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        • KCI등재SCOPUS

          Melatonin Treatment Against Remote Organ Injury Induced by Renal Ischemia Reperfusion Injury in Diabetes Mellitus

          Ersin,Fadillioglu,Zehra,Kurcer,Hakan,Parlakpinar,Mustafa,Iraz,Cebrail,Gursul 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6

          Oxidative stress may have a role in liver damage after acute renal injury due to various reasons such as ischemia reperfusion (IR). Diabetes mellitus (DM) is an important disease for kidneys and may cause nephropathy as a long term complication. The aim of this study was to investigate protective effect of melatonin, a potent antioxidant, against distant organ injury on liver induced by renal IR in rats with or without DM. The rats were divided into six groups: control (n=7), DM (n=5), IR (n=7), DM+IR (n=7), melatonin+IR (Mel+IR) (melatonin, 4 mg/ kg during 15 days) (n=7), and Mel+DM+IR groups (n=7). Diabetes developed 3 days after single i.p. dose of 45 mg/kg streptozotocin. After 15 day, the left renal artery was occluded for 30 min followed 24 h of reperfusion in IR performed groups. DM did not alter oxidative parameters alone in liver tissue. The levels of malondialdehyde, protein carbonyl and nitric oxide with activities of xanthine oxidase and myeloperoxidase were increased in liver tissues of diabetic and non-diabetic IR groups. Nitric oxide level in DM was higher than control. The activities of catalase and superoxide dismutase were increased in IR groups in comparison with control and DM. ALT and AST levels were higher in IR and DM+IR groups than control and DM. Melatonin treatment reversed all these oxidant and antioxidant parameters to control values as well as serum liver enzymes. We concluded that renal IR may affect distant organs such as liver and oxidative stress may play role on this injury, but DM has not an effect on kidney induced distant organ injury via oxidant stress. Also, it was concluded that melatonin treatment may prevent liver oxidant stress induced by distant injury of kidney IR. Oxidative stress may have a role in liver damage after acute renal injury due to various reasons such as ischemia reperfusion (IR). Diabetes mellitus (DM) is an important disease for kidneys and may cause nephropathy as a long term complication. The aim of this study was to investigate protective effect of melatonin, a potent antioxidant, against distant organ injury on liver induced by renal IR in rats with or without DM. The rats were divided into six groups: control (n=7), DM (n=5), IR (n=7), DM+IR (n=7), melatonin+IR (Mel+IR) (melatonin, 4 mg/ kg during 15 days) (n=7), and Mel+DM+IR groups (n=7). Diabetes developed 3 days after single i.p. dose of 45 mg/kg streptozotocin. After 15 day, the left renal artery was occluded for 30 min followed 24 h of reperfusion in IR performed groups. DM did not alter oxidative parameters alone in liver tissue. The levels of malondialdehyde, protein carbonyl and nitric oxide with activities of xanthine oxidase and myeloperoxidase were increased in liver tissues of diabetic and non-diabetic IR groups. Nitric oxide level in DM was higher than control. The activities of catalase and superoxide dismutase were increased in IR groups in comparison with control and DM. ALT and AST levels were higher in IR and DM+IR groups than control and DM. Melatonin treatment reversed all these oxidant and antioxidant parameters to control values as well as serum liver enzymes. We concluded that renal IR may affect distant organs such as liver and oxidative stress may play role on this injury, but DM has not an effect on kidney induced distant organ injury via oxidant stress. Also, it was concluded that melatonin treatment may prevent liver oxidant stress induced by distant injury of kidney IR.

        • KCI등재SCIESCOPUS

          Clinical and Prognostic Features of Erionite-Induced Malignant Mesothelioma

          Ersin,Demirer,Elamin,M.,Elamin,Christian,F.,Ghattas,Mohamed,O.,Radwan 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.2

          This review analytically examines the published data for erionite-related malignantpleural mesothelioma (E-MPM) and any data to support a genetically predisposedmechanism to erionite fiber carcinogenesis. Adult patients of age ≥18 years with erionite-related pleural diseases and genetically predisposed mechanisms to erionite carcinogenesis were included, while exclusion criteria included asbestos- or tremolite-related pleural diseases. The search was limited to human studies though not limited to a specific timeframe. A total of 33 studies (31042 patients) including 22 retrospective studies, 6 prospective studies, and 5 case reports were reviewed. E-MPM developed in some subjects with high exposures to erionite, though not all. Chest CT was more reliable in detecting various pleural changes in E-MPM than chest X-ray, and pleural effusion was the most common finding in E-MPM cases, by both tests. Bronchoalveolar lavage remains a reliable and relatively less invasivetechnique. Chemotherapy with cisplatin and mitomycin can be administered either alone or following surgery. Erionite has been the culprit of numerous malignantmesothelioma cases in Europe and even in North America. Erionite has a higher degree of carcinogenicity with possible genetic transmission of erionite susceptibilityin an autosomal dominant fashion. Therapeutic management for E-MPM remains very limited, and cure of the disease is extremely rare.

