40 °C. Reducing sodium dodecylsulfate-PAGE analysis indicated that ~28 kDa Kunitz-like trypsin inhibitor was present. Thus, we showed thatAlTIs, particularly, AlTI13 of A. lebbeck could be used as a transgene macromolecule to markedly increase insectresistance in genetically engineered plants.
Faiyaz Shakeel,Nazrul Haq,Fars K. Alanazi,Ibrahim A. Alsarra 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.56 No.-
The solubility of apremilast (APM) in different “Transcutol1+ water” cosolvent mixtures was determined and correlated at “T = 298.2 K–318.2 K” and ‘p = 0.1 MPa’. The experimental solubilities of APM were determined and correlated with “Apelblat, van’t Hoff, Yalkowsky and Jouyban–Acree equations”. The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 102 at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of APM.
In-situ X-ray micro-diffraction study of the metal–insulator phase transition in VO2 particles
Faiyaz Mohd,Ha Sung Soo,Oh Hojun,Choi Sukjune,Noh Do Young,Kang Hyon Chol 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.3
We report on the structural transformation of VO2 particles from the insulating monoclinic to the metallic rutile phase using in-situ synchrotron X-ray diffraction (XRD) in a grain-orientation-specific manner using a two-dimensional X-ray pixel detector. The XRD data averaged in all grain orientations corresponding to a typical powder XRD profile show that the transition occurred over a broad temperature range of about 8.9 K. However, we found that the transition temperature and range of individual grains vary greatly. We attribute the broadness of the transition in the averaged profile to this variance of the transition temperature among grains. Consistently, the transition was much sharper in the nanoparticle specimen with much fewer grains than the bulk powder specimen. To understand the intrinsic physical characteristics of VO2 , it is necessary to carefully analyze the data of the bulk system and it is preferable to study the VO2 single crystal.
Yadav, Deepak,Anwar, Mohammad Faiyaz,Garg, Veena,Kardam, Hemant,Beg, Mohd Nadeem,Suri, Suruchi,Gaur, Sikha,Asif, Mohd Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing adverse effects in normal body sites. In this study, we developed a polymeric nano drug carrier for safe delivery of the paclitaxel to the cancer that releases the drug in a sustained manner and reduces side effects. N-isopropylacrylamide/vinyl pyrrolidone (NIPAAm/VP) nanoparticles were synthesized by radical polymerization. Physicochemical characterization of the polymeric nanoparticles was conducted using dynamic light scattering, transmission electron microscopy, scanning electron microscopy and nuclear magnetic resonance, which confirmedpolymerization of formulated nanoparticles. Drug release was assessed using a spectrophotometer and cell viability assays were carried out on the MCF-7 breast cancer and B16F0 skin cancer cell lines. NIPAAm/VP nanoparticles demonstrated a size distribution in the 65-108 nm range and surface charge measured -15.4 mV. SEM showed the nanoparticles to be spherical in shape with a slow drug release of ~70% in PBS at $38^{\circ}C$ over 96 h. Drug loaded nanoparticles were associated with increased viability of MCF-7 and B16F0 cells in comparison to free paclitaxel. Nano loaded paclitaxel shows high therapeutic efficiency by sustained release action for the longer period of time, i increasing its efficacy and biocompatibility for human cancer therapy. Therefore, paclitaxel loaded (NIPAAm/VP) nanoparticles may provide opportunities to expand delivery of the drug for clinical selection.
Akshay P. Ware,Faiyaz K. Shaikh,Archana N. Panche,Sanjay N. Harke 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1
Gut proteases are accountable for survival of Helicoverpa armigera on protein rich parts of plant devastating many important agricultural crops. The aim of present study was to identify potential natural compounds having inhibitory potency against Helicoverpa armigera gut proteases. We have modeled structure of H. armigera serine protease (UniProt ID: O18447) and analyzed its interactions with maslinic acid (Zinc ID: ZINC38140521). A 3D model was generated using bovine trypsin in complex with analogues of sunflower inhibitor 1 as template with the help of Chimera Modeler 1.11. The PROCHECK and Modfold analysis have revealed 81.8% of residue in favored region. The POOL and COACH analysis have revealed 18 amino acids in the active site. In the 10 ns MD simulations of modeled structure, the RMSD of the protein backbone increased slightly and later stabilized from 7 ns to 10 ns. The modeled structure was stabilized at gyration distance of about 1.65 nm at 7 ns. Potential hit compounds from the ZINC database identified in this study showed good inhibitory bindings with modeled structure. Among these compounds maslinic acid, a plant based pentacyclic triterpenes was found to be potent lead compound with good binding affinity (−9.5 kcal/mol). RMSD profile was < 0.45 nm for complex with stabilization at about 18,000 ps (18 nm) suggesting stable interaction. This work demonstrates reasonable in silico inhibitory action of maslinic acid against H. armigera serine protease and depicts utility of in silico methodologies for designing competent strategies against dreaded insect pests like H. armigera.
