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DNA 코딩방법을 이용한 셀룰라 오토마타 신경망의 진화
이동욱,심귀보,Lee, Dong-Wook,Sim, Kwee-Bo 대한전자공학회 1999 電子工學會論文誌, S Vol.s36 No.12
셀룰라 오토마타 신경망(CANS)은 생물학적 발생과 진화에 기반한 신경망 모델이다. CANS에서 각 뉴런은 상호간에 국소적인 연결을 갖고 있으며 카오스 뉴런 모델의 동작 방정식에 따라 펄스의 형태로 동작한다. 신경망은 초기 패턴을 셀룰라 오토마타(CA) 규칙에 따라 발생시켜 얻어진다. 기존의 연구에서는 유용한 기능을 얻기 위하여 초기패턴을 진화시켰다. 그러나 이 방법은 신경망의 표현공간을 모두 나타낼 수 없다. 따라서 본 논문에서는 신경망의 표현공간이 작아지는 문제점을 개선하기 위한 CA의 발생규칙을 진화시키는 방법을 제안한다. DNA 코딩은 코딩의 중복과 여분을 효과적으로 사용하며 규칙의 표현에 매우 적합하다. 본 논문에서는 CA 규칙의 일반적인 표현방법을 제시하고 DNA 코드를 CA 규칙으로 해석하는 방법을 제안한다. 제안된 방법은 자율이동로봇의 제어기에 사용하여 주행 문제에 적용함으로써 그 유효성을 확인하였다. Cellular Automata Neural Systems(CANS) are neural networks based on biological development and evolution. Each neuron of CANS has local connection and acts as a form of pulse according to the dynamics of the chaotic neuron. CANS are generated from initial cells according to the CA rule. In the previous study, to obtain the useful ability of CANS, we make the pattern of initial cells evolve. However, it is impossible to represent all solution space, so we propose an evolving method of CA rule to overcome this defect in this paper. DNA coding has the redundancy and overlapping of gene and is apt for the representation of the rule. In this paper, we show the general expression of CA rule and propose translation method from DNA code to CA rule. The effectiveness of the proposed scheme was verified by applying it to the navigation problem of autonomous mobile robot.
편마비환자의 환측 하지 외회전 정도가 기립균형에 미치는 영향
이동욱,곽길환,배성수,Lee Dong-Wook,Kwak Kil-Hwan,Bae Sung-soo 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3
The two groups each consisting of 28 people who had an adult hemiplegia due to a brain injury received two different methods of exercises to reduce the angle to which the affected lower limb rotates externally. The comparisons between the two groups were made for the changes of the angle in external rotations measured between pre and post test. The static balance index values taken during pre and post tests were also compared. In addition, the correlations of the angle to which the affected lower limb rotates externally with static balance index values were analyzed. The result were as follows: 1. A statistical analysis indicated that in group one having taken simple R.O.M exercises, the angle to which the affected lower limb rotates externally and the static balance index values were both significantly different between pre and post test (P<.01). 2. A statistical analysis indicated that in group two having taken a pattern movement, both the angle to which the affected lower limb rotates externally and static balance index values were significantly different between pre and post test (P<.01). 3. A significant difference between simple R.O.M exercises group and pattern movement exercises groupwas shown only for the angle to which affected limb rotates externally not for static balance index values (P<.01), 4. Pearson correlation coefficient for the angle to which the affected limb rotates externally with static balance index values was found to be significant only in pattern movement exercises group (P < .05).
흰쥐 신장의 NAD 의존성 α - glycerophosphate 탈수소 효소의 정제 및 성상
이동욱,이희성 ( Dong Wook Lee,Hee Sung Lee,Sung Hye Cho ) 생화학분자생물학회 1988 BMB Reports Vol.21 No.3
NAD-linked α-glycerophosphate dehydrogenase(EC 1.1.1.8) in rat kidney existed as four different isozymic forms with an isoelectric point at pH 6.9, 6.6, 6.4 and 6.2, respectively. The major isozymic form(PI 6.6) was purified using several chromatographic procedures involving an ion exchange and two affinity chromatography steps. The 1,078 fold purified enzyme was homogeneous, nucleotide free protein. The molecular weight of the major isozyme was 62,000 daltons, the optimal pH and temperature for its catalytic activity were 10.0 and 55℃, respectively. At the optimal temperature this enzyme was rapidly inactivated(t_(1/2) = 1.5 min). The major isozyme was activated by the addition of cations such as K^+, Na^+, Mg^(++) or Ca^(++), and was strongly inhibited by alkylating agents such as P-hydroxymercurybenzoate or iodoacetamide. Glycerophosphate oxidation reaction obeyed the Michaelis-Menton behavior with Km values of 3.22 and 0.31 mM for glycerophosphate and NAD, respectively. The data suggest that although the isozyme pattern of NAD-linked α-glycerophosphate dehydrogenase is quite different by tissue or species of the animal the physico-chemical properties of the major isozymic form are very similar each other except the affinity for substrate and coenzyme.
