Endometrial cancer risk and survival by tumor MMR status

Christina M. Nagle,Christina M. Nagle,Tracy A. O'Mara,Yen Tan,Daniel D. Buchanan,Andreas Obermair,Penny Blomfield,Michael A. Quinn,Penelope M. Webb,Amanda B. Spurdle,Australian Endometrial Cancer Stud 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.3

Objective: The risk of developing endometrial cancer (EC) and/or survival following a diagnosis of EC might differ by tumor DNA mismatch repair (MMR) status. We assessed the association between tumor MMR status (classified as MMR-proficient, somatic MMR-deficient, germline MMR-deficient) and the risk of developing EC and survival following a diagnosis of EC. Methods: We analyzed data from women who participated in the Australian National Endometrial Cancer Study (ANECS) conducted between 2005 and 2007. Risk analyses (698 cases/691 population controls) utilized sociodemographic and lifestyle information obtained from telephone interviews at recruitment. For survival analyses (728 cases), patients' clinical data was abstracted from medical records, and survival data were obtained via linkage with the Australian National Death Index. We used logistic regression analysis to evaluate the associations between tumor MMR status and EC risk, and proportional hazards models to perform survival analyses with adjustment of known prognostic factors. Results: Established risk factors for EC did not differ significantly by tumor MMR status. In analyses including all EC subtypes, overall and EC-specific survival did not differ by tumor MMR status. Among women with the most common endometrioid subtype, EC-specific survival was worse for women with somatic MMR-deficient EC compared to women with MMR-proficient EC (hazard ratio [HR]=2.18; 95% confidence interval [CI]=1.19–4.01). Conclusion: The risk of EC is not associated with MMR status. Accurate separation of germline from somatic causes of MMR deficiency suggests that patients with endometrioid subtype somatic MMR-deficient tumors have poorer EC-specific survival than those with MMR-proficient tumors, after accounting for other prognostic factors.

Poster Session:PS 0172 ; Endocrinology : Laboratory Monitoring of Osseous Metabolism Parameters in Adults with Beta-Thalassaemia

( Christina Stefanidou ),( Efterpi Bogia ),( Christina Botziori ),( Eleftheria Nakou ),( Asimoula Koteli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The correlation between vitamin D, parathormone (PTH), Calcium (Ca), Phosphorus (P), Magnesium (Mg) and osteopenia or osteoporosis in patients with Thalassemia major. Methods: 43 thalassaemics patients 24-63 years old were included in the study. 31 of them were female and 12 male. 3 females were in menopause. 25 females were treated with oestogens and 3 diagnosed with hypogonadism. 3 males were diagnosed with hypogonadism, 5 were treated with testosterone and 4 had no treatment. The levels of Ca, P, Mg and 25(OH)D were measured with the method of Chemiluminescent Immunoassay (Architect c8000 ABBOTT Laboratories) where PTH with the method of radioimmunoassay RIA. The osseous density of COCCYX and trochanter femoral neck were both recorded via DEXA method. Results: All patients were diagnosed with osseous metabolism disorder either with osteopenia (Tscore from -1 to -2,5) or osteoporosis (Tscore = -2,5).18 of them were recorded with osteoporosis and 25 with osteopenia. In osteoporosis: the average range of 25(OH)D was 27,93 in men/16,3 in women (normal range:20-60,3 ng/ml), of PTH was15,0/23,2 (normal range:10-65 pg/ml), of Ca 8,83/9,0 (normal: 8,4-10,2 mg/dl). In osteopenia the average range of 25(OH)D was respectively 20,56 in men /20,36 in women, of PTH was 39,63 in men /38,33 in women, of Ca 8,71 in men /8,74 in women. Measurements of P and Mg were monitored within normal range. Conclusions: Females with osteoporosis or osteopenia were diagnosed with insuffi cient Vit.D and high levels of PTH. The inverse correlation of Vit.D with PTH occurs when levels of Vit.D were < 20.

