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Doğru Fatma Zehra,Arslan Olcay 한국통계학회 2023 Journal of the Korean Statistical Society Vol.52 No.1
In this paper, we propose a weighted extension of the family of multivariate Generalized Asymmetric Laplace (GAL) distributions. This extension is formed as a variance-mean mixture of the multivariate normal distribution and the weighted gamma distribution. By using the weighted gamma distribution as the mixing distribution, the resulting family of weighted GAL (WGAL) distributions gains an additional parameter to further regulate kurtosis and tail thickness; this is an advantage over the family of GAL distributions for modeling data sets. In particular, this new parameter provides great flexibility in adjusting the kurtosis and tail thickness for some members of the GAL distributions family, since these distributions are the widely used members of the GAL family without any shape parameter regulating kurtosis and tail thickness. After defning the multivariate WGAL distributions family and constructing the probability density function, we give some special cases of the new family and examine various properties of the new distributions, such as linear transformations, conditional distributions, and multivariate kurtosis measure. We study the maximum likelihood (ML) estimation to estimate the parameters and describe an algorithm based on the expectation maximization (EM) principle to obtain the ML estimates. We also provide simulation studies and real data examples to explore the modeling capacity of some distributions belonging to the newly proposed family of distributions.
Parametric study on energy demands for steel special concentrically braced frames
Selçuk Doğru,Bora Akşar,Bülent Akbaş,Jay Shen 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.24 No.2
Structures are designed in such a way that they behave in a nonlinear manner when subject to strong ground motions. Energy concepts have been widely used to evaluate the structural performance for the last few decades. Energy based design can be expressed as the balance of energy input and the energy dissipation capacity of the structure. New research is needed for multi degree of freedom systems (MDOFs)-real structures- within the framework of the energy based design methodology. In this paper, energy parameters are evaluated for low-, medium- and high-rise steel special concentrically braced frames (SCBFs) in terms of total energy input and hysteretic energy. Nonlinear dynamic time history analyses are carried out to assess the variation of energy terms along the height of the frames. A seismic energy demand spectrum is developed and hysteretic energy distributions within the frames are presented.
Şükran Doğru,Fatih Akkuş,Aslı Altinordu Atci,Ülfet Sena Metin,Mehmet Uyar,Ali Acar 대한산부인과학회 2024 Obstetrics & Gynecology Science Vol.67 No.1
Objective This study evaluated maternal and fetal outcomes of emergency uterine resection versus planned segmental uterine resection in patients with placenta percreta (PPC) and placenta previa (PP). Methods Patients with PP and PPC who underwent planned or emergency segmental uterine resection were included in this study. Demographic data, hemorrhagic morbidities, intra- and postoperative complications, length of hospital stay, surgical duration, and peri- and neonatal morbidities were compared. Results A total of 141 PPC and PP cases were included in this study. Twenty-five patients (17.73%) underwent emergency uterine resection, while 116 (82.27%) underwent planned segmental uterine resections. The postoperative hemoglobin changes, operation times, total blood transfusion, bladder injury, and length of hospital stay did not differ significantly between groups (P=0.7, P=0.6, P=0.9, P=0.9, and P=0.2, respectively). Fetal weights, 5-minute Apgar scores, and neonatal intensive care unit admission rates did not differ significantly between groups. The gestational age at delivery of patients presenting with bleeding was lower than that of patients who were admitted in active labor and underwent elective surgery (32 weeks [95% confidence interval [CI], 26-37] vs. 35 weeks [95% CI, 34-35]; P=0.037). Conclusion Using a multidisciplinary approach, this study performed at a tertiary center showed that maternal and fetal morbidity and mortality did not differ significantly between emergency versus planned segmental uterine resection.
Optimization of hybrid composite plates using Tsai-Wu Criteria
Mehmet Hanifi Doğru,İbrahim Göv,Eyüp Yeter,Kürşad Göv 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.88 No.4
In this study, previously developed algorithm is used for Optimization of hybrid composite plates using Tsai-Wu criteria. For the stress-based Design Optimization problems, Von-Mises stress uses as design variable for isotropic materials. Maximum stress, maximum strain, Tsai Hill, and Tsai-Wu criteria are generally used to determine failure of composite materials. In this study, failure index value is used as design variable in the optimization algorithm and Tsai-Wu criteria is utilized to calculate this value. In the analyses, commonly used design domains according to different hybrid orientations are optimized and results are presented. When the optimization algorithm was applied, 50% material reduction was obtained without exceeding allowable failure index value.
