임신 40주와 출산 후 6주에 있는 20대 임산부 보행의 역학적 특성 비교

윤희중,문동안,정남주,금명숙,이경식,유실,김영란,한윤수 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 임신 40주와 출산후 6주간에 있는 임산부의 보행 동작의 특정을 규명함으로써 이와 관련된 연구자들에게 기초자료를 제공하고자 실시하였다. 이를 위해 임신 4주에 있는 임산부를 대상으로 1차 실험을 실시하였으며 동일한 대상자를 출산후 6주에 2차로 실험하여 자료를 수집하였다. 디지타이징 시 오차를 최소화하고 인체관절점의 분별을 위해 21개의 반사마커를 부착하였다. 10m의 보행주로를 걷는 동안 두 대의 비디오카메라를 이용하여60Hz로 자료를 수집하였으며 동시에 100Hz 지면반력자료를 수집하였다.수집되어진 자료는 DLT 방법을 사용하여 분석하였으며 이의 분석에 Kwon3d 프로그램을 활용하였다. 분석결과 다음과 같은 결론을 얻었다. 1. 임신 40주와 출산 후 6주의 보행 시 지지시간과 스윙시간의 비율이 다르게 나타났으며 보폭과 보간, 활보장은 임신 40주에서 더 큰 값을 보였다. 상체 전경각 역시 임신 40주에서 더 큰 값을 보였다. 힙관절, 무릎관절, 발목관절각도는 S1이 출산후 6주에서 큰 값을 보인반면 S2는 출산전후에 큰 변화를 보이지 않다. 2. 상하지면반력의 경우 FP1과 FP2는 임신 40주보다는 출산 6주에서 큰값을 보였지만 FP3는 임신 40주에서 보다 큰값을 보이고 있었다. 전후지면반력의 경우 출산전과 후 모두 Fy2에서 보다 큰 값을 보이고 있었다. This Study was to investigate kinematical characteristic comparison of the gait pregnant 40weeks and after delivery 6weeks 20´s women and provide the basic data. To accomplish this study, in the first, carry out an experiment with the pregnant women in the pregnant 40weeks on the videotape, and than the second, make an experiment with the kinematic data. Kinematic data were filtered with a low-pass, fourth-order Butterworth filter with an effective cut off frequency of 6Hz. The conclusions were drawn as follows; 1. Floor contact Periods(stance and swing rate) were differed from before and after the delivery and a pregnant 40 weeks was greater than after delivery 6 weeks in the step, width, stride. Also, a pregnant 40 weeks was greater than after delivery 6 weeks in the front angular. And the other angular components were represented similar pattern. 2. In the vertical load, delivery 6 weeks was grater than a pregnant 40 weeks in the FP1(first peak) and FP2(valley). And FP3(second peak)was represent that a pregnant 40 weeks was greater than delivery 6 weeks. Also, in the horizontal shear, Fy2(progressional force)was greater than Fy1(breaking force) about time of the delivery.

A rare case of hyperplastic polyp of common bile duct mimicking CBD cancer (초)

Mun Kyung Chung,Chun Youn Joo,Chung Hee Sun,Jae Hyuck Chang,Sang Woo Kim,Myung Gyu Choi,Eun Sun Jung 대한내과학회 2009 대한내과학회지 Vol.77 No.4S

A rare case of hyperplastic polyp of common bile duct mimicking CBD cancer

Mun Kyung Chung,Chun Youn Joo,Chung Hee Sun,Jae Hyuck Chang,Sang Woo Kim,Myung Gyu Choi,Eun Sun Jung 대한내과학회 2009 대한내과학회 추계학술대회 Vol.2009 No.-

KOSPI200 지수선물가격의 일중괴리율행태와 위탁자의 차익거래기회 분석

정문경(Mun Kyung Chung) 한국증권학회 1999 Asia-Pacific Journal of Financial Studies Vol.24 No.1

갈색세포종의 임상 표현을 보인 부신 피질 선종 1예

정문경 ( Mun Kyung Chung ),김용철 ( Yong Cheol Kim ),전은경 ( Eun Kyoung Jeon ),이근호 ( Keun Ho Lee ),맹이소 ( Lee So Maeng ),한제호 ( Je Ho Han ),문성대 ( Sung Dae Moon ) 대한내과학회 2008 대한내과학회지 Vol.75 No.4

