Influence of Serum VEGF Levels on Therapeutic Outcome and Diagnosis/Prognostic Value in Patients with Cervical Cancer

Du, Ke,Gong, Hong-Ying,Gong, Zhi-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Objective: To explore the influence of serum vascular endothelial growth factor (VEGF) level on therapeutic outcome and diagnosis/prognostic value in patients with cervical cancer. Materials and Methods: A total of 37 patients diagnosed with cervical cancer by biopsy were selected and treated with concurrent chemoradiotherapy. Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was adopted before treatment to assess VEGF levels, and its relationships with clinicopathological features and short-term therapeutic effects were analyzed. Results: The median VEGF level in 37 patients before treatment was 647.15 (393.35~1125.16) pg/mL. Serum VEGF levels in patients aged <50 years, in International Federation of Gynecology and Obstetrics (FIGO) stage IIIa~IVa, with lymph node metastasis and tumor size >4 cm were significantly increased (P<0.05). The complete remission (CR) rate was 48.7% (18/37), partial remission (PR) rate was 35.1% (13/37), stable disease (SD) rate was 13.5% (5/37) and progressive disease (PD) rate was 2.70% (1/37), so the objective remission rate (ORR) after treatment was 83.8% (31/37). Logistic regression analysis showed that tumor size and serum VEGF level before treatment were independent risk factors affecting the therapeutic outcome, and the higher the level of serum VEGF, the worse the prognosis when tumor size>4 cm. Some 56.8% of patients manifested with myelosuppression, 37.8% with leucopenia, 24.3% with thrombocytopenia, 5.41% with diarrhea, 46.0% with nausea and vomiting, 21.6% with hair loss and 8.11% with hepatic and renal injury during the treatment. Conclusions: Serum VEGF level may reflect the degree of malignancy of cervical cancer and predict therapeutic effect, which is of great importance to cancer diagnosis and prognosis.

지각과민 완화제 함유 치약의 노출 상아세관 폐쇄효과에 대한 주사 전자현미경적 관찰

송덕한,김종여,정진형 단국대학교 치의학연구소 1995 논문집 Vol.7 No.1

After root surface denudation due to periodontitis or periodontal surgery, many patients complain of hypersensitivity. The main reason for this is thought to be, opening of dentinal tubules after denudation of dentin. Thus, the sealing effect on dentinal tubules of denuded root surfaces by desensitizing agent containing dentifrice, which is commonly used to relieve and restrain hypersensitivity, was observed. To do this the premolars of healthy humans were curettaged and etched to open dentinal tubules and then desensitizing agent containing dentifrice was applied to the root surface and observed with SEM. The results are as following. 1. On the control group, opened dentinal tubules could be seen on the root surface. 2. In the group applied with microcrystalline HA containing dentifrice, all the opened dentinal tubules and the root surface were obstructed and dentifrice covered the entire surface of the root. 3. In the group applied with strontium chloride containing dentifrice, obstruction of the opened dentinal tubule on the root surface could also be seen. 4. In the group applied with desensitizing agent containing dentifrice, besides showing obstruction of all the dentinal tubules, root surface covered with even thickness of dentifrice could also be seen.

