Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis

Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1

<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>

外貨換算會計에 대한 硏究

金議植 대구산업정보대학 1998 논문집 Vol.12 No.1

In accordance with internationalization of enterprise management, a new research problem of accounting for foreign currencies has been brought about in the field of accounting to measure and communicate the economic phenomena concerning the enterprise activity. The accounting for foreign currencies is a process to designate the title of accounts denominated and measured in foreign currencies into domestic currencies using the exchange rate. In generally, accounting for the translation of foreign currency has two directions. First, it is problem to reflect foreign currencies stated asset and liability which is resulted from our domestic firm's translation in financial statement. Second, it is the problem to reflect foreign currencies stated financial statement of oversea branch in parent company's financial statement. To solve that kind of problem, I used litereture on research method and compared the foreign currency translation of Korea with that of U.S.A In U.S.A Current-Non current method was officially accepted in 1953 and Menetary-Non monetary method in 1965. Temporal method was accepted in 1975. and Funtional currency method was accepted in 1983. In Korea, Menetary-Non monetary method was accepted in 1974 and modified four times till 1988. Our accounting standards adopt Menetary-Non monetary method for domestic firm's translation and current rate method for foreign subsidiary company's translation. The purpose of this study is to suggest the directions to improve present accounting standards of Korea. The result of this study is as follows. First, our accounting standards should be considered the characteristics of oversea operation and should be applied to proper exchange rate. Second, our accounting standards should be accorded with International accounting standards which will be accepted with more common agreement, because our economy is globalized. Thrid, It is more proper to apply to sole translation method for the translation of over ser branch foreign currency financial statement. Four, It is more proper to adopt temporal method than monetary- non monetary method for the translation of oversea branch foreign currency statement. Five, our accounting standards should be provided proper information which can be used as expetive measure for economic exposure. For that, our accounting standards must enlarge the scope of disclosure.

새로운 세파로스포린 유도체의 합성과 항균력에 관한 연구

박의석,김하정,최원식,황선암 순천향대학교 기초과학연구소 1996 순천향자연과학연구 논문집 Vol.2 No.1

New cephalosporin antibiotics, 7-[(3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl 1-oxide) -acetamido]-3-heterocyclothiomethyl-3-cephem-4-carboxylic acid derivatives (2a-2d) were synthesized. Anti-bacterial activities of these new cephalosporin derivatives and the relationship between their stucture and their activities were examined. Among them, 7-[3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4- thiazin-3-yl1-oxide)acetamido]-3-[(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid exhibited the broad antibacterial activities against Gram(+) and Gram(-) bacteria.

초등학교 수학에서 계산기 사용이 아동의 수학 학습력 및 성향에 미치는 영향

김의식, 최창우 대구교육대학교 과학교육연구소 2012 과학·수학교육연구 Vol.35 No.-

신라 중위제의 추이와 지배신분층의 변화

서의식 한국역사연구회 2003 역사와 현실 Vol.- No.50

Silla had the system of multiple official ranks; Nama, Great-Nama, and Achan, The system was designed to restrict the lower-class to a certain rank, and promoted them to upward-rank by its multiple ranks. This thesis explores the transition of the Multiple official Rank System of Silla in 6-7th centuries. One of its main proposals is that the transition of Nama's multiple ranks, from 7 ranks to 9 ranks, was the result of the complete provision of the Silla official Rank System to 17 ranks. Another is that the change of applied-rank of that system, from Great-Nama to Achan, was the result of the transition of the ruling class from 'Khan, the Captain of small region' to 'Jingol, the member of royalty ; its meaning is the real bone class'. First, Nama (later, Great-Nama) was the highest rank for the non-Khan class. Second, Achan was the highest rank for the non-Jingol class. The first restriction taking precedence over the second, 'Jingol' came to seize the ruling power. The rank to which the multiple official rank system was applied was always one. And it's transition is the evidence of the change of the ruling class of Silla. This procedure witnessed the appearance of royal families and 6th Head-Grade Class as a political system.

菟絲子 의效能에 대한 硏究

진상식,황의현,김형창,김천수,오광수,한종현 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

The purpose of this study is to determine the effect of Semen Cuscutae on phenylephrine(PE) and KCI induced contraction of isolated rat thoracic aorta. Contractile force was measured with force displacement transducer under 1.5 g loading tension. Contraction evoked by PE (ED_(50)) was relaxed significantly by Semen Cuscutae. The mean percent relaxing of PE induced contraction was 60.6% (p<0.01) after 300 ㎕/㎖ Semen Cuscutae, but the mean percent contraction of KCI induced contraction was 10.4% (p<0.05) after 300 ㎕/㎖ Semen Cuscutae. Vasorelaxation by Semen Cuscutae was significantly reduced after with and without endothelial cells. Pretreatment of aortic rings with L-NAME (100 μM), a nitric oxide synthase inhibitor, indomethacin (3 μM), an inhibitor of cyclooxygenase, methylene blue (10 μM), guanylyl cyclase inhibitor, propranolol (1 μM), a β-adrenoceptor antagonist, atropine (1 μM), a muscarinic receptor antagonist and diltiazem (10 μM), a Ca^(2+)-channel blocker was recovered the effect aorta. These results indicate that Semen Cuscutae can relax EP induced contraction of isolated rat thoracic aorta and that this increasing contraction related to epithelium and various effect.

