UV/TiO_(2) 수처리 공정에서의 살균에 관한 연구

이규환,이상진,이용재,이동석 강원대학교 산업기술연구소 2007 産業技術硏究 Vol.27 No.A

This study investigated disinfection effect by general water purifier and water purifier with UV light disinfection. The results are as follows : (ⅰ) The general bacteria existed plentifully in a storage tank before treatment (ⅱ) Water treated in water purifier did not meet the water treatment regulation standard since the presence of bacteria, whereas with UV light application the regulation standard is totally satisfied. (ⅲ) Photocatalytic disinfection process with UV light in the presence of TiO_(2) more effectively killed general bacteria than UV light only.

SJO¨GREN'S SYNDROME 환자에게 즉시 임프란트 술식을 행한 치험례

최정환,손동석,이지연,이윤서,안선희,이재목 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The old edentulous patients experience xerostomia commonly. They have considerable difficulty in wearing tissue-supported prosthesis and high risk rate of caries. One of them is Sj□gren's syndrome patient. Sj□gren's syndrome is a chronic inflammatory autoimmune disorder that results in a lymphocyte-mediated destruction of exocrine glands. We planned to place implants immediately after extraction in this case of autoimmune disease. The advantages of immediate implant placement include considerable decrease in time from tooth extraction to placement of the final prosthesis, fewer surgical procedures, and better acceptance of the overall treatment plan. We present a case of Sj□gren's syndrome patient treated with immediate implant placement & immediate loading in anterior region and immediate implant placement in posterior region.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

수술-교정 치료 환자의 통제 소재

이신재,안석준,백승학,김태우,장영일,양원식,서정훈,남동석 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.4

교정치료와 악교정 수술을 필요로 하는 환자가 점증하는 현 시점에 비추어, 이에 대한 기술적인 측면의 발전과는 달리 수술-교정 치료 환자에 대한 정신사회학적 혹은 정신심리적 양상에 대한 객관적인 정보는 그리 많은 주목을 받는 편이 아니었다. 수술-교정치료는 과학적인 치료과정이긴 하지만, 어느 정도 심미적 혹은 예술적인 측면을 지니는 선택 치료의 면모를 지닌다. 그러므로 치료에 대한 환자의 주관적인 느낌은 치료 기술이나 치료의 의학적 성공 여부보다 더 큰 영향을 미칠 수 있다. 그러므로, 수술-교정 (혹은 교정) 치료에 대한 환자의 반응을 예측하기 위한 정신심리적인 정보는 치료에 유용한 지표가 될 수 있다고 가정할 수 있다. 통제 소재에 대한 연구는 인간의 다양한 행동을 예측하기 위한 유용한 지표로 알려져 왔는데, 본 연구에서는 42명의 수술-교정치료 환자와 성별/연령별로 표본 추출된 42명의 통상적 교정치료 환자를 대상으로 삼아 정신=심리적 비교 및 분석의 방법으로 두 가지 종류의 내외 통제 소재(internal/external locus of control) 검사를 시행하였다. 그 결과 수술-교정치료군에서만 남자가 여자에 비하여 낮은 외적 통제(높은 내적 통제)의 경향을 보였다. 결론적으로 수술-교정치료 환자의 정신심리적 기반은 성형 수술 환자와는 달리 교정치료 환자와 유사한 경향을 지닌 것으로 생각되었다. Surgical-orthodontic treatment is an increasingly more common dental procedure whose unique psycho-social or psychological feature has not been fairly quantified objectively. Since the treatment of a surgical-orthodontic (or orthodontic) patient is part science and part art, a subjective recognition of a patient about his or her own treatment may be more important than technical success during and after treatment. Therefore, the knowledge of the patient''s underlying psychological status could be useful in the prediction of patient's response to surgical-orthodontic (or orthodontic) treatment. The purpose of this study was to investigate and evaluate the psychological difference between conventional orthodontic patient and surgical-orthodontic patient by using locus of control (LOC) examination. Locus of control scale has been proven to be extremely useful in the prediction of a variety of human behaviors. Two types of locus of control data (I-score, Internal locus of control score ; E-score, External locus of control score) were obtained for 42 surgical-orthodontic patients and randomly selected 42 conventional orthodontic patients (as a control group) matched for age and gender. No statistically significant difference was observed in the scale of internal and external locus of control between the groups of surgical-orthodontic patients, males showed lower E-score (external locus of control score, higher internal locus of control tendency) than females. The results of this study suggested that the psychological background of surgical-orthodontic patients, in contrast with that of cosmetic surgery patients, has a similar disposition with that of orthodontic patients.

