유방암의 위와 대장전이

유현아,김은영,서민지,정은,조민정,오현진,장지혜,박지찬,이정의,박석영 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2

Gastric metastasis from breast cancer is rare and only six cases have been reported in Korea. Colon metastasis is more rare than gastric metastasis. We report a 63-year-old woman with gastric and colon metastases of invasive lobular carcinoma of breast. She was diagnosed as right breast cancer, received right modified radical mastectomy 10 years ago and has been treated with chemotherapy and hormone therapy. Investigating for melena and a small caliber of stool, we found gastric and colon metastases. The diagnosis of metastatic breast cancer was made through gross pathologic and immunohistochemistry staining. We report a case with gastric and colon metastases from breast cancer and a review of the associated six case reports in Korea.

자궁원발성 비호지킨 악성림프종 -3예 보고-

박찬필,고영혜,이중달,박문일,김경태,조삼현 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.3

Goldman's Algorithm을 이용한 비외상성 흉통 환자의 분석

조석진,유진현,김찬웅,어은경,정구영 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Back ground : It is important to evaluate the patient presenting with non-traumatic chest pain in emergency department, and it is also difficult to classify appropriately. The purpose of this study is to predict probability of acute myocardial infarction(AMI) and assess the group for low probability of AMI that is target for observation-unit of chest pain in emergency department. Methods : A prospective, clinical study was performed from March 1998 to August 1998 at the department of emergency medicine, Ewha Womans University Mokdong hospital. We classified high-probability group and low-probability group of AMI according to Goldman's algorithm and then compared with the final diagnosis. Results : The study included 218 patients. 84 patients(39%) was the high-probability group and 134 patients(61%) was the low-probability group of AMI. As compared with final diagnosis, AMI was 47 patients(56%) among the high-probability group and 1 patient(0.7%) among the low-probability group. We observed sensitivity of 98%, specificity of 78% in predicting AMI. Conclusion : The classification according to Goldman's algorithm may be useful predictor of AMI and improve triage for emergency department patients with chest pain. It is also helpful for management of observation-unit of chest pain in emergency department.

뉴로-퍼지 모델의 최적화 기법 개발

조현찬,서재용 한국기술교육대학교 1999 論文集 Vol.6 No.1

This paper presents an approach to obtain a reduced neuro-fuzzy model for a plan. To decide which rules we may eliminate dependancy in rough set theory is used. The rapid convergence of the number of the redundant rules must be accomplished by our method. We don't need to cluster the input space from the raw data and furthermore don't worry about ε-completeness, which we have to consider when clustering the initial input space. However many rules it has, neuro-fuzzy model can be reduced rapidly for dependency seek for every rule worthless. Experimental results demonstrate the effectiveness of using dependency to measure the contribution of any rule to the model.

리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.

시클러 캡슐(세파클러 250㎎)에 대한 경보세파클러 캡슐의 생물학적동등성

조혜영,강현아,김세미,박찬호,오인준,임동구,문재동,이용복 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was to evaluate the bioequivalence of two cefaclor capsules, Ceclor (Lilly Korea Co., Ltd.) and Kyongbocefaclor (Kyongbo Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of cefaclor from the two cefaclor formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2. 4.0. 6.8 buffer solution and water). Twenty four healthy male subjects. 22.96±1.52 years in age and 67.03±7.90 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After one capsule containing 250 mg of cefaclor was orally administered, blood was taken at pre-determined time intervals and the concentrations of cefaclor in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition. the pharmacokinetic parameters such as AUC_(t), C_(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t). C_(max) and untransformed Tmaa. The results showed that the differences between two formulations based on the reference drug, Ceclor. were -1.90%, 2.68% and -7.60% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91-log 1.06 and log 0.92-log 1.18 for AU', and C_(max), respectively). Thus. the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kyongbocefaclor capsule was bioequivalent to Ceclor capsule.

적절한 용량 이하의 경구용 향응고제 사용 중 발생한 뇌출혈 환자의 임상 양상

조수진,황흥곤,나찬영,이영탁,최현배,조태구 世宗醫學硏究所 2000 世宗醫學 Vol.17 No.2

다공질 실리콘을 이용한 미세 기계구조의 제조

조찬섭,이봉희,이종현,최규만 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

Micromechanical structures such as cantilever beams and bridge array (~μm thick, 100~500 μm long) were fabricated by formation of porous silicon layer. The beam array of n/p samples have irregular etched surface and cusp. On the otherhand, beams of n/n^(+)/n structure have clear etched surface and no cusp.

