Poster Session : PS 0160 ; Diabetes : Qt Dispersion: Comparison Between Type 2 Diabetic with Microalbuminuria Positive and Negative Patients

( Esma Altunoglu ),( Mustafa Boz ),( Cuneyt Muderrisoglu ),( Fusun Erdenen ),( Ender Ulgen ),( Mustafa Duran ),( Nurcan Ozbas ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: It is shown that the variability of distance between QT derivations in twelve derivation ECG; is risk factor for sudden death as a predictor of cardiovascular mortality in both diabetic and general population. Diabetic nephropathy is one of the most common complication of diabetes. The purpose was to investigate the relationship between QT parameters and microalbumin/creatinine ratio; as an indicator of endothelial function and a cardiovascular risk factor. Methods: 100 patients were included our study who were follow up Istanbul Education and Research Hospital Diabetes Outpatient Clinic. 50 patients whose microalbumin/ creatinine ratio less than 30 mg/dl and ages between 36 and 77 years were chosen as control group; 50 patients whose microalbumin/ creatinine ratio between 30- 300 mg/dl and ages between 36 and 79 years were chosen as patient group. The QT interval was measured on the 12-lead resting ECG. QTd was calculated automatically using special software. Results: In patients group QTC min median value was higher; 380,63(361,44-397,30), (p=0,042),QTC max median value was significantly higher; 439,63(420,17-460,22), (p=0,005) and microalbumin/creatinine value 82(60-300), (p=0,0001) was very signifi cantly higher than control group. There was no signifi cant difference QTC dispersion median value 61,25(49,91-81,70, (p=0,066) in both groups. Also a good correlation in positive direction between QTC dispersion values and microalbumin/creatinine value was determined. Conclusions: We researched the relation between microalbumin/creatinine ratio and QTd levels in type 2 diabetic patients. QTc max period was determined signifi cantly high in the group with microalbumin/creatinine between 30-300 mg/dl (p<0,05). As a result of this correlation QT prolongation can be use as a contributory parameter for prediction of cardiovascular risk. This study make us that QTd can be used as early indicator of cardiovascular risk in diabetic patients who aren`t in microalbuminuric stage yet.

Effect of polymer addition on air void content of fine grained concretes used in TRCC

Esma Gizem Daskiran,Mehmet Mustafa Daskiran,Mustafa Gencoglu 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.20 No.2

Textile Reinforced Cementitious Composite (TRCC) became the most common construction material lately and have excellent properties. TRCC can be employed in the manufacture of thin-walled facade elements, load-bearing integrated formwork, tunnel linings or in the strengthening of existing structures. These composite materials are a combination of matrix and textile materials. There isn\'t much research done about the usage of polymer modified matrices in textile reinforced cementitious composites. In this study, matrix materials named as fine grained concretes (dmax 1.0 mm) were investigated. Air entraining effect of polymer modifiers were analyzed and air void content of fine grained concretes were identified with different methods. Aim of this research is to study the effect of polymer modification on the air content of fine grained concretes and the role of defoamer in controlling it. Polymer modifiers caused excessive air entrainment in all mixtures and defoamer material successfully lowered down the air content in all mixtures. Latex polymer modified mixtures had higher air content than redispersible powder modified ones. Air void analysis test was performed on selected mixtures. Air void parameters were compared with the values taken from air content meter. Close results were obtained with tests and air void analysis test found to be useful and applicable to fine grained concretes. Air void content in polymer modified matrix material used in TRCC found significant because of affecting mechanical and permeability parameters directly.

Reidemeister torsion and orientable punctured surfaces

Esma Dirican,Yasar Sozen 대한수학회 2018 대한수학회지 Vol.55 No.4

Let $\Sigma_{g,n,b}$ denote the orientable surface obtained from the closed orientable surface $\Sigma_g$ of genus $g\geq2$ by deleting the interior of $n\geq 1$ distinct topological disks and $b\geq 1$ points. Using the notion of symplectic chain complex, the present paper establishes a formula for computing Reidemeister torsion of the surface $\Sigma_{g,n,b}$ in terms of Reidemeister torsion of the closed surface $\Sigma_{g},$ Reidemeister torsion of disk, and Reidemeister torsion of punctured disk.

