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Paeoniflorin reduces the inflammatory response of THP-1 cells by up‐regulating microRNA-124
Danyun Huang,Zhijun Li,Yue Chen,Yan Fan,Tao Yu 한국유전학회 2021 Genes & Genomics Vol.43 No.6
Background The activation of macrophages and the release of infammatory cytokines are the main reasons for the progress of systemic lupus erythematosus (SLE). MicroRNA (miRNA)-124 is involved in the regulation of macrophages and is a key regulator of infammation and immunity. Objective To explore whether paeoniforin (PF) regulates the biological functions of macrophages depends on miR-124. Methods RT-PCR, WB, ELISA, CCK-8 and fow cytometry were used to evaluate that PF regulated the biological functions of THP-1 cells through miR-124. Results PF signifcantly inhibited the proliferation while promotes the apoptosis of THP-1 cells, and inhibited the release of IL-6, TNF-α and IL-1βin THP-1 cells. RT-PCR results shown that PF up-regulated the expression of miR-124 in THP-1 cells. Functional recovery experiments showed that compared with the LPS+mimic-NC group, LPS+miR-124 mimic signifcantly inhibited the proliferation and the release of IL-6, TNF-α and IL-1β, but promoted the apoptosis of THP-1 cells. In addition, compared with the LPS+PF+inhibitor-NC group, LPS+PF+miR-124 inhibitor signifcantly promoted the proliferation and the release of IL-6, TNF-α and IL-1β, but inhibited the apoptosis of THP-1 cells. Conclusions By down-regulating miR-124, PF inhibits the proliferation and infammation of THP-1 cells, and promotes the apoptosis of THP-1 cells.
Lei, Danyun,Devarayan, Kesavan,Li, Xiang-Dan,Choi, Woong-Ki,Seo, Min-Kang,Kim, Byoung-Suhk 한국탄소학회 2014 Carbon Letters Vol.15 No.4
New precursors, poly(acrylonitrile-co-crotonic acid) (poly(AN-CA)) and poly(acrylonitrile-co-itaconic acid-co-crotonic acid) (poly(AN-IA-CA)) copolymers, for the preparation of carbon fibers, were explored in this study. The effects of comonomers with acidic groups, such as crotonic acid (CA) and/or itaconic acid (IA), on the stabilization of nanofibrous polyacrylonitrile (PAN) copolymers were studied. The extent of stabilization, evaluated by Fourier transform infrared spectroscopy, revealed that the CA comonomer could retard/control the stabilization rate of PAN, in contrast to the IA comonomer, which accelerated the stabilization process. Moreover, the synthesized PAN copolymers containing CA possessed higher Mv than those of the IA copolymers and also showed outstanding dimension stability of nanofibers during the stabilization, which may be a useful property for improving the dimensional stability of polymer composites during manufacturing.
Lei, Danyun,Li, Xiang-Dan,Seo, Min-Kang,Khil, Myung-Seob,Kim, Hak-Yong,Kim, Byoung-Suhk Elsevier 2017 Polymer Vol.132 No.-
<P><B>Abstract</B></P> <P>Nanostructured binary metal oxide-decorated carbon nanofibers (CNFs) were utilized as flexible electrodes for hybrid supercapacitor applications. Polyacrylonitrile (PAN)/lignin based carbon nanofibers (PAN/lignin CNFs) with different contents of lignin were prepared by electrospinning, stabilization and carbonization. Afterwards, the NiCo<SUB>2</SUB>O<SUB>4</SUB> oxides were deposited on the surface of CNFs by a facile hydrothermal method without any toxic reagents. SEM images confirmed that the NiCo<SUB>2</SUB>O<SUB>4</SUB> (nanosheet and nanoneedle) nanostructures were uniformly grown on the surface of every carbon fiber. The obtained flexible NiCo<SUB>2</SUB>O<SUB>4</SUB>-decorated PAN/lignin CNFs with 50% lignin (NiCo<SUB>2</SUB>O<SUB>4</SUB>@CNF55) electrode exhibited high specific capacitance of the ∼1757 F g<SUP>−1</SUP> at 2 mA cm<SUP>−2</SUP> and excellent cyclability with ∼138% capacitance retention after 5000 cycles at 7 mA