Clear cell sarcoma of the kidney : Immunohistochemical study and flow cytometric DNA analysis of 7 cases

Choi, Yoon-Jung,Jung, Woo-Hee,Jung, Soon-Hee,Park, Chanil Yonsei University, College of Medicine 1994 Yonsei medical journal Vol.35 No.3

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

안면부에 발생한 고정형 스포로트리쿰증 3례

최윤애,류영욱,정재봉,송준영,이규석 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

We experienced 3 cases of fixed type cutaneous sporotrichosis confined to the face. Case 1 was a 32-month old child, affected over the nose. Case 2 was a 25-year old man, affected over the left cheek. Case 3 was a 71-year old man, affected over the nose. Histopathologically, chronic granulomatous inflammation with pseudoepitheliomatous hyperplasia was observed. Mycologically, typical dark brown to black colored colonines with moist, wrinkled and membranous surfaces were cultured. All patients were completely cured by oral administration of saturated KI and itraconazole combined therapy in a short period(40-90 days).

자궁적출술 후 통증에 Gabapentin 의 진통효과

최종호,김창성,김은성,유건희,이윤기,문동언,윤건중 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.6

상수도 배관의 부식감지시스템 개발 (Ⅱ)

최윤석,신동호,김상현,김정구 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.4

In order to develop a new corrosion sensor for detecting and monitoring the corrosion of buried pipeline, the electrochemical property of sensors and the correlation of its output to corrosion rate of steel pipe, were evaluated by electrochemical methods in synthetic groundwater, two soils of varying resistivity (5,000 ohm-cm, 10,000 ohm-cm), and synthetic tap water. In this paper, two types of electrochemical probes were used: galvanic cells containing of pipeline steel-copper and pipeline steel-stainless steel (Type 304). The results of EIS measurement indicated that the sensor current was inversely related to sensor resistance, which was governed by the corrosion behavior of cathode. In galvanic corrosion tests, the galvanic current of Cu-CS probe was higher than that of SS-CS probe. The comparison of the sensor output and corrosion rates revealed that a linear relationship was found between the probe current and the corrosion rates. A good linear quantitative relationship was found between the Cu-CS probe current and the corrosion rate of pipeline steel coupons in the soil resistivity of 5,000 ohm-cm, and synthetic tap water. In the case of the soil resistivity of 10,000 ohm-cm, although the SS-CS probe showed a better linear correlation than that of Cu-CS probe, the Cu-CS probe is more suitable than SS-CS probe, due to the high current output. (Received February 1, 2005)

