ECG PVC Classification Algorithm based on Fusion SVM and Wavelet Transform

Huang Dong,Liao Zhengquan,Li Changbin,Li Dan,Huang Wendong 보안공학연구지원센터(IJSIP) 2015 International Journal of Signal Processing, Image Vol.8 No.1

In the process of ventricular premature beat (PVC) and normal sinus rhythm (NSR) identification base on electrocardiogram (ECG), there exists problems like negative effect from ECG rhythm and low recognition rate. This paper proposes the electrocardiogram PVC classification algorithm based on support vector machine (SVM) and wavelet algorithm. The algorithm uses the wavelet transform to analyze ECG beating model, which is not influenced by the change of ECG waveform. The two feature sets respectively compose of statistical parameters of the wavelet coefficients and the selected wavelet coefficients. PVC and NSR are analyzed by using SVM. The experimental results show that this method improves the recognition rate of ECG.

Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis

Dan Huang,Hyundeok Joo,Nan Song,Sooyoung Cho,Woosung Kim,Aesun Shin 한국역학회 2021 Epidemiology and Health Vol.43 No.-

OBJECTIVES: Biliary tract cancers (BTCs) are rare but highly fatal. Although the etiology of BTC is poorly understood, gallstones are proposed to be a major risk factor. We conducted a systematic review and meta-analysis to examine the associations between gallstone characteristics and BTC risk. METHODS: We searched the MEDLINE, Embase, and Cochrane Central databases and systematically reviewed cohort and case-control studies published before April 9, 2018. All the included studies reported appropriate risk estimates and confidence intervals (CIs) for associations between the presence, size, number, or duration of gallstones and the risk of BTC, including gallbladder cancer (GBC), extrahepatic bile duct cancer (EBDC), and ampulla of Vater cancer (AOVC). Summary odds ratios (ORs) and their 95% CIs were calculated using a random-effects model in the meta-analysis. Subgroup analyses were conducted to inspect sources of potential heterogeneity, and the Egger test was performed to assess publication bias. RESULTS: Seven cohort studies and 23 case-control studies in Asian, European, and American populations were included. The presence of gallstones was associated with an increased risk of BTC (OR, 4.38; 95% CI, 3.23 to 5.93; I2=91.2%), GBC (OR, 7.26; 95% CI, 4.33 to 12.18), EBDC (OR, 3.17; 95% CI, 2.24 to 4.50), and AOVC (OR, 3.28; 95% CI, 1.33 to 8.11). Gallstone size (>1 vs. <1 cm; OR, 1.88; 95% CI, 1.10 to 3.22) was significantly associated with the risk of GBC. CONCLUSIONS: Gallstone characteristics, such as presence, size, and number, are associated with an increased risk of BTC. However, significantly high heterogeneity in the meta-analyses is a limitation of this study.

Gallstones, Cholecystectomy and the Risk of Hepatobiliary and Pancreatic Cancer: A Nationwide Population-based Cohort Study in Korea

Dan Huang,Joonki Lee,Nan Song,조수영,Sunho Choe,신애선 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.3

Several epidemiological studies suggest a potential association between gallstones or cholecystectomy and hepatobiliary and pancreatic cancers (HBPCs). The aim of this study was to evaluate the risk of HBPCs in patients with gallstones or patients who underwent cholecystectomy in the Korean population. A retrospective cohort was constructed using the National Health Insurance Service-National Sample Cohort (NHIS-NSC). Gallstones and cholecystectomy were defined by diagnosis and procedure codes and treated as time-varying covariates. Hazard ratios (HRs) in relation to the risk of HBPCs were estimated by Cox proportional hazard models. Among the 704,437 individuals who were included in the final analysis, the gallstone prevalence was 2.4%, and 1.4% of individuals underwent cholecystectomy. Between 2002 and 2015, 487 and 189 individuals developed HBPCs in the gallstone and cholecystectomy groups, respectively. A significant association was observed between gallstones and all HBPCs (HR 2.16; 95% CI 1.92-2.42) and cholecystectomy and all HBPCs (HR 2.03; 95% CI 1.72-2.39). However, when 1-, 3-, and 5-year lag periods were applied, the HBPC and subsites risk approached zero. A significant association was observed between cholecystectomy and intrahepatic bile duct cancer (IBDC) (HR 2.68; 95% CI 1.63-4.40). When 1-, 3- and 5-year lag periods were applied, the IBDC risk after cholecystectomy was 2.86-fold (95% CI 1.68-4.85), 2.92-fold (95% CI 1.51-5.64), and 4.08-fold (95% CI 1.94-8.61) higher, respectively, than that in the comparison group. In conclusion, gallstone diagnosis and cholecystectomy seem to correlate with HBPCs, especially cholecystectomy and IBDC.

Dynamic Output Feedback Control for Uncertain Networked Control Systems with Random Network-induced Delays

Dan Huang,Sing Kiong Nguang 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.5

This paper investigates the stabilization problem for a class of uncertain networked control systems (NCSs) with random communication network-induced delays. A dynamic output feedback controller is designed for the uncertain NCSs in the presence of network effects, i.e., network-induced delays and packet dropouts in both the sensor-controller and controller-actuator channels. Based on the Lyapunov-Razumikhin method, the existence of such controller is given in terms of the solvability of bilinear matrix inequalities. An iterative algorithm is proposed to change this non-convex problem into quasi-convex optimization problems, which can be solved effectively by available mathematical tools. The effectiveness of the proposed design methodology is verified by a numerical example.