cm<SUP>−2</SUP>, suggesting lower internal resistance and higher electrochemical reversibility. In addition, the NiCo<SUB>2</SUB>O<SUB>4</SUB>@CNFs//N-rGO solid state asymmetric supercapacitor devices were assembled in order to evaluate their practical applications. The NiCo<SUB>2</SUB>O<SUB>4</SUB>@CNF55//N-rGO asymmetric supercapacitor device exhibited a specific capacitance of 134.3 F g<SUP>−1</SUP> at a current densities of 1 A g<SUP>−1</SUP>, and possessed a maximum energy density of 47.75 Wh kg<SUP>−1</SUP> with a power density of 799.53 W kg<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PAN/lignin-based carbon fibers were prepared by electrospinning, stabilization and carbonization. </LI> <LI> The NiCo<SUB>2</SUB>O<SUB>4</SUB> nanostructures were fabricated on PAN/lignin-based carbon nanofibers. </LI> <LI> The NiCo<SUB>2</SUB>O<SUB>4</SUB>-decorated fiber electrode exhibits highest specific capacitance of the ∼1757 Fg<SUP>-1</SUP>. </LI> <LI> The NiCo<SUB>2</SUB>O<SUB>4</SUB>-decorated fiber electrode shows excellent capacitance retention of ∼138% after 5000 cycles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lei, Danyun,Song, Kyung-Hun,Li, Xiang-Dan,Kim, Hak-Yong,Kim, Byoung-Suhk Springer-Verlag 2017 JOURNAL OF MATERIALS SCIENCE - Vol.52 No.4
<P>Kenaf-derived porous carbon (KPC) is considered to be one of the most promising materials for applications of energy storage devices due to being eco-friendly, and low cost. In this work, a facile method was introduced to prepare the nano-textured polyaniline (PANi)-decorated KPCs (PANi/KPC). Such light weighted and porous structures of KPCs were utilized as a physical framework for supporting the nanostructured PANi, which could significantly reduce the weight (and consequently cost) and furthermore improve the electrochemical performances of the supercapacitors. Firstly, we carbonized two different kinds of kenafs (kenaf stem and NaOH retting kenaf) to obtain the kenaf-derived porous carbons (KPC1 and KPC2), and then PANi was synthesized by in situ polymerization in the presence of KPCs. The three-dimensional porous structures of the obtained KPCs were confirmed by SEM images. The SEM image of PANi-decorated KPCs (PANi/KPCs) demonstrates that the PANi was uniformly formed as fibrous and nano-textured structures on the surface of the KPCs. The specific capacitance of PANi/KPC1 and PANi/KPC2 were found to be around 76 and 136 F/g, which were obviously enhanced capacitance than pure KPC1 (26 F/g) and KPC2 (37 F/g), respectively. Further, it showed good cycle stability retaining more than 97 % of their capacitance after 2000 charge-discharge cycles at a scan rate of 5 mV/s.</P>
Lei Danyun,Li Xiang-Dan,Ma Min-Jung,Kim Da-Young,Noh Jae-Hyun,Kim Byoung-Suhk 한국탄소학회 2023 Carbon Letters Vol.33 No.3
In this study, we have fabricated the phenolic resin (PR)/polyacrylonitrile (PAN) blend-derived core-sheath nanostructured carbon nanofibers (CNFs) via one-pot solution electrospinning. The obtained core-sheath nanostructured carbon nanofibers were further treated by mixed salt activation process to develop the activated porous CNFs (CNF-A). Compared to pure PAN-based CNFs, the activated PR/PAN blend with PR 20% (CNF28-A)-derived core-sheath nanostructured CNFs showed enhanced specific capacitance of ~ 223 F g−1 under a three-electrode configuration. Besides, the assembled symmetric CNF28-A//CNF28-A device possessed a specific capacitance of 76.7 F g−1 at a current density of 1 A g−1 and exhibited good stability of 111% after 5,000 galvanostatic charge/discharge (GCD) cycles, which verifies the outstanding long-term cycle stability of the device. Moreover, the fabricated supercapacitor device delivered an energy density of 8.63 Wh kg−1 at a power density of 450 W kg−1.