        • SCOPUSSCIEKCI등재

          Evaluation of anxiety level changes during the first three months of orthodontic treatment

          Ersin,Yıldırım,and,Seniz,Karacay 대한치과교정학회 2012 대한치과교정학회지 Vol.42 No.4

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Objective: To determine the changes in dental anxiety, state anxiety, and trait anxiety levels of patients and their parents after 3 months of active orthodontic treatment. Methods: We evaluated 120 patients and one parent of each patient. State Anxiety (STAI-S), Trait Anxiety (STAI-T), and Corah s Dental Anxiety Scale (DAS) were administered before orthodontic treatment (T1) and after 3 months of treatment (T2). Differences in scores between T1 and T2 were compared using paired-sample t-tests and the relationship between the scores of the DAS and the STAI were analyzed using a bivariate two-tailed Pearson correlation test. Results: Dental anxiety and state anxiety levels decreased among the patients after adjustment to orthodontic treatment (p < 0.001). However, 3 months of treatment was not sufficient to decrease the anxiety levels of parents (p > 0.05). Patient trait anxiety affected patient state anxiety and dental anxiety (p < 0.01). Additionally, a significant correlation was found between patient dental anxiety and parent dental anxiety (p < 0.05). Conclusions: Dental anxiety and state anxiety levels decrease after patients become familiar with their orthodontist and they became accustomed to orthodontic treatment. However, 3 months is not a sufficient length of time to decrease parental anxiety levels. [Korean J Orthod 2012;42(4):201-206]

        • KCI등재SCOPUS

          Minimum dynamic response of cantilever beams supported by optimal elastic springs

          Ersin,Aydin 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.3

          In this study, optimal distribution of springs which supports a cantilever beam is investigated to minimize two objective functions defined. The optimal size and location of the springs are ascertained tominimize the tip deflection of the cantilever beam. Afterwards, the optimization problem of springs is set up to minimize the tip absolute acceleration of the beam. The Fourier Transform is applied on the equation of motion and the response of the structure is defined in terms of transfer functions. By using any structural mode, the proposed method is applied to find optimal stiffness and location of springs which supports a cantilever beam. The stiffness coefficients of springs are chosen as the design variables. There is an active constraint on the sum of the stiffness coefficients and there are passive constraints on the upper and lower bounds of the stiffness coefficients. Optimality criteria are derived by using the Lagrange Multipliers. Gradient information required for solution of the optimization problem is analytically derived. Optimal designs obtained are compared with the uniform design in terms of frequency responses and time response. Numerical results show that the proposed method is considerably effective to determine optimal stiffness coefficients and locations of the springs.

        • KCI등재SCIESCOPUS

          Effect of chitosan/carbon nanotube fillers on vibration behaviors of drilled composite plates

          Ersin,Demir,Hasan,Çallıoğlu,Metin,Sayer,Furkan,Kavla 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.35 No.6

          The effect of Chitosan (CS), Carbon Nanotube (CNT) and hybrid (CS-CNT) fillers on the natural frequency of drilled composite plate is investigated by experimentally in this study. The numerical validation is also made with a program based on Finite Element Method (SolidWorks). Nine types filled and one neat composite plates are used in the study. The fillers ratios are 1% CS, 2% CS, 3% CS, 0.1% CNT, 0.2% CNT, 0.3% CNT, 1% CS+0.3% CNT, 2% CS+0.3% CNT, 3% CS+0.3% CNT. The specimens cut to certain sizes by water jet from the plates 400 mm x 400 mm in dimensions. Some of them are drilled in certain dimensions with drill. The natural frequency of each specimen is measured by the vibration test set up to determine the vibration characteristic. The vibration test set up includes an accelerometer, a current source power unit, a data acquisition card and a computer. A code is written in Matlab program for the signal processing. The study are investigated and discussed in four main points to understand the effect of the fillers on the natural frequency of the composite plate. These are the effect of fillers contents and amounts, orientation angles of fibers, holes numbers and holes sizes. As results, the natural frequency of the plate with 1% CS and 0.1% CNT hybrid filler is lower than those of the plates with other fillers ratios for 45 orientation angle. Besides, in the composite plate with 0 orientation angle, the natural frequency increases with increasing the filler ratio. Moreover, the natural frequency increases until a certain hole number and then it decreases. Furthermore, the natural frequency is not affected until a certain hole diameter but then it decreases.

