조명광원의 색온도와 조도 및 스펙트럼 측정

최대욱,박성진,임춘우,석성수,오철한 慶北大學校 師範大學 科學敎育硏究所 1999 科學敎育硏究誌 Vol.23 No.-

The peak wavelength and temperatures of W-Halogen standard light source were measured by using the modified Wien's Law. In the case of graybody, the emissivity ε should be taken into account in using the Wien's Law. In the experiment, PDA spectroscope was used for the measurement of peak wavelength of intensity distribution of spectrum. As the current of light source increases from 5A to 7.4A, the peak wavelength of intensity distribution of the spectrum decreased from 717nm to 690nm, and temperature increased from 3127K to 3330K. Illuminations of three-wavelength lamps and light source were also measured. It was found that irradiation spectrum of those three-wavelength lamps are not coincident to blue(450nm), green(550nm) and red(610nm).

족삼리 침자극의 복통 억제기전 연구

임사비나,임형택,박히준,장지련,최일환,이석찬,김대수,신희섭 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : Acupuncture has been used for treatment of numerous disorders, especially for pain control in Oriental Medicine. However, the mechanism of pain control by acupuncture was not clear until now. This study was performed to prove analgesic mechanism of acupuncture treatment at acupoint ST_(36) by observing the changes of abdominal pain and c-Fos expression in the thalamus. Methods : Abdominal pain was induced by acetic acid, and the changes of writhing reflex after acupuncture treatment an ST_(36) and non-acupoints were measured. c-Fos immunohistochemistry was also performed to study the changes of the neuronal activity in the thalamus. Results : The writhing reflex decrease significantly after acupuncturing at ST_(36) compared with control group(p<0.05). The changes of the writhing reflex by non-acupoint acupuncture treatment also showed significant decrease compared with control group(p<0.05). c-Fos expression in the thalamus, especially periventricular part was significantly decreased after acupuncturing at ST_(36) compared with control groups(p<0.05). Conclusion : This study shows that the acupuncture has the analgesic effect in the abdominal pain induced by acetic acid and the thalamus might be a important area for this mechanism.

數 種 韓藥의 아세틸콜린에스터레이즈 酵素活性에 대한 효과

최재환,김미영,김현미,최훈,전훈,김대근,임종필,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

아세틸콜린에스터레이즈(AChE)는 신경조직에 분포하는 효소로 신경전달물질 중 아세틸콜린(ACh)을 분해하는 효소로 시냅스 신호전달체계에 있어 중요한 역할을 하는 효소이다. 현재 알츠하이머병과 치매치료에 사용하는 서양약물은 AChE의 활성을 저해하는 작용기전을 가진다. 목적 : 전통적으로 기억력 감퇴, 치매 등 치료에 사용되어 온 한약의 AChE에 대한 작용을 밝히기 위해 본 실험이 구상되었다. 방법 : 생쥐 대뇌신경세포의 균질 혼합액으로부터 효소의 활성을 Ellman 방법을 개선한 엘리자(ELISA)법을 이용하여 측정하였다. 결과 : 실험결과 天花? 의 6종이 2.5㎎/㎖의 농도에서 우수한 효소활성저해력을 보였고, 50% 효소활성 저해농도(ID_50)를 구한 결과, 天花?의 ID_50은 1.5㎎/㎖이었고, ??? 1.2 ㎎/㎖, ?? 2.0 ㎎/㎖, ??草 1.2 ㎎/㎖, ??? 1.0 ㎎/㎖, ??生 1.7㎎/㎖, 및 大?皮 2.0 ㎎/㎖를 나타내어 忍冬?의 저해력이 가장 우수하였다. 결론 : 치매 및 기억력감퇴 증상을 치료하는 한약의 작용기전 중 AChE 효소활성억제효과는 忍冬? 의 6종에서 나타났으며, 이는 전통적인 한방치료에 과학적인 기초자료를 제공할 것으로 생각한다.

