한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

열적 변화를 이용한 실내환경 가스의 분류

최낙진,심창현,송갑득,주병수,이윤수,이상문,이덕동,허증수 한국센서학회 2002 센서학회지 Vol.11 No.5

단일 기판위에 온도측정용 Pt 박막과 Pt 히터 그리고 가스 감지를 위하여 순수한 SnO_2 박막과 Pt가 첨가된 SnO_2박막을 설계하고 제작하였다. 제작된 소자는 실내환경가스인 이산화탄소, 프로판 그리고 부탄의 분류에 응용되었다. 동작 온도를 가변하기 위하여 히터의 입력 전압을 사다리꼴로 인가하면서 SnO_2 감지막의 반응특성과 실내환경가스들에 대한 분류여부를 조사하였다. 감지막 반응특성곡선에서 여러 변수들을 추출한 후 주성분분석(principal component analysis : PCA)을 통하여 가스 분류 특성을 검증하였다. Two SnO_2 based sensing films(pure SnO_2 and SnO_2/Pt) and a Pt thin film for temperature sensor on an alumina substrate were designed and fabricated for classifying the indoor environmental gases. By controlling the heating power in the shape of trapezoid, unique four sensing response curves created from both SnO_2 film and SnO_2/Pt film. Then, various parameters were extracted from sensing response curves and carried out principal component analysis(PCA). The results confirm that a sensor array with the proposed operating mode was extremely effective in classifying indoor environmental gases such as CO_2, C_3H_8, C_4H_10.

멀티 플랫폼상의 컴포넌트 연동 방법 연구

김정현,김태웅,김태공,전순미,최항묵 인제대학교 2002 仁濟論叢 Vol.17 No.1

소프트웨어 개발 방법론이 객체지향개발 방법론(OOD : Object Oriented Development)에서 점차 컴포넌트 기반 개발 방법론(CBD : Component Based Development)으로 변화되어 가는 추세이다. 경험이 많은 개발자에 의해 개발된 컴포넌트는 소프트웨어 재사용이 뛰어나고, 이미 많은 곳에서 사용 중이므로 안정성 및 신뢰성이 인정된다. 하지만 개발언어와 플랫폼의 특성에 따라 컴포넌트의 조합에 있어 어려움이 따른다. 이에 본 연구에서는 HTTP와 XML을 이용하여 개발언어와 플랫폼에 독립적으로 컴포넌트를 조합할 수 있는 방안에 대해 연구하고 기존의 컴포넌트에 HTTP와 XML을 이용한 컴포넌트 호출을 보인다.

CORBA 디자인 패턴에 관한 연구

김정현,박세명,최항묵 인제대학교 2001 仁濟論叢 Vol.16 No.1

소프트웨어의 객체지향 패러다임이 줄 수 있는 가장 큰 이점은 다형성(polymorphism)을 통한 재사용성(reusability)이다. 이러한 재사용성은 구현측면에서 코드의 재사용, 그래픽 사용자 인터페이스의 재사용, 분산 시스템에서의 인터페이스의 재사용에서는 잘 이루어지고 있으나, 설계단계에서의 재사용성은 아직 부족한 실정이다. 본 연구에서는 이러한 객체지향 설계단계에서 재사용할 수 있는 디자인 패턴(Design Pattern)으로서 분산 객체 환경인 CORBA 시스템 설계 시 적용할 수 있는 새로운 CORBA 디자인패턴을 제안한다. Designing object-oriented software is hard, and designing reusable object-oriented software is even harder. Design should be specific to the problem at hand but also general enough to address future problem and requirement. Expert Designers reuse solutions that have worked for them in the past. This solution is Design Pattern. The propose of this paper is to record experience in designing distributed-object CORBA software as CORBA design pattern.

