http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
End-to-end Service Assurance in 5G Crosshaul Networks
Che-Chun Teng,Mei-Chun Chen,Min-Han Hung,Hong-Jie Chen 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09
More and more telecom operators around the world began to build and to deploy fifth-generation (5G) mobile networks. With the advent of 5G service scenarios, it brings new challenges and increases the complexity of management. To deliver good quality of experience of these 5G applications for customers, service assurance is important. In this paper, we propose an end-to-end service assurance solution for 5G crosshaul networks. The 5G crosshaul network architecture consists of fronthaul, midhaul, and backhaul networks. Our solution deployed in 5G trial network in Chunghwa Telecom in Taiwan. The solution focus on slicing service assurance and synchronization monitoring. Besides, our solution adjusts most of network management in the operation support system (OSS) to apply to 5G crosshaul network. Our goal is to provide stable 5G transport network and to assure quality of experience for customers.
Conductivity relaxation in NiTiO3 at high temperatures
Teng Li,Chun Chang Wang,Chang Mei Lei,Xiao Hong Sun,Guo Jing Wang,Liu Na Liu 한국물리학회 2013 Current Applied Physics Vol.13 No.8
NiTiO3 ceramics were prepared via the traditional solid-state reaction route. The dielectric properties of NiTiO3 ceramics have been systematically investigated in the temperature range from room temperature to 1073 K NiTiO3 ceramics exhibit intrinsic dielectric response in the temperature range below 400 K. Two relaxations were observed in the temperature range higher than 400 K. The relaxation activation energy is 0.95 eV and 1.17 eV for the low- and high-temperature relaxations, respectively. Our results strongly indicate that the two relaxations are related to conductivity relaxation associated with the singly and doubly ionized oxygen vacancies.
말단 수산화기를 가진 폴리락타이드와 이미다졸로 블록된 이소시아네이트를 이용한 폴리우레탄 바이오접착제의 합성 및 물성 평가
Teng Fei Shen,Ying Juan Sun,Chun Feng Sun,Man Geng Lu 한국고분자학회 2013 폴리머 Vol.37 No.2
A series of novel imidazole-blocked diisocyanate bioadhesives (IBAs) were synthesized from reaction of toluene 2, 4-diisocyanate (TDI), isophorone diisocyanate (IPDI), hydroxyl-terminated polylactide (HO-PLA-OH), 1,1,1-trimethylolpropane (TMP), and imidazole. Synthesis of IBAs was confirmed by Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). Differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA) revealed that the TDI-based IBA had lower thermal dissociation temperature and a faster deblocking rate than IBA based on IPDI. Hydroxyl-terminated polyurethane (HPU) was introduced to study the adhesive effect of the synthesized IBAs. Improvement on elastic modulus, tensile strength and water resistance of IBA-modified HPU in comparison with neat HPU suggested the good adhesive effect of IBA due to the strong chemical reaction between released NCO groups from IBA and hydroxyl groups from HPU.
Yao-Chun Yang,Min-Hong Hsieh,Jui-Teng Chien,Keng-Chang Liu,Chang-Chen Yang 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.1
Objectives: Sacral insufficiency fracture (SIF) is not an uncommon osteoporosis fracture among the elderly. Aside from traditional treatments, sacroplasty and teriparatide (TPTD) injection have been introduced. This report aims to compare the effects of sacroplasty and teriparatide on clinical outcomes of SIF. Methods: Thirty-one elderly patients with SIF were enrolled in this retrospective observational study. Four male patients were excluded. Fourteen patients who received TPTD for 6 months were classified into the TPTD group (TT), and 13 who underwent sacroplasty were classified into the sacroplasty group (SS). All patients in both groups were instructed to take calcium and vitamin D supplements daily. Their symptoms and signs, visual analog score (VAS), Oswestry disability index (ODI), and radiographic studies were retrospectively reviewed. Results: The TT group showed significantly lower VAS than SS group after 3 (P < 0.001) and 6 months of treatment (P < 0.001). The TT group also has significant lower ODI than SS group after 1 (P = 0.010), 3 (P = 0.005) and 6 months (P < 0.001) of treatment. Upon generalized estimating equations (GEE) analysis, the TT group showed significantly more reduction in both VAS and ODI compared to the SS group at 1 month (P = 0.022, P = 0.001), 3 months (P < 0.001, P < 0.001), and 6 months (P < 0.001, P < 0.001) post-treatment. Conclusions: Postmenoposal woman with SIF who received TPTD healed better than those who underwent sacroplasty after 1 month treatment.
Triangular No-arbitrage Estimation through Bitcoin: An Application in Venezuelan Bolivars
Yuan-Teng Hsu,Jying-Nan Wang,Chih-Chun Chen 한국증권학회 2018 Asia-Pacific Journal of Financial Studies Vol.47 No.4
In this study, we apply the Bitcoin to estimate the price of the Venezuelan bolivar, due to the unreliability of this currency’s official exchange rate. Our approach is based on the triangular no-arbitrage condition and takes the Bitcoin as an intermediate currency. To verify its validity, in addition to bolivars, six currencies are first considered in the empirical study. We find that trading through the Bitcoin market produces higher transaction costs or requires higher risk compensation than trading through the conventional exchange market. Then, we explore the Venezuelan case. Comparing the estimates of the black market bolivars, which are generated from several popular media sources and the Web site Dolartoday.com, using Bitcoin can produce reliable bolivar exchange rates quickly and easily. To sum up, we verify the feasibility of using the triangular no-arbitrage condition in foreign exchange markets to estimate exchange rates through the Bitcoin. This is especially useful when capital controls exist such as they do in Venezuela.
GPU-Accelerated Single Image Depth Estimation with Color-Filtered Aperture
( Yueh-teng Hsu ),( Chun-chieh Chen ),( Shu-ming Tseng ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.3
There are two major ways to implement depth estimation, multiple image depth estimation and single image depth estimation, respectively. The former has a high hardware cost because it uses multiple cameras but it has a simple software algorithm. Conversely, the latter has a low hardware cost but the software algorithm is complex. One of the recent trends in this field is to make a system compact, or even portable, and to simplify the optical elements to be attached to the conventional camera. In this paper, we present an implementation of depth estimation with a single image using a graphics processing unit (GPU) in a desktop PC, and achieve real-time application via our evolutional algorithm and parallel processing technique, employing a compute shader. The methods greatly accelerate the compute-intensive implementation of depth estimation with a single view image from 0.003 frames per second (fps) (implemented in MATLAB) to 53 fps, which is almost twice the real-time standard of 30 fps. In the previous literature, to the best of our knowledge, no paper discusses the optimization of depth estimation using a single image, and the frame rate of our final result is better than that of previous studies using multiple images, whose frame rate is about 20fps.
Wei Peng,Teng-wei Qiu,Chun-yan Yao,Chen Tang,Wei Zhang 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
This paper proposes a method of free-abrasive wire sawing in the magnetic field. Magnetic abrasive grains are absorbed on surface of the wire by magnetic force, and therefore more magnetic abrasive grains are carried into cutting area. This mechanism is helpful to improve the cutting performance of wire saws. Theoretical modeling of the movement trajectory of magnetic abrasive grains is done in the magnetic field, and it is also verified by observation experiments of movement trajectory of magnetic abrasive grains. Absorption angle, which is used as the indicator of adsorption capacity about magnetic abrasive grain on surface of the wire, is proposed in this paper. The effect of magnetic field intensity on absorption angle is analyzed through computer simulations and observation experiments. Practical experiments and cutting results show that the change of magnetic field intensity has a significant impact on cutting efficiency, surface roughness, and kerf width.