어린이의 사시교정술시 인공호흡수와 심박수와의 상관관계

강종만,김종성,김희수,염명걸 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.4

Correlation between Respiratory Rates and the Degree of Bradycardia in Strabismus Surgery in Children Jong-Man Kang, M.D., Hee-Soo Kim, M.D., Chong0Sung Kim, M.D. and Myung-Kul Yum, M.D.^* Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, and ^*Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea Background: Strabismus surgery is frequent in pediatric ophthalmic surgery. Traction on the extra-ocular muscles can trigger an oculocardiac rdflex. We investigated the correlation between respiratoy rates and the degree of bradycardia to find another management for preventing oculocardiac reflex. Methods: NO premedications were administered. They were induced with thiopental and vecuronium and maintained with O_@-enflurane-N_2O. The tidal volume was 10 ml/kg. Respiratory rate of group 1 (n = 18) was fixed at 24 bpm, group 2 (n = 18) at 20 bpm, and group 3 (n = 19) at 16 bpm. We measured the mean heart rate from intubation to the beginning of surgery and defined this as the basal heart rate. We defined the lowest heart rate after traction of the extraocular muscles as the minimal heart rate. We calculated the correlation coefficient between the respiratory rate and basal heart rate, minimal heart rate, the change of heart rates and E_tCO_2. Results: There was a positive correlation between the respiratory rate and the basal heart rate, and minimal heart rate. There was no correlation between the respiratory rate and the change of heart rate. There was no difference in E_tCo_2 among the 3 groups. Conclusions: Can be increased both basal heart rate in anesthetized patients and minimal heart rate induced by oculocardiac reflex by making the respiratory rate more rapid if there is no significant difference of E_tCO_2. The oculocardiac reflex may be reduced by making respiratory rate more rapid if there is no significant influence on minute ventilation. (Korean J Anesthesiol 2001; 41: 450~454)

高速道路 터널區間에서의 運轉者 視覺情報 特性에 관한 硏究

金明洙,延基錫,姜宗實 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

It is very important to analyse drivers' visual behavior because visual information accounts for more than 90 percent of information for driving. There is a research that adjustment factor a tunnel is 0.95 and for a continuous tunnel is 0.09. The reason is that a vehicle slowed down for visual trouble in the tunnel section of highway. This problem usually happens but there has never been studied of human factor which is operated as causes. Therefore the importance of researches on stable driving, smooth travel and coping with traffic safety is increasing day by day. In this regard, this study has an eye to visual aspect among things which influence drives' activity.

Neuroendocrine Tumors of the Lung: Clinical, Pathologic, and Imaging Findings

Chong, Semin,Lee, Kyung Soo,Chung, Myung Jin,Han, Joungho,Kwon, O Jung,Kim, Tae Sung Radiological Society of North America 2006 Radiographics Vol.26 No.1

<P>Neuroendocrine tumors of the lung arise from Kulchitzky cells of the bronchial mucosa and comprise typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma (LCNEC), and small cell lung cancer (SCLC). At histopathologic analysis, these tumors demonstrate a progressive increase in the number of mitotic figures per 10 high-power fields of viable tumor and in the extent of necrosis, with typical carcinoid having the lowest values and SCLC having the highest. Typical carcinoid is less aggressive than atypical carcinoid, although these tumors have similar gross pathologic and radiologic features; LCNEC has a prognosis between that of atypical carcinoid and that of SCLC. SCLC is the most aggressive pulmonary neuroendocrine tumor and has the most specific imaging feature: mediastinal or hilar lymphadenopathy. At CT, carcinoid tumors appear as a spherical or ovoid nodule or mass with a well-defined and slightly lobulated border. When nonspherical, the tumor is elongated with its long axis parallel to adjacent bronchi. Calcification or ossification is seen in up to 30% of cases. The CT findings of LCNEC are nonspecific and are similar to those of other non-small cell lung cancers. Although there are some overlapping features between these tumors, integration of the clinical and imaging features may be helpful in differentiation of pulmonary neuroendocrine tumors.</P>

환자와 자연환경에서 분리된 Aeromonas의 균종 및 항균제 감수성

정윤섭,이삼열,홍천수,고춘명,곽창길 대한감염학회 1987 감염 Vol.19 No.3

Aeromonas is known to cause gastrointestinal as well as various extraintestinal infections in man. Strains of Aeromonas isolated from mam used to be identified as A. hydrophila, but other species is now known to cause infection. In this study, strains of Aeromonas isolated from clinical materials during July 1983 to December 1986 and identified as A. hydrophila were reexamined to ascertain presence of other species. Also attempted was to isolate Aeromonas from environmental sources during September to October 1986. Identification of species were done by various biochemical tests. Antimicrobial susceptibility was tested by the agar dilution method. Among the clinical isolates 15 were A. hydrophila, 7 A. sobria and 4 A. caviae. From the environment 11 were A.sobria, 7 A. hydrophila and 2 A. caviae. A. hydrophila as well as A. sobria (7) and A. caviae (4) were isolated from such specimens as wound, blood and bile. From environmental sources, fish bowl water often yielded the organism. The isolates included 10 A. sobria, 6 A. hydrophila and 2 A. caviae. All of the isolates were susceptible to amikacin, gentamicin, tobramycin, cefotaxime and ciprofloxacin, most were susceptible to cefamandole, cefoperazone, cefoxitin, cefuroxime, moxalactam, chloramphenicol and tetracycline, and a few were susceptible to cefazolin and cotrimoxazole. All were resistant to ampicillin. It is concluded that from clinical materials A. hydrophila as well as A. sobria and A. caviae are isolated, that among the environmental isolates A. sobria outnumber others, and that the most active antimicrobial agents are aminoglycosides, cefotaxime and ciprofloxacin.

