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임철현 ( Churl Hyun Im ),이은봉 ( Eun Bong Lee ),강은하 ( Eun Ha Kang ),박정진 ( Jeong Jin Park ),김만호 ( Man Ho Kim ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Systemic sclerosis is a rare, autoimmune, connective tissue disorder which involves skin and other internal organs. However, central nervous system involvement including seizure, is a very rare event. This 29-year-old woman experienced repeated episodes of typical generalized tonic clonic seizure. T2 weighted and flare images of magnetic resonance image showed a mass-like high signal intensity lesion in the left temporal lobe. Atypical spikes and waves were present in a eclectroencephalogram. Her seizure episodes were controlled with anticonvulsants, corticosteroids and immunosuppresants. We report a rare case of systemic sclerosis which showed central nervous system involvement.
A Case of Chronic Periaortitis with Retroperitoneal Fibrosis
박선희,Churl Hyun Im,Dong Heon Yang,Jong Wan Kang,Jae Yong Yoon,Hyun Jun Cho,박헌식,조용근,Shung Chull Chae,Jae-Eun Jun 대한심장학회 2012 Korean Circulation Journal Vol.42 No.12
A 73-year-old man with a history of hypertension and ascending aortic dissection was hospitalized for aggravated abdominal pain and general ache for 3 months. Follow-up CT showed aggravated abdominal aortic hematoma with aneurysm, atherosclerotic periaortitis and bilateral hydronephrosis. An initial laboratory finding showed elevated levels of inflammatory markers and renal dysfunction. Positron emission tomography-CT showed an increased standardized uptake values level in the aortic arch, descending thoracic aorta, major branch, abdominal aorta, and common iliac artery. For bilateral hydronephrosis, a double J catheter insertion was performed. Tissue speci-mens obtained from previous surgery on the aorta indicated the infiltration of lympho-plasma cells without granuloma formation in the aortic wall. After a combined therapy of high dose steroid therapy with azathioprine, the patient’s initial complaints of abdominal pain,weakness and azotemia improved. This case was diagnosed as chronic periaortitis based on aortic inflammation at biopsy, which was complicated with retroperitoneal fibrosis and ureteric obstruction.
A Case of Hypertrophic Osteoarthropathy Associated with Epithelioid Hemangioendothelioma
Kim Jin Hyun,이은봉,Kim Sunyoung,Kang Hyoun Woo,Suh Jung Won,Yoon Won Jae,Kim Su Hwan,Kang Eun Ha,Im Churl Hyun,송영욱,이효석 대한의학회 2004 Journal of Korean medical science Vol.19 No.3
Epithelioid hemangioendothelioma is a rare vascular tumor, which occurs in the lung, liver, bone, and soft tissue. Hypertrophic osteoarthropathy is a syndrome character-ized by subperiosteal new bone formation, joint effusion and clubbing, and may be associated with cyanotic heart disease, chronic pulmonary disease, liver disease, and other miscellaneous diseases. The activation of endothelium and platelets has been suggested to be involved in the development of hypertrophic osteoarthropathy. We report a rare case of hypertrophic osteoarthropathy, which developed in association with hepatic epithelioid hemangioendothelioma with pulmonary metastasis. We also discuss the role of vascular endothelial growth factor in its pathogenesis.
A Case of Renal Crisis in a Korean Scleroderma Patient with Anti-RNA polymerase I and III Antibodies
Kang, Eun Ha,Im, Churl Hyun,Kim, Su Ho,Chung, Jae Rak,Lee, Eun Young,Kim, Dong Jo,Lee, Eun Bong,Song, Yeong Wook The Korean Academy of Medical Sciences 2006 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.21 No.6
<P>Scleroderma (SSc) renal crisis has been reported to be associated with anti-RNA polymerase I and III (RNAP I/III) antibodies in Caucasians and the Japanese. However, no report is available for Korean SSc patients. Here, we describe the case of a 65-yr-old female SSc patient who developed renal crisis and whose serum contained anti-RNAP I/III antibodies. She was finally diagnosed as having diffuse cutaneous SSc based on skin thickening proximal to the elbows and knees. Sudden hypertension, oliguria, and pulmonary edema were features of her renal crisis. Despite the use of captopril and adequate blood pressure control, her renal function deteriorated. Subsequent renal biopsy findings showed severe fibrinoid necrosis with luminal obliteration in interlobar arteries and arterioles consistent with SSc renal crisis. Serum anti-RNAP I/III antibodies were detected by radioimmunoprecipitation. This is the first report of a renal crisis in a Korean SSc patient with RNAP I/III antibodies.</P>
Bilateral Involvement of Juvenile Temporal Arteritis Associated with Kimura Disease
( Na Ri Kim ),( Churl Hyun Im ),( Jong Wan Kang ),( Ji Hun Kim ),( Tae-in Park ),( Han-ik Bae ),( Eon Jeong Nam ),( Young Mo Kang ) 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.1
Juvenile temporal arteritis (JTA) is a localized nodular arteritis confined to the temporal artery without evidence of systemic inflammation, and it occurs mainly in patients younger than 50 years. From the first case report, the pathological features of JTA have been suspected to be the morphological equivalent of Kimura disease (KD), which has been supported further by the concurrent cases of JTA with KD. We present the first case of bilateral JTA accompanying KD, which was confirmed by histological and ultrasound evaluations and supports the hypothesis that JTA is a manifestation of KD. The un-excised JTA lesion was resolved completely after corticosteroid therapy with no recurrence. (J Rheum Dis 2018;25:65-68)
Kang, Eun Sil,Kim, Gil Hyeong,Woo, Im Sun,Kim, Hyo Jung,Eun, So Young,Ham, Sun Ah,Jin, Hana,Kim, Min Young,Park, Myung Hyun,Kim, Hye Jung,Chang, Ki Churl,Lee, Jae Heun,Kim, Jin-Hoi,Yabe-Nishimura, Chi Harwood Academic ; Distributed by STBS Ltd 2008 Free radical research Vol.42 No.11
<P>Aldose reductase (AR) is abundantly expressed in a variety of cell lineages and has been implicated in the cellular response against oxidative stress. However, the exact functional role of AR against oxidative stress remains relatively unclear. This study investigated the role of AR in acrolein- or hydrogen peroxide-induced apoptosis using the J774.A.1 macrophage cell line. Ablation of AR with a small interference RNA or inhibition of AR activity significantly enhanced the acrolein- or hydrogen peroxide-induced generation of reactive oxygen species and aldehydes, leading to increased apoptotic cell death. Blockade of AR activity in J774A.1 cells markedly augmented the acrolein- or hydrogen peroxide-induced translocation of Bax to mitochondria along with reduced Bcl-2 and increased release of cytochrome c from the mitochodria. Taken together, these findings indicate that AR plays an important role in the cellular response against oxidative stress, by sequestering the reactive molecules generated in cells exposed to toxic substances.</P>