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

釜山地域産業의 成長要因分析 : 1985-1990

이대식,임정덕,최기환 부산대학교 1995 地域經濟硏究 Vol.- No.4

노인의 낙상경험에 따른 병력과 약물, 그리고 체력수준에 대한 비교분석

최대우,김창림 충남대학교 체육과학연구소 2007 體育科學硏究誌 Vol.25 No.1

The purpose of this study is to figure it out whether the Medical history, Medication, Fitness level are the factors of Fall experience among elderly people. This study was carried by using questionnaires with 236 of at emergency room in D city. This experimental group consists of 147 of fall experienced and 89 of non-fall experienced at the age of over 60. These are the conclusions of study. First, there were differences between 2 groups concerning fall experience in Medication and Medical history. Secondly, there were differences between 2 groups concerning fall experience in healthe level. Needs to keep on researching about not only the elderly who ere hospitalized but including who were not hospitalized by falling. Instrument that can estimate the factors of fall must be developed and give them a training program that can increase Health level. So we must try to prevent the relapsing. After the fall, to prevent the physical injuring and suffering from a fracture, these must be checked. 1) Checking the health of elderly people periodically. 2) Decrease of external obstacle in daily life. 3) Expanding of facilities. Also place like local community, hospital and public health center must treat a patient a medical administration and safety education during increase rate of fall. In a word, Medical history, Medication, Health level can be the primary factor of the fall experience. So to prevent the accident of falling there must be a program to elevate the ability of Health level.

실험실적 당뇨성 흰쥐에서 acetaminophen의 대사에 관한 연구

임은주,윤병재,윤병재,조희숙,김대재,최종원 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1

Acetaminophen is one of the most important drugs used for the treatment of mild to moderate pain when an anti-inflammatory effect is not necessary. Phenacetin, a prodrug that is metabolized to acetaminophen, is more toxic than its active metabolite and has no rational indications. In this study, we were observed activities of free radical generating enzymes, free radical scavenging enzymes and glutathione-related enzymes as well as detoxification mechanism of against acetaminophen-induced hepatotoxicity in STZ-induced hyperglycemic rat. Activities of cytochrome p450, cytochrome b5, aminopyrine demethylase and aniline hydroxylase were changed by the treatment acetaminophen in hyperglycemic rats. It was also observed that activities of conjugating enzymes as sulfotransferase and UDP-glucuronyltransferase was slightly changes against acetaminophen-induced in hyperglycemic rats. Acetaminophen results in the significantly decrease in the level of hepatic glutathione concentration and √-glutamylcysteon, synthetase activities in hyperglycemic rats. And, glutathine S-transferase, superoxide dismutase and glutathione peroxidase activities were significantly increased against acetaminophen-inducedas in hyperglycemic rats. Glutathione reductase and catalase were not affected for experimental state. Furthemore, acetaminophen highered serum alanine, aspartate aminotransferase, sorbitol dehydrogenase, √-glutamylpeptidase, alkaline phosphatase and lactate dehydrogenase activities in hyperglycemic rats. Key Words: Hepatotoxicity, D/M, Acetaminophen, Glutathione, Glutathlone S-transferase, √-glutamylcystein synthetase