흰쥐 간 마이크로좀의 cytochrome P - 450 의존성 testosterone hydroxylase 의 활성도 측정
이동욱,박기현 ( Dong Wook Lee,Ki Hyun Park ) 생화학분자생물학회 1988 BMB Reports Vol.21 No.3
A rapid and one time determinable TLC method for the monohydroxytestosterones formed by microsomal cytochrome P-450(P-450) was established, and applying this method the activity of P-450-dependent testosterone hydroxylases was observed in liver microsomes of rats pretreated with phenobarbital(PB). The 14 testosterone metabolites were found on the TLC plate. The amounts of 6-monohydroxytestosterones (2α-, 2β-, 6α-, 6β-,7α-and 16α-OH-T) were determined. The formation of these metabolites showed a good linearity(r = 0.9687-0.9999) corresponding to the concentration of P-450 added up to about 1.0 nmol/min/reaction mixture, and an excellent reproducibility (C.V.= 1.8 ± 1.0%) when determined with 0.5 nmol P-450 in this assay system. The hydroxylation of testosterone to its 2β-OH-T by PB-inducible P-450 was increased (2 fold), while 2α- and 7α-OH-T was rather decreased to 48 and 32%, respectively, compared with those of uninduced one. The 6β-OH-T was predominantly formed by uninducible and PB-inducible P-450, especially PB-inducible P-450 hydroxylated stereospecifically onto the C2-position of testosterone (2α/2β =1: 3.8). However, the oxidation rates of testosterone to its 6α-, 6β- and 16α-OH-T, and the total amount of testosterone metabolites identified were not changed, significantly by the administration of PB.
소나무 꽃가루에서 분리한 Trehalase 의 정제 및 성상에 관한 연구
이동욱,이희성,조성희 ( Dong Wook Lee,Hi Sung Lee,Sung Hee Cho ) 생화학분자생물학회 1981 BMB Reports Vol.14 No.2
Trehalose, the alpha-1, 1 linked disaccharide of glucose, occurs widely in nature. This sugar has been isolated from bacteria, yeast, fungi and a number of invertebrates, where it functions as reserve carbohydrate. Trehalase(α,α-trehalose 1-D-glucohydrolase, EC 3. 2. 1. 28. ) responsible for the hydrolysis of trehalose was isolated from pine pollen(Pinus densiflora Siebold) and purified 81 times by DEAE-cellulose column and Sephadex G-200 column chromatography. The activity of trehalase was measured by method of Lapp and Mason. The enzyme activity in pine pollen was detected 80.46% in cytosolic fraction, 4.09% in mitochondria) fraction and 10.33% in nucleic fraction. The pH optimum for enzymatic activity was found to be 5.4 and optimal temperature was 60℃ and the Km value for trehalose was estimated to be about 2. 56 × 10^(-3)M. The product of reaction was identited as D-glucose by paper chromatographic method. The trehalase activity was activated as much as 14∼17% by 1 × 10^(-4)M∼1 × 10^(-3)M concentration of Na^+, and 27∼15% by 1 × 10^(-5)∼1 × 10^(-4)M of Mg^(++), and the other cations(K+, Ca++) were tested for their abillity to replace Mg^(++), but none was effective. The molecular weight of trehalase was estimated to be approximately 70,000 by Sephadex G-200 gel filtration.
