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조기이유 (14±2일령) 자돈 사료에 roasting 처리를 한 대두박 (roasted soybean meal; rSBM)의 수준이 자돈의 성장에 미치는 효과를 알아보기 위하여 64마리의 14일령 조기이유자돈을 4처리로 나누어 시험을 실시하였다. Phase I (이유 후 0∼14일)에는 22.5%의 조단백질을 함유하는 시험사료에 처리별로 rSBM의 수준을 각각 5%, 10%, 15%, 20%로 하였고, phase II(14∼51일)에는 모든 돼지에게 20% 조단백질을 함유하며 22.5%의 rSBM을 함유하는 사료를 급여하였다. Phase I의 일당증체량, 일당사료섭취량은 유의적인 차이가 발견되지 않았으나, 사료효율은 20% rSBM을 급여한 구에서 5%, 10%, 15% rSBM구에 비해 각각 4.32%, 4.32%, 9.35%가 나쁜 것으로 나타났다 (P$lt;0.05). 그러나 phase II와 전체 사양기간을 고려했을 때 성장성적은 rSBM의 수준에 따른 영향을 받지 않는 것으로 조사되었다. 전체사양기간 중 가장 좋은 사양성적은 15% rSBM구에서 발견되었다. Phase I에서는 분에서 외관상 아미노산 소화율이 5%, 10%, 15% rSBM구가20% rSBM구보다 9.91%, 6.46%, 5.83% 높으나, phase II에서는 arginine을 제외하고는 차이가 발견되지 않았다. 건물, 조단백질, 조지방, 총에너지의 이용율은 5% rSBM구가 20% rSBM구보다 높은것으로 나타났으나(P$lt;0.05), rSBM 수준이 15% 이하에서는 통계적인 유의성이 발견되지 않았다. 본 시험의 결과는 조기이유자돈 사료내 rSBM의 수준이 20% 이하일 때는 조기이유자돈의 성장에 심각한 영향을 주지 않는다는 점을 시사하고 있으며, 적절한 rSbm 급여 수준은 15% 정도인 것으로 나타났다. Sixty-four pigs weaned at 14±2 days of age were allotted to one of four treatments with different levels of rSBM incorporated in the phase I high nutrient dense diets. From d 0 to 14 postweaning (phase I), piglets were fed diets formulated to 22% crude protein (CP), 1.6% lysine with graded levels of rSBM (5%, 10%, 15% and 20%, respectively). For the period of d 14 to 51 postweaning (phase II), all pigs fed a diet formulated to 20% crude protein and 1.35% lysine with 22.5% rSBM. During phase I, there was no significant difference in average daily gain (ADG) and average daily feed intake (ADFI) among piglets fed diets with different rSBM levels, however, the feed conversion ratio (FCR) of piglets fed diet with 20% rSBM was 4.32%, 4.32% and 9.35% higher than that of the piglets fed diets with 5%, 10% and 15% rSBM incorporation levels, respectively. However, during phase II and overall period, no evident effect was observed on ADG, ADFI and FCR among dietary treatments. But the highest ADG and the best FCR were obtained in piglets fed diet with 15% rSBM during the entire period. The fecal amino acid digestibilities of piglets fed fiets containing 5%, 10% and 15% rSBM were 9.91%, 6.46% and 5.83% higher, respectively, than that of piglets fed diet with 20% rSBM during phase I. For phase II, the difference was not significant in amino acid digestibility among treatments except proline whose digestibility was higher in piglets fed diet with 20% rSBM (P$lt;0.05) than in piglets fed diet with 5% rSBM. Digestibilities of dry matter, crude protein, crude fat and gross energy were higher in piglets fed diet with 5% rSBM than in the piglets provided the diet with 20% rSBM, but no significant difference was found among groups under 15% of rSBM incorporation level during phase I. During d 14 to 51 postweaning, trends were similar to that the phase I. However, digestibility of gross energy was almost same among dietary treatments. These data showed that there was no adverse effect of rSBM incorporation below 20% level on the growth performance of early-weaned (14 days of age) piglets in the phase I high nutrient dense diet. It appeared that the optimal rSBM incorporation level was 15% of the diet. The result of this experiment suggested that some amounts of rSBM ($lt;20%) incorporated in the phase I high nutrient dense diets did not adversely affect growth performance of piglets weaned at 14 d of age. rSBM incorporated in the phase I diet at ratio of 15% was favorable for growth performance of piglets. However, for piglets weaned at different days of age, the optimum level of rSBM incorporated in the phase I high nutrient dense diet still needs to be studies. This will be a valuable suggestion to decrease the cost in feeding piglets.
