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      • KCI등재

        기능성 위장관장애 환자의 자율신경계기능과 음-양(陰陽)체질 특성에 관한 연구

        이정호,송지영,황의완,정두훈,김영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        연구목적 : 기질적 원인이 없이 장기간 소화장애 및 복통이 지속되는 기능성 위장관 장애 환자를 대상으로 하여, 음양체질의 특성이 위장관을 조절하는 자율신경계 기능 이상과 관련되는지를 알아보기 위하여, 사상체질 특성에 따른 자율신경계 기능의 차이유무를 측정해 보고자 하였다. 이로써 이들 환자에서 보이는 자율신경계 기능의 불균형 상태가 한의학에서 말하는 음양(陰陽)이론으로 설명할 수 있을지 알아 보고자 하였다. 그리고 만일 이러한 설명이 가능하게 되면 향후 기능성 위장관 장애 환자에 대한 음양이론에 입각한 치료의 이론적 배경이 될 것으로 기대하였다. 방 법 : 기능성 위장관 장애 환자 27명과 대조군으로서 위장관 증상 이외의 증상을 가진 신체형 장애 환자(이하 기타 신체형 장애) 28명과 건강 대조군 26명을 조사 대상으로 하였다. 이들에게 사상체질(四象體質)분류검사를 이용하여 소음 체질과 기타 체질군으로 나누고, 자율신경 기능검사를 실시하여 체질에 따른 자율신경계 기능을 비교해 보았다. 결 과 : 기능성 위장관 환자군에서 소음체질이 의미있게 많은 빈도를 차지하지는 않았으며, 기능성 위장관 장애군과 기타 신체형 장애군과의 비교에서 자율신경 기능의 차이는 없었다. 이로서 비기질성 기능 장애의 하나인 기능성 위장 장애에서 체질 특성과 부교감신경계 기능 저하와는 관련성은 거의 없다고 추정된다. 단지 기능성 위장 장애군과 기타 신체형 장애군을 합한 신체형 장애 환자군에서는 건강 대조군에 비하여 소음체질의 빈도가 높았으며 부교감신경 기능이 의미있게 낮은 소견을 보였다. 결 론 : 비기질성 기능 장애인 기능성 위장관 장애에서는 한의학에서의 음양가설이라는 일원론에 입각한 이분법적인 개념이 자율신경계의 교감, 부교감 신경계 기능과 일치하는 부분은 적은 것으로 추정된다. 기능성 위장관 장애를 대상으로 해서 앞으로는 음양의 체질이라는 포괄적인 개념보다는 확실한 증상 몇 개 중심으로 하는 좀 더 세분화된 부분으로부터 접근해 볼 필요가 있으리라 사료된다. Objectives : It was revealed that autonomic dysfunction especially decreased parasympathetic functions, seems to be one of the major etiological factors in functional gastrointestinal disorders(FGID). The physiological characteristics of sympathetic and parasympathetic functions are externally similar to the features of Yin and Yang based on oriental medicine theory. And it was also revealed that gastrointestinal symptoms are prevalent in Lesser Yin con-stitutional type(少陰) originated from four types of constitution shown in Sasang constitutional theory(四象醫學). If we obtain the findings on the similarities or compatibilities between autonomic nervous functions and physical constitutional features in functional gastrointestinal disorders, we could apply various oriental treatment modalities to the patients with functional disorders, especially according to Yin-Yang constitutional concept. Methods : We investigated the correlations between characteristics of physical constitution (Yin and Yang) and imbalance of the autonomic functions in patients with FGID. Subjects consisted with three groups : 27 patients with FGID (including irritable bowel syndrome, functional dyspepsia, functional abdominal pain syndrome according to the Rome criteria), 28 patients with somatoform disorders who had symptoms other than abdominal symptoms(other somatoform disorders), and 26 normal healthy controls. Characteristics of constitutions were evaluated and divided into two major groups, i.e., Lesser Yin constitution and other constitutions(Greater Yin & Yang and Lesser Yang included) according to the Je-Ma Lee's Classification Questionnaire for Four Constitutional Types(Song et al. 1993). For evaluating the autonomic functions, three parasympathetic functions and two sympathetic functions were measured. Levels of anxiety and depression were also evaluated to be used as a covariant controlling the autonomic functions. Results : 1) FGID group showed significantly lower parasympathetic functions compared to healthy controls, however, there was no differences between FGID and other somatoform disorder groups. 2) Lesser Yin constitutional type was not so prevalent in FGID group. 3) When FGID and other somatoform disorder groups were combined and compared with normal healthy controls, the former group showed significantly lower parasympathetic functions than the latter group. Conclusions : According to these results, Lesser Yin constitutional type do not seem to be closely related with FGID. However, it was suggested that decreased parasympathetic functions were partly associated with this group. We could not find any correlations or compatibilities between two constitutional characteristics and autonomic dysfunction in FGID. This means that functional symptoms of FGID when those were deducted as Yin and Yang characteristics based on oriental medicine could not be understood as two oppositional and co-operative functions such as autonomic functions. Further research with more restricted symptoms selected in the functional disorders and with other physiological cues applied would be needed.