하나의 부신 세포에서 피질과 수질의 특징이 함께 공존하는 피질-수질세포에 관한 예들이 1960년대 이후로 보고되어 왔다. 저자들은 갈색세포종의 임상적 특징을 보이지만, 수술 후 갈색세포종의 임상증상과 생화학적 특징이 정상으로 회복되었으며 광학현미경상 부신 피질 선종의 특징을 보이지만, 면역조직화학 검사와 전자현미경 검사에서 피질-수질세포를 보인 1예를 경험하였기에 문헌고찰과 함께 국내 처음으로 보고하는 바이다. The coexpression of cortical and medullary features in a single adrenal cortical cell has been recognized, leading to terms such as cortico-medullary cells. Here, we reported a case of adrenocortical adenoma consisting of cortico-medullary cells that clinically mimicked pheochromocytoma. A 52-year-old woman was admitted to our hospital complaining of an 8-month history of paroxysmal palpitation with refractory hypertension. A 24-hour urine study revealed increased norepinephrine and metanephrine levels. Computed tomography of the abdomen revealed a 1.0×0.9-cm mass in the left adrenal gland. The patient subsequently underwent unilateral laparoscopic adrenalectomy for a presumptive pheochromocytoma. Light microscopic findings of the left adrenal mass indicated an adrenocortical adenoma, but electron microscopy identified lipid vacuoles and smooth endoplasmic reticulum, along with dense core neurosecretory granules, so-called cortico-medullary cells. This is the first report of the detection of cortico-medullary cells in adrenocortical adenoma presenting as pheochromocytoma in Korea. (Korean J Med 75:479-483, 2008)

KOSPI200 지수선물가격의 일중괴리율행태와 위탁자의 차익거래기회 분석

정문경(Mun Kyung Chung) 한국증권학회 1999 한국증권학회지 Vol.24 No.1

일 도시 여고생의 음주관련 요인에 관한 연구

김주형,김은경,김효정,문현숙,오선민,박나경,신혜정,이경원,이지선,최연옥,최진희,한유정,현수인 대한간호학회정신간호학회 2002 정신간호학회지 Vol.11 No.1

This study was designed to examine the factors associated with alcohol consumption among the Korean high schools girls. 283 female students were sampled from two high school in Seoul, Korea. They were given questionnaires and were asked to fill in and return them during a class hours. The factors included in the questionnaire were analyzed to see their contributions to alcohol consumption using chi-square. Alcohol consumption was associated with lower school performance(p=.001). High alcohol expectancies increased alcohol consumption(p=.000); however, depression did not show a statistically significant relationship to alcohol consumption. Mothers' alcohol consumption, having many alcohol consuming friends and watching TV commercials picturing alcohol were found to be associated with alcohol consumption, p=.049, .000, .000. respectively. Results may imply that alcohol consumption may not be a coping behavior of the depressed high school girls. Parents in Korea should be more concerned about alcohol consumption and its impacts on their daughters. Media effects on alcohol consumption need to be stressed and deserve attention from the public.

외상후 사망한 환자의 임상적 분석

정경석,송대기,이계균,문성하 대한외상학회 1995 大韓外傷學會誌 Vol.8 No.1

Trauma is a leading cause of death in Korea, but trauma care system are not well developed. To characterize cause of death and unexpected death following trauma, 295 traumatic deaths from January, 1987 to December, 1994 at Kangnam Sacred Heart Hospital were retrospectively reviewed for mechanism of injury, trauma indices, cause of death, and preventability. Of the 295 traumatic deaths, 119 patients(40%) died in the emergency room (ER) and 176 patients(60%) died in operating room or intensive care unit (ICU). Male-to-female ratio was 2.2:1 and the mean age was 36 + 20 years (range, 1-86 years). The mean time between the injury and initial treatment in ER was 227 + 888 minutes (441 + 1295 minutes for prehospital care group vs. 86+393 minutes for non- prehospital care group), but there was no significant difference hetween prehospital care group and non-prehospital care group in trauma indices. There were 209(70.8%) motor vehicle crashes, 51(17.4%) fall downs, 16(5.4%) violences, 16(5.4%) stab wounds, and 3(1. 0%) other injuries. Brain injury was judged to be the main cause of death in 51. 5% of patients. The causes of 20 unexpected deaths in ICU inspite of Ps>0.5 via TRISS methodology were hypovolemic shock(40.0%) and brain injury(25.0%). The APACHE II system significantly overestimated the risk of cleath in the lower ranges of predicted risk and underestimated the deaths in the higher ranges. Although TRISS methodology was not developed for ICU trauma patients, it tended to perform better than APACHE II system in our sample.

