Erratum : Erratum to "Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells" [Biomol. Ther. 22 (2014) 355-362]

( Da Mi An ),( Kwang Mi Kim ),( Jeong Yun Kim ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.5

Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells

( Dami An ),( Kwang Mi Kim ),( Jeong Yun Kim ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4

We have developed a fully automated high throughput drug screening (HTDS) system based on the microfl uidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell culture chambers where the sequential combinatorial concentrations of two different drugs can be generated by two microfl uidic diffusive mixers. Each diffusive mixer has two integrated micropumps connected to the media and the drug reservoirs respectively for generating the desired combination without the need for any extra equipment to perfuse the solution such as syringe pumps. The cell array is periodically exposed to the drug combination with the programmed LabVIEW system during a couple of days without extra handling after seeding the cells into the microfl uidic device and also, this device does not require the continuous generation of solutions compared to the previous systems. Therefore, the total amount of drug being consumed per experiment is less than a few hundred micro liters in each reservoir. The utility of this system is demonstrated through investigating the viability of the prostate cancer PC3 cell line with the combinational treatments of curcumin and tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL). Our results suggest that the system can be used for screening and optimizing drug combination with a small amount of reagent for combinatorial chemotherapy against cancer cells.

경제위기와 저임금 고용

Damian Grimshaw 한국노동연구원 2011 국제노동브리프 Vol.9 No.9

Performance of attachments used in implantsupported overdentures: review of trends in the literature

Damian J. Lee 대한치주과학회 2013 Journal of Periodontal & Implant Science Vol.43 No.1

The purpose of this review is to examine the performance of attachments used in implant-supported overdenture (IOD) in both clinical and in vitro settings and report the compiled findings, comparisons, and trends in the research literature. Articles published in PubMed on IOD attachment systems and performance were reviewed. Non-original articles were excluded. For each article included, the type of study, number of implants, number of attachment systems, and study outcome were recorded. Of the 283 articles found, 158 met the inclusion criteria. Ninety-four articles were clinical studies and 64 articles were in vitro studies. Studies on retention were the most common for in vitro studies, and four or more attachment systems were compared in most articles with significant differences in outcome. A clinical outcome of one attachment system was most common for clinical studies, while most studies had neutral outcomes overall. Ball attachment was the most commonly tested IOD attachment system. The trend in the literature showed that there is a large discrepancy between the study designs and outcomes between the clinical and the in vitro studies for IOD. Further clinical studies that can validate in vitro research should be encouraged to address this discrepancy between the two areas.

Numerical analysis of steel-soil composite (SSC) culvert under static loads

Damian Beben,Michal Wrzeciono 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.6

The paper presents a numerical analysis of a steel-soil composite (SSC) culvert in the scope of static (dead and live) loads. The Abaqus program based on the finite element method (FEM) was used for calculations. Maximum displacements were obtained in the shell crown, and the largest stresses in the haunches. Calculation results were compared with the experimental ones and previous calculations obtained from the Autodesk Robot Structural Analysis (ARSA) program. The shapes of calculated displacements and stresses are similar to those obtained with the experiment, but the absolute values were generally higher than measured ones. The relative differences of calculated and measured values were in the range of 5-23% for displacements, and 15-42% for stresses. Developed calculation model of the SSC culvert in the Abaqus program allows obtaining reasonable values of internal forces in the culvert. Using both calculation programs, the relative differences for displacements were in the range of 15-39%, and 17-44% for stresses in favour of the Abaqus program. Three design methods (Sundquist-Pettersson, Duncan and CHBDC) were used to calculate the axial thrusts and bending moments. Obtained values were compared with test results. Generally, the design methods have conservative assumptions, especially in the live loads distribution, safety factors and consideration the interaction between soil and steel structure.

Synthesis, properties and adjuvant activity of docusate-based ionic liquids in pesticide formulations

Damian krystian Kaczmarek,Tomasz Rzemieniecki,Katarzyna Marcinkowska,Juliusz Pernak 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.78 No.-

Anionic surfactants are the largest group of surface-active compounds used in industry; therefore, theaim of this study was to adjust the properties of docusate salts by the introduction of appropriatecounterions. Thus, low-toxicity cations were selected to obtain ionic liquids with the desired surfaceactivity. The fundamental influence of the cation on the physicochemical properties was observed. Although the cations were characterized by low amphiphilicity, their selection has a significant impact onthe surface parameters. Due to the surface properties of the obtained compounds, they were effectivepesticide adjuvants with higher efficacy compared to the currently used additives

