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고혈압(高血壓) 뇌졸중(腦卒中) 환자(患者)에 대한 사혈(瀉血)의 강압효과(降壓效果)
문장혁,안호진,정동화,윤형선,장재원,김경선,문익렬,백종엽,이상무,Mon, Jang-hyuk,Ahn, Ho-jin,Jeong, Dong-hwa,Yoon, Hyung-sun,Jang, Jae-won,Kim, Kyung-sun,Moon, Ik-ryoul,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2
Objective : The aim of this research was to investigate the depressive effect of depletion of B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patients. Methods : Depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient who were admitted in Dong-Seo Oriental Medical Hospital every other day form 4 weeks, without western antihypertensive drug. Results : After treatment in 2nd week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug increased the systolic and diastolic blood pressure. After treatment in 4th week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug decreased the systolic and diastolic blood pressure. After treatment in 4th week, values of RBC and hemoglobine were not significantly changed. Conclusions : Continous depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient without western antihypertensive drug implies decreasement of blood pressure, without change of values of RBC and hemoglobine.
( Dong Won Lee ),( Tae Hyung Ryu ),( In Hyuk Kwon ),( Heesang Kye ),( Soo Hong Seo ),( Hyo Hyun Ahn ),( Young Chul Kye ),( Jae Eun Choi ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Bowen’s disease (BD) is a squamous cell carcinoma in situ with potential for significant lateral spread. It clinically presents as well-demarcated erythematous plaques. BD may occur at any cutaneous site, frequently on lower extremities and on the head and neck. The disease can be aroused on both occasions of sun-exposed and unexposed sites. A 36-year-old man presented with Asymptomatic well-demarcated, flesh-colored velvety plaque on the right middle fingertip. He was an office worker who is accustomed to routine act of typing. Clinically it was shown as hand eczema rather than BD. It was not recognizable in meantime but its bizarre features could be seen when swollen up by water. The diagnosis was confirmed by histopathologic findings as a Bowen’s disease. Onwards, HPV typing was done and the following result of HPV Genotype 51 (High risk) came out. Interestingly, the finger right beside had the lesion of the same feature as the other. The excision biopsy was done to this lesion and the histopathologic findings came out as wart. The HPV is assumed as an etiologic factor for the first BD lesion. Since the lesion is located on the tip of the fingers, the cryotherapy is currently being held instead of complete excision showing gradual resolution. Herein, we report an interesting case of Bowen’s disease on the fingertip associated with HPV 51.
Ahn Yura,Koo Hyun Jung,Kang Joon-Won,Choi Won Jin,Kim Dae-Hee,Song Jong-Min,Kang Duk-Hyun,Song Jae-Kwan,Kim Joon Bum,Jung Sung-Ho,Choo Suk Jung,Chung Cheol Hyun,Lee Jae Won,Yang Dong Hyun 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.8
Objective: To investigate the prognostic value of preoperative cardiac magnetic resonance imaging (MRI) for long-term major adverse cardiac and cerebrovascular events (MACCEs) in patients undergoing tricuspid valve (TV) surgery for functional tricuspid regurgitation (TR). Materials and Methods: The preoperative cardiac MR images, New York Heart Association functional class, comorbidities, and clinical events of 78 patients (median [interquartile range], 59 [51–66.3] years, 28.2% male) who underwent TV surgery for functional TR were comprehensively reviewed. Cox proportional hazards analyses were performed to assess the associations of clinical and imaging parameters with MACCEs and all-cause mortality. Results: For the median follow-up duration of 5.4 years (interquartile range, 1.2–6.6), MACCEs and all-cause mortality were 51.3% and 23.1%, respectively. The right ventricular (RV) end-systolic volume index (ESVI) and the systolic RV mass index (RVMI) were higher in patients with MACCEs than those without them (77 vs. 68 mL/m2, p = 0.048; 23.5 vs. 18.0%, p = 0.011, respectively). A high RV ESVI was associated with all-cause mortality (hazard ratio [HR] per value of 10 higher ESVI = 1.10, p = 0.03). A high RVMI was also associated with all-cause mortality (HR per increase of 5 mL/m2 RVMI = 1.75, p < 0.001). After adjusting for age and sex, only RVMI remained a significant predictor of MACCEs and all-cause mortality (p < 0.05 for both). After adjusting for multiple clinical variables, RVMI remained significantly associated with all-cause mortality (p = 0.005). Conclusion: RVMI measured on preoperative cardiac MRI was an independent predictor of long-term outcomes in patients who underwent TV surgery for functional TR.