공동주택 하자의 유형과 예방에 관한 연구

김의식,안민재 朝鮮大學校 建設技術硏究所 1999 建設技術硏究 Vol.19 No.2

This study classifies the types of the defects to 8,442 households among 10th and 22nd floors of 81 apartment houses at 19 apartment house construction sites constructed in Kwangju and Chonnam regions from March 1997 to March 1999 and makes them the data. The defects on based to the classified data is divided into each type including construction finish work, installation work, and electrical work. Then they are analyzed. The results is represented following: In the incidence of defects in each area of apartment houses, of total 42,211 defect cases, construction part is represented 33,051 cases(78.3%), installation part 4,981 cases(ll.8%) and electrical part 4,179(9.9%). In the defect found in construction work, wood windows are represented most(17.2%), followed by papering(23.8%), floor materials(l3.3%) and tile(7.1%). Also the defects of installation work are found in sanitary instruments(51.1%), heating apparatus(29.1%), piping(7.2%), and heating pipes(7.296). The defects of electrical work are shown in illumination equipments(57.6%) and piping systems(34.2%). First, as a means to prevent the defect in apartment house construction on based to this results. quality control system should be complemented and the production control system in each process should be introduced. It is considered that a potential of defect can be reduced through the reinforcement of production management in each process with quality control of finished buildings. Second, for preventing the occurrence of defect in apartment house Construction, it is necessary for constructor to select superior construction company in determining contractors, to have willingness of construction with good quality. Trough it, the more synergy will can create in respect with the managerial and supervisory. Third, construction of apartment houses accompanies many processes and the delay of construction period is frequently caused by irrational process management and the conflict between process and process. Therefore it is considered difficult having traffic line in construction work due to the process conflict and the delay of construction period. Also, it is considered that causes the defects of construction work. So it should be prepare alternatives log adjusting construction period through periodical calculation of processes.

建設工事 入札制度의 實態와 改善方向에 關한 硏究

김의식,김창범 朝鮮大學校 建設技術硏究所 1999 建設技術硏究 Vol.19 No.3

The bid and contract system of public sector with such a great scale prepared the various bid systems to prevent the waste of budget according to the highest bid price, but it has not achieved the actual effects in the rapidly changing domestic and overseas environment according to the globalization and openness. Therefore, this study examines the major bid and contract systems of domestic construction works and their changes, compares and analyzes the them to foreign conditions and aims at minimizing the operational problems in the current bid and contract system and presenting the improvement methods for the settlement of fair order. This research is not focused on settling the current problems, but seeks the developmental directions for the standardization of bid and contract system. The suggestions of this research are made as follows; First, the specialization of ordering agency is improved through the cultivation of private professionals and the operation of professional education system and the extended right of discretion is given to the ordering agency with the introduction of dispersed ordering system and the legalization of the various ordering methods. Second, the survey price of actual transaction is reflected as the estimated price through the improvement of government cost calculation system to achieve the rationalization of the estimated price calculation. Third, the incentive system, a kind of value engineering of a new technology, should be legalized for the improvement of competitiveness through the encouragement of the will to develop a new technology and construction and technical ability, escaping from the price centered current system. Fourth, the number of selecting the proper companies is reduced to under 10 companies as the PQ system related improvement method, the computerized system of ordering agencies is prepared, the regular qualification screening is conducted, the work efficiency by the screening system of each case is maximized and the simplification of administrative procedures is pursued.

監理業務의 問題點을 通한 CM制度 發展方案에 關한 硏究

김의식,안민재,문종희 朝鮮大學校 建設技術硏究所 1999 建設技術硏究 Vol.19 No.3

This study compares and analyzes foreign construction management systems and CM according to the actual conditions of domestic supervision system and the introduction of CM system, draws the problems of supervision system with the engineers and technicians at construction work site and presents the improvement methods. The service adjustment is required to execute CM service according to the selection of ordering company with the maintenance of current responsible supervision system rather than to replace the current system in consideration of the service, nature and application objects of construction project management system, and the division of construction supervision to the type of consortium with construction company rather than only by supervision company will be desirable. In addition, faulty work is prevented and competitiveness to foreign construction companies in the time of openness of construction market can be secured by achieving EC(Engineering Construction) function through the unification of designand construction work. As the developmental stages for the settlement of CM, first package introduction of CM of design and construction work is developed and the service range of CM should be extended with the progress of EC. And CM type construction method which CM company controls the whole services from the survey of a project validity to final maintenance should be introduced, and in the early period of its introduction, joint venture or consortium with foreign construction companies should be devised and after accumulating know-how, sole CM project should be progressed. For the successful introduction and development of CM, the cultivation of CMr(Construction Manager) with the handing capacity from project planning to maintenance and management stage is necessary. The training and cultivation methods of such CMr include overseas field survey for the personnels having rich experiences and know-how and high-level CMr education, education of business administration-centered project control and special education. Also for the cultivation of special CMr, the acquisition of promising foreign qualifications is recommended to overseas construction engineers.

관계특성, 협력, 그리고 성과간 관계에 대한 연구 : 의약품유통경로를 중심으로

김의식 대구산업정보대학 2000 논문집 Vol.14 No.1

Cooperation is a neglected topic of research among marketers. Yet, Cooperation is required if a behavior system is to act as a unit. Marketing channels cannot function without sustained cooperation in which each party knows what to expect from his opposite number. The purpose of this study is to propose strategic implication to wholesalers who must play an important part in medicine distribution channel by analyzing the interrelationships among relationship characteristics, cooperation, and performance. Data were collected from pharmacists at work in the pharmacy stores located in Teagu and Kyungbuck province. Results are as follows; First, relationalism, trust, and dependence were significantly and positively related to cooperation, but reward power had no effect on cooperation. Second, cooperation had no effect on performance. Implication is as follow; Medicine wholesalers can induce pharmacies' cooperation by enhancing the relationship with them and becoming trustful and dependable channel partner. When Pharmacies are more cooperated with wholesalers than manufacturers, Pharmaceutical companies will concentrate on production and wholesalers on distribution. Based on the aboved discussion, the conclusion can be reached that the unification of medicine distribution channel will be established.