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Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7
<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>
Anoop, G.,Cho, I. H.,Suh, D. W.,Yoo, J. S. WILEY‐VCH Verlag 2012 Physica status solidi. PSS. A, Applications and ma Vol.209 No.12
<P><B>Abstract</B></P><P>Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors were synthesized using high temperature solid state reaction. The effect of Ba incorporation on the structural and luminescence characteristics of SrSi<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors were studied. The phosphors were crystallized in triclinic crystal structure and the cell volume increases monotonically with Ba addition. The PL emission peak wavelength red shifts with Ba up to <I>x</I> = 0.50 beyond which no red shift is observed. The XPS analysis shows that nitrogen is being incorporated into the host lattice along with Ba addition up to <I>x</I> = 0.50. The as synthesized phosphors show high thermal stability. Phosphor converted light emitting diodes were realized using Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors (<I>x</I> = 0 and <I>x</I> = 0.40) showing luminance efficacies of 108 and 101 lm W<SUP>−1</SUP>. </P><P>The CIE chromaticity coordinates of Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu (<I>x</I> = 0 and <I>x</I> = 0.40) phosphors.</P>
LIGA-like 공정을 이용한 마이크로 부품 복제용 Ni과 Ni-W 금형 제조 및 특성
황완식,박준식,강영철,조진우,박순섭,이인규,강성군,Hwang, W.S.,Park, J.S.,Kang, Y.C.,Cho, J.W.,Park, S.S.,Lee, I.G.,Kang, S.G. 한국재료학회 2003 한국재료학회지 Vol.13 No.1
Electroplated Ni and Ni-W micro-molds using LIGA-like process for replication of micro-components such as microfluidic parts and micro optical parts have been investigated. In general, it is hard to produce micro-parts using conventional mechanical processes. Micro-mold formed by LIGA-like process could fabricate micro-parts with high aspect ratio. In this paper, fabrication and properties of electroplated Ni molds with varying applied current types as well as those of Ni-W molds were investigated. Ni molds fabricated under pulse-reverse current showed the highest hardness value of about 160 Hv. Ni-W molds showed the hardness of about 500 Hv which was much harder than that of Ni electroplated molds. The above results suggested that high quality micro-molds could be fabricated by using Ni electroplating of pulse-reverse type for core molds and sequential Ni-W alloys coating.
Kim, S.W.,Kwon, S.,Park, S.I.,Lee, C.,Cho, D.L.,Lee, H.J.,Ko, K.,Kim, S.J. Universitetsforlaget ; Elsevier Science Ltd 2016 Lithos Vol.262 No.-
<P>The Cretaceous tectonomagmatism of the Korean Peninsula was examined based on geochemical and geochronological data of the Cretaceous plutonic rocks, along with distribution of volcano-sedimentary nonmarine N- to NE-trending fault bounded sedimentary basins. We conducted sensitive high-resolution ion microprobe (SHRIMP) zircon U-Pb ages and whole-rock geochemical compositions of 21 Cretaceous plutonic rocks, together with previously published data, from the central to southern Korean Peninsula. Four age groups of plutonic rocks were identified: Group I (ca. 119-106 Ma) in the northern to central area, Group II (ca. 99-87 Ma) in the central southern area, Group III (ca. 85-82 Ma) in the central to southern area, and Group IV (ca. 76-67 Ma) in the southernmost area. These results indicate a sporadic trenchward-younging trend of the Cretaceous magmatism in the Korean Peninsula. The Group I, II, and III rocks are dominated by high-K calc-alkaline I-type rocks with rift-related A-type granitoids. In contrast, the Group IV rocks are high-K calc-alkaline I-type plutonic rocks with no A-type rocks. The geochemical signatures of the entire groups indicated LREEs (light rare earth elements) enrichments and negative Nb, Ta, and Ti anomalies, indicating normal arc magmatism. A new tectonic model of the Cretaceous Korean Peninsula was proposed based on temporal and spatial distribution of the Cretaceous plutons represented by four age groups; 1) magmatic quiescence throughout the Korean Peninsula from ca. 160 to 120 Ma, 2) intrusions of the I- and A-type granitoids in the northern and central Korean Peninsula (Group I plutonic rocks from ca. 120 to 100 Ma) resulted from the partial melting of the lower continental crust due to the rollback of the Izanagi plate expressed as the conversion from flat-lying subduction to normal subduction. The Gyeongsang nonmarine sedimentary rift basin in the Korean Peninsula and adakite magmatism preserved in the present-day Japanese Islands supported the slab rollback followed by steepening of the Izanagi plate with an injection of upwelling of the hot asthenosphere into the mantle wedge. 3) Alternating shallow (from similar to 100 to 85 Ma) to steep (from similar to 85 to 65 Ma) subduction resulted in the migration of the normal arc magmatism in the southern Korean Peninsula, expressed as the intruded I- and A-type (Group III) and I-type granitoids (Group IV), respectively. The tectonomagmatism of, the Korean Peninsula showed the unique style of evolution, different from those of South China and Japanese Islands. (C) 2016 Elsevier B.V. All rights reserved.</P>