Agomelatine versus Sertraline: An Observational, Open-labeled and 12 Weeks Follow-up Study on Efficacy and Tolerability

Esma Akpınar,Cem Cerit,Anıl Talas,Ümit Tural 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.4

Objective: In this open-labeled, 12 weeks follow-up study, we aimed to compare the efficacy and tolerability of agomelatine with sertraline Methods: The outpatients of adult psychiatry clinic who have a new onset of depression and diagnosed as ‘major depressive episode’ by clinician according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition and prescribed agomelatine (25 mg/day) or sertraline (50 mg/day) were included in the study. Results: The decline of mean Montgomery-Asberg Depression Rating Scale (MADRS) scores of agomelatine group was significantly higher than the sertraline group at the end of 2nd week; however, the difference was not significant at the end of 3 months. Mean Clinical Global Impression-Improvement scale (CGI-I) scores of agomelatine group was lower than sertraline group at first week. Mean CGI-Severity scale and CGI-I scores were favour to sertraline group at the end of the study. Remission rates were 46.7% for sertraline group and 33.3% for agomelatine group while response rates were 76.7% for both groups. Any patient from agomelatine group dropped-out due to adverse effects. The amount of side effects was also less with agomelatine. Conclusion: Agomelatine has a rapid onset efficacy on depressive symptoms and this can be beneficial for some critical cases. Considering MADRS scores, agomelatine seems to have similar efficacy with sertraline but we also point the need for long term studies since CGI scores were favour to sertraline group at the end of the study. Agomelatine has a favourable tolerability profile both in terms of discontinuation and the amount of side effects compared to sertraline.

Development of fine grained concretes for textile reinforced cementitious composites

Esma Gizem Daskiran,Mehmet M. Daskiran,Mustafa Gencoglu 사단법인 한국계산역학회 2016 Computers and Concrete, An International Journal Vol.18 No.2

A new innovative composite material is textile reinforced cementitious composite (TRCC). To achieve high flexural performance researchers suggest polymermodification of TRCCmatrices. In this study, nine readymix repair mortars commonly used in construction industry and the production of TRCC elements were examined. Mechanical properties such as compressive and flexural strength, drying shrinkage were studied. Being a significant durability concern, alkali silica reaction tests were performed according to related standards. Results showed that, some ready repair mortar mixes are potentially reactive due to the alkali silica reaction. Two of the ready mortar mixes labelled as non-shrinkage in their technical data sheets showed the highest shrinkage. In this experiment, researchers designed new matrices. These matrices were fine grained concretes modified with polymer additives; latexes and redispersible powders. Two latexes and six redispersible powder polymers were used in the study. Mechanical properties of fine grained concretes such as compressive and flexural strengthswere determined.Results showed that some of the fine grained concretes cast with redispersible powders had higher flexural strength than ready mix repair mortars at 28 days. Matrix composition has to be designed for a suitable consistency for planned production processes ofTRCCandmechanical properties for load-carrying capacity.

Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome?

Deveci, Esma Ozturk,Incebiyik, Adnan,Selek, Salih,Camuzcuoglu, Aysun,Hilali, Nese Gul,Camuzcuoglu, Hakan,Erdal, Mehmet Emin,Vural, Mehmet The Korean Society for Reproductive Medicine 2014 Clinical and Experimental Reproductive Medicine Vol.41 No.2

Objective: The objective of this study was to investigate whether there was a correlation between catechol-o-methyltransferase (COMT) gene polymorphism, which is believed to play a role in the etiology of psychotic disorders, and premenstrual syndrome (PMS). Methods: Fifty-three women with regular menstrual cycles, aged between 18 and 46 years and diagnosed with PMS according to the American Congress of Obstetrics and Gynecology criteria were included in this study as the study group, and 53 healthy women having no health problems were selected as the controls. Venous blood was collected from all patients included in the study and kept at $-18^{\circ}C$ prior to analysis. Results: There was no significant difference between the groups in terms of demographic features such as age, body mass index, number of pregnancies, parity, and number of children. No statistically significant difference was observed in terms of COMT gene polymorphism (p=0.61) between women in the PMS and the control groups. However, a significant difference was found between arthralgia, which is an indicator of PMS, and low-enzyme activity COMT gene (Met/Met) polymorphism (p=0.04). Conclusion: These results suggested that there was no significant relationship between PMS and COMT gene polymorphism. Since we could not find a direct correlation between the COMT gene polymorphism and PMS, further studies including alternative neurotransmitter pathways are needed to find an effective treatment for this disease.

