분무 열분해에 의한 Ba1-xSrxFe12O19계 자성 미립자의 제조 및 특성 변화

김동현,김광만,김경남,최세영,심인보,이용근 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.1

Magnetic particles with alternating magnetic field are expected to be useful as thermoseeds in hyperthermic cancer treatment, since they can be targeted and confined to the cancer site. Hard magnetic ferrites such as barium ferrite and strontium ferrite are good candidates for thermoseeds of hyperthermia because of their great hysteresis loss. In order to verify the effect of Sr-substitution to Ba-site, synthesized Ba1-xSrxFe12O19 microspheres with various compositions through spray pyrolysis followed by sol synthesis using barium nitrate, strontium acetate and iron nitrate. Coercive force was increased with increasing substitution amount of Sr whereas magnetic saturation was almost constant. Spherical microspheres with average diameter of 11.7~17.0 ㎛ were produced by spray pyrolysis at 400~1000℃. The mean size was dependent on the pyrolysis temperature and flow rate of carrier gas. In order to obtain a single phase of SrFe12O19 crystal, the spray pyrolyzed spheres were undertaken subsequent heat-treatment above 1000℃. During the subsequent heat-treatment, however, spherical microspheres were agglomerated because of necking between particles. Further study has to be continued working on synthesis of pure SrFe12O19 crystal by means of improvement of pyrolysis temperature scheme and extend the heating period.

Phenotypic Diversity within Collected Sesame Germplasm

Kang-Bo Shim,Churl-Whan Kang,Chung-Dong Hwang,Suk-Bok Pae,Kyung-Jin Choi,Keum-Yong Park,Jae-Cheon Byun 한국국제농업개발학회 2008 韓國國際農業開發學會誌 Vol.20 No.2

Development of Black Sesame Variety ‘Dahuck’ with Disease Resistance, High Yield Potential

Kang-Bo Shim,Choung-Dong Hwang,Suk-Bok Pae,Sung-Up Kim,Choon ki-Lee,Chang-Whan Park,In-Youl Baek,Ramalingam Radhakrishnan,Jong Ki-Lee 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07

This experiment was conducted to develop new black sesame variety with multi-disease resistance and high yield potential. A new sesame variety ‘Daheuk’ was developed from Yeongnam Agricultural Research Institute in 2009. Cross was made by ‘Whahuck’ with high disease resistance and F1 line of ‘Yoosung’ and ‘Keunhuck’ with high yields capacity & disease resistance, followed by pedigree selection, yield test and RYT by the sesame breeding team at the National Institute of Crop Science and Yeongnam Agricultural Research Institute up to 2009. The variety showed higher disease resistance and yield potential rather than that of check variety ‘Yangheuk’. Average stem length and the number of capsules per plant were 117cm, 75 respectively. It’s 1000 grains weight was about 2.80g indicating 0.20g higher than that of ‘Yangheuk’, and it’s protein content was about 25.7% which is higher than that of check variety. ‘Daheuk’ also contained total 3.0mg/g of lignan compounds which is lower than that of ‘Yangheuk’. The average yield of ‘Daheuk’ was 97kg per 10a at the national-wide regional performance.

Salicylate가 성체줄기세포의 골분화에 미치는 영향

김보규(Bo Gyu Kim),이아람(A ram Lee),이보영(Bo Young Lee),심성보(Sungbo Shim),문동규(Dong kyu Moon),황선철(Sun-Chul Hwang),변준호(June-Ho Byun),우동균(Dong Kyun Woo) 한국생명과학회 2018 생명과학회지 Vol.28 No.12