항암제(Adriamycin, Cyclophosphamide, 5-Fluorouracil)로 유발된 흰쥐의 간독성에 대한 Squalene의 효과

최영복,김종세,윤중식 조선대학교 기초과학연구소 1998 自然科學硏究 Vol.21 No.1

The objective of the present study was to investigate the cytotoxicity of Adriamycin〔ADM〕. Cyclophosphamide〔CP〕, 5-Fluorouracil〔5-FU〕 in mouse liver cells (group A, B, c), and the protective effect of squalene to the hepatocytes to which ADM, CP, and 5-Fu-induced cytotoxicity(group A-1, B-1, C-1) was examined by transmission electron microscope. In the group A, The cisternae of rough endolplasmic reticulum(RER) and smooth endoplasmic reticulum(SER) are dilated/disoriented at 24 hours and 48 hours. The inner and outer membrane of mitochondria are detached or destructed, and attached ribosomes of RER are diminished in number. The cisternae of the SER are dilated, and the cristae of mitochondria are disrupted at 72 hours and 96 hours. In the group A-1, the cisternae of the RER and the SER are dilated at 24 hours. The cisternae of the SER are dilated at 48 hours. The cell organelles of hepatocytes are recovered from cytotoxicity at 72 hours. At 96 hours, hepatocytes were simillar to those of normal hepatocytes. In the group B, the cisternae of RER were partially destructed and attached ribosomes were remarkable decreased at 24 hours. A number of the mitochondria were dilated and increased in number, the filamentous materials also detected at 72 hours. In the group B-1, the difference between the normal and the treated groups were not detected at 24 hours, but the few mitochondria were expanded at the 72 hours. In the group C, the nucleus was destroyed at 24 hours and 48 hours group, however, somewhat repaired at 72 hours group. The dilated inner cavity and the irregular lamellae of the RER were observed continually until 72 hours group. The inner cavity of the SER were dilated in all groups. However, the destroyed and the normal membrane were observed simultaneously at 72 hours group. The inner membrane of the mitochondria were almost repaired at 96 hours group. In the group C-1, the nucleus was a little finfluenced by the toxicity of 5-Fu at 24 hours and 48 hours, RER were observed to keep the typical lamella structure of cisternae from 24 to 72 hours group, but inner cavity kept on dilating. In SER, inner cavity were also observed to flatten from 24 to 72 hours group. Mitochondria were always shown normal. All cell organelles were similar to those of normal at 96 hours. Accordingly, it can be said that the treatment of SQ prevents the cytotoxicity of ADM, CP, 5-FU on cell organelles of liver cell and that is concerned with the formation of membrane system of cell organelles.

SJO¨GREN'S SYNDROME 환자에게 즉시 임프란트 술식을 행한 치험례

최정환,손동석,이지연,이윤서,안선희,이재목 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The old edentulous patients experience xerostomia commonly. They have considerable difficulty in wearing tissue-supported prosthesis and high risk rate of caries. One of them is Sj□gren's syndrome patient. Sj□gren's syndrome is a chronic inflammatory autoimmune disorder that results in a lymphocyte-mediated destruction of exocrine glands. We planned to place implants immediately after extraction in this case of autoimmune disease. The advantages of immediate implant placement include considerable decrease in time from tooth extraction to placement of the final prosthesis, fewer surgical procedures, and better acceptance of the overall treatment plan. We present a case of Sj□gren's syndrome patient treated with immediate implant placement & immediate loading in anterior region and immediate implant placement in posterior region.

상수도 배관의 부식감지시스템 개발 (Ⅰ)

최윤석,김정구 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.10

In order to develop a new corrosion sensor for detecting and monitoring the corrosion of buried pipeline, sensor element design and the correlation of its output to corrosion rate of steel pipe itself were evaluated by laboratory test methods in synthetic groundwater. It uses well-known principles of galvanic corrosion and consists of two dissimilar metals (anode and cathode) installed on the buried pipeline. In this paper, two types of electrochemical probes were used: galvanic cells containing pipeline steel (CS)-copper (Cu) and pipeline steel (CS)-type 304 stainless steel (SS) couples. The corrosion behavior in synthetic groundwater for the different electrodes was investigated by potentiodynamic test. The galvanic corrosion test was accomplished by a zero resistance ammeter technique. Weight loss measurements were conducted to obtain the corrosion rates of pipeline steel in synthetic groundwater. The correlation between galvanic current and corrosion rate was obtained by galvanic current measurement and corrosion rate measurements. The results of the potentiodynamic test indicated that copper exhibited an active corrosion behavior, while stainless steel demonstrated spontaneous passivation. In galvanic corrosion tests, the galvanic current of copper-steel couple was higher than that of other couple. The comparison of the sensor output and corrosion rate revealed that a linear relationship was found between the probe current and the corrosion rate. Especially, a better linear quantitative relationship was found between the Cu-CS probe current and the weight loss data of the pipeline steel coupons. In addition, the Cu-CS probe is more suitable for high resistance soil than SS-CS probe, due to the high current output.