The Outcome of Fungal Pneumonia with Hematological Cancer

Eren Esma,Alp Emine,Cevahir Fatma,Tok Tuğba,Kılıç Ayşegül Ulu,Kaynar Leylagül,Yüksel Recep Civan 대한감염학회 2020 Infection and Chemotherapy Vol.52 No.4

Background: Fungal pneumonia is a common infectious complication of hematological cancer (HC) patients. In this retrospective study, the objective was set to identify the risk factors and outcome of fungal pneumonia in adult HC patients. Materials and Methods: This retrospective study was conducted with adult (>16 years) HC patients from January 2017 and December 2018. Results: During the study period, of 181 patients included 76 were diagnosed with fungal pneumonia. The most common HC was identified as acute myeloid leukaemia (40%). Of the participating patients, 52 (29%) were hematopoietic stem cell transplant (HSCT) recipients. The median age of patients with fungal pneumonia was significantly greater: 57 vs. 48 (odds ratio [OR]: 1.08) and they had longer hospitalization durations (OR: 1.14). Overall, 37 patients (20%) died, and 28-day mortality was significantly greater among patients with fungal pneumonia than without fungal pneumonia (33% vs. 11%). The most significant risk factors for mortality in fungal pneumonia were identified as need of intensive care unit (ICU) (OR: 191.2, P <0.001) and the need of vasopressor support (OR:81.6, P <0.012). ICU-mortality was (88%). Conclusion: Fungal pneumonia is a lethal complication in HC patients. Intensive care need is the most important predictive factor for mortality

REIDEMEISTER TORSION AND ORIENTABLE PUNCTURED SURFACES

Dirican, Esma,Sozen, Yasar Korean Mathematical Society 2018 대한수학회지 Vol.55 No.4

Let ${\Sigma}_{g,n,b}$ denote the orientable surface obtained from the closed orientable surface ${\Sigma}_g$ of genus $g{\geq}2$ by deleting the interior of $n{\geq}1$ distinct topological disks and $b{\geq}1$ points. Using the notion of symplectic chain complex, the present paper establishes a formula for computing Reidemeister torsion of the surface ${\Sigma}_{g,n,b}$ in terms of Reidemeister torsion of the closed surface ${\Sigma}_g$, Reidemeister torsion of disk, and Reidemeister torsion of punctured disk.

Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer

Yagdi Efe, Esma,Mazumder, Aloran,Lee, Jin-Young,Gaigneaux, Anthoula,Radogna, Flavia,Nasim, Muhammad Jawad,Christov, Christo,Jacob, Claus,Kim, Kyu-Won,Dicato, Mario,Chaimbault, Patrick,Cerella, Claudia Elsevier 2017 Cancer letters Vol.410 No.-

<P><B>Abstract</B></P> <P>Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binders, validated by <I>in cellulo</I> α-tubulin degradation. BRAF(V600E)-mutated HT-29 cells were resistant to DBTTS, as evidenced by mitotic arrest for 48 h prior to apoptosis induction compared to KRAS(G12V)-mutated SW480/620 cells, which committed to death earlier. The prolonged mitotic block correlated with autophagy impairment and p62 protein accumulation in HT-29 but not in SW480/620 cells, whereas siRNA-mediated p62 inhibition sensitized HT-29 cells to death. <I>In silico</I> analysis with 484 colorectal cancer patients associated higher p62 expression and reduced autophagic flux with greater overall survival. Accordingly, we hypothesized that DBTTS targets CRC survival/death through autophagy interference in cell types with differential autophagic capacities. We confirmed the therapeutic potential of DBTTS by the inhibition of spheroid and colony formation capacities in CRC cells, as well as in HT-29 zebrafish xenografts <I>in vivo</I>.</P>