Mean Square Consensus of Multi-agent systems with multiplicative noises and time delays under directed fixed topologies

Dan Huang,Lei Song,Sing Kiong Nguang,Shan Fu 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.1

This paper investigates the mean square consensus problem of multi-agent systems impacted by thecombined uncertainty of multiplicative noises and time delays. Considering general network under directed fixedtopologies, we propose consensus protocol that take into account both the multiplicative noises and time delays. Using tools from stochastic differential delay equation (SDDE), martingale theory and stochastic inequality, weestablish sufficient conditions and obtain the explicit consensus gain and delay upper bounds under which theproposed protocol leads to mean square consensus. In addition, we compare the impact of multiplicative andadditive noise and reach the conclusion that multiplicative noises have the property of stabilizing effect. Simulationsdemonstrate the theoretical results.

Damage Evolution and Integrity Assessment of Jointed Rock Mass Based on Synthetic Rock Mass Approach

Dan Huang,Xiaoqing Li,Wen-chao Song 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5

The integrity coefficient Kv of bed rock is one of the important approaches to evaluate the stability of engineering rock mass, but this parameter is difficult in frequent field tests. The integrity coefficient is the quantitative index for evaluating the complete deformation of rock mass, while the damage variable represents the level of damage of the jointed rock mass, and both have similar physical meanings and represent the degree of deterioration of surrounding rock. Damage variables and damage constitutive models were constructed based on Weibull distribution damage model and Synthetic Rock Mass (SRM) model. The relationship between damage variables and numerical calculation and damage constitutive curves of different weathered granite rocks in Hongtuzhang tunnel was calculated. A new method for evaluating integrity coefficient of rock mass is proposed.

Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

Dan Xiao,Kaisen Huang,Qingyong Chen,Baotao Huang,Wei Liu,Yong Peng,Mao Chen,Dejia Huang,Tong Zou,Jiefu Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.7

Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.

Chigger Mite (Acari: Trombiculidae) Survey of Rodents in Shandong Province, Northern China

Xiao-Dan Huang,Peng Cheng,Yu-Qiang Zhao,Wen-Juan Li,Jiu-Xu Zhao,Hong-Mei Liu,Jing-Xuan Kou,Mao-Qing Gong 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.5

Preparation and Characterization of a Novel pH-Sensitive Coated Microsphere for Duodenum-Specific Drug Delivery

Dan Zhou,Yuan Huang,Xi Zhu,Yang Wang,Yun Jin,Xuefan Xu,Tingting Fan,Yan Liu,Zhirong Zhang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5

The aim of this study is to develop a duodenum-specific drug delivery system on the basis of a pH-sensitive coating and a mucoadhesive inner core for eradication of Helicobacter pylori (H. pylori) in the ulcer duodenum. Hydroxypropyl methylcellulose acetate maleate (HPMCAM) was used as the pH-sensitive material, which dissolves around pH 3.0. The mucoadhesive microspheres loaded with furazolidone (FZD-ad-MS) were prepared by the emulsification-solvent evaporation method using Carbopol 971NP as the mucoadhesive polymer. The prepared pH-sensitive coated mucoadhesive microspheres (AM-coated-MS) were characterized in regards to particle size, drug loading efficiency, morphological change, drug stability, drug release and in vitro anti-H. pylori activity. The particle size was 160.97 ± 47.24 μm and 336.44 ± 129.34 μm, and the drug content was 42.33 ± 3.43% and 10.96 ± 1.29% for FZD-ad-MS and AM-coated-MS, respectively. The morphological changes in different pH media were characterized by scanning electron microscopy (SEM). HPMCAM coating improved the stability of the FZD-ad-MS and these particles were expected to remain intact until their arrival in the duodenum. The drug release was extremely suppressed at pH 1.2 for AM-coated-MS, but increased at pH 4.0 after regeneration of FZD-ad-MS. In addition, FZD-ad-MS exhibited excellent anti-H. pylori activity in vitro. Thus, the HPMCAM-coated microspheres developed in this study hold great promise for use as a duodenum-specific drug delivery system for H. pylori clearance.

Streptozotocin Diabetes Attenuates the Effects of Nondepolarizing Neuromuscular Relaxants on Rat Muscles

Huang, Lina,Chen, Dan,Li, Shitong The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.6

The hypothesis of this study was that diabetes-induced desensitization of rat soleus (SOL) and extensor digitorum longus (EDL) to non-depolarizing muscle relaxants (NDMRs) depends on the stage of diabetes and on the kind of NDMRs. We tested the different magnitude of resistance to vecuronium, cisatracurium, and rocuronium at different stages of streptozotocin (STZ)-induced diabetes by the EDL sciatic nerve-muscle preparations, and the SOL sciatic nerve-muscle preparations from rats after 4 and 16 weeks of STZ treatment. The concentration-twitch tension curves were significantly shifted from those of the control group to the right in the diabetic groups. Concentration giving 50% of maximal inhibition ($IC_{50}$) was larger in the diabetic groups for all the NDMRs. For rocuronium and cisatracurium in both SOL and EDL, $IC_{50}$ was significantly larger in diabetic 16 weeks group than those in the diabetic 4 weeks group. For SOL/EDL, the $IC_{50}$ ratios were significantly largest in the diabetic 16 weeks group, second largest in the diabetic 4 weeks group, and smallest for the control group. Diabetes-induced desensitization to NDMRs depended on the stage of diabetes and on the different kind of muscles observed while was independent on different kind of NDMRs. The resistance to NDMRs was stronger in the later stage of diabetes (16 versus 4 weeks after STZ treatment). Additionally, when monitoring in SOL, diabetes attenuated the actions of neuromuscular blockade more intensely than that in EDL. Nonetheless, the hyposensitivity to NDMRs in diabetes was not relevant for the kind of NDMRs.