교정적 치아초기배열단계시 발생하는 치근 변화에 관한 주사전자현미경적 연구 : A SCANNING ELECTIRON MICROSCOPIC STUDY

최정윤,정규림 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.4

본 연구는 교정치료를 목적으로 발치가 예정된 치아를 대상으로 임상적으로 매우 중요한 치료과정 중의 한 부분인 초기치아배열단계에서 다양한 기간과 크기의 교정력을 가하여 치아배열기간, 교정력의 크기, 치아이동방향에 따라 치근표면에 일어나는 흡수와 회복 양상에 대한 정보를 얻기 위하여 시행되었다. 치료받지 않은 13개의 치아를 대조군으로 하고 교정치료계획상 제1소구치를 발거하기로 예정된 37개의 치아를 실험군으로 하여 20-450gm의 초기교정력을 가한 후 주사전자현미경적 관찰을 통하여 다음과 같은 결과를 얻었다. 1. 실험군 37개 중 22개의 치아(59.5%)에서 치근흡수가 발견되었다. 치근흡수는 최소실험기간인 3주군부터 나타났으며 흡수부위의 회복은 3개월군부터 나타났다. 2. 교정력의 기간 증가에 따라 치근흡수의 발생빈도가 증가하는 경향을 보였다. 3. 교정력이 클수록 상아질을 포함하는 흡수가 증가하는 경향을 보였다. 4. 치근 흡수의 부위는 하중 받는 부위와 일치하는 경향을 보였다. 5. 치근 흡수 부위는 면적과 가장 상관성이 높은 변수는 교정력의 크기였다. The purpose of this study was to investigate the root resorption and repair pattern of human teeth according to the force magnitude, direction and duration during the initial leveling and alignment phase. 40gms to 500gms of force applied to the 37 experimental teeth with duration of 3 weeks to 7 months. Then, the experimental teeth were extracted. 13 control teeth were extracted without treatment. The results are as follows: 1. 59.5% of 37 teeth exhibited root resorption. The initial resorption site was visible at the apex within 3 weeks with 100 gms samples, and the initial repair site was visible at the apex within 3 months with 400 gms samples. 2. Number of resorbed teeth increased with the duration of the force. 3. The depth of the resorption increased with the magnitude of the force. 4. The areas of resorbed root corresponded with the loading pattern. 5. The areas of resorbed root were highly correlated with the magnitude of the force. The result of this study suggest that root resorption could occur during the initial leveling and alignment phase. These initial injuries are all small and insignificant. It is the extensive type of apical root resorption that must be regarded as deleterious to the function and stability of the tooth moved. During the initial leveling and alignment phase lighter force of the interrupted type and short treatment period would be favorable with regard to avoidance of root resorption and repair of resorbed root surface.

Cr, Co, Cu, Ni와 Ca의 첨가에 따른 지하매설배관의 전기화학적 특성에 관한 연구

최윤석,신동호,심재주,김정구 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.1

Aqueous corrosion characteristics of low carbon steel with small amounts of Cr, Co, Cu, Ni and Ca, in synthetic groundwater was studied by electrochemical corrosion tests (potentiodynamic test and electrochemical impedance spectroscopy (EIS) measurements) and analytical techniques. Neither carbon steel nor newly alloyed steels showed passive behavior in this synthetic groundwater. Newly alloyed steels, containing Cr-Co, Cr-Cu-Ni and Cr-Cu-Ni-Ca showed higher corrosion resistance than carbon steel in the potentiodynamic tests. EIS measurements showed that the Nyquist plot presented two time constants. The high frequency resistance component (R_(rsut)) and low frequency resistance component (R_(et)) were affected by the alloying elements. The polarization resistance (RP= R_(et) +Ra) of steels could be clearly ranked as Cr-Cu-Ni-Ca steel >> Cr-Cu-Ni steel > Cr-Co steel > carbon steel. Results of surface analyses (XPS and EPMA) showed that Cr and Cu were concentrated in the inner region of rust. However, Co and Ni were uniformly distributed all over the rust layer. These alloying elements improved corrosion resistance of low alloy steel in synthetic groundwater. Especially, Cr-Cu-Ni-Ca steel had the lowest corrosion rate due to the inner rust film formation during the initial stage of corrosion, which suggested a potential for substituting carbon steel in soil environment (Received October 29, 2004)