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단클론항체를 이용한 타액 내 Streptococcus mutans 수준의 측정
김추성,김재곤,양연미,백병주,이경열,김미아,임수민 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2
Streptococcus mutans는 구강 내에 상존하는 치아우식증의 주요 원인균으로서 치면의 피막에 부착 후 glucan을 형성하여 세균의 군락을 이루며, 외부로부터 공급된 자당대사를 통하여 유기산을 생성함으로써 법랑질을 탈회시킨다. 치아우식 활성도의 평가를 위한 단클론항체를 이용한 방법은 진료실에서 빠른 시간 내에 간편하게 타액에 존재하는 Streptococcus mutans의 정량분석이 가능한 방법이다. 이 연구는 3세에서 6세 사이의 어린이 15명을 대상으로 자극성 타액을 채취하여 시판 중인 단클론항체를 이용한 Salivacheck Mutans, strip을 이용한 Dentocult-SM 그리고 MSB배지 배양법으로서 타액 내 Streptococcus mutans를 측정한 후 그 값을 우식경험치아수와 비교하여 상관관계를 알아보았다. Saliva-check Mutans를 이용한 방법은 Dentocult-SM과 MSB배지법과 통계학적으로 유의한 상관관계를 보였으나 (p<0.05), MSB배지법은 어린이의 우식경험치아수와 통계학적으로 유의한 결과를 나타내지 않았다 (p=0.34). Streptococcus mutans, one of the major causal agents of dental caries, is component of the dental plaque. It produces various organic acids such as lactic acid which is the end-product of glycolysis, and this leads to dental caries. A new system using species-specific monoclonal antibodies was developed to detect Streptococcus mutans in saliva. The system quickly detects salivary Streptococcus mutans in 30min and classifies the result into two levels. The purpose of this study was to investigate correlation between monoclonal antibody-based detecting system and selective medium-based detecting methods. Children's deft indices were also compared with Streptococcus mutans counts in MSB agar plate. Subjects consisted of 15 children in the age of 3 to 6 years. They were assigned to three groups: Group Ⅰ (deft index = 3), Group Ⅱ (deft index ≤ 3), Group Ⅲ (deft index ≥ 4). The results are as follows : 1. The rate of children with positive response was 13.3% and with negative response was 86.7% in the result of Saliva-check Mutans test kit. 2. There was a positive correlation between monoclonal antibody-based detecting system and selective medium-based detecting methods (p<0.05). 3. Streptococcus mutans counts in MSB agar plate were irrelevant to deft of children(p=0.34).
A strategy for forming robust adhesion with the substrate in a carbon-nanotube field-emission array
Lim, Seong Chu,Choi, Ha Kyu,Jeong, Hee Jin,Song, Young Il,Kim, Gil Yong,Jung, Kyung Taek,Lee, Young Hee Elsevier 2006 Carbon Vol.44 No.13
<P><B>Abstract</B></P><P>A method of how to form a strong adhesion of carbon nanotubes (CNTs) to substrate by introducing an intermediate metal layer in fabricating spray-based field emitters and its effect to the field-emission properties were addressed. An Indium or tin layer was deposited on an indium-tin-oxide glass substrate and thermally annealed to hold the CNTs tightly. This underlying metal layer forms a strong bond to CNTs by wetting while melting without any detectable evaporation of metal atoms. This gave rise to a stable field-emission current at high voltage, which was confirmed by a mass spectrometer. The tube density and field-emission characteristics strongly depend on the annealing temperature of metal layers.</P>
Reflective Colored Organic Light-Emitting Diodes for Light-Adaptable Display
Lim, Jong Tae,Ahn, Joon Tae,Lee, Jonghee,Moon, Jaehyun,Cho, Seong M.,Ah, Chil Seong,Lim, Seong Chu,Lee, Jeong-Ik American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.11
<P>A new light-adaptable display (LAD), consisting of reflective, colored, organic light-emitting diodes (RCOLEDs) and an optical shutter (OS), was fabricated. The RCOLED is composed of a color-selective reflective filter (CSRF) functioning in reflective mode under bright conditions, and a transparent OLED (TOLED) working in emissive mode under relatively dark conditions. The OS functions to pass or shield the light generated in the TOLED or from the outer environment. In this RCOLED, the CSRF was designed based on the concept of Fabry-Perot interferometry to represent a specific color of red, blue, and green. The TOLED was designed using a low-reflective multi-layered graphene as an top electrode to suppress the distorted optical interference from reflective mirrors in the RCOLED. The color reproduction range calculated from RCOLEDs with a graphene top electrode was dramatically improved (35.0%), compared to that computed from RCOLEDs with a semi-transparent thin-silver top electrode (2.4%). Finally, we demonstrate that the new dual-mode LAD works well.</P>
Effect of Gas Exposures on Field Emission Properties of Carbon Nanotube Arrays
Lim, Seong-Chu,Choi, Young-Chul,Jung, Hee-Jin,Shin, Young-Min,Bae, Dong Jae,Lee, N. S.,Kim, J. M.,Lee, Young Hee 선문대학교 첨단과학기술연구소 2001 첨단과학기술연구소 논문집 Vol.5 No.-
We have investigated the field emission properties from the CNT-FEA by exposing various gases, We find that gas adsorbates played a crucial role in the formation of saturation currents at high field. The existence of the hysteresis loop during the rise and fall sweeps originates from the presence of the gas adsorbates. Oxygen and nitrogen gases show different trends in the change of the emission properties from hydrogen gases. The changes of the slopes. turn-on voltages, and saturation currents at high field are strongly correlated to the electronegativity of the individual Species and nature of the adsorption. We conclude that oxygen gases dominate the filed emission properties upon adsorption and even degrade the surface morphologies with possible oxidative etching process, whereas hydrogen gases give the least effects to the field emission properties, by simply cleaning up the surface of the CNT-FEA.