        • KCI등재SCOPUS

          Elasto-plastic thermal stress analysis of functionally graded hyperbolic discs

          Ersin,Demir,Hasan,Çallıoğlu,Metin,Sayer 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.5

          The objective of this analytical study is to calculate the elasto-plastic stresses of Functionally Graded (FG) hyperbolic disc subjected to uniform temperature. The material properties (elastic modulus, thermal expansion coefficient and yield strength) and the geometry (thickness) of the disc are assumed to vary radially with a power law function, but Poisson's ratio does not vary. FG disc material is assumed to be non-work hardening. Radial and tangential stresses are obtained for various thickness profile, temperature and material properties. The results indicate that thickness profile and volume fractions of constituent materials play very important role on the thermal stresses of the FG hyperbolic discs. It is seen that thermal stresses in a disc with variable thickness are lower than those with constant thickness at the same temperature. As a result of this, variations in the thickness profile increase the operation temperature. Moreover, thickness variation in the discs provides a significant weight reduction. A disc with lower rigidity at the inner surface according to the outer surface should be selected to obtain almost homogenous stress distribution and to increase resistance to temperature. So, discs, which have more rigid region at the outer surface, are more useful in terms of resistance to temperature.

        • KCI등재SCOPUS

          Paliperidone Palmitate-induced Urinary Incontinence: A Case Report

          Ersin,Hatice,Karslıoglu,Elvan,Özalp,Ali,Çayköylü 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Urinary incontinence, although rarely reported, is one of the most important adverse effects of antipsychotic medication. It can be an embarrassing, distressing, and potentially treatment-limiting. Several antipsychotics, including both typical and atypical varieties, are known to induce urinary incontinence. Many antipsychotic drugs target the neural pathways controlling continence by binding to receptors of some neurotransmitters such as serotonin, dopamine, acetylcholine, and adrenaline. Pharmacological management of incontinence should be considered if there is a risk of cessation of the antipsychotic therapy or any decline in patients' compliance. Amitriptyline, desmopressin, ephedrine, and anticholinergics such as oxybutynin and trihexyphenidyl are the most frequently used agents to treat incontinence. We think that the frequency of incontinence is higher than reported in the literature, and that follow-up routines should include a form of standardized screening for all possible adverse effects, including incontinence, of any given antipsychotic. In this article, we report a case of urinary incontinence as an adverse effect of paliperidone palmitate use during maintenance therapy in a patient with schizophrenia.

        • KCI등재SCIESCOPUS

          A study on natural frequencies and damping ratios of composite beams with holes

          Ersin,Demir 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.21 No.6

          In this study, free vibration and damping characteristics of composite beams with holes are investigated, experimentally and numerically. Two types of samples with different fabrics are used: unidirectional and woven. The effects of diameter, number and location of circular holes on the vibration characteristics of composite beams are examined. The effects of rotation angle and minor to major diameter ratio of the elliptical hole are also investigated numerically. Moreover, the mode shapes of all types of beams are obtained numerically. According to the results, the natural frequency decreases with increasing hole diameter but increases very little with increasing the distance between the hole center and the clamped end. Damping ratio decreases by increasing the diameter of hole. But it fluctuates by increasing the diameters of holes of beam having three holes. Furthermore it decreases by increasing the distance between hole center and clamped end except for the range 50 mm to 100 mm.

        • KCI등재SCOPUS

          Vibration and damping behaviors of symmetric layered functional graded sandwich beams

          Ersin,Demir 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.6

          In this study, free vibration and damping behaviors of multilayered symmetric sandwich beams and single layered beams made of Functionally Graded Materials were investigated, experimentally and numerically. The beams were composed of Aluminum and Silicon Carbide powders and they were produced by powder metallurgy. Three beam models were used in the experiments. The first model was isotropic, homogeneous beams produced by using different mixing ratios. In the second model, the pure metal layers were taken in the middle of the beam and the weight fraction of the ceramic powder of each layer was increased towards to the surfaces of the beam in the thickness direction. In the third model, the pure metal layers were taken in the surfaces of the beam and the weight fraction of the ceramic powder of each layer was increased towards to middle of the beam. Then the vibration tests were performed. Consequently, the effects of stacking sequence and mixing ratio on the natural frequencies and damping responses of functionally graded beams were discussed from the results obtained. Furthermore, the results obtained from the tests were supported with a finite-element-based commercial program, and it was found to be in harmony.

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