수평원관속에 동심으로 놓여있는 얼음 봉의 융해현상에 관한 보험적 연구
이동욱,유상신,Lee, Dong-Wook,Yoo, Sang-Sin 대한설비공학회 1986 설비저널 Vol.15 No.2
The melting phenomena of horizontal cylindrical ice-bar immersed in water and air concentrically in the cylinder are experimentally investigated for the temperature range from $3.5^{\circ}C\;to\;2.5^{\circ}C$. The shapes of the melting ice-bar are recorded photographically by the shadowgraph method. The shadowgraphs of the melting ice-bar show that water adjacent to the bar flows upward for the temperature range from $3.5^{\circ}C\;to\;5.8^{\circ}C$ while above $5.8^|\circ}C$ the flow is downward direction. The local and average Nusselt numbers are obtoined with the recorded shadowgraphs and comparator. Melting shapes of the ice-bar in the air show the vortex motion in the bottom portion of the bar, whereas no vortex motion appears in the bottom portion when the bar is melted in the water.
이동욱,김상윤,Lee, Dong-Wook,Kim, Sang-Youn 대한소아외과학회 1995 소아외과 Vol.1 No.1
Torsion of the wandering spleen is a rare condition especially in children. Unfortunately, splenectomy was the advocated treatment of choice for wandering spleen in many children up to 1985 in spite of the well-known possibility of overwhelming postsplenectomy sepsis. Because of the conclusive evidence of the vital function of the spleen in infection, indication of splenectomy have been revised and more attention has been paid to preserving the spleen where possible. We are presented a girl with splenic torsion, seen as a migratory abdominal mass and intermittent vague abdominal pain. Splenopexy by fixation of the spleen to the diaphragm and posterolateral peritoneum and the use of Avitene in the splenic bed was successfully performed. Complete fixation of the spleen was confirmed by ultrasound a year after this procedure was carried out. The clinical presentation, etiology, diagnostic procedures and management are discussed also.
이동욱,강문봉,Lee, Dong-Wook,Kang, Mun-Bong 한국융합신호처리학회 2010 융합신호처리학회 논문지 (JISPS) Vol.11 No.2
디인터레이싱 방식은 일반적으로 화면 간 디인터레이싱과 화면 내 디인터레이싱으로 나뉜다. 화면 내 디인터레이싱에서 가장 보편적인 방식은 라인카피와 라인별 평균값을 취하는 선형적인 방식이다. 또한 ELA(Edge Based Line Average), ELA를 변형시킨 방식 등이 에지를 이용한 디인터레이싱 방식들이다. 하지만 선형적 보간법은 에지 블러링이나 계단현상을 발생시키고, ELA나 변형된 ELA를 이용한 방식은 특정방향에지 정보가 부족해서 다양한 형태의 에지 부분에서의 디인터레이싱이 좋지 못하다. 본 논문은 7방향의 에지 방향 보간법과 수평방향의 에지라인을 고려한 화면 내 디인터레이싱 방식을 소개한다. 기존 방식에서 나타나던 오브젝트의 계단현상을 최대한 줄여줌으로써 보다 낳은 화질을 보인다. Deinterlacing methods are usually divided into inter-field deinterlacing and intra-field deinterlacing. The most common method of intra-field deinterlacing is the linear method which uses line doubling or line averaging. There are also some edge-enhancement methods such as ELA(Edge Based Line Average) and modified ELA. However, the linear interpolation generates edge blurring or staircase artifacts. The methods using ELA or modified ELA show poor deinterlacing at various types of edges because of insufficient edge information in a certain direction. This paper presents an intra-field deinterlacing algorithm that considers the interpolation based on edges in 7 directions and an edge line in the horizontal direction. It demonstrates better picture quality by reducing the staircase phenomenon of object in the conventional methods.