Moderate Coffee Consumption Lowers the Likelihood of Developing Left Ventricular Systolic Dysfunction in Post-Acute Coronary Syndrome Normotensive Patients

Christina-Maria Kastorini,Christina Chrysohoou,Demosthenes Panagiotakos,Panagiotis Aggelopoulos,Catherine Liontou,Christos Pitsavos,Christodoulos Stefanadis 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.1

The aim of the present work was to evaluate the association between coffee consumption and the development of left ventricular systolic dysfunction (LVSD) in patients who had had an acute coronary syndrome. During 2006–2007, 144 male (65 ± 14 years) and 50 female (71 ± 12 years) post-acute coronary syndrome patients who developed LVSD (ejection fraction <40%) after the cardiac event and 129 male (64 ± 12 years) and 51 female (67 ± 10 years) post-acute coronary syndrome patients without LVSD (ejection fraction >50%) were included in the study. Participants were consequently selected. Detailed information regarding their medical records, sociodemographic and anthropometric data, and various psychological and lifestyle characteristics (physical activity, smoking habits, etc.) were recorded. In particular, nutritional habits, including coffee consumption, were evaluated using a semiquantitative food-frequency questionnaire. Multi-adjusted analysis revealed that in normotensive patients coffee consumption of 1–2 cups/day was associated with 88% (95% confidence interval, 0.02–0.84) lower likelihood of developing LVSD and consumption of >3 cups/day with 90% (95% confidence interval, 0.01–0.88) lower likelihood for LVSD, compared with no history of consumption of coffee and after adjusting for various confounders. In contrast, in hypertensive patients coffee consumption of >3 cups/day was associated with 4.5-fold higher likelihood for developing LVSD (95% confidence interval, 0.89–22.58) as compared with no history of coffee consumption. Coffee consumption has opposite effects on the likelihood of developing LVSD in post-acute coronary syndrome patients depending on their blood pressure levels.

Issues in Hiriong People with Disabilities Expressed by Employers

Christina Kim,Heidi Paul 국립특수교육원 2007 특수교육연구 Vol.14 No.1

고용주의 장애인 고용에 대한 현안사항 탐색-미국 캘리포니아 지역을 중심으로 -Christina Kimm* Heidi Paul**이 연구는 장애인을 고용할 때 고용주가 갖는 기대와 문제점을 주목적으로 장애인의 고용률을 증가시킬 수 있는 요소가 무엇인지를 알아보고자 하는 연구이다 . 연구의 참가자는 미국 캘리포니아주 남부(남가주)에 사업체를 가지고 있는 2,000여 명의 고용주들에게 설문지를 보내어 약 665명으로부터 얻은 결과를 기록했다 . 참가자는 남가주 지역사회의 구성인원의 비율보다는 동양인과 히스패닉

Moderate Coffee Consumption Lowers the Likelihood of Developing Left Ventricular Systolic Dysfunction in Post-Acute Coronary Syndrome Normotensive Patients

Kastorini, Christina-Maria,Chrysohoou, Christina,Panagiotakos, Demosthenes,Aggelopoulos, Panagiotis,Liontou, Catherine,Pitsavos, Christos,Stefanadis, Christodoulos The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1

The aim of the present work was to evaluate the association between coffee consumption and the development of left ventricular systolic dysfunction (LVSD) in patients who had had an acute coronary syndrome. During 2006.2007, 144 male ($65\;{\times}\;14$ years) and 50 female ($71\;{\times}\;12$ years) post-acute coronary syndrome patients who developed LVSD (ejecti fraction 40%) after the cardiac event and 129 male ($64\;{\times}\;12$ years) and 51 female ($67\;{\times}\;10$ years) post-acute coronary syndrome patients without LVSD (ejection fraction >50%) were included in the study. Participants were consequently selected. Detailed information regarding their medical records, sociodemographic and anthropometric data, and various psychological and lifestyle characteristics (physical activity, smoking habits, etc.) were recorded. In particular, nutritional habits, including coffee consumption, were evaluated using a semiquantitative food-frequency questionnaire. Multi-adjusted analysis revealed that in normotensive patients coffee consumption of 1-2 cups/day was associated with 88% (95% confidence interval, 0.02-0.84) lower likelihood of developing LVSD and consumption of >3 cups/day with 90% (95% confidence interval, 0.01-0.88) lower likelihood for LVSD, compared with no history of consumption of coffee and after adjusting for various confounders. In contrast, in hypertensive patients coffee consumption of >3 cups/day was associated with 4.5-fold higher likelihood for developing LVSD (95% confidence interval, 0.89-22.58) as compared with no history of coffee consumption. Coffee consumption has opposite effects on the likelihood of developing LVSD in post-acute coronary syndrome patients depending on their blood pressure levels.