Integrated PET/CT of pulmonary neuroendocrine tumors: diagnostic and prognostic implications.

Chong, Semin,Lee, Kyung Soo,Kim, Byung-Tae,Choi, Joon Young,Yi, Chin A,Chung, Myung Jin,Oh, Dae-Kun,Lee, Ji-Young American Roentgen Ray Society 2007 American Journal of Roentgenology Vol.188 No.5

<P>OBJECTIVE: The purpose of this study was to describe retrospectively integrated PET/CT findings on pulmonary neuroendocrine tumors and to correlate the findings with prognosis. MATERIALS AND METHODS: Between May 2003 and February 2005, 37 consecutively enrolled patients (33 men and four women; mean age, 60 years) with histopathologically proven pulmonary neuroendocrine tumors underwent 18F-FDG PET/CT after enhanced standalone CT. CT was used to analyze the morphologic features of the tumors and PET to measure maximum standardized uptake value (SUV). Maximum SUVs of carcinoid tumors, large-cell neuroendocrine carcinomas (LCNECs), and small-cell lung carcinomas (SCLCs) were compared, and maximum SUV and tumor stage and prognosis were correlated. RESULTS: Four (two typical and two atypical) of the seven carcinoid tumors had no FDG uptake or less than mediastinal uptake. The maximum SUVs of primary tumors, in increasing order, were significantly different for carcinoids (mean, 4.0; median, 3.4), LCNECs (mean, 12.0; median, 10.7), and SCLCs (mean, 11.6; median, 11.7) (p = 0.006, Kruskal-Wallis test). There was no significant correlation between maximum SUV of the primary tumor and the tumor stages of carcinoids, LCNECs, or SCLCs (p = 0.08, Jonckheere-Terpstra test; p = 0.768, Mann-Whitney test). Results of receiver operating characteristics analysis showed a maximum SUV greater than 13.7 suggested a poor survival period in cases of LCNEC and SCLC. CONCLUSION: The maximum SUVs of neuroendocrine tumors are significantly different for carcinoid tumors, LCNECs, and SCLCs, and a high maximum SUV suggests short survival of patients with LCNEC or SCLC.</P>

센서 기반 동적 모델역변환 제어 개발

김종섭(Chong-sup Kim),양인석(In-seok Yang),강명수(Myung-soo Kang),고기옥(Gi-Oak Koh),김병수(Byoung-Soo Kim) 항공우주시스템공학회 2018 항공우주시스템공학회 학술대회 발표집 Vol.2018 No.4

The relationship between antifungal usage and antifungal susceptibility in clinical isolates of<i>Candida</i>: a multicenter Korean study

Kim, Soo Hyun,Shin, Jong Hee,Kim, Eui-Chong,Lee, Kyungwon,Kim, Mi-Na,Lee, Won Gil,Uh, Young,Lee, Hye Soo,Lee, Mi-Kyung,Jeong, Seok Hoon,Jung, Sook In,Park, Kyung Hwa,Lee, Jin-Sol,Shin, Myung Geun,Suh, Oxford University Press 2009 Medical mycology Vol.47 No.3

<P>There have been very few multicenter studies of the relationship between the use of antifungals and resistance to them. We investigated the antifungal susceptibility of 1,301 clinical isolates of Candida collected from nine Korean hospitals during a 3-month period in 2006 to explore the existence of this type of relationship. Antifungal usage in the preceding year, defined as the daily dose per 1,000 patient days (DDD/1,000 PD), was calculated for each hospital. Resistance to fluconazole, itraconazole, and amphotericin B was detected in 2, 9, and 0.2% of the isolates, respectively. The MIC(50)/MIC(90) values were 0.03/0.125 mg/L for voriconazole, 0.06/0.25 mg/l for caspofungin, and 0.03/0.125 mg/l for micafungin. The total usage of systemic antifungals varied considerably among the nine hospitals, ranging from 6.1 to 96.2 DDD/1,000 PD. No relationship was found between the use of fluconazole (MIC> or =64 mg/l) or itraconazole (MIC> or =1 mg/l) and resistance in the Candida species (P>0.05). However, significant correlations were found between the percentage of Candida isolates that were non-susceptible to fluconazole (MIC> or =16 mg/l) and fluconazole usage (r=0.733, P=0.025) or total antifungal usage (r=0.767, P=0.016).</P>