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

Mun, Seon Ju,Ryu, Jae-Sung,Lee, Mi-Ok,Son, Ye Seul,Oh, Soo Jin,Cho, Hyun-Soo,Son, Mi-Young,Kim, Dae-Soo,Kim, Su Jung,Yoo, Hyun Ju,Lee, Ho-Joon,Kim, Janghwan,Jung, Cho-Rok,Chung, Kyung-Sook,Son, Myung Elsevier 2019 Journal of hepatology Vol.71 No.5

<P><B>Background & Aims</B></P> <P>The development of hepatic models capable of long-term expansion with competent liver functionality is technically challenging in a personalized setting. Stem cell-based organoid technologies can provide an alternative source of patient-derived primary hepatocytes. However, self-renewing and functionally competent human pluripotent stem cell (PSC)-derived hepatic organoids have not been developed.</P> <P><B>Methods</B></P> <P>We developed a novel method to efficiently and reproducibly generate functionally mature human hepatic organoids derived from PSCs, including human embryonic stem cells and induced PSCs. The maturity of the organoids was validated by a detailed transcriptome analysis and functional performance assays. The organoids were applied to screening platforms for the prediction of toxicity and the evaluation of drugs that target hepatic steatosis through real-time monitoring of cellular bioenergetics and high-content analyses.</P> <P><B>Results</B></P> <P>Our organoids were morphologically indistinguishable from adult liver tissue-derived epithelial organoids and exhibited self-renewal. With further maturation, their molecular features approximated those of liver tissue, although these features were lacking in 2D differentiated hepatocytes. Our organoids preserved mature liver properties, including serum protein production, drug metabolism and detoxifying functions, active mitochondrial bioenergetics, and regenerative and inflammatory responses. The organoids exhibited significant toxic responses to clinically relevant concentrations of drugs that had been withdrawn from the market due to hepatotoxicity and recapitulated human disease phenotypes such as hepatic steatosis.</P> <P><B>Conclusions</B></P> <P>Our organoids exhibit self-renewal (expandable and further able to differentiate) while maintaining their mature hepatic characteristics over long-term culture. These organoids may provide a versatile and valuable platform for physiologically and pathologically relevant hepatic models in the context of personalized medicine.</P> <P><B>Lay summary</B></P> <P>A functionally mature, human cell-based liver model exhibiting human responses in toxicity prediction and drug evaluation is urgently needed for pre-clinical drug development. Here, we develop a novel human pluripotent stem cell-derived hepatocyte-like liver organoid that is critically advanced in terms of its generation method, functional performance, and application technologies. Our organoids can contribute to the better understanding of liver development and regeneration, and provide insights for metabolic studies and disease modeling, as well as toxicity assessments and drug screening for personalized medicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pluripotent stem cell (PSC)-derived expandable human hepatocyte-like liver organoids were generated. </LI> <LI> PSC-derived human hepatic organoids are capable of long-term expansion with competent liver functionality. </LI> <LI> PSC-derived human hepatic organoids provide a robust hepatic model for toxicity prediction and drug screening. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Inactivation of Enterobacter sakazakii Inoculated on Formulated Infant Foods by Intense Pulsed Light Treatment

Mun-Sil Choi,Chan-Ick Cheigh,Eun-Ae Jeong,Jung-Kue Shin,Ji-Yong Park,Kyung-Bin Song,Jong-Hyun Park,Ki-Sung Kwon,Myong-Soo Chung 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.6

Enterobacter sakazakii is a representative microorganism whose presence in infant foods can cause serious disease. The purposes of this study were to determine the inactivation effects of intense pulsed light (IPL) on E. sakazakii and the commercial feasibility of this sterilization method. The inactivation of E. sakazakii increased with increasing electric power and treatment time. The cells were reduced by 5 log cycles for 4.6 and 1.8 msec of treatment at 10 and 15 ㎸ of electric field strength, respectively. The sterilization effects on commercial infant foods were investigated at 15 ㎸. The cell population in an infant beverage, an infant meal, and an infant powdered milk product inoculated with E. sakazakii were inactivated exponentially as a function of time and reduced by 4.0, 2.5, and 1.5 log cycles for 9.4, 7.0, and 7.0 msec of treatment time, respectively.