복합레진의 표면거칠기에 따른 투명도와 표면 색상의 차이에 관한 연구

조규정,박수정,조현구,김동준,황윤찬,오원만,황인남 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.4

본 연구는 복합레진의 표면 연마에 의한 표면 거칠기가 표면 색상과 투명도에 어떤 영향을 미치는가를 알아보고자 시행하였다. Charisma (Heraeus Kulzer GmbH, Domagen, Germany)의 B1과 A3, Esthet-X (DENTSPLY Caulk, Milford, USA)의 B1과 B3 레진으로 거칠기에 따른 표면 색상을 평가하기 위한 직경 8㎜, 두께 5㎜의 시편을 제작하고, Sof-Lex finishing & polishing system(3M, ESPE Dental Products. St. Paul USA)의 C, M, F, 및 SF 디스크로 시편의 한쪽 면을 연마하였으며, 연마 전 Mylar strip으로 압축된 면을 대조군으로 하였다. 거칠기에 따른 투명도의 차이를 평가하기 위한 두께 1 ㎜의 시편을 Charisma의 A3로 제작하여, 한쪽 면을 600, 1000, 1500 및 2000번 사포로 연마하였다. 각 시편의 연마 전과 후, 연마면의 CIE L^(*)a^(*)b^(*)값과 1 ㎜ 시편의 백색과 흑색 배경판 상에서의 Y값을 spectrophotometer인 Spectrolino (GretagMacbech, Regensdorf, Switzerland)를 사용해 측정 분석하였으며, 각 시편의 연마 전과 후의 평균 표면 조드 (Ra)값을 Surface Roughness Tester SJ-301 (Mytutoyo, Tokyo, Japan)로 측정했다. L^(*)값은 재료와 색상에 상관없이 가장 거친 Sof-lex C 디스크로 연마한 군에서 가장 높은 값을 보였으며 (p < 0.05). Esthet-X B3군을 제외한 모든 군에서 Ra값이 감소함에 따라 L^(*)값도 낮아졌다. a^(*)값은 표면 거칠기에 따라 특정한 변화 양상을 보이지 않았으며, b^(*)값은 Esthet-X B1군을 제외한 모든 군에서 Sof-lex SF 디스크로 연마 시 가장 높은 값을 보였으며 (p < 0.05), Charisma B1과 Esthet-X B3군에서 Ra값과 비교적 높은 상관 관계를 보였다. Contrast ratio는 1000번과 1500번 사포로 연마한 군간을 제외한 모든 군 간에 유의한 차이를 보여으며 (p < 0.05). 표면 거칠기가 감소함에 따라 contrast ratio도 감소하였다(R2 = 0.801). The objectives of this were to evaluate the effect of surface roughness on the surface color and translucency of the composite reins. Two composite resins (Esthet-X, Dentsply, Milford, USA and Charisma, Kulzer, Domagen, Germany) were used to investigate the surface color. Charisma was used to investigate the translucency. 40 disc samples (diameter: 8 ㎜, thickness: 5 ㎜) were made by each product to measure the surface color. Ploymerized each sample's one side was treated by Sof-Lex finishing and polishing system (Group C, M, F, SF). 40 disc samples (diameter: 6 ㎜, thickness: 1 ㎜) were prepared to measure the opacity. 1 ㎜ samples were ground one side with #600, #1000, #1500 and #2000 sandpapers. CIE L^(*)a^(*)b^(*) values of each 5 ㎜ thickness samples, and XYZ values of 1 ㎜ thickness samples on the white and black background were measured with spectrophotometer (Spectrolino, GretagMacbeth, Regensdorf, Switzerland). Mean surface roughness (Ra) of all samples before and after surface treatment was measured using the Surface Roughness Tester SJ-301 (Mytutoyo, Tokyo, Japan). Regardless of type and shade of the composite resin, L^(*) values measured in group C were higher than others (p < 0.05), and L^(*) value decreased as the Ra value decreased except B3 shade of Esthet-X. But there were no significant difference in a^(*) values among groups. In control group and SF, highest b^(*) values were measured (p < 0.05), except B1 shade of Esthet-X. Contrast ratio decreased as the Ra value decreased (p < 0.05). With the above results, difference of surface roughness has influence on surface color and translucency of dental composite resins. 〔J Kor Acad Cons Dent 31(4):312-322, 2006〕

임피던스와 수중체중 측정법을 이용한 체지방의 평가 및 잔기량 측정방법의 타당성에 관한 연구

조현철,정찬수 龍仁大學校 體育科學硏究所 2001 體育科學硏究論叢 Vol.11 No.1

The purpose of this study is to examine the between difference of body fat produtction methods and residual volume measurement method in 20 adult men. Subjects were conducted to body fat produtction through underwater weighing method and impedance method, and residual volume measurement through vital capacity, spirometer, pure oxygen re-respiratory method(land and underwater) for analysis of validity The results of this study were as follows; 1. It was significant difference between difference of body fat produtction methods and residual volume measurement method. and correlation coefficint was .833. Therefore it was suggested that regression equation was UW=1.033inbody-0.833 for body fat produtction. 2. It was showed that residual volume was highest in pure oxygen re-respiratory method in land and pure oxygen re-respiratory method underwater, vital capacity, spirometer in order. Considering the results, It was indicated to higher correlationship between densitometry method using the underwater weighing method and impedance method using bioelectricity but significantly difference in body fat measurement. Therefore, it shoud be concider in measurement, also residual volume measurement through vital capacity, spirometer.