Success stories and issues in transition services for youths with intellectual disabilities in the United State of America

Christina H. Kimm,Cailine Kim,SungPhil Yoon 한국발달장애학회 2018 발달장애연구 Vol.22 No.3

지적장애학생들의 학교교육에서 취업으로의 성공적인 전환은 수년간 특수교육과 재활상담분야의 주 관심사가 되어왔다. 지적장애학생들은 학교를 졸업하고 취업을 하는 과정에서 현저히 저조한 결과를 내었고 그 주요원인으로는 현실성이 결여된 특수교육과 전환교육의 실천, 장애학생의 선호도를 고려하지 않은 목표설정, 비효과적인 훈련과정, 그리고 교사와 부모와 지역사회와의 협력체계의 부적절성들을 들 수 있다. 이러한 문제점들은 관심분야가 제한되어있고 자기주장능력이 부족한 지적장애학생들에게는 더욱 두드러진다. 이 논문에서는 미국에서의 전환교육 실천방법과 성공사례를 제시하고 지적장애 학생들이 성공적인 전환교육을 받을 수 있는 주요 요인들을 살펴보는 것이다. The successful outcomes of transition from school to employment has been the critical issues and concerns in Special Education and Rehabilitation Counseling in the U.S. Youths with intellectual disabilities achieve limited outcomes as they leave school and try to access employment. Some of the essential factors associated with t ese limitations are impractical special education and transition services, goal setting without individual preference consideration, inefficient preparation of youths with disabilities, and insufficient collaboration among professionals, parents, business, and community leaders. These problems can be anticipated to be enormous in case of youths with intellectual disabilities who have limited interest and self-advocacy skills. In this paper, the practice of transition services and success stories in the U.S. will be introduced and the key elements how to assist youths with intellectual disabilities to achieve successful transition from school to employment will be discussed.

교회교육 지도자들을 위한 전문지 / 신학에세이 : ' 나의 탄생 ; 여성사역으로서의 성인교육

(Christina Stainhauer Wohlfahrt),박신경 (역) 장로회신학대학교 기독교교육연구원 1990 교육교회 Vol.- No.166

Soziale Sicherheit für Selbständige - Das österreichische Modell im europäischen Kontext -

Christina Hießl 전북대학교 동북아법연구소 2015 동북아법연구 Vol.8 No.3

유럽 대륙의 복지국가에서 `전형적인` 근로자에게 상대적으로 유리한 사회보장체계를 가지는 반면, 자영인들은 전통으로 오히려 의붓자식 취급을 받아오고 있다. 이 연구에서 주목할 만한 점은 오스트리아의 사회보장제도는 이웃한 다른 유럽국가들보다 `실질적인 근로자` 와 경제적으로 유사한 상태에 있는 사람들의 사회보장권을 조화시키며, 그 사회보장제도가 더욱 `진짜의 사업가들`에도 점차적으로 확대된다는 점이다. 본 연구에서 사회,역사적인 배경과 오늘 날의 경제 현실에 대한 영향들 및 발전방향에 대한 논의를 살펴보려고 한다. Across continental European countries, with their at times very generous social protection systems for "classical" employees, the self-employed have traditionally been subject to a kind of Cinderella treatment. This contribution turns the spotlight on the social policy approach of Austria - a country that has probably gone further than any of its neighbours in harmonising standards of protection by social security between "real workers" and those in a similar economic position, and gradually extending the system also to "genuine entrepreneurs". The article discusses the socio-historical background, consequences for present-day economic reality and the way forward.

Massively-Parallel Pattern Recognition through Evolutionary Molecular Hypernetwork in DNA Computing

Christina Baek(백다솜),Je-Hwan Ryu(류제환),Ji-Hoon Lee(이지훈),Byoung-Tak Zhang(장병탁) 한국정보과학회 2015 한국정보과학회 학술발표논문집 Vol.2015 No.6

Engineering Yeast to Synthesize Medicinal Compounds via an Integrated Systems Approach

Christina SMOLKE 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4