CORBA 기반 의료영상 회의 시스템 설계

김정현,서재현,최항묵 인제대학교 1997 仁濟論叢 Vol.13 No.1

본 연구에서는 CORBA를 기반으로 하여 JAVA언어로 개발된 의료 영상 회의 시스템(MICS :Medical Image Conference System)을 설계 제안한다. MICS는 정지영상, 텍스트 데이터 그리고 음성정보를 ORB를 통해서 전달하는 시스템이다. 플랫폼에 독립적이면서 미들웨어(Middle ware)인 CORBA를 이용한 MICS는 시스템을 개발, 확장성 및 유지 보수가 쉽다는 장점과 비용 절감 효과를 가진다. CORBA의 이러한 장점과 JAVA 언어의 특성을 이용하여 원거리 병원간의 MRI영상이나 X-ray영상, CT영상 등 정지 영상에 관한 회의 시스템을 설계하였다. In recent years, many researchers have worked on CORBA which is independent of platform, object oriented and makes real-time processing possible in distributed objdct environment. And, as the superhigh speed network systems are generalized, the studies on image conference, cyber university, virtual classroom and group co-working are actively pursued. In this paper, Medical Image Conference System based on CORBA in JAVA language is suggested. MICS is a system that can transmits static image, text data and voice information through the ORB. MICS can provides good facilities of development, extensibility and maintenance with reduced cost by using CORBA which is independent of platform and a middleware. For the demonstration, we will show the conference system which can transmit especially the static images such as MRI, X-ray, CT images between remote hospitals, considering those advantages of CORBA and the features of JAVA.

韓醫學的 診斷類型에 따른 韓藥方劑의 抗癌 및 免疫調節作用에 미치는 影響

朴鐘鉉,金楨氾,崔昇勳,安圭錫 대한동의병리학회 1994 동의생리병리학회지 Vol.9 No.1

연구배경 : 암은 사망의 주요한 원인이 되는 질환으로서, 우리나라에 있어서도 급격히 증가하는 추세이다. 한의학에서는 암의 유형을 크게 간울기체형, 기체혈어형, 비허습담형, 음허내열형 등으로 분류하고 있는데, 각 유형에 응용할 수 있는 소요산, 소복축어탕, 사군자탕, 육미지황탕의 항암효능을 비교 연구함으로써, 암치료에 대한 한약재의 임상활용도를 높이고자 함. 방법 : Mouse에 Sarcoma-180으로 복강암을 유발한 후, 약제를 21일 간 투여하고 생존율, T cell, B cell, 혈청항체가, IL-2 생산능, NK cell의 세포살상능을 측정하였다. 결과 : 생존기간의 연장효과는 모든군에서 증가하는 경향이 있었으나 유의성이 없었고, T cell 및 B cell은 모든군에서 증가하였으며, 임파구 증식반응 및 IL-2 생산능은 사군자탕과 육미지황탕에서, NK cell 활성도는 소복축어탕 엑기스 투여군에서 유의성이 있었다. 결론 : 이상으로 보아 이들 처방은 면역조절작용을 통한 항암효과가 있을 것으로 볼 수 있으며, 변증분형에 따라 처방을 달리해야 함을 알 수 있다. In order to investigate the effects of Formules according to Pattern Identification on anti-tumor and immunodulatory reaction to the ICR and C57BL/6 mice which have abdominal tumor after Sarcoma-180 cells were transplanted, the extracts of herbal medicines above mentioned were orally administered to the mice for 21 days to observe the extention of survial duration of the mice, quantitation of T cells and B cells, productivity of interleukin-2, lymphocytes transformation, hemagglutinin titer and hemolysin titer and activity of splenic natural killer cells. The results are summarized as follows ; 1. In the effect of life extention, all groups appeared to survive longer than the Control group, which are not meaningful. 2. Considering T cell and B cell content, all groups had a meaningful increase in both T cell and B cell (P<0.01). 3. Considering serum antibody titer was no significant difference between all groups. 4. In lymphocyte transformation marked a significant increase the sijunzitang-medicated mice group, marked a significant (P<0.01), and showed a significant increase the mice group medicated with Liuweidihuangtang (P<0.05). 5. As for the productivity of interleukin-2, showed a significant increase the mice group medicated with Sijunzitang ans Liuweidihuangtang (P<0.05). 6. In the effect of activity of NK cells, Shaofuzhuyutang-medicated mice group had a meaningful increase (P<0.05).