Adverse fetal outcomes in pregnant rabbits experimentally infected with rabbit hepatitis E virus
Ahn, Hee-Seop,Han, Sang-Hoon,Kim, Yong-Hyun,Park, Byung-Joo,Kim, Dong-Hwi,Lee, Joong-Bok,Park, Seung-Yong,Song, Chang-Seon,Lee, Sang-Won,Choi, Changsun,Myoung, Jinjong,Choi, In-Soo 3M Company 2017 Virology Vol.512 No.-
<P>Hepatitis E virus (HEV) causes severe hepatitis in pregnant women, with associated poor fetal outcomes. To study HEV viral pathogenesis, pregnant rabbits were infected with low-and high-dose rabbit HEV at 2 weeks gestation. HEV was identified in the serum, feces, and liver tissue of infected rabbits, and dose-dependent fetal mortality rates ranging from 67% to 80% were observed. The aspartate transaminase (AST)/alanine transaminase ratio was significantly higher (P < 0.01) in high-dose infected rabbits than low-dose infected and negative control rabbits 14 days post infection (dpi). Tumor necrosis factor-alpha (TNF-alpha) was significantly higher in low dose (P < 0.01) and high-dose infected rabbits (P < 0.001) than in negative controls 7 dpi. High-dose HEV-infected rabbits produced significantly more interferon-gamma (IFN-gamma; P < 0.05) than negative control rabbits at 7 and 14 dpi. High levels of AST, TNF-alpha, and IFN-gamma may substantially influence adverse fetal outcomes in pregnant rabbits infected with high-dose HEV.</P>
Tricuspid Valve Imaging and Right Ventricular Function Analysis Using Cardiac CT and MRI
Ahn Yura,Koo Hyun Jung,Kang Joon-Won,Yang Dong Hyun 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.12
Cardiac computed tomography (CT) and cardiac magnetic resonance imaging (CMR) can reveal the detailed anatomy and function of the tricuspid valve and right ventricle (RV). Quantification of tricuspid regurgitation (TR) and analysis of RV function have prognostic implications. With the recently available transcatheter treatment options for diseases of the tricuspid valve, evaluation of the tricuspid valve using CT and CMR has become important in terms of patient selection and procedural guidance. Moreover, CT enables post-procedural investigation of the causes of valve dysfunction, such as pannus or thrombus. This review describes the anatomy of the tricuspid valve and CT and CMR imaging protocols for right heart evaluation, including RV function and TR analyses. We also demonstrate the pre-procedural planning for transcatheter treatment of TR and imaging of postoperative complications using CT.
Screening of anti-Nosema substances from entomopathogenic fungi by polar tube germination assay
Dong Jun Kim,Won Seok Gwak,Yong Oh Ahn,Seung Hee Lee,In Hui Kim,See Nae Lee,Dong Woo Kim,Tae Young Shin,Sung Min Bae,Soo Dong Woo 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
The population of managed honey bees has been dramatically declining the recent past in worldwide. The one of most common disease of bees is nosemosis, the nosemosis is caused by microsporidia in the genus Nosema. Nosema apis and N. ceranae have been described as honeybee pathogens. These microsporidia are highly evoloved fungi with an obligately intracellular parasitic lifstyle. The disease causes significant detriment to honey production and results in economic losses. In our knowledge, Fumagillin is the only antibiotic approved for control of nosemosis in honey bees, however this antibiotic may have unintended effects on the honey bee host, ultimately contributing to increased prevalence and pathogenicity of Nosema. Therefore, we screened anti-Nosema substances from entomopathogenic fungal culture filtrates using in vitro polar tube germination assay. These fungal metabolites are employed as antibiotic agents. As results, Total 3 samples (23% of 13 total samples) showing the germinating inhibition against N. ceranae. This screening method may be useful for the detection of anti-Nosema substances from various samples and selected samples in this study may be a good feature to be used in the development of a new biocontrol method of nosemosis.
Ahn, Young-Chel,Kim, Hae-Won,Park, Dong-Gun The Korean Society for Computational and Applied M 2009 Journal of applied mathematics & informatics Vol.27 No.5
In this paper, we consider the existence, uniqueness of the solutions and controllability for the neutral functional integro-differential equations with delay terms by Sadovskii's fixed point theorem.
The Influence of Antiplatelet Drug Medication on Spine Surgery
Won Shik Shin,Dong Ki Ahn,Jung Soo Lee,유인선,이호영 대한정형외과학회 2018 Clinics in Orthopedic Surgery Vol.10 No.3
Background: The incidence of cardiovascular and neurovascular diseases has been increasing with the aging of the population, and antiplatelet drugs (APDs) are more frequently used than in the past. With the average age of spinal surgery patients also increasing, there has been a great concern on the adverse effects of APD on spine surgery. To our knowledge, though there have been many studies on this issue, their results are conflicting. In this study, we aimed to determine the influence of APDs on spine surgery in terms of intraoperative bleeding and postoperative spinal epidural hematoma complication. Methods: Patients who underwent posterior thoracolumbar decompression and instrumentation at our institution were reviewed. There were 34 APD takers (APDT group). Seventy-nine non-APD takers (NAPDT group) were selected as a control group in consideration of demographic and surgical factors. There were two primary endpoints of this study: the amount of bleeding per 10 minutes and cauda equina compression by epidural hematoma measured at the cross-sectional area of the thecal sac in the maximal compression site on the axial T2 magnetic resonance imaging scans taken on day 7. Results: Both groups were homogeneous regarding age and sex (demographic factors), the number of fused segments, operation time, and primary/revision operation (surgical factors), and the number of platelets, prothrombin time, and activated partial thromboplastin time (coagulation-related factors). However, the platelet function analysis-epinephrine was delayed in the APDT group than in the NAPDT group (203.6 seconds vs. 170.0 seconds, p = 0.050). Intraoperative bleeding per 10 minutes was 40.6 ± 12.8 mL in the APDT group and 43.9 ± 9.9 mL in the NAPDT group, showing no significant difference between the two groups (p = 0.154). The cross-sectional area of the thecal sac at the maximal compression site by epidural hematoma was 120.2 ± 48.2 mm2 in the APDT group and 123.2 ± 50.4 mm2 in the NAPDT group, showing no significant difference between the two groups (p = 0.766). Conclusions: APD medication did not increase intraoperative bleeding and postoperative spinal epidural hematoma. Therefore, it would be safer to perform spinal surgery without discontinuation of APD therapy in patients who are vulnerable to cardiovascular and neurovascular complications.