<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>
<P><B>Abstract</B></P><P>Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors were synthesized using high temperature solid state reaction. The effect of Ba incorporation on the structural and luminescence characteristics of SrSi<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors were studied. The phosphors were crystallized in triclinic crystal structure and the cell volume increases monotonically with Ba addition. The PL emission peak wavelength red shifts with Ba up to <I>x</I> = 0.50 beyond which no red shift is observed. The XPS analysis shows that nitrogen is being incorporated into the host lattice along with Ba addition up to <I>x</I> = 0.50. The as synthesized phosphors show high thermal stability. Phosphor converted light emitting diodes were realized using Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors (<I>x</I> = 0 and <I>x</I> = 0.40) showing luminance efficacies of 108 and 101 lm W<SUP>−1</SUP>. </P><P>The CIE chromaticity coordinates of Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu (<I>x</I> = 0 and <I>x</I> = 0.40) phosphors.</P>
Electroplated Ni and Ni-W micro-molds using LIGA-like process for replication of micro-components such as microfluidic parts and micro optical parts have been investigated. In general, it is hard to produce micro-parts using conventional mechanical processes. Micro-mold formed by LIGA-like process could fabricate micro-parts with high aspect ratio. In this paper, fabrication and properties of electroplated Ni molds with varying applied current types as well as those of Ni-W molds were investigated. Ni molds fabricated under pulse-reverse current showed the highest hardness value of about 160 Hv. Ni-W molds showed the hardness of about 500 Hv which was much harder than that of Ni electroplated molds. The above results suggested that high quality micro-molds could be fabricated by using Ni electroplating of pulse-reverse type for core molds and sequential Ni-W alloys coating.
<P>The Cretaceous tectonomagmatism of the Korean Peninsula was examined based on geochemical and geochronological data of the Cretaceous plutonic rocks, along with distribution of volcano-sedimentary nonmarine N- to NE-trending fault bounded sedimentary basins. We conducted sensitive high-resolution ion microprobe (SHRIMP) zircon U-Pb ages and whole-rock geochemical compositions of 21 Cretaceous plutonic rocks, together with previously published data, from the central to southern Korean Peninsula. Four age groups of plutonic rocks were identified: Group I (ca. 119-106 Ma) in the northern to central area, Group II (ca. 99-87 Ma) in the central southern area, Group III (ca. 85-82 Ma) in the central to southern area, and Group IV (ca. 76-67 Ma) in the southernmost area. These results indicate a sporadic trenchward-younging trend of the Cretaceous magmatism in the Korean Peninsula. The Group I, II, and III rocks are dominated by high-K calc-alkaline I-type rocks with rift-related A-type granitoids. In contrast, the Group IV rocks are high-K calc-alkaline I-type plutonic rocks with no A-type rocks. The geochemical signatures of the entire groups indicated LREEs (light rare earth elements) enrichments and negative Nb, Ta, and Ti anomalies, indicating normal arc magmatism. A new tectonic model of the Cretaceous Korean Peninsula was proposed based on temporal and spatial distribution of the Cretaceous plutons represented by four age groups; 1) magmatic quiescence throughout the Korean Peninsula from ca. 160 to 120 Ma, 2) intrusions of the I- and A-type granitoids in the northern and central Korean Peninsula (Group I plutonic rocks from ca. 120 to 100 Ma) resulted from the partial melting of the lower continental crust due to the rollback of the Izanagi plate expressed as the conversion from flat-lying subduction to normal subduction. The Gyeongsang nonmarine sedimentary rift basin in the Korean Peninsula and adakite magmatism preserved in the present-day Japanese Islands supported the slab rollback followed by steepening of the Izanagi plate with an injection of upwelling of the hot asthenosphere into the mantle wedge. 3) Alternating shallow (from similar to 100 to 85 Ma) to steep (from similar to 85 to 65 Ma) subduction resulted in the migration of the normal arc magmatism in the southern Korean Peninsula, expressed as the intruded I- and A-type (Group III) and I-type granitoids (Group IV), respectively. The tectonomagmatism of, the Korean Peninsula showed the unique style of evolution, different from those of South China and Japanese Islands. (C) 2016 Elsevier B.V. All rights reserved.</P>
채보원,함기백,고준호,강한걸,이광재,김진홍,조성원,안병옥,김원배,양중의 ( B . W . Chae,K . B . Hahm,J . H . Ko,H . G . Kang,K . J . Lee,J . H . Kim,S . W . Cho,B . O . Ahn,W . B . Kim,J . I . Yang ) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1