Lim, Seong Chu,Jeong, Hee Jin,Kim, Keun Soo,Lee, Im Bok,Bae, Dong Jae,Lee, Young Hee Elsevier 2005 Carbon Vol.43 No.13
<P><B>Abstract</B></P><P>We have characterized the emission properties of multi-walled carbon nanotubes (MWCNTs) grown by thermal chemical vapor deposition (CVD). Our characterizations have been conducted in the thermal-field (T-F) zone, a narrow transition zone between field emission and thermionic emission. The characteristic <I>I</I>–<I>V</I> curve in T-F zone, designated to Christov plot, is advantageous to extract independently the field enhancement factor and work function at the emitting site. Our approach is more reliable than Fowler–Nordheim (F–N) plot whose linear region provides the solution with two unknowns. On the other hand, the Christov plot in the T-F zone provides the solution with only the field enhancement factor. Using the general theory of electron emission, we find that the work function and field enhancement factor of the CVD-grown MWCNTs are 4.7±0.4eV and 3300±200, respectively.</P>
( Lim Jihye ),( Yung Sang Lee ),( Young-hwa Chung ),( Han Chu Lee ),( Young-suk Lim ),( Kang Mo Kim ),( Ju Hyun Shim ),( Jonggi Choi ),( Danbi Lee ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: As aging is worldwide phenomenon, the elderly patients with hepatocellular carcinoma (HCC) have been increased. However, little is known about the prognosis of trans-arterial chemoembolization (TACE) in elderly HCC patients. As the body composition reflects frailty and geriatric conditions in older adults, its clinical significance has been emphasized. So, we investigated the prognostic factors of elderly HCC patients treated with TACE including body composition and clarify its clinical significance. Methods: A total of 237 patients with HCC, aged 65 or older, who received TACE as initial treatment were included [age (years, mean ± SD: 70.0 ± 4.5); sex (M/F: 168/69); etiology (HBV/HCV/NBNC: 139/51/47); Barcelona Clinic Liver Cancer (BCLC) stage (A/B: 136/101)]. They were followed up regularly for a median of 44 months (range, 22.6 - 69.2). When diagnosed with HCC, we analyzed skeletal muscle index (SMI), calculated as the total abdominal muscle area divided by height squared in meters, and visceral to subcutaneous fat ratio (VSR) around third lumbar vertebra using CT scan. We defined muscle depletion with visceral adiposity (MDVA) as SMI less than 50 percentile and VSR more than 50 percentile, sex specifically. We analyzed the survival rates in relation to the presence of MDVA and other clinical factors. Results: The medians of SMI were 49.5 ㎠/㎡ (range 45.3 - 54.9) and 43.6 ㎠/㎡ (range 38.4 - 48.1) and those of VSR were 1.0 (range 0.7 - 1.4) and 0.5 (range 0.4 - 0.7) for men and women, respectively. About 60.8% patients had multiple HCCs, and average size of maximal diameter of tumor was 3.9 ± 2.9 cm. The Model for end stage liver disease (MELD) score was 8.4 ± 2.3. During the follow-up periods, 170 patients (71.7%) died and overall cumulative survival rates were 88.9% at 1 year and 59.8% at 3 years after TACE. The mortality was not quite different from BCLC stage (the survival rate of BCLC A vs. B; 89.5% vs. 88.1% at 1 year; 61.1% vs. 58.1% at 3 years, P=0.653). The MDVA group showed significantly lower survival rates compared with those without MDVA. (85.1% vs. 90.4% at 1 year and 47.8% vs. 64.7% at 3 years, P=0.016). Also, multivariate analysis revealed that in addition to older age (HR 1.077, P<0.001), presence of ascites (HR 2.364, P=0.009), and higher MELD score(HR 1.104, P<0.001), the presence of MDVA (HR 1.448, P=0.026) was an important prognostic factor to predict mortality after TACE in elderly patients with HCC. Conclusions: Our data indicate that body composition, especially MDVA, might be a crucial factor for clinical outcome in aged 65 years or more HCC patients treated with TACE along with age, presence of ascites, and liver function.