A NEW EXTENSION OF BESSEL FUNCTION

Chudasama, Meera H. Korean Mathematical Society 2021 대한수학회논문집 Vol.36 No.2

In this paper, we propose an extension of the classical Bessel function by means of our ℓ-hypergeometric function [2]. As the main results, the infinite order differential equation, the generating function relation, and contour integral representations including Schläfli's integral analogue are derived. With the aid of these, other results including some inequalities are also obtained. At the end, the graphs of these functions are plotted using the Maple software.

Development of self emulsifying drug delivery system of itraconazole for oral delivery: formulation and pharmacokinetic consideration

Arpan Chudasama,Brijesh Shah,Vineetkumar Patel,Manish Nivsarkar,Kamala Vasu,Chamanlal Shishoo 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.3

Poorly water-soluble drug, itraconazole (ITZ) offers a challenge in developing a drug product with adequate bioavailability. The potential for lipidic self-emulsifying drug delivery system to improve the oral bioavailability of ITZ was investigated in fasted rats. A series of ITZ SEDDS were prepared in three groups based on oil:S/CoS mixture ratios (1:9, 1:6 and 1:4) using Capryol 90 (oil), a mixture of Labrasol and Tween 20 (- surfactants) and Transcutol P (co-surfactant). The multicomponent delivery systems were optimized by evaluating their ability to self-emulsify when introduced in simulated gastric fluid, without pepsin, under gentle agitation and by determination of droplet size and visual observation. Three formulations (F5, F21 and F27), one from each group were selected based on droplet size and visual observation. The effect of oil and surfactants content on mean globule size of resulting emulsions was studied. It was clear that oil to surfactant and co-surfactant ratio has the main impact on the droplet size of the emulsion formed after dilution. However, the relation between droplet size and in vivo absorption of ITZ was futile. The order of AUC was 1:4>1:6>1.9 for oil:S/CoS mixture ratios. Following an oral administration of developed SEDDS and marketed capsule to rats, a 1.7, 2.0 and 2.33-fold increase in bioavailability was observed for F5, F21 and F27 respectively, compared with marketed capsule. The results from this study demonstrate the potential use of SEDDS to provide an effective way of improving oral absorption of lipophilic drugs.

Resident Participation in International Surgical Missions is Predictive of Future Volunteerism in Practice

Shruti Chudasama Tannan,Thomas J Gampper 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.2

Background Interest in global health and international mission trips among medical student and resident trainees is growing rapidly. How these electives and international mission experiences affect future practice is still being elucidated. No study has identified if participation in international surgical missions during residency is a predictor of participation in international surgical missions in practice after training completion. Methods All trainees of our plastic surgery residency program from 1990 to 2011, during the implementation of optional annual international surgical missions, were surveyed to determine if the graduate had gone on a mission as a resident and as a plastic surgeon. Data were compared between graduates who participated in missions as residents and graduates who did not, from 1990 to 2011 and 1990 to 2007. Results Of Plastic Surgery graduates from 1990 to 2011 who participated in international missions as residents, 60% participated in missions when in practice, versus 5.9% of graduates participating in missions in practice but not residency (P<0.0001). When excluding last 5 years, graduates participating in international missions in practice after doing so as residents increases to 85.7%, versus 7.41% who participate in practice but not residency P<0.002. Conclusions Results reveal plastic surgeons who participate in international surgical missions as residents participate in international surgical missions in practice at higher rates than graduates who did not participate in missions during residency. International missions have significant intrinsic value both to trainee and international communities served, and this opportunity should be readily and easily accessible to all plastic surgery residents nationwide.

Resident Participation in International Surgical Missions is Predictive of Future Volunteerism in Practice

Tannan, Shruti Chudasama,Gampper, Thomas J. Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.2

Background Interest in global health and international mission trips among medical student and resident trainees is growing rapidly. How these electives and international mission experiences affect future practice is still being elucidated. No study has identified if participation in international surgical missions during residency is a predictor of participation in international surgical missions in practice after training completion. Methods All trainees of our plastic surgery residency program from 1990 to 2011, during the implementation of optional annual international surgical missions, were surveyed to determine if the graduate had gone on a mission as a resident and as a plastic surgeon. Data were compared between graduates who participated in missions as residents and graduates who did not, from 1990 to 2011 and 1990 to 2007. Results Of Plastic Surgery graduates from 1990 to 2011 who participated in international missions as residents, 60% participated in missions when in practice, versus 5.9% of graduates participating in missions in practice but not residency (P<0.0001). When excluding last 5 years, graduates participating in international missions in practice after doing so as residents increases to 85.7%, versus 7.41% who participate in practice but not residency P<0.002. Conclusions Results reveal plastic surgeons who participate in international surgical missions as residents participate in international surgical missions in practice at higher rates than graduates who did not participate in missions during residency. International missions have significant intrinsic value both to trainee and international communities served, and this opportunity should be readily and easily accessible to all plastic surgery residents nationwide.

A STUDY OF THE RIGHT LOCAL GENERAL TRUNCATED M-FRACTIONAL DERIVATIVE

Chauhan, Rajendrakumar B.,Chudasama, Meera H. Korean Mathematical Society 2022 대한수학회논문집 Vol.37 No.2

We introduce a new type of fractional derivative, which we call as the right local general truncated M-fractional derivative for α-differentiable functions that generalizes the fractional derivative type introduced by Anastassiou. This newly defined operator generalizes the standard properties and results of the integer order calculus viz. the Rolle's theorem, the mean value theorem and its extension, inverse property, the fundamental theorem of calculus and the theorem of integration by parts. Then we represent a relation of the newly defined fractional derivative with known fractional derivative and in context with this derivative a physical problem, Kirchoff's voltage law, is generalized. Also, the importance of this newly defined operator with respect to the flexibility in the parametric values is described via the comparison of the solutions in the graphs using MATLAB software.

Birth of a healthy infant after bone marrow-derived cell therapy

Nayana H Patel,Yuvraj D Jadeja,Niket H Patel,Molina N Patel,Harsha K Bhadarka,Piyush N Chudasama,Harmi R Thakkar 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.3

Bone marrow-derived cell (BMDC) therapy has numerous applications as potential biological cells for use in regenerative medicine. Here, we present an original case of endometrial atrophy associated with genital tuberculosis in a woman who achieved a live birth with BMDC. This 27-year-old woman came to our center with endometrial atrophy and primary infertility. She had a past history of genital tuberculosis and amenorrhea. Her husband’s semen quality was normal. The patient was counseled for hysteroscopy due to thin endometrium and advised in vitro fertilization (IVF) with donor eggs in lieu of poor ovarian reserve. Several attempts of IVF with hormone replacement therapy (HRT) were made, but the desired thickness of the endometrium was not achieved. Uterine artery injection of BMDC through interventional radiology was given, followed by HRT for three months, which resulted in improved endometrium. This was subsequently followed by IVF with donor egg. The treatment resulted in the conception and delivery of a 3.1-kg baby boy through lower segment caesarean section with no antenatal, intranatal or postnatal complications. Recently, there has been massive interest in stem cells as a novel treatment method for regenerative medicine, and more specifically for the regeneration of human endometrium disorders like Asherman syndrome and thin endometrium, which was the reason behind using this strategy for treatment.