시험관내 심내막염 모델에서 Methicillin 내성 포도구균에 대한 Vancomycin, Arbekacin, Gentamicin 단독 혹은 병합효과

이동건,전혜선,임동석,최수미,최정현,유진홍,신완식,강문원 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

목적 : Methicillin 내성 포도구균(methicillin resistant Staphylococcus aureus, MRSA)은 병원감염의 중요한 원인균으로 vancomycin이 선택약제이다. 그러나 심내막염 등의 중증감염에서는 vancomycin의 치료실패와 함께 최근 내성균도 증가하고 있어 vancomycin을 대체할 수 있는 항균제와 보다 효과적인 항균요법의 개발이 필요하다. 본 연구에서는 사람의 환경과 유사한 시험관내 감염 모델을 적용하여 MRSA 치료를 위한 vancomycin, arbekacin, gentamicin의 단독 및 병합효과를 비교하였다. 방법 : 임상에서 분리된 MRSA 2균주(GRI 53, gentamicin 내성 : GS171, gentamicin 감수성)로 fibrin clot을 제작하여 시험관내 심내막염 모델을 만들어 vancomycin, arbekacin, gentamicin을 단독 혹은 병합주입하였다. 반감기와 최고 및 최저농도는 사람의 약동학을 기준으로 하였다. Vancomycin은 6, 12, 24시간마다 주입하거나 24시간 연속주입하였고 arbekacin은 12, 24시간마다, gentamicin은 8, 24시간마다 주입하였다. 병합주입의 경우 vancomycin은 12시간마다, gentamicin, arbekacin은 24시간마다 투여하였다. 각 투여군의 살균효과는 0, 8, 24, 32, 48, 72시간째의 fibrin clot내 집락수로 측정하였다. 결과 : GRI153에 gentamicin을 주입한 군 이외의 모든 실험군에서 대조군에 비해 의미있게 fibrin clot내 집락수가 감소하였다(P<0.001). Vancomycin과 arbekacin 단독주입군내서 8시간째의 집락수는 GRI153보다 GS171에서 의미있게 낮았고(P=0.02), GS171에 arbekacin 12시간마다 투여한 군의 집락수가 가장 낮았다(P=0.01). 72시간째 집락수는 균주의 종류나 vancomycin 혹은 arbekacin의 투여간격에 따른 차이가 없었다. GRI153에서 vancomycin과 arbekacin의 병합주입군은 24시간까지 상가작용이 있었으나 vancomycin과 gentamicin 병합주입에서는 무관작용이었고 GS171에서도 72시간 동안 무관작용을 보였다. 또한 전 실험기간 동안 내성균은 발현되지 않았다. 결론 : 시험관내 심내막염 모델에서 MRSA에 대한 arbekacin의 항균력은 vancomycin과 유사하여 단독주입이 가능함을 시사한다. Gentamicin 내성균주의 경우 두가지 항균제의 병합주입으로 24시간까지 상가작용을 보이고 있으나 임상에 적용하기 위해서는 추가연구가 필요할 것으로 생각된다. Background : Glycopeptide has been used for the one-and-only treatment of choice in methicillin resistant Staphylococcus aureus (MRSA) infection, but its exclusive use for the MRSA infection has led to the increased risk of glycopeptide-resistance. To find an alternative (s), we employed an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VCM). arbekacin (ABK), and gentamicin (GM) alone or in combination. Methods : Using two strains of clinically isolated MRSA, one GM susceptible (GS171) and the other GM resistant (GR153), fibrin clots were prepared and suspended in IVIEM. Antibiotics were added as a bolus to simulate human pharmacokinetics of regimens, including q 6 h, q 12 h, q 24 h, or continuous infusion with VCM, q 12h or q 24 h with ABK, and q 8 h or q 24 h with GM. In cases of combination, regimens were VCM q 12 h plus ABK q 24 h, and VCM q 12 h plus GM q 24 h. Fibrin clots were removed from each model at 0, 8, 24, 32, 48. and 72 h, and the bacterial densities (in CFU/g) were determined. Results : At 8 hour, the colony counts of GS171 were lower than those of GR153 (P=0.02), and the lowest with the ABK q12h against GS171 (P=0.01). At 72 hour, monotherapy with ABK or VCM produced same degree of bacterial reductions in IVIEM, regardless of dosing frequency or GM-resistance. In the case of GM-resistance, combination of VCM and ABK did show additive effect until 24 hours, although VCM and GM showed no indifference during all the experiments. Development of resistance during experiment was not observed with any regimens. Conclusions : Our data suggest that ABK monotherapy could be used as an alternative to VCM even in the treatment of GM-resistant staphylococcal endocarditis. Further studies will clinical trials are warranted to evaluate the additive effect of VCM and ABK.

