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RISS 인기검색어
- 검색키워드
- 저자 : Dileep Reddy Rampa (검색결과 2 건)
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NIR Dye-Conjugated Maltodextrin for Photothermal Therapy of Cancer
Dileep Reddy Rampa,고창곤,이유진,이동원 한국고분자학회 2021 Macromolecular Research Vol.29 No.4
Photothermal therapy (PTT) is one of recently emerging anticancer treatment modalities that involve the use of laser and photosensitizers. To fully explore the therapeutic potential of PTT, it is critical to deliver photosensitizers to tumors specifically. Maltodextrin is a hydrophilic polysaccharide consisting of D-glucose units and has been used as a pharmaceutical excipient because of its excellent biocompatibility. IR820 is a derivative of indocyanine green (ICG), a clinically used imaging agent and has potential as a photosensitizer for PTT. However, the clinical translation of IR820 has been limited by its lack of cancer targeting ability and poor stability in physiological environments. In this study, we hypothesized that IR820-conjugated maltodextrin (MDir) preferentially accumulates in tumors and serves as photothermal agents. Combination of MDir and near-infrared (NIR) laser irradiation significantly increased the temperature, leading to photothermal-mediated apoptosis of cancer cells. In a mouse xenograft models, MDir preferentially accumulated in tumors and induced almost complete thermal ablation of tumors upon NIR laser irradiation. Based on its tumor targeting ability, photothermal conversion efficiency and excellent biocompatibility, we anticipate that MDir holds great translational potential as a fluorescence imaging-guided photothermal agent for cancer treatment.
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Photothermal Therapy Agent NIR Dye-conjugated Maltodextrin for Anticancer
송난희,이동원,이유진,Dileep Reddy Rampa 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Photodynamic therapy (PDT) is one of the anticancer treatment methods that using laser and photosensitizers. In PDT, it is critical to deliver photosensitizers to tumors specifically. In this study, we hypothesized that IR820-conjugated maltodextrin (MDir) has ability of preferentially uptake to cancer cells and serve as photothermal agents. Maltodextrin is selectively uptake to cancer cell depending on the presence or absence of maltodextrin transporters. IR820 is a clinically used imaging agent and has potential as a photosensitizer for PDT. In the studies of a xenograft mouse model, These newly conjugated MDir preferentially accumulated in tumors and induced almost complete thermal ablation of tumor NIR laser irradiation. Based on its cancer targeting ability, photothermal conversion efficiency and excellent biocompatibility, we anticipate that MDir could serve as great translational potential as fluorescence-guided photothermal agent for cancer treatment.
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