토양물리성 및 엽내 무기성분과 적과수준이 감 대봉 품종의 낙과에 미치는 영향

이상현,최현석,조정안,김월수 전남대학교 농업과학기술연구소 2000 農業科學技術硏究 Vol.35 No.-

This experiment was conducted on persimmon (Diospyros kaki Thunb) to study the cultural method reducing preharvest drop through analysis of the character of dropped fruit, thinning degree and the nutrient state of tree. Fifteen 10-year-old 'Hachiya' persimmom trees were used. Thinning were applied to one fruit per one twig (A treatment), one fruit per two twigs (B treatment) and one fruit per three twigs (C treatment) which had about six-leaf on 20 June. The number of fruit seed was investigated on dropped and harvested fruit on 20 June, 11 July and 1 Oct. Leaf analysis was conducted on both tree with heavy fruits drop and tree without fruit drop on 20 July, 1999. Preharvest drop rate with thinning degree tended to more decrease in B treatment and C treatment than in A treatment and harvest quantity of fruit was higher on B treatment than on C treatment. Preharvest drop rate seemed to be higher on the upper part of tree than on the lower part. The number of seed in fruit was about 2.1 per dropped fruit and 3.9 per harvested fruit, which showed the tendency that Preharvest drop was decreased in the fruit with many seeds. The tree with high preharvest drop rate has lower N, Ca, Mg concentration and higher Mn concentration within leaves than that with low preharvest drop rate. Thinning degree, setting point and the number of seed in fruit, the concentration of mineral nutrient in leaf had an effect on preharvest drop. Therefore we guessed that movement and supply of nutrient could affect preharvest drop.

이종장기이식에 의한 면역거부반응에서 IL-18의 역할

명평근,최연실,심정현,김은미 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Although transplantation immunology as a distinctive field began with the development of experimental models that showed the feasibility of bone marrow tranaplantation (BMT), organ engraftment was accomplished first in humans, and was though for many years to occur by drastically different mechanism. The liver, skin, and gastrointestinal tract are major target organs of acute graft-versus-host disease (GVHD), the major complication of allogenic BMT. The pathophysiology of acute GVHD involves in the dysregulation of pro-inflammatory cytokine cascade and donor T-cell responses to host alloantigens. Interukine-l8 (IL-18) was initially known as interferon-g-inducing factor with potent immunomodulatory effects. The level of IL-18 is increased in acute GVHD, but little has been known about its role in thepathophysiology of acute GVHD. It reduces the severity of acute GVHD as a Thl-inducing cytokine early after BMT to the lethally irradiated recipients. When administered to the donor, it can also reducing the severity of acute GVHD, as a Th2-inducing cytokine. Therefore, IL-18 has the remarkable capacity to modulate acute GVHD when administered either to the donor or the recipient through distinct mechanism. Here, we present our view of the concepts of transplantation immunology and the role of IL-18 in the graft rejection.

이종장기이식에 의한 면역거부반응에서 IL-18의 역할

명평근,최연실,심정현,김은미 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.2

Although transplantation immunology as a distinctive field began with the development of experimental models that showed the feasibility of bone marrow transplantation (BMT), organ engraftment was accomplished first in humans, and was though for many years to occur by drastically different mechanism. The liver, skin, and gastrointestinal tract are major target organs of acute graft-versus-host disease (GVHD), the major complication of allogenic BMT. The pathophysiology of acute GVHD involves in the dysregulation of pro-inflammatory cytokine cascade and donor T-cell responses to host alloantigens. Interukine-18 (IL-18) was initially known as interferon-g-inducing factor with potent immunomodulatory effects. The level of IL-18 is increased in acute GVHD, but little has been known about its role in thepathophysiology of acute GVHD. It reduces the severity of acute GVHD as a Thl-inducing cytokine early after BMT to the lethally irradiated recipients. When administered to the donor, it can also reducing the severity of acute GVHD, as a Th2-inducing cytokine. Therefore, IL-18 has the remarkable capacity to modulate acute CVHD when administered either to the donor or the recipient through distinct mechanism. Here, we present our view of the concepts of transplantation immunology and the role of IL-18 in the graft rejection.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.