Epidural anesthesia for pilonidal sinus surgery: ropivacaine versus levobupivacaine
Zeynep Nur Orhon,Emine Nursen Koltka,Sibel Devrim,Sevil Tüfekçi,Serkan Doğru,Melek Çelik 대한마취통증의학회 2015 Korean Journal of Anesthesiology Vol.68 No.2
Background: Epidural anesthesia is one of the best options for lower abdominal and lower limb surgery. However, therehave been insufficient reports regarding the use of epidural anesthesia for pilonidal sinus surgery. The present study wasperformed to compare the clinical profiles of epidural block performed with 0.75% levobupivacaine and 0.75% ropivacainein this procedure. Methods: Thirty patients undergoing pilonidal sinus surgery were randomly allocated into two groups: one group receivedlevobupivacaine and the other received ropivacaine at 0.75% in a volume of 10 ml. Arterial blood pressure, heartrate, oxygen saturation, the onset time of analgesia and duration of block, highest sensory block level, perioperative andpostoperative side effects, and patients’ and surgeons’ satisfaction were recorded. Results: Hemodynamic stability was maintained in both groups throughout surgery. The onset time of analgesia (thetime from epidural injection of local anesthetic to reach L2 sensorial block) was 6.26 ± 3.49 min in the levobupivacainegroup and 4.06 ± 1.75 min in the ropivacaine group (P = 0.116). The duration of sensorial block (time for regression ofsensory block to L2) was 297.73 ± 70.94 min in group L and 332.40 ± 102.22 min in group R (P = 0.110). Motor block wasnot seen in any of the patients in the study groups. Patients’ and surgeons’ satisfaction with the anesthetic technique weremostly excellent in both groups. Conclusions: In patients undergoing pilonidal sinus surgery, both levobupivacaine and ropivacaine produce rapid andexcellent epidural block without leading to motor block or significant side effects. Although not statistically significant,the onset time of anesthesia was shorter and the duration of effect was longer with ropivacaine than with levobupivacainein this study.
Is the diagnosis of calcified laryngeal cartilages on panoramic radiographs possible?
Leyla Berna Çağırankaya,Nursel Akkaya,Gökçen Akçiçek,Hatice Boyacıoğlu Doğru 대한영상치의학회 2018 Imaging Science in Dentistry Vol.48 No.2
Purpose: Detecting laryngeal cartilages (triticeous and thyroid cartilages) on panoramic radiographs is important because they may be confused with carotid artery calcifications in the bifurcation region, which are a risk factor for stroke. This study assessed the efficiency of panoramic radiography in the diagnosis of calcified laryngeal cartilages using cone-beam computed tomography (CBCT) as the reference standard. Materials and Methods: A total of 312 regions (142 bilateral, 10 left, 18 right) in 170 patients (140 males, 30 females) were examined. Panoramic radiographs were examined by an oral and maxillofacial radiologist with 11 years of experience. CBCT scans were reviewed by 2 other oral and maxillofacial radiologists. The kappa coefficient (κ) was calculated to determine the level of intra-observer agreement and to determine the level of agreement between the 2 methods. Diagnostic indicators (sensitivity, specificity, accuracy, and false positive and false negative rates) were also calculated. P values <.05 were considered to indicate statistical significance. Results: Eighty-two images were re-examined to determine the intra-observer agreement level, and the kappa coefficient was calculated as 0.709 (P<.05). Statistically significant and acceptable agreement was found between the panoramic and CBCT images (κ=0.684 and P<.05). The sensitivity, specificity, diagnostic accuracy rate, the false positive rate, and the false negative rate of the panoramic radiographs were 85.4%, 83.5%, 84.6%, 16.5%, and 14.6%, respectively. Conclusion: In most cases, calcified laryngeal cartilages could be diagnosed on panoramic radiographs. However, due to variation in the calcifications, diagnosis may be difficult.
이송실,강중원,백용현,최도영,박동석,김덕윤,김강일,박상도,양하루,지미영,이제동,Lee, Song-shil,Kang, Jung-won,Back, Yong-hyeon,Choi, Do-young,Park, Dong-seok,Kim, Deog-yoon,Kim, Kang-il,Park, Sang-do,Yang, Ha-ru,Ji, Mi-young,Lee, Jae-do 대한침구의학회 2004 대한침구의학회지 Vol.21 No.3
Background : Angiogenesis is the proliferation of a network of blood vessels emanating from pre-existing vessels, supplying nutrients and oxygen and removing waste products. Angiogenesis occurs in a variety of normal physiologic and pathologic conditions and is regulated by a balance of stimulatory and inhibitory angiogenic factors. Excessive angiogenesis should be suppressed. However, if blood supply is insufficient, it should be encouraged. Hyul-Mek(血脈) or Hyul-Rark(血絡), known as blood vessels in western medicine, is deeply related to Chung-Ki-Hyul(精 氣 血). The goal of this study is to review the effects of herbal medicines on angiogenesis that is involved in wound healing and enhancement of blood supply. Methods : We conducted a systematic and comprehensive literature search for the identification, retrieval, and bibliographic management of independent studies to locate information on the topic. A computerized search of the published literature of Korea(KISS, RISS), China(CNKI), Japan(Kampo medicine, etc), and western countries(MEDLINE) was performed, and further supplemented with manual searches of print sources(1999 to 2003). Results : The herbal medicines with angiogenic activity were mainly found among herbs that carry replenish Shin-Cheng(補腎益精), foster Eum and improve the circulation of blood(養陰活血), or warm and circulate Kyung-Rark(溫經通絡). In particular, herbs with improve the circulation of blood and clear blood(活血化瘀) activity contain a significant amount of tannin, saponin, and pyrazine. Conclusion : Replenish Ki-Hyul(補氣血) and circulate Kyung-Rark(通經絡) could contribute to the induction of angiogenesis because various growth factors and proliferation, differentiation, and migration of vascular endothelial cells are involved in angiogenic activity.
