한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

당뇨병 백서의 간세포에서 Glucokinase 활성도 및 유전자 발현에 대한 인슐린의 영향

강성이,팽정령,서광식,안규정,우정택,김성운,양인명,김진우,김영설,김광원,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

목적 당대사의 조절 상태에 따른 생체 변화를 분자 수준에서 이해하고자 식이 조건을 달리한 정상 백서와 화학적으로 유도된 당뇨병 백서의 간조직에서 혈당수준과 인슐린치료 정도에 따라 나타나는 글루코키나제 활성도 및 유전자 발현을 분석하였다. 방법 스트렙토조토신 정맥투여 후 당뇨병의 유발을 확인하고, 인슐린을 1일 3회 3일간 복강내로 투여하여 상태를 안정시킨 후, 인슐린 투여군은 인슐린 투여 6시간이내에 그리고 인슐린 비투여군은 24시간 후 단두하여 채혈하고 복강을 열어 간조직을 채취하였다. 채취한 간조직에서 글루코키나제 활성도는 인산화된 포도당에서 NADH의 형성을 형광분광계로 측정하였으며, 글루코키나제 유전자 mRNA발현은 Northern 분석법을 이용하였다. 성적 정상 백서에서 공복상태와 식이를 섭취한 경우에 간조직의 글루코키나제 효소의 활성은 차이가 없었으나, 글루코키나제 유전자 mRNA 발현은 증가되었다. 당뇨병이 유발된 백서의 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현은 정상 백서에 비하여 낮았다. 인슐린 투쳐 후 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현이 증가되었고, 특히 혈당이 정상화된 경우에서 글루코키나제 유전자의 mRNA 발현이 증가도었다. 결론 인슐린에 의한 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA을 증가를 볼수 있었다. 당뇨병 백서에서 인슐린 투여 후에 혈당조절이 안된 경우 간조직의 글루코키나제 유전자의 mRNA 발현이 증가가 없는 것으로 보아 글루코키나제 mRNA의 발현에는 인슐린 이외의 다른 요소가 관여할 것으로 생각된다. The liver-specific hexokinase isoenzyme, referred to as glucokinase, is thought to play a key reglulatory role in hepatic glucose metabolism. The glucokinase gene is, therefore, of interest both because of its tissue-specific expression and because of the several regulatory processes that can be analyzed. The level of hepatic glucokinase activity appears to be determined essentially by regulation of the rate of enzyme synthesis, with insulin playing a leading role as an inducer. We investigated the role of insulin for the induction of glucokinase in the liver of diabetic rats. Experimental diabetes was induced by injection of streptozotocin 7 days before the experiment. Regular insulin was given by three days intraperitoneal injection at 8-h interval. The glucokinase mRNA in the liver was estimated by Nothern blot assay, as well as by fluorometric enzyme activity assay. Glucokinase activity was not reduced in the liver of normal fasting rats as compared to normal fed rats. And glucokinase activity was reduced in the liver of diabetic rats as compared to normal rats. In diabetic rats treated with insulin, glucokinase enzyme activity were increased. But glucokinase mRNA expression was only increased in normoglycemic diabetic rat with treated with insulin as compared to hyperglycemic rat. These data indicate that insulin stimulates hepatic glucokinase enzyme activity and mRNA expression. But other hormonal or metabolic factors may be contribute to regulation of glucokinase mRNA expression.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

3축 자세 제어용 센서 시스템의 구현

정종원,최우진,이준탁 동아대학교 정보기술연구소 2001 情報通信硏究所論文誌 Vol.9 No.1

In this paper, were developed the 3 axes attitude control sensor system to control and monitoring the moving object. The proposed sensor system has been studied in Japan, America for a year ago. But it is high expensive and has a difficulty in application. To overcome these problems, proposed the 3 axes attitude control sensor system is low cost and easily applied. Proposed sensor system is equipped with the 3 gyro sensors, 2 tilt sensors and 3 MR sensors using 80C51 microprocessor for signal processing. It's output value transmit at long distance using RS232 serial communication protocol. We expect this system shall have a good performances in many applications of control and monitoring the moving object.

