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( Lilian Yan Liang ),( Hye Won Lee ),( Vincent Wai-sun Wong ),( Terry Cheuk-fung Yip ),( Yee-kit Tse ),( Vicki Wing-ki Hui ),( Grace Chung-yan Lui ),( Henry Lik-yuen Chan ),( Grace Lai-hung Wong ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.3
Background/Aims: Serum fibrosis scores comprised of common laboratory tests have high utility to assess severity of liver fibrosis. We aimed to derive and validate a hepatocellular carcinoma (HCC) risk score based on serum fibrosis scores to predict HCC in treatment-naive chronic hepatitis B (CHB) patients. Methods: Fifteen thousand one hundred eighty-seven treatment-naive adult CHB patients were identified to form the training cohort in this retrospective study. Individual fibrosis score was included to construct a new HCC prediction score. The score was externally validated in an independent treatment-naive Korean CHB cohort. Results: 180/15,187 patients (1.2%) in training cohort and 47/4,286 patients (1.1%) in validation cohort developed HCC during a mean follow-up of 52 and 50 months, respectively. The newly developed HCC risk score, Liang score, is composed of gender, age, hepatitis B virus DNA, fibrosis-4 (FIB-4) index, and ranges from 0 to 22. Area under the time-dependent receiver operating characteristic curve of Liang score was 0.79 (95% confidence interval, 0.70-0.89). A cutoff value of nine provided an extremely high negative predictive value of 99.9% and high sensitivity of 90.0% at 5 years in the validation cohort. Patients with Liang score ≤9 had HCC incidence <0.2% per year in both training and validation cohorts, in whom HCC surveillance might be exempted. Conclusion: A novel HCC risk score, Liang score, based on FIB-4 index, is applicable and accurate to identify treatment-naive CHB patients with very low risk of HCC to be exempted from HCC surveillance. (Clin Mol Hepatol 2021;27:499-509)
Miu Chung Yan,김은기 한국학술연구원 2013 Korea Observer Vol.44 No.1
Canada has been credited as one of the leading countries for embracing multiculturalism not only in its national policy but also in everyday social discourse. A question that has been raised in many parts of the world is whether Canadian multiculturalism can be a model for them. However, some people argue that the Canadian experience of multiculturalism may be restricted to Canada’s unique historical and geographical conditions. For example, the rationalization of the immigration system in the late 1960s has resulted in a diversification of the ethnic composition of the nation. Canada’s isolated geography has also prevented a massive influx of migrants, particularly from poor countries, and the existence of the two founding ethnic groups has historically fostered a politics of accommodation of the minority. In this paper, we first examine the nature of Canadian multiculturalism, particularly focusing on its civic and judicial characteristics. Then we argue that despite the unique situations of Canada, the Canadian multiculturalism has some transferrable features and essences, such as embracing diversity and upholding human rights protection, that may have important implications for Korean society, which is currently experiencing a rapid ethnocultural diversification.
Methylome-wide Association Study of Patients with Recent-onset Psychosis
Yan-Hong Piao,Yin Cui,Fatima Zahra Rami,Ling Li,Maryam Karamikheirabad,Shi Hyun Kang,Sung-Wan Kim,Jung-Jin Kim,Bong Ju Lee,Young-Chul Chung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls. Methods: The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis. Lifestyle factors, such as smoking, alcohol, exercise, and diet, were controlled. Results: We identified 2,912 differentially methylated CpG sites in patients with RO psychosis compared to controls. Most of the genes associated with the top 20 differentially methylated sites had not been reported in previous methylation studies and were involved in apoptosis, autophagy, axonal growth, neuroinflammation, protein folding, etc. The top 15 significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways included the oxytocin signaling pathway, long-term depression pathway, axon guidance, endometrial cancer, long-term potentiation, mitogen-activated protein kinase signaling pathway, and glutamatergic pathway, among others. In the patient group, significant associations of novel methylated genes with early trauma and psychopathology were observed. Conclusion: Our results suggest an association of differential DNA methylation with the pathophysiology of psychosis and early trauma. Blood DNA methylation signatures show promise as biomarkers of future psychosis.
Yan, Shuailing,Chung, Yeongjee The Institute of Internet 2020 International Journal of Internet, Broadcasting an Vol.12 No.3
Ad Hoc network is a special wireless network, mainly because the nodes are no control center, the topology is flexible, and the networking could be established quickly, which results the transmission stability is lower than other types of networks. In order to guarantee the transmission of data packets in the network effectively, an improved Queue Ad Hoc On-demand Distance Vector Routing protocol (Q-AODV) for node detection by using blockchain technology is proposed. In the route search process. Firstly, according to the node's daily communication record the cluster is formed by the source node using the smart contract and gradually extends to the path detection. Then the best optional path nodes are chained in the form of Merkle tree. Finally, the best path is chosen on the blockchain. Simulation experiments show that the stability of Q-AODV protocol is higher than the AODV protocol or the Dynamic Source Routing (DSR) protocol.