( Ru Hui Song ),( Do Hyeon Yu ),( Jun Hwan Kim ),( Hyun Seok Lee ),( Da Mi Lee ),( Chul Park ),( Il Jung Yu ),( Jin Ho Park ) 한국가축위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.3
Lymphoma is the most common hematopoietic malignancy in dogs. Diagnosis of lymphoma is classically performed by morphological assessment and immunohistochemistry. But some cases in the early stage are difficult to distinguish and need more objective and accurate methods. So, Polymerase chain reaction (PCR) for antigen receptor rearrangements (PARR) and flow cytometric immunophenotype of lymphoma have been developed continuously. In this study, we performed these two methods to classify lymphoma type in 3 cases. According to PARR analysis, B cell origin lymphoma was diagnosed in two of three cases by testing PBMC and lymph node. All fine needle aspiration (FNA) samples of lymph nodes had high expression of CD21 on >88% of total cell population and PBMC samples also showed high expression of CD21 on >30% of total lymphocytes in those two cases, while the expression of CD3, CD4 and CD8 was absent. These results suggest that concurrent use of PARR and flow cytometric immunophenotype is more effective and valuable tool for the diagnosis and monitoring of canine lymphoma patients.
Puerariae Radix induces Angiogenesis in vitro and in vivo
Choi Do-Young,Kang Jung-Won,Cho Eun-Mi,Lee Jae-Dong,Hyh Jeong-Eun,Yang Ha-Ru,Baek Yong-Hyeon,Kim Deog-Yoon,Cho Yoon-Je,Kim Kang-il,Park Dong-Suk 대한침구의학회 2005 대한침구의학회지 Vol.22 No.2
Background & Objective : Angiogenesis consists of the proliferation, migration, and differentiation of endothelial cells, and angiogenic factors and matrix protein interactions modulate this process. The aim of this study was to determine whether Puerariae radix could induce angiogenic activity in human umbilical vein endothelial cells (HUVECs).Methods : The angiogenic activity of Puerariae radix were evaluated by using BrdU assay, chemotactic migration assay, tube formation assay, measurement of bFGF in HUVECs, and Matrigel plug assay in mice.Results : Puerariae radix significantly increased HUVECs proliferation in a dose-dependent manner. In addition, Puerariae radix increased migration and tube-like formation in HUVECs. Interestingly,the expression of basic fibroblast growth factor (bFGF), an angiogenesis-stimulating growth factor, was dose-dependently increased by Puerariae radix. The angiogenic activity of Puerariae radix was confirmed using an in vivo Matrigel angiogenesis model, showing promotion of blood vessel formation. Conclusion : Puerariae radix significantly induces angiogenesis in vitro and in vivo. These results suggest that Puerariae radix is a potent angiogenic agent, and a promising drug, for the induction of neovascularization.
Song, Ru-Hui,Yu, Do-Hyeon,Kim, Jun-Hwan,Lee, Hyun-Seok,Lee, Da-Mi,Park, Chul,Yu, Il-Jung,Park, Jin-Ho The Korean Society of Veterinary Service 2011 韓國家畜衛生學會誌 Vol.34 No.3
Lymphoma is the most common hematopoietic malignancy in dogs. Diagnosis of lymphoma is classically performed by morphological assessment and immunohistochemistry. But some cases in the early stage are difficult to distinguish and need more objective and accurate methods. So, Polymerase chain reaction (PCR) for antigen receptor rearrangements (PARR) and flow cytometric immunophenotype of lymphoma have been developed continuously. In this study, we performed these two methods to classify lymphoma type in 3 cases. According to PARR analysis, B cell origin lymphoma was diagnosed in two of three cases by testing PBMC and lymph node. All fine needle aspiration (FNA) samples of lymph nodes had high expression of CD21 on >88% of total cell population and PBMC samples also showed high expression of CD21 on >30% of total lymphocytes in those two cases, while the expression of CD3, CD4 and CD8 was absent. These results suggest that concurrent use of PARR and flow cytometric immunophenotype is more effective and valuable tool for the diagnosis and monitoring of canine lymphoma patients.