Gamal A. Shazly,Nazrul Haq,Faiyaz Shakeel 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
Solution thermodynamics and solubility of glibenclamide(GBN) in binary co-solvent mixtures of Transcutol? water at temperature range of 298.15–333.15 Kwere investigated in present study. The modified Apelblatmodel was used to predict the solubility of GBN in co-solventmixtures at various temperatures. The highest andlowest solubility of GBN were observed in pure Transcutoland pure water, respectively. Moreover, all co-solvent mixtureshad highest solubility at 333.15 K. The experimentalsolubility data of GBN was correlated well with the modifiedApelblat model at each temperature studied with relativeabsolute deviation in the range of 0.008–5.903 %. The correlationcoefficients in co-solvent mixtures were observed inthe range of 0.995–0.999 which indicated good fitting ofexperimental data with calculated one. The enthalpies andentropies for GBN dissolution were observed in the range of2.012–38.215 kJ mol-1 and 6.748–114.709 J mol-1 K-1,respectively indicating its dissolution is endothermic and anentropy-driven process. These results indicated that Transcutolcan be used as a co-solvent in preformulation studiesand formulation development of GBN.
Robi-10 Minute School: The Future of the Largest Classroom of Bangladesh
Md. Ridhwanul Haq,Sibbir Riyan,Mahir Hossain,Akibur Rahman,Faiyaz Uddin Ayeshik,null null Academy of Asian Business (AAB) 2020 Academy of Asian Business Review Vol.6 No.2
The case study aims to explore the exponential rise of Robi-10 Minute School and seek a complete business model for the online platform that teaches 1 million students. Riddled with poverty, insufficient infrastructure, and inefficient administration, the macroeconomic condition and the education landscape of Bangladesh are similar to those of major South Asian countries. Hence, the case firstly traces the development of Robi- 10 Minute School from a mere Facebook page to the largest online classroom of Bangladesh. Secondly, it will investigate the major milestones that transformed 10 Minute School. The milestones will uncover how to pioneer online education in Asian countries with low internet penetration. Thirdly, it will further undercover the prime success factors. In doing so, the case will exemplify how low-fund startups can harness the power of communities to drive reach and growth. Fourthly, we sought to unearth the current and future challenges of 10 Minute School and what future steps the company is undertaking to combat those challenges. Moreover, the future outlook also presents how one can leverage networks to expand beyond boundaries. Finally, the case offers further recommendations that will demonstrate how to channel expertise in the education industry to enter related industries and create a solid revenue model in the process. Understanding how 10 Minute School overcame and turned common Asian challenges into prospects can provide a general guideline for booming Asian EdTech startups who are struggling with inadequate funding, incomplete revenue model, and unfavorable macro factors.
Hard X-ray von Hamos Spectrometer for Single-Pulse Emission Spectroscopy
Muhammad Ijaz Anwar,Sung Soo Ha,Byung-Jun Hwang,Seonghyun Han,Maverick S. H. Oh,Mohd Faiyaz,Do Young Noh,Hyon Chol Kang,Sunam Kim 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.75 No.7
We developed a hard X-ray spectrometer for the purpose of measuring X-ray emission spectrum excited by using single X-ray free electron laser (XFEL) pulses. A highly oriented pyrolytic graphite (HOPG) crystal was placed in the von Hamos geometry to focus X-rays of the equal energy on a specific point in detector plane. The spectrometer was tested at PAL-XFEL using Ni and NiO films. The Ni $K_{\beta_{13}}$ X-ray emission line excited by using a single X-ray pulse was successfully resolved. If the much weaker Ni $K_{\beta_{25}}$line is to be observed, data must be accumulated with a few thousands of X-ray pulses. The spectrometer energy resolving power, E/$\Delta E$, was estimated to be 7500. This spectrometer can be utilized to conduct various X-ray emission and absorption measurements using XFELs.