이동욱,임장섭,정창모,전영찬,Lee, Dong-Wook,Im, Jang-Seop,Jeong, Chang-Mo,Jeon, Yeong-Chan 대한치과보철학회 2000 대한치과보철학회지 Vol.38 No.1
The purpose of this study was to investigate the effect that three resin indexing materials had on the distortion of split cast in the procedures of solder indexing and block fabrication. The specimen had two cylinders and connecting bar Two cylinders were a reference cylinder and a test cylinder that were machined precisely and placed on metal base. The total of specimens were 30 and they were divided into 3 groups according to the resin indexing materials : Acrylic $solder^{(R)}$, G-C Pattern $resin^{(R)},\;Z-100^{(R)}$. The relative coordinates (X, Y, Z) of centroids of both cylinders were measured by using 3-D cool dinates measuring machine. The value of indexing distortion was obtained after application of indexing material, and the value of the block distortion was obtained after fabrication of soldering block, and the value of total distortion was a value sum of indexing distortion and block distortion. Intercentroidal linear distortion ${(\sqrt{X^{'2}+Y^{'2}+Z^{'2}}-{\sqrt{X^2+Y^2+Z^2)}$ and global distortion $(\sqrt{{(X^'-X)}^2+{(Y^'-Y)}^2+{(Z^'-Z)}^2}$ were calculated from data of coordinates of centroids at each measuring stages. The results of this study were as belows ; 1. The intercentroidal distance between the split casts was reduced by indexing distortion and increased by block distortion. 2. The indexing global distortion between the split casts was smaller than block global distortion. 3. The intercentroidal linear distortion and the global distortion were no significant difference between indexing materials.
공간 데이터웨어하우스에서 효율적인 공간 데이터 적재를 위한 이기종 데이터 소스의 비중복 추출기법
이동욱,백성하,김경배,배해영,Lee, Dong-Wook,Baek, Sung-Ha,Kim, Gyoung-Bae,Bae, Hae-Young 한국공간정보학회 2009 한국공간정보시스템학회 논문지 Vol.11 No.2
공간 데이터웨어하우스는 공간 DBMS 또는 다양한 소스데이터로부터 시간에 따라 추출된 공간데이터를 ETL 과정을 통해 가공된 데이터를 관리하는 시스템이다. 적재 주기 마다 추출된 공간데이터는 비공간 데이터와 달리 같은 주제의 중복된 공간 정보가 유용하지 않으며, 공간 데이터의 특징으로 저장 공간의 낭비가 크다. 또한 이기종간의 시스템에서 소스 데이터를 추출할 경우 서로 다른 공간데이터 타입 및 스키마를 가지고 있어 이를 위한 공간데이터 추출 기법이 요구된다. 기존 기법에서는 기준이 되는 Geocoding DB를 이용하여 추출된 공간데이터에 대한 주소 매칭과정을 수행함으로써, 정형화된 데이터 셋을 적재한다. 하지만 이 기법은 추출 데이터를 매번 Geocoding DB와 비교 연산이 발생하며, 주제별로 공간 데이터를 통합 관리함에 따라 이 기종 공간 DBMS 사이에 중복된 데이터를 고려하지 않는 문제점이 있다. 본 논문에서는 공간 데이터웨어하우스 구축기 내에서 이 기종의 소스 시스템으로부터 추출된 갱신질의 통합을 이용한 효율적 추출 기법을 제안한다. 이는 이 기종의 공간 DBMS로부터 발생한 과거 적재 시점부터 현재까지 발생한 질의 중 삽입이나 삭제 등의 업데이트 관련 질의만을 추출하여 공간데이터의 불필요한 추출 연산 비용을 제거한다. 또한 소스 공간 데이터베이스 관리시스템의 업데이트 질의를 이용하여 추출된 공간 데이터를 주제별로 중복 제거 및 통합 한다. 제안 기법은 데이터 중복 저장에 의한 저장 공간의 낭비를 줄이고, 적재시점 별 통합된 데이터를 적재함으로써 빠른 공간데이터 분석을 지원할 수 있다. Spatial data warehouses are a system managing manufactured data through ETL step with extracted spatial data from spatial DBMS or various data sources. In load period, duplicated spatial data in the same subject are not useful in extracted spatial data dislike aspatial data and waste the storage space by the feature of spatial data. Also, in case of extracting source data on heterogeneous system, as those have different spatial type and schema, the spatial extract method is required for them. Processing a step matching address about extracted spatial data using a standard Geocoding DB, the exiting methods load formal data set. However, the methods cause the comparison operation of extracted data with Geocoding DB, and according to integrate spatial data by subject it has problems which do not consider duplicated data among heterogeneous spatial DBMS. This paper proposes efficient extracting method to integrate update query extracted from heterogeneous source systems in data warehouse constructer. The method eliminates unnecessary extracting operation cost to choose related update queries like insertion or deletion on queries generated from loading to current point. Also, we eliminate and integrate extracted spatial data using update query in source spatial DBMS. The proposed method can reduce wasting storage space caused by duplicate storage and support rapidly analyzing spatial data by loading integrated data per loading point.