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- 저자 : Debasrita (검색결과 3 건)
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Rath, Surya Narayan,Das, Debasrita,Konkimalla, V Badireenath,Pradhan, Sukanta Kumar Korea Genome Organization 2016 Genomics & informatics Vol.14 No.3
Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer. In silico study reveals, miRNAs namely, miR-106a, miR-21, and miR-29b-2 have a strong binding affinity towards PTEN, TGFBR2, and VEGFA genes, respectively, suggested as important factors in RNA silencing mechanism. Furthermore, interaction between AGO protein (PDB ID-3F73, chain A) with selected miRNAs and with miRNAs-mRNAs duplex were studied computationally to understand their binding at molecular level. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding miRNAs based gene silencing mechanism in solid cancer.
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Surya Narayan Rath,Debasrita Das,V Badireenath Konkimalla,Sukanta Kumar Pradhan 한국유전체학회 2016 Genomics & informatics Vol.14 No.3
Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer. In silico study reveals, miRNAs namely, miR-106a, miR-21, and miR-29b-2 have a strong binding affinity towards PTEN, TGFBR2, and VEGFA genes, respectively, suggested as important factors in RNA silencing mechanism. Furthermore, interaction between AGO protein (PDB ID-3F73, chain A) with selected miRNAs and with miRNAs-mRNAs duplex were studied computationally to understand their binding at molecular level. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding miRNAs based gene silencing mechanism in solid cancer.
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Akhil Syed,Saeed Al Musawi Mahdi Jawad,Majety Syam Sundar,Mullamuri Bhanu,Majji Ganesh,Bharatiya Debasrita,Mosali Venkata Sai Sriram,Bollikolla Hari Babu,Chandu Basavaiah 한국탄소학회 2021 Carbon Letters Vol.31 No.6
Green synthesis of graphene using leaf extracts as sustainable reducing and capping agents is a thrust area of research owing to its simplicity, eco-friendly nature and the ease of access to graphene. Moringa (Moringa oleifera Lam) plant is widely cultivated in India owing to its important medicinal and nutritional values. Inspired by these reports, herein we report a simple, green and economic synthesis of graphene, Moringa leaf extract employed reduced graphene oxide (MRGO) with excellent dye removal efciencies. The MRGO is prepared by refuxing a mixture of aqueous dispersion of graphene oxide and Moringa leaf extract for 10 h. Further, we elucidated the role of synthesized MRGO in the removal of methylene blue (MB) and rhodamine B (RB) dyes through the sonochemical method. This as-synthesized material exhibited excellent dye removal efciencies of about 93% and 87% against MB and RB dyes, respectively. Graphene with huge surface area expedited the better adsorption of dye molecules, thus, facilitated the better removal of the latter. Therefore, the superior dye removal efciencies of MRGO were attributed to its adsorption capacity. This cost-efective synthetic approach of MRGO nanomaterial has a great potential for the innovative applications in water purifcation technology and fnd its place in further industrialization.
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