오이(Cucumis sativus L.) 떡잎의 노쇠화와 수분 스트레 스 관련 유전자들의 발현 연구

최선림, 김대재 충북대학교 과학교육연구소 2011 과학교육연구논총 Vol.26 No.2

본문 참고

생활폐기물을 이용한 세라믹스 판재 개발

신대용,임현태,최돈량 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

생활하수처리장에서 발생하는 하수슬러지의 용융슬래그와 장석, 물유리 및 전분을 이용하여 세라믹스 다공판을 제조하였다. 슬래그의 주성분은 SiO_2와 Al_2O_3로서 점토와 유사한 성질을 갖고 있어 세라믹스의 대체원료로 사용이 가능하였다. 하수슬러지를 1,200℃에서 2시간 열처리하여 얻어진 용융물을 수증에 급랭시켜 1∼3mm 입경의 슬래그 분말을 제조하고 80∼95wt%의 슬래그, 5∼20wt%의 장석, 5∼15wt%의 물유리 및 2wt%의 전분을 혼합하여 1,100∼1,200℃에서 2시간 소성하여 시편을 제조하였다. 슬래그의 첨가량과 소성온도가 증가함에 따라 시편의 부피비중 및 압축강도는 증가하였으나, 기공률과 흡수율은 감소하였다. 1,030℃에서 2시간 소성한 No. 1, 4 및 7번 시편은 부피비중 1.52∼1.67, 기공률과 흡수율 23.3∼ 32.5% 및 14.1∼19.3%, 압축강도 81∼173kgf/㎠의 값을 나타내었다. 또한, 슬래그의 첨가량과 소성온도가 동등한 시편은 물유리의 첨가량이 증가함에 따라 부피비중과 압축강도가 증가하여 No.7, 8 및 9번 시편은 부피비중 1.52∼1.94, 압축강도 81∼385kgf/㎠의 값을 나타내었다. 시편의 중금속용출량은 미량으로서 매립지 침출수배출 허용기준치보다 낮게 측정되어 주위환경에 해가 없고 흡음특성이 양호하여 본 연구에서 제조한 세라믹스 다공판은 흡음판으로의 이용이 가능하였다. Utilization of sewage sludge from the sewage sludge treatment facilities and the municipal wastes became very important matter to be solve for the environmental protection and recycling of waste materials. The reusability of sewage sludge slag as a raw material in the manufacturing process of ceramics was highly expected because the chemical composition of slag was mostly SiO_2 and Al_2O_3 and its properties were very similar with clay. Sewage sludge slag was fabricated by sintering at 1,200℃ for 2 hours and it was crushed into powder with particle size of 1∼3mm by a rapid cooling treatment in water. Then, the mixture of 80∼95 wt% of slag, 5∼20 wt% of feldspar, 5∼15 wt% of water glass and 2 wt% of starch were heated at 1,000∼1,100℃ for 2 hours. The density and compressive strength of specimen increased with increasing the sintering temperature and the addition amount of slag, No. 1, 4 and 7, specimens were shown 1.52∼1.67 of bulk density, 23.3∼32.5% of porosity, 14.1∼19.3% of water absorption and 81∼173 kgf/㎠ of compressive strength. And, that of the specimen at the same sintering temperature and addition amount of slag increased with increasing the addition amount of water glass, No. 7, 8 and 9 specimens, bulk density was 1.52∼1.94 and the compressive strength was 81∼385kgf/㎠. An extraction test for specimen to detect the toxic materials, such as Cu, Cd, Cr, Pb and As, showed below the permitted standard of land-filling extractable heavy metal contents. Sound absorption coefficients of specimen had a good properties in No. 7 specimen, and can be used as a sound absorption plate.

Prostacyclin synthase 유전자의 C1117A 다형성과 이형협심증과의 관련성

성인환,임대승,김정희,이재환,최시완,정진옥 대한내과학회 2004 대한내과학회지 Vol.66 No.4

목적 : Thromboxan A2의 혀관수축반응을 저해하는 prostacylin synthase exon 8 C117A의 변이가 관동맥 연축과 관련성이 있는지를 알아보고자 하였다. 방법 : 1998년 1월 1일부터 2000년 12월 31일까지 충남대학교병원 순환기내과에서 관동맥조형술과정맥내 에르고노빈 유발검사를 시행하여 관동맥 연축이 확진된 이형협심증 환자군(45예)과 정상 대조군(59예)을 대상으로 중합효소 연쇄반응법 및 restriction fragment length polymorphism을 이용하여 분석하였다. 결과 : Prostacyclin synthase exon 8 C117A 유전자형의 빈도는 대조군에서 A/A : A/C : C/C =3.4% : 30.5% : 66.1%, 이형협심증 환자군에서 A/A : A/C : C/C = 8.9% : 42.4% : 48.9%로 두 군간에 유의한 차이가 없었다. 대조군에 비해 변이형 협심증 환자군에서 남자의 비율과 흡연률이 높았지만, prostacyclin synthase exon 8 C117A 유전자형에 따른 군에서 당뇨병, 고혈압, 흡연, 고지혈증, 비만 등의 유의한 차이는 없었다. 결론 : 한국인에서 prostacyclin synthase exon 8 C117A 유전자 다형성과 관동맥 연축이 있는 이형협심증과의 유의한 연관성은 발견할 수 없었다. Backround : Coronary artery spasm plays an important role in the pathogenesis of variant angina(VA). Prostacyclin is one of the endothelium derived relaxing factors. The association between the novel single nucleotide polymorphism in the prostacyclin synthase gene and VA is not known. Therefore, we investigated the association between VA and the polymorphysm in the prostacyclin synthase gene. Methods : We compared 45 variant angina patients who had positive intravenous ergonovine test by coronary angiography with 59 control subjects who had negative intravenouis ergonovine test and normal coronary angiogram. Using the polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. Results : There was no significant difference in characteristics between the control group and the VA group, and there was no significant difference in the genotype distributions between the control group and the VA group. Conclusion : The C117A polymorphism in exon 8 of the prostacyclin synthase gene is not associated with variant angina.