      • SCISCIESCOPUS

        Activation of Rac1-dependent redox signaling is critically involved in staurosporine-induced neurite outgrowth in PC12 cells

        Kim, Du Sik,An, Jeong Mi,Lee, Han Gil,Seo, Su Ryeon,Kim, Seon Sook,Kim, Ju Yeon,Kang, Jeong Wan,Bae, Yun Soo,Seo, Jeong Taeg Informa Healthcare 2013 Free radical research Vol.47 No.2

        <P>Staurosporine, a non-specific protein kinase inhibitor, has been shown to induce neurite outgrowth in PC12 cells, but the mechanism by which staurosporine induces neurite outgrowth is still obscure. In the present study, we investigated whether the activation of Rac1 was responsible for the neurite outgrowth triggered by staurosporine. Staurosporine caused rapid neurite outgrowth independent of the ERK signaling pathways. In contrast, neurite outgrowth in response to staurosporine was accompanied by activation of Rac1, and the Rac1 inhibitor NSC23766 attenuated the staurosporine-induced neurite outgrowth in a concentration-dependent manner. In addition, suppression of Rac1 activity by expression of the dominant negative mutant Rac1N17 also blocked the staurosporine-induced morphological differentiation of PC12 cells. Staurosporine caused an activation of NADPH oxidase and increased the production of reactive oxygen species (ROS), which was prevented by NSC23766 and diphenyleneiodonium (DPI), an NADPH oxidase inhibitor. Staurosporine-induced neurite outgrowth was attenuated by pretreatment with DPI and exogenous addition of sublethal concentration of H<SUB>2</SUB>O<SUB>2</SUB> accelerated neurite outgrowth triggered by staurosporine. These results indicate that activation of Rac1, which leads to ROS generation, is required for neurite outgrowth induced by staurosporine in PC12 cells.</P>

      • KCI등재

        Two-stage revision anterior cruciate ligament reconstruction

        ( Du-han Kim ),( Ki-cheor Bae ),( Dong-wan Kim ),( Byung-chan Choi ) 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.0

        With the rising number of anterior cruciate ligament (ACL) reconstructions, revision ACL reconstructions are becoming increasingly common. A revision procedure may be performed to improved knee function, correct instability, and facilitate a return to normal activities. When performing a revision reconstruction, the surgeon decides between a single-stage or a two-stage revision. Two-stage revisions are rarely performed, but are particularly useful when addressing substantial tunnel-widening, active infection, and concomitant knee pathology (e.g., malalignment, other ligamentous injuries, meniscal or chondral lesions). Among these potential scenarios requiring a two-stage revision, tunnel-widening is the most common cause; the first stage involves graft removal, tunnel curettage, and bone grafting, followed by revision ACL reconstruction in the second stage. The purpose of this article is to review the preoperative planning, surgical considerations, rehabilitation, and outcomes of two-stage revision ACL reconstructions and summarize the recent literature outlining treatment results.