하악 이부에 발생한 방선균증의 치험례

李暲東,孫東錫,金成國 대구효성가톨릭대학교 1996 연구논문집 Vol.52 No.2

Actinomycosis is a chronic infection of inhibitant oral bacteria, especially Actinomyces israelii. A. israelii are Gram positive, non acid-fast, anaerobic, filamentous organisms. The most frefguent form of actinomycosis is the cervicofacial type. Its involved skin is purplished red and indurated, tending to form multiple draining sinus tract. The characteristic “sulfur granule”appear in the abscess center. The infection of the soft tissue may extend to involve the mandible or less commomly, the maxilla. The treatment is antibiotic therapy and adequete drainage. We experienced actinomycosis occured in chin area and treated this disease with antibiotics &surgical drainage. The patient showed good prognosis.

인진쑥(Artemisia iwayomogi) 올리고당류(AIP1)의 기능성 탐색

이동석,최현주,윤현주 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective: We examined the effects of the AIPI on the cell apoptosis, colonal and pathogenic microbial activities in vitro, and glycemic controls in vivo. Methods and Materials: The oligosaccharide fraction AIPI was isolated and purified from Artemisia iwayomogi by the aqueous extraction and gel filtration chromatography. Results: In the experiment of murine macrophage culture, the AIPI decreased the apoptotic cell death. In the mircrobiological experiments of the Bifidobacterium and Lactobacillus from the human intestine, the AIPI stimulated these colonal microbialactivities. However, the AIPI showed a strong inhibition against activities of the Listeria monocytogenes and Klebsiella pneumoniae in the experiments of the agar-diffusion and the estrase-FDA. In the animal experiment, the AIPI lowered the blood glucose curves of the glucose tolerance test in the diabetic rats. Conclusion: It is concluded that the oligosaccharide fraction AIPI from the Artemisia lwayomogi may have several beneficial functions as an immune booster, colonal probiotics, antimicrobial agent, and glucose intolerance alleviatin-biohealth material.

수산화아파타이트 생체재료의 표면용해 특성

이종국,서동석 조선대학교 생산기술연구소 2003 生産技術硏究 Vol.25 No.1

Grain boundary dissolution and separation of hydroxyapatite (HA) in distilled water were investigated For the preparation of HA ceramics, a laboratory synthesized HA powder with different Ca/P molar ratio was used. After preparing powder compacts, the specimens were sintered at 1200℃ for 2h in air with under moisture protection. Microstructural degradation related to the grain boundary dissolution could be induced by microstructures and composition of HA ceramics.

소아 신장질환에 대한 임상 통계적 관찰 : 11년간의 고찰 An Eleven-Years Experience

이재호,정기영,유재홍,최동석 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

Statistical analysis of renal inpatients admitted to the department of pediatric ward of Chungnam National University Hospital from 1978 to 1988 was performed according to their annual incidence of each disease, disease pattern, and age distribution. Renal diseases were found in 628(6.16%) among 10,194 total inpatients from 1978 to 1988. Male to famale ratio of renal disease was 1.99 to 1. Annual incidence of acute glomerulonephritis was decreased but no significant change was noted in the incidence of nephrotic syndrome and urinary tract infection. Acute glomerulonephritis was the leading cause of admission in all age groups and it constituted 28.82% of total renal patients. It was followed by nephronic syndrome(23.24%), urinary tract infection(16.56%). Wilms’ tumor(7.64%), Henoch-Schonlein nephritis(6.21%), and recurrent hematuria(4.45%). Urinary tract infection showed relatively high incidence in infancy and acute glomerulonephritis and nephrotic syndrome were high in older age group. Renal diseases were most frequently found in 7-9 years old age group. Chronic renal failure and recurrent hematuria were relatively frequent in over 12 years old age group.

PM線을 利用한 III級 不正咬合 兒童의 顎顔面 形態에 關한 硏究

李東烈,南東錫 대한치과교정학회 1985 대한치과교정학회지 Vol.15 No.1

This investigation was designed to compare the craniofacial morphology of Class Ⅲ malocclusions with that of normal occlusions using PM line. The subjects consisted of forty-four normal occlusions (twenty-three males and twenty-one females) and sixty-nine Class Ⅲ malocclusions ( thirty males and thirty-nine females), aged eghit through ten. Using the tracings of the standard lateral cephalograms, various angles, linear measurements and linear ratios of counter-part were recorded and analyzed by t-test. The following characteristics of craniofacial morphology of Class Ⅲ malocclusion were obtained by this study. 1. Maxillary anteroposterir position was balanced with mandible because maxillary bony arch was small and positioned posteriorly and mandibular corpus was large and positioned relatively anteriorly. 2. Upper and lower alveolar bony arch were not balanced each other in its size. 3. In counterpart analysis, Class Ⅲ malocclusion was more horizontally unbalanced than normal occlusion. 4. Class Ⅲ malocclusion was divied into 11 groups by maxillary and mandibular bony arch position, size and alveolar bony arch size. Unbalanced bony size of the maxilla and mandible was a major charactersistics of Class Ⅲ malocclusion.