최근 들어 급속한 고령화 사회가 진행되고 있으며 이로 인해 골관절염과 골다공증 등의 퇴행성 골질환 환자수도 동반하여 증가하고 있다. 따라서 고령화에 따른 골관련 질환의 새로운 제어와 치료법 개발을 위해 성체줄기세포의 골세포 분화유도를 활용한 재생의학도 활발히 연구되고 있다. 또한 관련 연구에서 줄기세포의 분화과정에서 미토콘드리아의 산화적인산화가 중요하다고 알려지고 있다. 흥미롭게도 최근 연구에서 아스피린의 주성분인 salicylate가 동물세포의 미토콘드리아 생합성을 증진시키는 효과가 보고되었다. 그러나 성체줄기세포에서 salicylate가 골세포분화나 미토콘드리아 생합성을 유도할 수 있는지에 대한 연구결과는 미비한 실정이다. 본 연구에서는 인체 골막 유래의 성체줄기세포를 이용하여 골세포분화나 미토콘드리아 생합성에 대한 salicylate의 영향을 분석하였다. 골막 유래 성체줄기세포의 골세포 분화유도 과정에 동반한 salicylate 처리는 잘 알려진 골세포분화 표지자인 alkaline phosphatase의 활성을 증가시키는 결과를 본 연구에서 얻었다. 이러한 연구결과는 salicylate가 줄기세포로부터 골세포로의 분화를 조절할 수 있는 물질이 될 수 있음을 제시한다. 또한 이러한 골세포 분화과정에서 미토콘드리아 생합성도 salicylate 처리에 의해 증가됨이 관찰되었다. 따라서, 미토콘드리아 생합성이나 기능을 조절하는 물질이 성체줄기세포의 골세포 분화과정에도 영향을 줄 수 있으며, 이러한 물질이 골세포분화나 재생의학의 새로운 조절 물질로 응용될 수 있음을 제시한다. Due to a rapidly expanding aging population, the incidence of degenerative bone disease has increased, and efforts to handle the issue using regenerative medicine have become more important. In order to control various bone diseases such as osteoarthritis and osteoporosis, regenerative medicine utilizing adult stem cells has been extensively studied. And it is now clear that the mitochondrial energy metabolism, oxidative phosphorylation, is important for the process of stem cell differentiation. Interestingly, a recent study reported that salicylate promotes mitochondrial biogenesis by regulating the expression of PGC-1α in murine cells. However, the possible effects of salicylate on osteogenic differentiation through increased mitochondrial biogenesis in stem cells remain unknown. Thus, here we investigated whether salicylate could influence osteogenic differentiation and mitochondrial biogenesis of periosteum-derived mesenchymal stem cells (POMSCs). We found that salicylate treatments of POMSCs undergoing osteogenic differentiation increased the activity of alkaline phosphatase, a well-known early marker of bone cell differentiation. In addition, we observed that mitochondrial mass was increased by salicylate treatments in POMSCs. Together, these results indicate that salicylate can enhance osteogenic differentiation and mitochondrial biogenesis in POMSCs. Therefore, the findings in this study suggest that small molecules augmenting mitochondrial function such as salicylate can be a novel modulator for osteogenic differentiation and regenerative medicine.

Comparison of Physiochemical Characters of Sesame Seeds according to the Different Producing Origin

Kang-Bo Shim,Chung-Dong Hwang,Suk-Bok Pae,Myoung-Hee Lee,Tae-Jung Ha,Chang-Hwan Park,Keum-Yong Park 한국국제농업개발학회 2010 韓國國際農業開發學會誌 Vol.22 No.4

초등학생의 창의적 가정환경, 창의성, 자기조절능력, 대인관계형성능력과 창의적 리더십의 구조적 관계

심명보(Shim Myung Bo),이신동(Lee Shim Dong) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.6

Creativity as a cognitive factor, interpersonal relationship skills as an affective factor and the creative family environment as an environmental factor were selected to prove the structural relationships with creative leadership of 408 5th and 6th grade students. We looked at how cognitive, affective, and environmental factors affected creative leadership of elementary school students. The results of the study were as follows: First, creativity, self-regulation ability, and interpersonal relationship skills had significant direct effects on the creative leaderships in the structural relationship of creative home environment, creativity, self-regulation ability, interpersonal relationship formation ability, and creative leadership. Second, self-regulation ability had the greatest effect on creative leadership among potential variables. Third, the creative home environment did not have a direct effect on creative leadership, but there was an indirect effect as a mediator, and the total effect was next to self-regulation ability and creativity. Based on these findings, the implications for teachers and parents were suggested to develop creative leadership of elementary school students. 초등학생의 창의적 리더십은 인지적 요인, 정의적 요인, 환경적 요인으로부터 모두영향을 받는다는 관점으로 인지적 요인으로서 창의성, 정의적 요인은 대인관계형성능력, 자기조절능력, 환경적 요인으로 창의적 가정환경을 선정하여 초등학교 5,6학년 학생 408명을 대상으로 창의적 리더십과의 구조적 관계를 검증하였다. 연구 결과 첫째, 창의적 가정환경, 창의성, 자기조절능력, 대인관계형성능력, 창의적 리더십의 구조적 관계에서 창의성, 자기조절능력, 대인관계형성능력은 창의적 리더십에 유의한 직접효과가 있었다. 둘째, 잠재변인 중 자기조절능력이 창의적 리더십에 미치는 효과가 가장 컸다. 셋째, 창의적 가정환경은 창의적 리더십에 직접 효과는 유의하지 않았으나, 매개변인으로서 간접효과가 있었으며, 총 효과에서는 자기조절능력과 창의성 다음으로 그 효과가 큰 것으로 나타났다. 이러한 연구 결과를 바탕으로 초등학생의 창의적 리더십을 계발하기 위해 교사와 부모들에게 줄 시사점을 제시하였다.

대수심, 대심도 초연약지반에서의 DCM공법의 최적 설계

심민보(Min-Bo Shim),김동후(Dong-Hoo Kim),심성현(Seong-Hyeon Shim),강민수(Min-Soo Kang),변기준(Gi-Jun Byun) 한국항해항만학회 2008 한국항해항만학회 학술대회논문집 Vol.2008 No.추계

심층혼합처리공법인 DCM(Deep Cement Mixingd)공법은 연약지반에 시멘트 슬러리를 주입하여 교반날개의 회전에 의해 시멘트 슬러리와 지반을 화학적으로 결합시켜 견고한 지반을 형성하는 공법을 말하며, 주로 기초처리공, 흙막이공에 적용되고 있다. 국내에는 1980년대 중반이후에 도입되었으며, 2005년도에는 4축3연의 해상장비 전용선이 개발되어 대심도, 대심도의 초연약지반에서 기초처리공으로 적용성이 확대되고 있다. 본 논문에서는 21m의 대수심, 최대 32m두께의 초연약지반에 방파제 기초처리공법으로 적용된 DCM공법에 대하여 시공 및 품질관리 측면에서의 설계적용기법을 설명하고자 한다. 대수심 적용성을 높이고자 기존 10cm의 시공중첩을 30cm로 확폭하고, 시공조인트를 계획하였으며, 초연약지반 적용성을 높이고자 심도별 시멘트량 적용, 시멘트 토출방식 개선 등을 계획하였다.