      • KCI등재

        Amphiregulin (AREG) Genotypes, Allele Frequencies and the First Parity Litter Size in the Pig

        Du-Wan Kim,Yoon Seok Nam,Hee-Bok Park,Jong Gug Kim 한국수정란이식학회 2015 한국동물생명공학회지 Vol.30 No.2

        Amphiregulin (AREG), a glycoprotein that is a member of the epidermal growth factor (EGF) family, is expressed by the porcine conceptus and endometrium. AREG genotypes were determined based on an SNP in the intron 3 of the gene. Contradictory effects of AREG genotypes on reproductive traits in different pig breeds were reported previously. G allele had undesirable effect on reproductive trait in Meishan breed, while it had favorable effects in Polish Landrace and Large White. We determined AREG genotypes of 179 pigs including the Duroc, Landrace, Yorkshire, Korean native pig (KNP), and Meishan breeds. Two new SNPs were identified near the previously reported SNP in the intron 3 of AREG. Frequencies of AREG alleles among the Duroc, Landrace, Yorkshire, and KNP sows were significantly different (p<0.001), indicating association between AREG genotypes and pig breeds. The first parity litter size was significantly affected by the breeds (p=0.014), but not by AREG genotypes (p=0.148). However, there were breed and AREG genotype associated trends in the first parity litter size. The first parity litter size appeared to be higher in Duroc and KNP sows with G allele, while it appeared to be lower in Landrace sows with G allele. Significant variability of AREG alleles among pig breeds, for the first time in Duroc and KNP sows, was identified. AREG genotypes may influence reproductive traits differentially for each breed and thus, AREG genotypes may need to be considered when sows are bred to increase litter size.

      • KCI등재

        Amphiregulin (AREG) Genotypes, Allele Frequencies and the First Parity Litter Size in the Pig

        Kim, Du-Wan,Nam, Yoon Seok,Park, Hee-Bok,Kim, Jong Gug The Korean Society of Embryo Transfer 2015 한국동물생명공학회지 Vol.30 No.2

        Amphiregulin (AREG), a glycoprotein that is a member of the epidermal growth factor (EGF) family, is expressed by the porcine conceptus and endometrium. AREG genotypes were determined based on an SNP in the intron 3 of the gene. Contradictory effects of AREG genotypes on reproductive traits in different pig breeds were reported previously. G allele had undesirable effect on reproductive trait in Meishan breed, while it had favorable effects in Polish Landrace and Large White. We determined AREG genotypes of 179 pigs including the Duroc, Landrace, Yorkshire, Korean native pig (KNP), and Meishan breeds. Two new SNPs were identified near the previously reported SNP in the intron 3 of AREG. Frequencies of AREG alleles among the Duroc, Landrace, Yorkshire, and KNP sows were significantly different (p<0.001), indicating association between AREG genotypes and pig breeds. The first parity litter size was significantly affected by the breeds (p=0.014), but not by AREG genotypes (p=0.148). However, there were breed and AREG genotype associated trends in the first parity litter size. The first parity litter size appeared to be higher in Duroc and KNP sows with G allele, while it appeared to be lower in Landrace sows with G allele. Significant variability of AREG alleles among pig breeds, for the first time in Duroc and KNP sows, was identified. AREG genotypes may influence reproductive traits differentially for each breed and thus, AREG genotypes may need to be considered when sows are bred to increase litter size.

      • KCI등재

        Amphiregulin (AREG) Genotypes, Allele Frequencies and the First Parity Litter Size in the Pig

        Du-Wan Kim,Yoon Seok Nam,Hee Bok Park,김종국 사단법인 한국동물생명공학회 2015 한국동물생명공학회지 Vol.30 No.2

