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Rai, Ranjana,Yunos, Darmawati M.,Boccaccini, Aldo R.,Knowles, Jonathan C.,Barker, Ian A.,Howdle, Steven M.,Tredwell, Gregory D.,Keshavarz, Tajalli,Roy, Ipsita American Chemical Society 2011 Biomacromolecules Vol.12 No.6
<P><named-content content-type='genus-species' xlink:type='simple'>Pseudomonas mendocina</named-content> was found to produce a unique homopolymer of poly(3-hydroxyoctanoate), P(3HO), rather than a copolymer, when grown on sodium octanoate as the sole carbon source. Although this polymer has been produced by other organisms, interestingly this is the first time an absolute homopolymer has been produced by a wild type organism. In addition, a detailed study on the effects of different extraction methods on the yield, molecular weight, thermal properties, and lipopolysaccharide content of P(3HO) has been carried out. The organism was able to accumulate P(3HO) up to 31.38% of its dry cell weight within 48 h in mineral salt medium. Characterization of the monomer was carried out using FTIR, GC-MS, <SUP>13</SUP>C, <SUP>1</SUP>H, and HSQC NMR spectroscopy. The polymer had a crystallinity of 37.5%, Young’s modulus value of 11.6 MPa and contact angle of 77.3°. Microstructural studies of solvent cast polymer films revealed a smooth surface topography with a root-mean-square roughness value of 0.238 μm.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-6/bm2001999/production/images/medium/bm-2011-001999_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm2001999'>ACS Electronic Supporting Info</A></P>
Evidence of electron neutrino appearance in a muon neutrino beam
Abe, K.,Abgrall, N.,Aihara, H.,Akiri, T.,Albert, J. B.,Andreopoulos, C.,Aoki, S.,Ariga, A.,Ariga, T.,Assylbekov, S.,Autiero, D.,Barbi, M.,Barker, G. J.,Barr, G.,Bass, M.,Batkiewicz, M.,Bay, F.,Bentham American Physical Society 2013 PHYSICAL REVIEW D - Vol.88 No.3
Silva, M.,Daheron, L.,Hurley, H.,Bure, K.,Barker, R.,Carr, Andrew J.,Williams, D.,Kim, H.W.,French, A.,Coffey, Pete J.,Cooper-White, Justin J.,Reeve, B.,Rao, M.,Snyder, Evan Y.,Ng, Kelvin S.,Mead, Ben Cell Press 2015 Cell stem cell Vol.16 No.1
Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21<SUP>st</SUP> century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.