역해석을 이용한 압밀정수의 재평가

정진섭,최우정 원광대학교 대학원 2007 論文集 Vol.39 No.-

The purpose of this paper is to estimate settlement using the measurement data and to verify the application back-analysis by finite element analysis. It is very important to predict settlement in pre-loading method used to improve soft ground. But the settlement measured in the field shows a considerable difference from the predicted settlement due to various factors such as non-homogeneous soft layers, sampling disturbance, erroneous selection of soil parameters and deficiency of consolidation theories among others. Therefore, analysis of actual settlement behavior based on the measurement data during consolidation period is a very useful procedure in evaluating the rates of consolidation settlement. This study estimates settlement using analysis methods such as Hyperbolic, Hoshino and Asaoka method. Because these prediction method of ultimate primary settlement are analytically simple and economical, they are widely used in the field. To search consolidation parameter for site, back-analysis technique was performed using finite element analysis. From the results of analysis, the back-analysis technique for consolidation parameter is verified. Because a feed-back system to combine the data measured in construction field with priorly estimated information at the design stage is necessary.

능동 클램프 ZVS 플라이백 컨버터의 역률개선에 관한 연구

최태영,류동균,이우석,안정준,원충연,김수석 성균관대학교 2002 학술회의지원논문목록집 Vol.2002 No.-

본 논문에서는 single-stage, two-stage 두가지 역률보상(PFC)기법을 기존의 능동 클램프 플라이백 컨버터에 적용하여 역률 개선을 하였다. 삽입된 플라이백 컨버터의 능동클램프회로가 주스위치와 보조스위치의 영전압스위칭(ZVS)을 구현하며, 스위칭 손실을 줄임으로써 고효율을 얻을 수 있고, 높은 주파수에서의 스위칭이 가능하다. 하지만 일반적으로 사용되는 다이오드정류기, 평활용커패시터에 의한 낮은 역률의 문제점이 남아있다. 본 논문에서는 300W급 능동 클램프ZVS플라이백 컨버터를 설계하여 single-stage, two-stage방식을 적용, 입력역률개선을 시뮬레이션과 실험에 의해 입증하고자 한다. This paper analyzed PFC of active clamp ZVS flyback converter by adding two method PFC (Power Factor Correction) circuit - two-stage and single-stage. The addition of active clamp circuit also provide a mechanism for achieving ZVS of both the primary and auxiliary switches. ZVS also limits the turn off di/dt of the output rectifier, reducing rectifier switching loss and switching noise, due to diode reverse recovery. As a results, the proposed converters have characteristics of the reduced switching noise and high efficiency in comparison to conventional flyback converter. The simulation and experimental results show that the proposed converters improve the input PF of 300W ZVS flyback converter by adding single-stage, two-stage PFC circuit.

HPLC를 사용한 쌀 중 잔류농약 동시분석법

최재천,이영자,김소희,최수영,최희주,정성욱,박흥재,김우성 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

A simple and sensitive analytical method based on RP-HPLC with UV detector(225 nm) and mobile phases using 0.1% phosphoric acid and acetonitrile was developed for simultaneous determination of quinclorac, bentazone, 2,4-D, bensulfuron-methyl, dymuron, capropamide, pencycuron, ethofenprox. This method was resulted in recovery of 78~ 96% with RSD 3.3~7.5%. LODs 0.12~0.84 and LOQs 0.34~1.20 ㎎/L. Calibration curves were linear with r of 0.9995~ 0.9999.

학교 내에서의 종교의 자유 : 교내에서의 강제적 채플수업에 대한 문제를 중심으로

최우정 慶北大學校 法學硏究所 2004 법학논고 Vol.21 No.-

Die Religionsfreiheit in der Schule in Korea ist umstritten, ob und welchem Bereich die Schule ihre Religionsfreiheit leisten konnen. In diesem Bereich verwirkt ein Grundrechtskollision zwischen der negativen Religionsfreiheit der Schuler mit ihrern Eltern und padagogische Autonomie den Schulen. Es ist nicht angemessene Auslosungsmethode, die ein verfassungsrechtliche Grundrecht der Einerseits ohne Beruchsichtigung der Wesentlichlichkeit der kollidierenden Grundrechte vollig ausschliessen kann. Es ist berucksichtigt, dass die kollidierende Grundrechte miteinander praktische Konkordanz einzutreffen. In diesem Verfahren muss man die Gutersabwgung, die der wesentliche Inhalt der Grundrechte zwischen kollidierende Grundrechte miteineinander messen soll, berucksichtigen. Schließlich ist die vollige Ausschließung der negativen Religionsfreiheit den Schulern in der Schuler ist verfassungsrechtlich nicht vereinbar und nichtig.

동양 전통과학의 탐구방법론 연구 : 朱子의 格物致知論을 중심으로

최영제,이우붕,정원우,김용수,문장수,방경곤,김기정 경북대학교사범대학과학교육연구소 2005 科學敎育硏究誌 Vol.29 No.-