경찰의 지식관리가 조직유효성에 미치는 영향

정덕영 한국경찰학회 2003 한국경찰학회보 Vol.5 No.2

지식기반사회와 학습 사회의 도래로 경찰조직은 다양한 변화의 요구에 놓여있다. 우리나라의 경찰에 대한 개선의 노력도 지속되어 왔다. 다양한 경찰조직의 개선방안이 실험되어 왔으나, 이 연구는 지식관리에 초점을 두었다. 지식관리는 지식기반시대에 적응하기 위해 조직을 효과적으로 운영하려는 실천 지향적이고 전략적인 모형이라고 할 수 있다. 경찰지식관리는 조직이 지니는 지적자산 뿐만 아니라 경찰관 개개인의 지식이나 노하우를 체계적으로 발굴하여 경찰조직 내부의 보편적인 지식으로 공유하고, 이의 활용을 통해 경찰 전체의 성과를 향상시키는 관리방식이라고 할 수 있다. 경찰지식관리는 다양한 지식과 정보가 경찰관 개인 수준 및 집단 수준, 조직 수준에서 학습이 이루어지는 것을 목표로 한다. 이 연구에서는 경찰관들의 조직몰입과 직무만족을 조직유효성으로 보고, 지식관리가 조직유효성에 미치는 영향을 실증적 연구를 통해 분석해 보았다. The main idea of this thesis is to find out the effects of Knowledge Management in Korean Police Organization. We can call it Knowledge Management that every police officer holds knowledge and information in common. In order to prove knowledge management to police, it needs to be supported by four sub-systems. Those are acquisition, creation, storage, and transfer and utilization. But the most important factor of implementation is that all police officers share vision and participate in knowledge management project voluntarily. This research was analyzed empirically the survey on 720 police officers in Korea. Altogether 720 questionnaires were collected from 23 police stations and one training institution. The sample group were composed of ranks and file sworn officers selected among the total police stations in Korea proper. We can find out from this research that acquisition, creation, storage, and transfer and utilization, as subsystems of knowledge management, directly related to organizational commitment and job satisfaction.

과학수사기법의 발전과 효율적 활용 방안

정덕영 한국경찰학회 2004 한국경찰학회보 Vol.6 No.2

이 연구는 경찰의 수사능력 제고를 위한 여러 분야 가운데 과학수사기법의 활용에 관하여 살펴보았다. 이를 위해 법과학과 범죄수사학이 범위와 경찰수사에서의 활용, 그리고 과학수사의 기원과 최근 발전된 기법들인 거짓말탐지기, DNA분석, 범죄자 프로파일링, 심령술·최면술, 법곤충학 등을 살펴보았고, 우리나라에서의 효율적 활용방안으로 과학수사 전문인력의 확보, 국립과학수사연구소의 기능 조절, 민관 협력체계의 강화 등을 제시하였다. The evolution of forensic evidence, criminalistics, and criminal investigation is the product of a successful symbiosis of science and policing. This study has shown the improvement of scientific investigation technique, in it I discussed not only the influence of the hard sciences as computer science, biology and physics, but also the assistance of psychology. I explained that the Finger Prints, Polygraph, DNA Analysis, Criminal Profiling, Spiritualism?Hypnotism and Forensic Entomology in scientific investigation technique. There is Little doubt that the future holds greater advances in the realm of forensic science. Thus, policing should continue to reap the benefits of continually progressing scientific aids for the solution of crime.

Are Loyalty and Disloyalty the Same Concept? : A Conceptual Framework with Dichotomous Approach

Duke Hyun Choi 한국교통대학교 2015 한국교통대학교 논문집 Vol.50 No.-

Under pressure of intensified price competition and low profitability, many retailers have disappeared form market failing to gain and maintain a loyal customer base. This paper suggests a generalized conceptual framework that argues that raising customers’ willingness to pay more via two-dichotomy customer management strategies (managing customers’ loyal behavior and managing customers’ disloyal behavior) are essential. In the conceptual model, how customers’ loyal behavior and disloyal behavior mediate the relationship between antecedent quality factors and price sensitivity is presented.

A Review on the Social Factors in Social Networking Service Context

Duke Hyun Choi 한국교통대학교 2014 한국교통대학교 논문집 Vol.49 No.-

With the recent development of wireless internet, people can experience variety of services of the social networking service (SNS) platforms via the smart phones. Taking into account the characteristics of SNS and the roles of its users, this study presents a review on the roles of social factors in SNS and an empirical investigation on their impacts on users’ behavioral intention. With an empirical analysis using 259 samples, the result of multiple regression analysis showed the differences in the impact of each social factor (i.e., perceived responsiveness, perceived critical mass, and trust in other users) on continuance intention. The results of this exploratory study can be useful for future research on the technology adoption within this area.

