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The Effects of Maglev Chopper’s Control Cycle on Suspension Performance in EMS System
Da Liang,Kunlun Zhang,Qilong Jiang,Hongyun He 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The cascade control strategy of current inner loop and airgap outer loop is usually adopted in electromagnetic suspension (EMS) system. The current loop and airgap loop adopt different control cycles in controller design, and the current loop control cycle is required to be shorter than the airgap loop control cycle. In theory, the shorter the control cycle of the inner loop, the better the following effect of the chopper current, and the more beneficial to the suspension system. However, it also needs the higher controller performance and control algorithm efficiency. With the suspension control performance permitted, reducing the current loop control frequency can effectively reduce the requirements of the controller performance and expand the selection range of the controller. In order to determine the appropriate control period of the current loop in the digital suspension system, the mathematical model of the suspension system and the maglev chopper is established, then the quantitative relationship between the current loop control period and the coil current ripple is deduced. Based on Simulink, the coupling simulation model of the maglev chopper and the suspension system is established, where the influence of the chopper control period on the performance of the suspension system is simulated and analyzed.
Si-Qi Dong,Tong-Min Wang,Jiang-Bo Zhang,Yong-Qiao He,Wen-Qiong Xue,Zi-Yi Wu,Da-Wei Yang,Lian-Jing Cao,Jing-Wen Huang,Xi-Zhao Li,Pei-Fen Zhang,Xiao-Hui Zheng,Wei-Hua Jia 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3
Purpose Capecitabine is an extensively used oral prodrug of 5-fluorouracil in treatment of colon cancer and is known to cause hand-foot syndrome (HFS). As the target enzyme for capecitabine, thymidylate synthase (TYMS) plays a key role for 5-fluorouracil metabolism and has been associated with some side effects caused by capecitabine. The aim of our study is to identify the possible genetic predictors of capecitabine-induced HFS (CAP-HFS) in Chinese colorectal cancer patients.Materials and Methods Whole exons of TYMS were sequenced for 288 extreme phenotype HFS patients, including 144 severe or early-onset (first 2 cycles) moderate HFS extreme cases and 144 extreme controls with no reported HFS. The associations between polymorphisms and CAP-HFS were analyzed using logistic regression under an additive model.Results We identified a novel risk mutation (c.1A>G, chr18:657743), was associated with severe HFS in an extreme case who was affected during the first cycle of treatment. Moreover, we identified three new variants, rs3786362, rs699517, rs2790, and two previously reported variants, 5’VNTR 2R/3R and 3′-untranslated region 6-bp ins-del, which were significantly associated with CAP-HFS (p < 0.05). In silico analysis revealed that the effect of these polymorphisms in the TYMS region on the development of HFS might not be restricted solely to the regulation of TYMS expression, but also the TYMS catalytic activity through the indirect effect on ENOSF1 expression.Conclusion This study identified new polymorphisms in TYMS gene significantly associated with CAP-HFS, which may serve as useful genetic predictors for CAP-HFS and help to elucidate the underlying mechanism of HFS.