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RISS 인기검색어
- 검색키워드
- 저자 : Ching-Sung Chiang (검색결과 4 건)
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Chiang, Chien-Sung,Huang, Ching-Hui,Chieng, Hockling,Chang, Ya-Ting,Chang, Dory,Chen, Ji-Jr,Chen, Yong-Cyuan,Chen, Yen-Hui,Shin, Hee-Sup,Campbell, Kevin P.,Chen, Chien-Chang Ovid Technologies Wolters Kluwer -American Heart A 2009 Circulation research Vol.104 No.4
<P>Voltage-gated T-type Ca(2+) channels (T-channels) are normally expressed during embryonic development in ventricular myocytes but are undetectable in adult ventricular myocytes. Interestingly, T-channels are reexpressed in hypertrophied or failing hearts. It is unclear whether T-channels play a role in the pathogenesis of cardiomyopathy and what the mechanism might be. Here we show that the alpha(1H) voltage-gated T-type Ca(2+) channel (Ca(v)3.2) is involved in the pathogenesis of cardiac hypertrophy via the activation of calcineurin/nuclear factor of activated T cells (NFAT) pathway. Specifically, pressure overload-induced hypertrophy was severely suppressed in mice deficient for Ca(v)3.2 (Ca(v)3.2(-/-)) but not in mice deficient for Ca(v)3.1 (Ca(v)3.1(-/-)). Angiotensin II-induced cardiac hypertrophy was also suppressed in Ca(v)3.2(-/-) mice. Consistent with these findings, cultured neonatal myocytes isolated from Ca(v)3.2(-/-) mice fail to respond hypertrophic stimulation by treatment with angiotensin II. Together, these results demonstrate the importance of Ca(v)3.2 in the development of cardiac hypertrophy both in vitro and in vivo. To test whether Ca(v)3.2 mediates the hypertrophic response through the calcineurin/NFAT pathway, we generated Ca(v)3.2(-/-), NFAT-luciferase reporter mice and showed that NFAT-luciferase reporter activity failed to increase after pressure overload in the Ca(v)3.2(-/-)/NFAT-Luc mice. Our results provide strong genetic evidence that Ca(v)3.2 indeed plays a pivotal role in the induction of calcineurin/NFAT hypertrophic signaling and is crucial for the activation of pathological cardiac hypertrophy.</P>
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Sustainable Development Strategy for CasinoIndustIy of Hualien Area
( Shiunn-der Kuo ),( Ching-sung Chiang ),( Chia-yon Chen ) 세계문화관광학회 2008 International Journal of Culture and tourism Resea Vol.1 No.1
In the past years, liberalizing casino operation inTaiwan has been long a controversial issue. They questioned why Hualien shouldn``t follow the path to success in Las Vegas to resolve povelty and economical depression commonly occun``ed in Hualien area. Due to tourism downtum in recent years, as a result aggravating the budget deficit of local government, casino establishment is urgently considered as a way to prosper local economic activities. Casinos will be legally established at the time of ripeness in the near future. Based on this assumption, this study summarizes preliminarily a number issues potentially present on the development of gaming business at Hualien with respect to infi-asnucture and tourism development at Hualien according to the analyses of reviewing the literature on the definition and categories of casino, influence of gaming indusny in all aspects, and cun``Cntsituation and perspective of tourism development at Hualien. This study firstly employed Participatory Local Appraisal to form a consensus from local resident for sustainable development of Hualien area. Then, SWOT matrix analysis, expert judged Fuzzy Delphi method to determine the most valuable issues on the development of casino industly at Hualien in both respects.
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Sustainable Development Strategy for CasinoIndustry of Hualien Area
Shiunn-Der Kuo,Ching-Sung Chiang,Chia-Yon Chen 세계문화관광학회 2008 International Journal of Culture and tourism Resea Vol.1 No.1
In the past years, liberalizing casino operation in Taiwan has been long a controversial issue. They questioned why Hualien shouldn't follow the path to success in Las Vegas to resolve poverty and economical depression commonly occurred in Hualien area. Due to tourism downturn in recent years, as a result aggravating the budget deficit of local government, casino establishment is urgently considered as a way to prosper local economic activities. Casinos will be legally established at the time of ripeness in the near future. Based on this assumption, this study summarizes preliminarily a number issues potentially present on the development of gaming business at Hualien with respect to infrastructure and tourism development at Hualien according to the analyses of reviewing the literature on the definition and categories of casino, influence of gaming industry in all aspects, and current situation and perspective of tourism development at Hualien. This study firstly employed Participatory Local Appraisal to form a consensus from local resident for sustainable development of Hualien area. Then, SWOT matrix analysis, expert judged Fuzzy Delphi method to determine the most valuable issues on the development of casino industry at Hualien in both respects.
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Jia-Ming Chen,Wan-Li Chiang,Bin-Chuan Ji,Ruei-Jhe Jhang,Pei-Hsin Chen,Ya-Lun Li,Che-Ju Chang,Sung-Yen Huang,Tsung-Chieh Lee,Chia-Yun Chen,Ching-Hsiung Lin,Sheng-Hao Lin 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.4
Background: In intensive care units, mechanical ventilation is an important therapy to help patients with dysp- nea. However, long-term ventilator dependence would consume huge medical resources and increase the risk of morbidity and mortality. The aim of the study was to examine the efficacy of the acupuncture combined with western medical care on ventilator parameters in ventilator-dependent patients. Methods: In this clinical trial, 80 ventilator-dependent patients aged 20 to 80 years old were randomly assigned to acupuncture group and control group in the respiratory care center (RCC) of Changhua Christian Hospital. Besides regular medical care and therapy, participants in the acupuncture group received acupuncture therapy at the same 17 acu-points for 20 minutes once a day, a total of 12 sessions. The ventilator parameters were recorded to evaluate the respiratory efficiency for all participants. The primary outcome was rapid shallow breathing index (RSBI), and secondary outcomes were respiratory rate (RR), tidal volume (TV) and ventilation per minute (MV). Results: Though there was no significant difference in the parameter between the acupuncture group and the control group, we found the trend of decreasing RSBI in the acupuncture group. In subgroup analyses, the mean of RSBI significantly decreased 16.02 (with the SD in 60.84) in acupuncture group, while it increased 17.84 (with the SD in 39.38) in control group (p = 0.036) after 12 sessions. Conclusion: Acupuncture treatment can improve breathing ability of patients with respirator dependence in respiratory care center.
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