Bacteremia in Hematopoietic Stem Cell Recipients Receiving Fluoroquinolone Prophylaxis: Incidence, Resistance, and Risk Factors

Eryilmaz-Eren Esma,Izci Feyza,Ture Zeynep,Sagiroglu Pinar,Kaynar Leylagul,Ulu-Kilic Aysegul 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.3

Background Bacteremia is a common complication in hematopoietic stem cell transplant (HSCT) recipients. Prophylactic fluoroquinolone is recommended and used in these individuals. Breakthrough infections can occur with fluoroquinolone-resistant strains. We aimed to identify the incidence, resistance, and risk factors for bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Materials and Methods This retrospective study was performed on patients who received fluoroquinolone prophylaxis and underwent autologous and allogeneic HSCT between 2015 and 2019. The incidence of bacteremia, comorbidity, treatment, and invasive procedures was compared in these patients with and without bacteremia. Results There were 553 patients included in the study, 68 (12.3%) had bacteremia. The incidence of bacteremia is 8.2% of autologous HSCT recipients and 18.4% of allogeneic HSCT recipients. The significant risk factors associated with bacteremia were steroid-using (odds ratio [OR]:13.83, 95% confidence interval [CI]: 2.88 - 66.40), higher Charlson Comorbidity Index (CCI)-mean (OR: 1.57, 95% CI: 1.15 - 2.16), diabetes mellitus (OR: 4.29, 95% CI: 1.11 - 16.48) in autologous HSCT, steroid-using (OR: 6.84, 95% CI: 1.44 - 32.33), longer duration of neutropenia (OR: 1.05, 95% CI: 1.01 - 1.09) using central venous catheter (OR: 7.81, 95% CI: 1.00 - 61.23) in allogeneic HSCT. Seventy-three pathogens were isolated from a total of 68 bacteremia episodes. The most commonly occurring agents were Escherichia coli, Klebsiella pneumoniae and Enterococcus spp. Resistance to fluoroquinolones was 87.2%, 70.0% and 60.0% among these strains, respectively. Conclusion High CCI, diabetes mellitus, use of steroids and long-term neutropenia and use of central venous catheters were significantly associated with the breakthrough bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Fluoroquinolone prophylaxis may reduce the incidence of bacteremia but may select strains resistant to fluoroquinolone. Background Bacteremia is a common complication in hematopoietic stem cell transplant (HSCT) recipients. Prophylactic fluoroquinolone is recommended and used in these individuals. Breakthrough infections can occur with fluoroquinolone-resistant strains. We aimed to identify the incidence, resistance, and risk factors for bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Materials and Methods This retrospective study was performed on patients who received fluoroquinolone prophylaxis and underwent autologous and allogeneic HSCT between 2015 and 2019. The incidence of bacteremia, comorbidity, treatment, and invasive procedures was compared in these patients with and without bacteremia. Results There were 553 patients included in the study, 68 (12.3%) had bacteremia. The incidence of bacteremia is 8.2% of autologous HSCT recipients and 18.4% of allogeneic HSCT recipients. The significant risk factors associated with bacteremia were steroid-using (odds ratio [OR]:13.83, 95% confidence interval [CI]: 2.88 - 66.40), higher Charlson Comorbidity Index (CCI)-mean (OR: 1.57, 95% CI: 1.15 - 2.16), diabetes mellitus (OR: 4.29, 95% CI: 1.11 - 16.48) in autologous HSCT, steroid-using (OR: 6.84, 95% CI: 1.44 - 32.33), longer duration of neutropenia (OR: 1.05, 95% CI: 1.01 - 1.09) using central venous catheter (OR: 7.81, 95% CI: 1.00 - 61.23) in allogeneic HSCT. Seventy-three pathogens were isolated from a total of 68 bacteremia episodes. The most commonly occurring agents were Escherichia coli, Klebsiella pneumoniae and Enterococcus spp. Resistance to fluoroquinolones was 87.2%, 70.0% and 60.0% among these strains, respectively. Conclusion High CCI, diabetes mellitus, use of steroids and long-term neutropenia and use of central venous catheters were significantly associated with the breakthrough bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Fluoroquinolone prophylaxis may reduce the incidence of bacteremia but may select strains resistant to fluoroquinolone.