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권강범,김은경,문형철,송용선,류도곤 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1
The aim of this study was to investigate the cytotoxic effect and its mechanism on Radix Aconiti(RA) extract in lung cancer cell lines. RA extract treatment decreased the cell viability in a dose-dependent fashions in lung cancer cells including A549, H460, H23 and H157 cells. Many investigators reported that A549 and H460 cells expressed wild-type p53, but H23 and H157 cells preserved mutated p53. After treatment with RA extract in A549 and H460 cells, we measured the expression of p53 protein levels using Western blot, analysis. In both cells treated with RA extracts, p53 protein expressions were increased in a dose-dependent manner. In our experiments, RA extracts also have cytotoxic effects in H23 and H157, which have mutated p53. Treatment with RA extract decreased bcl-2 protein expressions in both cells. These results suggest that RA extracts have cytotoxic effects via p53 expression increase and bcl-2 inhibitable pathways in A549, H460 cells and H23, H157 cells, respectively.
김성범,서정주,곽철훈,김상민,이보라,민선경,황은구,김용인,조욱현,최석구 인제대학교 2008 仁濟醫學 Vol.29 No.-
Lutembacher's syndrome is rare combination of mitral stenosis (MS) and atrial septal defect (ASD). The hemodynamic interplay between the MS and ASD leads to wide variation of clinical presentation. Here we describe a 43-year-old female with Lutembacher's syndrome and tricuspid regurgitation with pulmonary hypertension, who underwent direct closure of ASD and tricuspid valvuloplasty successfully. We also reviewed other literatures in an effort to increase awareness of this condition.
다치 논리 회로를 이용한 32 × 32 Modified Booth 승산기
이은실,김정범 강원대학교 정보통신연구소 2002 정보통신논문지 Vol.6 No.-
Current mode CMOS multiple-valued logic circuits have various applications in digital signal processing and computing. This paper proposes new multiple-valued current mode CMOS integrated circuits for high-density arithmetic systems. The proposed 32×32 modified Booth multiplier using Radix-4 algorithm give the improved operation speed by using the elimination method of sign-bit extension at the most upper bit of each row. This circuit is simulated with HSPICE under 0.35㎛ CMOS standard technology, 10㎂ unit current, and 3.3V VDD voltage. The simulation results shows the satisfying characteristics.
다상 교호 승압컨버터의 인덕터 커플링에 따른 소신호 교류 해석
장은승,신휘범 慶尙大學校 經營行政大學院 2004 工學硏究院論文集 Vol.20 No.-
This paper addresses the small-signal ac analysis of the multi-phase interleaved boost converter with the coupled inductors operated in the continuous inductor current mode. The analytical expressions for the transfer functions of interest are derived for various inductor couplings. The dynamic characteristics are analyzed according to the inductor couplings and verified experimentally.
비산재 중에 함유된 중금속의 용출특성에 관한 연구(1)
이우근,김진범,김은미 江原大學校 附設 環境硏究所 1997 環境硏究 Vol.14 No.-
The secondary environmental contamination is now feared by the land-fill treatment os fly ash from MSWI. It is urgently necessary to study the development of a proper technology for fly ash. considering the governmental plan for enhancing the rate of incineration. The leaching characteristics of MSWI ash were analyzed for pH, L/S ratio and leaching time in our study. According to the result, pH was decreased as the leaching time elapsed. The amounts of leached heavy metal were affected by L/S ratio. pH is the most important among the factors for affecting the amounts. Therefore, the leaching experiment must be excuted under the pseudo-actual condition(actual pH at the land-fill site)evaluating the risk.