Multi-Criteria Group Decision Making under Imprecise Preference Judgments : Using Fuzzy Logic with Linguistic Quantifier

Duke Hyun Choi(최덕현),Byeong Seok Ahn(안병석),Soung Hie Kim(김성희) 한국지능정보시스템학회 2006 지능정보연구 Vol.12 No.3

본 논문에서는 각 대안의 속성 평가와 속성 자체의 중요도에 대한 평가에 있어 불명료한 선호정보 형태로 주어진 경우, linguistic quantifier를 통한 퍼지논리를 활용하여 그룹의사결정을 지원하는 방법을 제시하였다. 불명료한 선호정보는 의사결정 관련 문헌에서 의사결정자에게 요구되는 선호정보 명시의 부담을 줄여주고, 판단의 모호성을 받아들이고자 하는 시각으로서 다뤄져 왔다. 그러나 불명료한 유형의 선호정보를 허용할 경우 의사결정그룹이 원하는 대안의 명확한 선택이 보다 어려워진다. 따라서 추가적인 정보획득을 위한 의사결정자들과의 상호작용이 요구되지만, 이는 불명료한 선호정보를 허용하였던 초기의 취지를 반감시킬 뿐더러, 반드시 최적의 대안을 보장하는 것도 아니다. 이러한 상황을 타계하기 위하여, fuzzy majority의 의미를 반영하고 있는 linguistic quantifier를 활용함으로써 satisfying solution을 구하는 절차를 제시하였다. 이는 mathematical programming을 활용한 의사결정 기법과 다수의 객체를 집성하기 위한 개략적 해법을 결합한 접근방식이다. The increasing complexity of the socio-economic environments makes it less and less possible for single decision-maker to consider all relevant aspects of problem. Therefore, many organizations employ groups in decision making. In this paper, we present a multiperson decision making method using fuzzy logic with linguistic quantifier when each of group members specifies imprecise judgments possibly both on performance evaluations of alternatives with respect to the multiple criteria and on the criteria. Inexact or vague preferences have appeared in the decision making literatures with a view to relaxing the burdens of preference specifications imposed to the decision-makers and thus taking into account the vagueness of human judgments. Allowing for the types of imprecise judgments in the model, however, makes more difficult a clear selection of alternative(s) that a group wants to make. So, further interactions with the decision-makers may proceed to the extent to compensate for the initial comforts of preference specifications. These interactions may not however guarantee the selection of the best alternative to implement. To circumvent this deadlock situation, we present a procedure for obtaining a satisfying solution by the use of linguistic quantifier guided aggregation which implies fuzzy majority. This is an approach to combine a prescriptive decision method via a mathematical programming and a well-established approximate solution method to aggregate multiple objects.

Anatomic Reduction of Mallet Fractures Using Extension Block and Additional Intrafocal Pinning Techniques

Duke Whan Chung,이재훈 대한정형외과학회 2012 Clinics in Orthopedic Surgery Vol.4 No.1

Background: The purpose of this article is to report the effi cacy of the extension block pinning and additional intrafocal pinningtechnique applied to cases whose mallet fractures were not reduced with extension block pinning alone. Methods: We retrospectively reviewed 14 digits with 14 patients who were treated with the extension block pinning and additionalintrafocal pinning technique. There were eight men and six women with an average age of 34 years. The average articularsurface involvement was 52%. The average follow-up was 16 months and the mean time from injury to operation was 23 days. Results: All the cases achieved anatomic reduction of fractures. By Crawford’s classifi cation, 9 were excellent and 5 were good. The average active fl exion of the distal interphalangeal joint was 78 degrees and the average extension loss was 1.8 degrees. Bone union was observed in all cases after a postoperative mean of 38.4 days. Complications such as skin necrosis, fracture ofbony fragments, and nail-plate deformity were not found. Conclusions: Additional intrafocal pinning technique is considered a simple and useful method to obtain anatomic reduction ofmallet fractures in cases where extension block pinning alone is insuffi cient to restore the anatomic confi guration of the articularsurface.

Upper Extremity Injuries in Snow Skiers

Duke-Whan Chung(정덕환),Ki-Tack Kim(김기택),Kang-Il Kim(김강일) 대한정형외과학회 1998 대한정형외과학회지 Vol.33 No.6

The Role of Trust in Other Users in Social Networking Service Context

Duke-Hyun Choi(최덕현) 국제e-비즈니스학회 2010 e-비즈니스 연구 Vol.11 No.4