Development of an Automatic Packer Using Vacuum Packaging and its Effects on the Rice Quality
Yan, T.Y.,Chung, J.H.,Rhee, C.O. Korean Society for Agricultural Machinery 2004 바이오시스템공학 Vol.29 No.2
본 연구에서는 배아미, 현미, 가능성쌀들 및 진공을 요하는 식품의 품질을 보존하기 위해서 연속식 자동진공포장기를 국내 최초로 개발하였다. 배아미의 진공포장 성공률은 92.6%이었고, 실패율 7.4%에서 진공포장기 자체에서 불완전 테이핑의 밀봉작업으로 진공이 서서히 풀리는 경우가 5.5%, 그리고 진공하기 전 자동비닐포장기에서 포장시 봉지 윗부분 밀봉이 불완전해 1.9%가 진공이 풀렸다. 이에 개발한 자동진공포장기의 진공포장성공률은 약 94.5%수준이었다. 진공포장기로 진공시간에 따른 진공압력을 측정하였고, 배아미 2, 3, 5 kg를 진공포장하는데 소요되는 시간은 각각 6, 8, 11초이었다. 진공포장으로 처리한 배아미와 진공포장 처리하지 않은 배아미를 각각 3재월간 저장실험하여 백도, 함수율, 과산화물가, 산가를 저장기간별로 분석하였다. 그 결과, 백도는 진공처리가 2 감소, 비처리가 4 감소하였고, 함수율은 진공처리가 0.8%감소, 비처리가 1.3%감소, 과산화물가는 진공처리가 최대 1.89 meq/kg까지 서서히 증가하였고, 비처리가 3.45 meq/kg까지 급속히 증가하였다가 서서히 감소하였다. 산가 역시 진공처리가 최대 0.71 mg/g까지 서서히 증가하였고, 비처리의 경우는 0.98 mg/g까지 급속히 증가하였다. 그리고 현미의 진공포장에서도 산가 및 과산화물가 변화가 배아미 경우와 비슷하였다. 또한 진공포장 제품에 인위적으로 쌀벌레들을 넣은 경우 15일 지나면 산소부족으로 모두 사멸하였다. 따라서 개발한 진공포장기로 진공포장한 경우 배아미 및 현미의 품질을 잘 보존할 수 있었다.
Fermentation Characteristics for Extruded Hair of Tissue Cultured Mountain Ginseng
Yan-Qing Ji,Hye-Jin Yang,Jin Tie,Mi-Hwan Kim,Jae-Ghan Yang,Ki-Wha Chung,Gi-Hyung Ryu 한국식품영양과학회 2009 Preventive Nutrition and Food Science Vol.14 No.2
Effects of extrusion conditions (barrel temperature and moisture content) and fermentation time on the antioxidant properties of root hair of tissue cultured raw mountain ginseng (MG) were investigated. The barrel temperature/moisture combinations were: 110oC/25% (MG1), 140oC/25% (MG2), 110oC/35% (MG3) and 140oC/35% (MG4). Red ginseng (RG) was also investigated. The contents of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and polyphenolic increased after fermentation in RG and even more in MG, while extruded ginseng samples exhibited little change. The increases noted with MG and RG occurred during the first 4 days of fermentation. DPPH radical scavenging activity decreased after extrusion and was significantly higher in MG (20.93%) than RG (1.63%) on the first day of fermentation. DPPH radical scavenging activity in the barrel temperature/moisture combinations were 19.01% (MG1), 14.45% (MG2), 20.37% (MG3) and 15.78% (MG4). The content of polyphenolic compounds in ginseng samples displayed a similar trend. Acidic polysaccharide in RG and MG1~MG4 were higher than MG, but decreased during fermentation. Crude saponin in RG and MG1~MG4 decreased after 15 days of fermentation, while increasing in MG.
Yan, Xiang Mei,Kim, Chung-Hyo,Lee, Chul-Kyu,Shin, Jang-Sik,Cho, Il-Hwan,Sohn, Uy-Dong The Korean Society of Pharmacology 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.2
To investigate the intestinal absorption of a fibrinolytic and proteolytic lumbrokinase extracted from Eisenia andrei, we used rat everted gut sacs and an in situ closed-loop recirculation method. We extracted lumbrokinase from Eisenia andrei, and then raised polyclonal antibody against lumbrokinase. Fibrinolytic activity and proteolytic activity in the serosal side of rat everted gut sacs incubated with lumbrokinase showed dose- and time-dependent patterns. Immunological results obtained by western blotting serosal side solution using rat everted gut sacs method showed that lumbrokinase proteins between 33.6 and 54.7 kDa are absorbed mostly by the intestinal epithelium. Furthermore, MALDI- TOF mass spectrometric analysis of plasma fractions obtained by in situ recirculation method confirmed that lumbrokinase F1 is absorbed into blood. These results support the notion that lumbrokinase can be absorbed from mucosal lumen into blood by oral administration.
Node-Level Trust Evaluation Model Based on Blockchain in Ad Hoc Network
Yan, Shuai-ling,Chung, Yeongjee The Institute of Internet 2019 International journal of advanced smart convergenc Vol.8 No.4
Due to the characteristics of an ad hoc network without a control center, self-organization, and flexible topology, the trust evaluation of the nodes in the network is extremely difficult. Based on the analysis of ad hoc networks and the blockchain technology, a blockchain-based node-level trust evaluation model is proposed. The concepts of the node trust degree of the HASH list on the blockchain and the perfect reward and punishment mechanism are adopted to construct the node trust evaluation model of the ad hoc network. According to the needs of different applications the network security level can be dynamically adjusted through changes in the trust threshold. The simulation experiments demonstrate that ad-hoc on-demand distance vector(AODV) Routing protocol based on this model of multicast-AODV(MAODV) routing protocol shows a significant improvement in security compared with the traditional AODV and on-demand multipath distance vector(AOMDV) routing protocols.