        Amphiregulin (AREG), a glycoprotein that is a member of the epidermal growth factor (EGF) family, is expressed by the porcine conceptus and endometrium. AREG genotypes were determined based on an SNP in the intron 3 of the gene. Contradictory effects of AREG genotypes on reproductive traits in different pig breeds were reported previously. G allele had undesirable effect on reproductive trait in Meishan breed, while it had favorable effects in Polish Landrace and Large White. We determined AREG genotypes of 179 pigs including the Duroc, Landrace, Yorkshire, Korean native pig (KNP), and Meishan breeds. Two new SNPs were identified near the previously reported SNP in the intron 3 of AREG. Frequencies of AREG alleles among the Duroc, Landrace, Yorkshire, and KNP sows were significantly different (p<0.001), indicating association between AREG genotypes and pig breeds. The first parity litter size was significantly affected by the breeds (p=0.014), but not by AREG genotypes (p=0.148). However, there were breed and AREG genotype associated trends in the first parity litter size. The first parity litter size appeared to be higher in Duroc and KNP sows with G allele, while it appeared to be lower in Landrace sows with G allele. Significant variability of AREG alleles among pig breeds, for the first time in Duroc and KNP sows, was identified. AREG genotypes may influence reproductive traits differentially for each breed and thus, AREG genotypes may need to be considered when sows are bred to increase litter size.

      • KCI등재

        Two-stage revision anterior cruciate ligament reconstruction

        Du-Han Kim,,Ki Cheor Bae,Dong-Wan Kim,Byung-Chan Choi 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.0

        With the rising number of anterior cruciate ligament (ACL) reconstructions, revision ACL reconstructions are becoming increasingly common. A revision procedure may be performed to improved knee function, correct instability, and facilitate a return to normal activities. When performing a revision reconstruction, the surgeon decides between a single-stage or a two-stage revision. Two-stage revisions are rarely performed, but are particularly useful when addressing substantial tunnel-widening, active infection, and concomitant knee pathology (e.g., malalignment, other ligamentous injuries, meniscal or chondral lesions). Among these potential scenarios requiring a two-stage revision, tunnel-widening is the most common cause; the first stage involves graft removal, tunnel curettage, and bone grafting, followed by revision ACL reconstruction in the second stage. The purpose of this article is to review the preoperative planning, surgical considerations, rehabilitation, and outcomes of two-stage revision ACL reconstructions and summarize the recent literature outlining treatment results.

      • KCI등재

        Risk factors of uncontrolled periprosthetic knee joint infection after two-stage reimplantation

        Kim Du-Han,배기철,Kim Dong-Wan,Choi Byung-Chan 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

        Background: Periprosthetic infection after total knee arthroplasty is a challenging problem, and physicians should identify risk factors to decrease recurrence. However, risk factors for reinfection with two-stage reimplantation have not yet been well established. The purpose of this study was to assess treatment outcomes of subsequent twostage knee reimplantation and identify risk factors for uncontrolled periprosthetic knee joint infections. Methods: We retrospectively reviewed 70 knees diagnosed with a periprosthetic knee joint infection treated with two-stage reimplantation between September 2011 and October 2016 at our institution. Patients in the controlled infection group (group C) required no further medication or surgical treatment within 2 years after reimplantation. Patients in the uncontrolled infection group (group U) displayed symptoms of active infection after resection arthroplasty or were reinfected after two-stage reimplantation. We compared group C and group U, and analyzed potential risk factors for uncontrolled prosthetic joint infection (PJI). Results: Of 70 knees included in this analysis, 53 (75.7%) were clinically deemed free from infection at the latest follow-up. The remaining 17 knees (24.3%) required additional surgical procedures after two-stage reimplantation. Demographics were not statistically significantly different between the two groups. Wound complications were statistically more frequent in group U (p = 0.030). Pre-reimplantation C-reactive protein (CRP) was statistically different between groups C and U (0.44 and 1.70, respectively, p = 0.025). Among the cultured microorganisms, fungus species were statistically more frequently detected in group U compared with group C (p = 0.031). Conclusions: The reinfection rate of our two-stage reimplantation protocol was 24.3% in the included cases. Wound complications, higher pre-reimplantation CRP levels, and fungus species were statistically more common in group U compared with group C. Our findings will help in counseling patients and physicians to understand that additional caution may be required when treating PJI if the aforementioned risk factors are present.

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