꽁치(Cololabis saira) 과메기의 지질산화 및 biogenic amine 생성에 건조조건이 미치는 영향

심길보 ( Kil Bo Shim ),임치원 ( Chi Won Lim ),이소정 ( So Jeong Lee ),정혜연 ( Hye Youn Jung ),심혜진 ( Hye Jin Shim ),윤호동 ( Ho Dong Yoon ) 한국수산과학회(구 한국수산학회) 2011 한국수산과학회지 Vol.44 No.5

This study reviewed the effect of the drying conditions on the production of biogenic amines and lipid oxidation in semi-dried Pacific saury Cololabis saira or Guamegi. The moisture content of the Guamegi ranged from 32.71±2.37 to 45.9±2.60 g/100 g. The respective ranges of the acid value (AV) and peroxide value (POV) were 1.39±0.40 to 15.79±0.47 mg KOH/g and 76.14±2.19 to 282.84±2.34 meq/kg on drying for 3 days. The AV and POV increased for up to 3 days of drying and the values differed according to the amount of sunlight and temperature. However, lipid oxidation was reduced in Guamegi manufactured using a cold-air drying method. The fatty acid composition and the biogenic amine content in Guamegi during drying did not differ significantly with the drying method or drying date. The main saturated, monoene and polyene fatty acids were palmitic acid, eicosenoic & erucic acids, and eicosapentaenoic & docosahexaenoic acids, respectively. At 16.67 to 71.89 mg/kg, the histamine content was higher than that of other biogenic amines and it increased significantly during drying. In conclusion, this study showed that the packaging and drying conditions of Guamegi products need to be improved to inhibit lipid oxidation and biogenic amine formation.

수온 및 절식에 따른 넙치 (Paralichthys olivaceus) 근육의 물리화학적 특성 변화

심길보 ( Kil Bo Shim ),이소정 ( So Jeong Lee ),윤호동 ( Ho Dong Yoon ),임치원 ( Chi Won Lim ),신윤경 ( Yun Kyung Shin ),정민환 ( Min Hwan Jeong ),이동길 ( Dong Gil Lee ),박태일 ( Tae Ii Park ) 한국수산과학회(구 한국수산학회) 2012 한국수산과학회지 Vol.45 No.5

The effects of low temperature and starvation on the physiochemical characteristics of the muscle of the olive flounder Paralichthys olivaceus, were examined. Fish were deprived of feed for 28 days at 2, 4, 6, 8, 10, 12, and 20°C in order to establish suitable conditions for live fish transportation. Throughout most of the 4 weeks of feed restriction, the physiochemical characteristics of the muscle of olive flounder were found to be dependent on the acclimation temperature. The breaking strength of muscle did not show a significant reduction during feed restriction at 2 and 4°C. With increasing temperatures, however, the breaking strength of muscle differed significantly according to the individual and feed restriction period (P<0.05). The moisture content in muscle acclimated at 10, 12, and 20°C increased steadily over the feed-restriction period, while the crude lipid content decreased during the same period (P<0.05). At water temperatures above 2-8°C, no significant differences were shown during the same period. After it reached 6, 8, 10, 12, and 20°C, the muscle had an accumulation of lactate, and a loss of ATP. There was no change in the lactate or ATP content during the feed restriction period at 2 and 4°C, although there were differences among the water temperature groups, These results clearly show that temperature can have an important influence on the of muscle of physiochemical characteristics of muscle during live fish transportation.

Recent Progress of PepMoV Resistant GM Pepper

Eun Mi Jeon,Sun Hee Shin,Soon Ho Choi,Dong Bo Shim,Nam Han Her,Jang Ha Lee,Min Jung,Ki Hyun Ryu,Soon-Chun Jeong,Chee Hark Harn 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

The PepMoV has been considered the most frequently detected potyvirus. When it co-infects with CMV or PMMoV, it gives severe impact to total pepper harvest in Korea. Since F1 hybrid that resistant to PepMoV has not been developed, we have developed transgenic peppers using Agrobacterium-mediated transformation with a Hc-Pro gene of the PepMoV. A large number of GM peppers were tested for resistance to the PepMoV, and after consequent self-crossing up to T4 generation, a highly tolerant pepper to PepMoV called T20 was selected. So far, BC4F1 lines have been selected by back-crossing with 4 elite lines through a breeding program. Very recently, based on molecular analysis, we have selected another event, #10-2, which is also resistant to PepMoV. Horticultural difference was investigated for both GM lines, #T20 and 10-2, and no significance was found comparing to non-GM lines.