위궤양환자에서 Rebamipide의 자유산소유리기제거에 의한 궤양치료효과

박수헌(Soo Heon Park),정운태(Woon Tae Jung),서정한(Jung Han Suh),정명희(Myung Hee Chung),정인식(In Sik Chung),이용찬(Yong Chan Lee),박인서(In Suh Park),송근암(Guen Am Song),양웅석(Ung Suk Yang),유종선(Jong Sun Rew),윤종만(Chong Mann 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5

N/A Background/Aims: Helicobacter pylori has been shown to be an important pathogen of gastric disorder including gastritis and gastric ulcer. One of the potential toxic factors involving gastric mucosal cell injury is reactive oxidants, which are released from activated neutrophils. Rebamipide had been reported to promote mucus synthesis, mucosal prostaglandin content, and rapid ulcer healing, It has recently been reported to inhibit the production of oxygen derived free radicals from stimulated neutrophils. We conducted this study to evaluate the effects of rebamipide on gastric ulcer healing and reactive oxygen metabolite production. Methods: In this multicenter study conducted in Korea, combination treatment of rebamipide and ranitidine was compared with ranitidine alone in 108 patients with gastric ulcer patients. Pre- and post-treatment endoscopic findings and concentration of reactive oxygen metabolite produced were used to evaluate efficacy. The efficacy of rebamipide and ranitidine versus ranitidine was evaluated using endoscopy results, and tissue lipid peroxides by thiobarbituric acid and myeloperoxide concentration. Results: The percentage of ulcer size reduction was significantly higher with rebamipide and ranitidine group than with placebo and ranitidine group(size reduction: 71.5% vs 58.3% P=0.04556). The myeloperoxidase activities at ulcer margin in rebamipide and ranitidine group patients were 96.7+-13.4 unit/mg protein in baseline and 53.8+9.9 unit/mg protein in follow up (P=0.0065). The myeloperoxidase activities at ulcer margin in placebo and ranitidine group patients were 90.2+9.1 unit/mg protein in baseline and 63.1+6.7 unit/mg protein in follow up (P=0.0668). The thiobarbituric acid activities at ulcer margin in rebamipide and ranitidine group patients were 34.7+5.3 nmol of MDA/mg protein in baseline and 24.1W3.1 nmol of MDA/mg protein in follow up. The thiobarbituric acid activities at ulcer margin in placebo and ranitidine group patients were 14.8+1.5 nmol of MDA/mg protein in baseline and 24.3+2.7 nmol of MDA/mg protein in follow up (P=0.0059). The thiobarbituric acid activities at ulcer margin in H. pylori positive and negative patients were 28.1+2.1 nmol of MDA/mg protein and 25.3+4.7 nmol of MDA/mg protein, respectively. The myeloperoxidase activities at ulcer margin in H. pylori positive and negative patients were 79.9+5.3 unit/mg protein and 40.4+25.3 unit/mg protein, respectively (P=0.0001). The cumulative relapse rate was examined starting at 24 week after ulcer treatment. The rate was lower in rebamipide and ranitidine group patients, but insignificantly(19.2% vs 27.3%, P=0.0857). Conclusions: These results suggest that rebamipide promote gastric ulcer healing by decreasing reactive oxygen metabolite production in patients with gastric ulcer. (Korean J Gastroenterol 1997;29:569-578)

Quantile confidence region using highest density

Hong, Chong Sun,Yoo, Myung Soo The Korean Statistical Society 2019 Communications for statistical applications and me Vol.26 No.1

Multivariate Confidence Region (MCR) cannot be used to obtain the confidence region of the mean vector of multivariate data when the normality assumption is not satisfied; however, the Quantile Confidence Region (QCR) could be used with a Multivariate Quantile Vector in these cases. The coverage rate of the QCR is better than MCR; however, it has a disadvantage because the QCR has a wide shape when the probability density function follows a bimodal form. In this study, we propose a Quantile Confidence Region using the Highest density (QCRHD) method with the Highest Density Region (HDR). The coverage rate of QCRHD was superior to MCR, but is found to be similar to QCR. The QCRHD is constructed as one region similar to QCR when the distance of the mean vector is close. When the distance of the mean vector is far, the QCR has one wide region, but the QCRHD has two smaller regions. Based on these features, it is found that the QCRHD can overcome the disadvantages of the QCR, which may have a wide shape.

위장관 이식편대 숙주질환 4 예

박수헌,정인식,박종원,정규원,김부성,최황,최명규,조세현,선희식,김춘추,한준열,김석은,김동집 대한내과학회 1995 대한내과학회지 Vol.49 No.2

Graft-versus-host disease(GVHD) is a major cause of morbidity and mortality following bone marrow transplantation(BMT). Moderate to severs GVHD occurs in nearly one half of recipients of HLA identical sibling BMT, and 10-30% of these patients die due to acute GVHD or its complications. Target organs injured by GVHD include the skin, liver, and gastrointestinal tract. The clinical staging and grading of acute GVHD are based on the degree of target organ damage. In Korea, the occurrence of GVHD is about 20%. We report four typical eases of histologically con- firmed GUHD after allogeneic BMT, and review the literature to compare the difference$quot; in primary ill-ness, clinical manifestations, and disease progression.