http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Endler (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors
Li Chen,Alexander Endler,Futoshi Shibasaki 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.12
The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are modulated by several pro- and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have been established as the basic and major inducers of angiogenesis, but understanding the role of interacting proteins is becoming increasingly important to elucidate the angiogenic processes of a hypoxic response. In particular, with regard to wound healing and the novel therapies for vascular disorders such as ischemic brain and heart attack, it is essential to gain insights in the formation and regulation of HIF transcriptional machineries related to angiogenesis. Further, identification of alternative ways of inhibiting tumor growth by disrupting the growth-triggering mechanisms of increasing vascular supply via angiogenesis depends on the knowledge of how tumor cells develop their own vasculature. Here, we review our findings on the interactions of basic HIFs, HIF-1α and HIF-2α, with their regulatory binding proteins, histone deacetylase 7 (HDAC7) and translation initiation factor 6 (Int6), respectively. The present results and discussion revealed new regulatory interactions of HIF-related mechanisms. The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are modulated by several pro- and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have been established as the basic and major inducers of angiogenesis, but understanding the role of interacting proteins is becoming increasingly important to elucidate the angiogenic processes of a hypoxic response. In particular, with regard to wound healing and the novel therapies for vascular disorders such as ischemic brain and heart attack, it is essential to gain insights in the formation and regulation of HIF transcriptional machineries related to angiogenesis. Further, identification of alternative ways of inhibiting tumor growth by disrupting the growth-triggering mechanisms of increasing vascular supply via angiogenesis depends on the knowledge of how tumor cells develop their own vasculature. Here, we review our findings on the interactions of basic HIFs, HIF-1α and HIF-2α, with their regulatory binding proteins, histone deacetylase 7 (HDAC7) and translation initiation factor 6 (Int6), respectively. The present results and discussion revealed new regulatory interactions of HIF-related mechanisms.
-
Raphael J. Hochstrasser,P. Christian Endler,Sabine D. Klein 사단법인약침학회 2015 Journal of Acupuncture & Meridian Studies Vol.8 No.4
So far, most research attempts to explain the mechanism of the action of acupuncture have focused mostly on mechanically-triggered active factors and have produced inconclusive findings. In this study, we investigate whether acupuncture might also involve nonmechanical, nonpsychological active factors originating in the therapist. In 30 individuals, an acupuncture needle was inserted in the acupoint PC6 using a special device without touching the needle. A second device was used to fix the needle rigidly in place, excluding any mechanical transmission of movement from the handle to the needle's tip. Each participant was exposed in random order to a control and a stimulation phase. During the stimulation phase, the free needle's end was held by the therapist to allow the transmission of Qi; during the control phase, it was left untouched. Participants' subjective sensations during the stimulation phase and the control phase were recorded using a questionnaire. Twenty-two of 28 (79%; p = 0.003) test participants believed that they had received stimulation when it had actually been performed, and 26 (93%; p < 0.001) sensed differences between the two experimental phases. Thus, participants were able to sense the transmission of therapeutic Qi in the absence of mechanical or psychological factors.
-
<i>Arabidopsis</i> ABCG14 is essential for the root-to-shoot translocation of cytokinin
Ko, Donghwi,Kang, Joohyun,Kiba, Takatoshi,Park, Jiyoung,Kojima, Mikiko,Do, Jihye,Kim, Kyung Yoon,Kwon, Mi,Endler, Anne,Song, Won-Yong,Martinoia, Enrico,Sakakibara, Hitoshi,Lee, Youngsook National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.19
<P>Cytokinins are phytohormones that induce cytokinesis and are essential for diverse developmental and physiological processes in plants. Cytokinins of the <I>trans</I>-zeatin type are mainly synthesized in root vasculature and transported to the shoot, where they regulate shoot growth. However, the mechanism of long-distance transport of cytokinin was hitherto unknown. Here, we report that the <I>Arabidopsis</I> ATP-binding cassette (ABC) transporter subfamily G14 (<I>AtABCG14</I>) is mainly expressed in roots and plays a major role in delivering cytokinins to the shoot. Loss of <I>AtABCG14</I> expression resulted in severe shoot growth retardation, which was rescued by exogenous <I>trans</I>-zeatin application. Cytokinin content was decreased in the shoots of <I>atabcg14</I> plants and increased in the roots, with consistent changes in the expression of cytokinin-responsive genes. Grafting of <I>atabcg14</I> scions onto wild-type rootstocks restored shoot growth, whereas wild-type scions grafted onto <I>atabcg14</I> rootstocks exhibited shoot growth retardation similar to that of <I>atabcg14</I>. Cytokinin concentrations in the xylem are reduced by ∼90% in the <I>atabcg14</I> mutant. These results indicate that AtABCG14 is crucial for the translocation of cytokinin to the shoot. Our results provide molecular evidence for the long-distance transport of cytokinin and show that this transport is necessary for normal shoot development.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