Observations on Selected Aspects of Liu Kang’s Painting Practice

Damian Lizun 한국문화재보존과학회 2022 보존과학회지 Vol.38 No.5

This article gathers, for the first time, some intriguing technical features of Liu Kang’s painting practice, which spans seven decades. These features encompass retouching, alteration as well as the painting over of rejected compositions and painting on the reverse sides of earlier artworks. As Liu Kang (1911–2004) did not discuss the technical details of his artistic process, an exploration of these aspects of the artist’s expression helps us understand the motivation behind his unconventional decisions. The paint layers were characterised through imaging methods like visible light (VIS), ultraviolet fluorescence (UVF), near-infrared (NIR), reflectance transformation imaging (RTI), digital optical microscopy (DOM) and X-ray radiography (XRR). The technical analyses were additionally supplemented with archival sources. The results showed that some aspects of the artist’s painting practice may distort the provenance of the paintings, impact dating, visual interpretation of his painting technique and style, as well as future conservation and display decisions. The presented case studies discuss the influence of Liu Kang’s unconventional painting approaches on the perception and interpretation of his artworks. Additionally, some hidden alterations and entirely new compositions were revealed for the first time and presented here, adding to growing knowledge about the artist’s painting technique. Moreover, universal aesthetical and ethical considerations were discussed in the context of the conservation and display approach to the artist’s retouching work and double-sided paintings. Besides, this research promotes a need for obtaining a comprehensive understanding of Liu Kang’s painting practice and coherent guidelines to ensure proper presentation of his artworks and to prevent misinterpretation of his technique and artistic outcomes.

Dynamic testing of a soil-steel bridge

Damian Beben,Zbigniew Manko 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.35 No.3

The paper presents the results and conclusions of dynamic load tests that were conducted on a road bridge over the Mokrzyca river in Wroclaw (Poland) made of galvanized corrugated steel plates (CSP). The critical speed magnitudes, velocity vibration, vibration frequency were determined in the paper. The dynamic analysis is extremely important, because such studies of soil-steel bridges in the range of dynamic loads are relatively seldom conducted. Conclusions drawn from the tests can be most helpful in the assessment of behaviour of this type of corrugated plate bridge with soil. In consideration of application of this type of structure in the case of small-to-medium span bridges, the conclusions from the research will not be yet generalized to all types of such solutions. The detailed reference to all type of such bridge structures would be requiring additional analysis (field tests and calculations) on the other types of soil-steel bridges.

Simulation Tests of the Accuracy of Fitting Two Freeform Surfaces

Damian Groch,Małgorzata Poniatowska 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.1

The presented method is introduced to simulate and predict the accuracy of fitting two freeform surfaces. For this purpose, the CAD models of both actual surfaces should be determined on the basis of coordinate measurement data obtained in measurements along regular grids of points in the UV space. The NURBS regression surfaces are modeled on the measurement data. Adequate regression models are sought with the iterative procedure. In the following steps of the procedure, the number of control points and/or the degree of the surface is/are changed, and the autocorrelation of residuals from the models is tested using the spatial statistics methods. The designated models are optimal CAD representations of the actual surfaces. Tests of the accuracy of fitting the surfaces are carried out virtually by fitting together both models in the CAD software. The outcome of the study is a spatial model of the gap between the studied surfaces. The obtained model was verified experimentally by measuring the dimensions of the actual gap between the surfaces, applying a measuring microscope. The proposed method is a useful tool in analyzing and improving the accuracy of injection molds machining.

Comparison of Coronary Artery Bypass Grafting with Percutaneous Coronary Intervention for Unprotected Left Main Coronary Artery Disease

Damian Kawecki,Beata Morawiec,Marcin Fudal,Wojciech Milejski,Wojciech Jachec‘,Ewa Nowalany-Kozielska 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.1

Purpose: Coronary artery bypass grafting (CABG) is the optimal treatment option for left main coronary artery disease (LMCAD). However, LMCAD remains a constant topic of discussion between cardiac surgeons and interventional cardiologists. The aim of this study was to assess the efficacy of LMCAD treatments by comparing the mid-term outcomes of CABG and percutaneous coronary intervention (PCI) using bare metal stents or drug-eluting stents (DESs). Materials and Methods: The study population was comprised of 199 consecutive patients admitted with unprotected LMCAD. All of the patients were assigned to PCI (88 patients) or CABG (111 patients). The primary clinical end point indicated death, stroke of acute coronary syndrome (ACS). Results: Patients assigned to PCI were at higher operative risk than patients scheduled for CABG (6.49±4.09 vs. 4.81±2.67, p=0.0032). Comparison of the group that received DESs with the CABG group did not reveal any differences in major adverse cardio-cerebral events (MACCE) occurrence (21% vs. 16%, p=NS). Patients in the CABG and PCI groups died with similar frequency (11% vs. 16%, p=NS). The mortality rate in the CABG group was higher than among those treated with DES (11% vs. 3%, p=0.049). The rate of ACS was higher in the PCI group than in the CABG group (13% vs. 4%, p=0.016). Conclusion: Despite the fact that patients treated with PCI were at higher operative risk, PCI with DES was shown to be comparable to CABG in terms of mortality, stroke and ACS. However, the frequency of repeat revascularizations remains a constant concern with PCI.