손창식,권강범,김상범,이호승,서은아,이호섭,류도곤 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.2
In order to elucidate toxic mechanism of myocardial damage and protective effect of herbal extract, Dansamyeum (丹參飮) against cytotoxic effect of xanthine oxidase/hypoxanthine(XO/HX) and cardioprotective effect of Dansamyeum (丹參飮) were examined by MTT assay and heart beating rate after cultured myocardial cells derived from neonatal mouse were treated with various concentrations of XO/HX, a free radical. The results of these experiments were fellows : XO/HX, a oxygen radical, decreased the survial rate on MTT assay in cultured myocardial cells. Dansmyeum(丹參欲) water extract have efficacy of increasing heart beating rate decreased by XO/HX in cultured myocardial cells. Radix Salviae Miltiorrhizae and Lignum Santali Album water extract have efficacy of increasing heart beating rate decreased by XO/HX in cultured myocardial cells. From above the results, it is suggested that XO/HX showed toxic effect in cultured myocardial cell derived from neonatal mouse and herbal extract such as Dansamyeum(丹參飮) is very effective in the prevetion of XO/HX cardiotoxicity. Key ward : Dansamyeum(丹參飮), Xanthine Oxidase/Hypoxanthine(XO/HX), myocardial Cell, Radix Salviae Miltiorrhizae, Lignum Santali Album, MTT, beating rate
서정석,류은정,이상미,한미희,최귀순,손인기,남범우 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-
Purpose: IS prelminary study was designed to assess the clinical variables influencing on the ward atmosphere in psychiatric closed ward and to promote the quality of psychiatric inpatient treatment. Method: 41 psychiatric inpatients were selected in Chung-ju hospital, Konkuk university. Ward Atmosphere Scale(W AS) was used to evaluate patients' perception of ward milieu. WAS score were compared among subgroups with respect to the clinical variables such as duration of admission, frequency of admission, and diagnosis. Results: Significantly, patients who have hospitalized for 1 month to 2 months reported lower score of WAS and patients who have hospitalized for longer than 2 months reported higher score of WAS. The relationship between educated levels and WAS score was not significant. First admitted patients reported significantly lower score of WAS. Bipolar patients reported significantly higher score of WAS and alcohol related patients reported significantly lower score of WAS. Conclusion: The 1st admitted patients, patients with alcohol problem and educated patients were had less satisfied with psychiatric closed ward. Thus, by considering these factors, more specified therapeutic approach and plan should be conducted.
월경전증후군의 진단분류학적 개념 및 원인과 치료 : Nosology, Etiology, and Treatment
문석우,서정석,류은정,남범우 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Since the emergence of the term premenstrual syndrome (PMS) in the 1950s, PMS has become an increasingly discussed topic in popular media sources. Thus self management techniques are easily accessed by women through the media or through their peers. Premenstrual dysphoric disorder (PMDD) comprises extremely distressing emotional and behavioral symptoms. Women with PMDD report premenstrual symptoms, primarily mood symptoms, that are severe enough to seriously interfere with their life style and relationships and usually do not respond to conservative and conventional interventions. Although women with PMS are most often seen in primary care or by their obstetricians/gynecologists, the result of recent study suggested a high rate of missed diagnoses. The premenstrual syndromes include the more common PMS, the less prevalent PMDD, and menstrual psychosis. The etiology of PMS and PMDD is still largely unknown. That PMS and PMDD are primarily biological phenomena is underscored by recent, convincing evidence. Therapeutic interventions for PMS and PMDD range from the conservative to treatment with psychotropic medication and, for the more extreme cases, hormonal therapy or surgical procedures.
김병수,장성종,부귀범,조운택,박찬국,김만우,변주남,김정용,전호종 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1
Small bowel leiomyoma is a rare tumor which may occur wherever smooth muscle is present. The small bowel is the most common site and it makes up 20~30% of all benign small intestinal neoplasms. A spectrum of symptoms are common ranging from nausea, vomiting, abdominal pain, to massive intestinal bleeding. Bleeding is the most common symptom and is usually gross and recurrent. Occasionally it may be life threatening. But, the most serious problem is both the absence of specific clinical symptoms, and the difficulties shown in radiological diagnostics of the small bowel. If conventional diagnostic methods fail to reveal any positive findings for gastrointestinal bleeding, the diagnosis of intestinal leiomyoma should be suspected and an SMA angiography shoud be performed. The angiographic criteria of small bowel leiomyoma is very characteristic. We present a case of leiomyoma with considerable and prolonged gastrointestinal bleeding, which was diagnosed by angiography. A 61-year old woman was admitted with a history of melena over the last 10 days. An SMA angiography showed a hypervascular mass with a diameter of 3×3cm. A segmental resection was performed under the impression of the gastrointestinal bleeding due to leiomyoma of the small bowel. Microscopic examination of the lesion shows interlacing or whorl bundles of spindle shaped ces and no mitosis.