Chest-wall Surface Dose During Post-mastectomy Radiation Therapy, with and without Nonmagnetic Bolus

Cheon Woong Choi,Joo Wan Hong,Cheol Soo Park,Jae Ouk Ahn 한국자기학회 2016 Journal of Magnetics Vol.21 No.2

For mastectomy patients, sufficient doses of radiation should be delivered to the surface of the chest wall to prevent recurrence. A bolus is used to increase the surface dose on the chest wall, whereby the surface dose is confirmed with the use of a virtual bolus during the computerized treatment-planning process. The purpose of this study is an examination of the difference between the dose of the computerized treatment plan and the dose that is measured on the bolus. Part of the left breast of an Anderson Rando phantom was removed, followed by the attainment of computed tomography (CT) images that were used as the basis for computerized treatment plans that were established with no bolus, a 3 mm-thick bolus, a 5 mm-thick bolus, and a 10 mm-thick bolus. For the computerized treatment plan, a prescribed dose regimen was dispensed daily and planning target volume (PTV) coverage was applied according to the RTOG 1304 guidelines. Using each of the established computerized treatment plans, chest-wall doses of 5 points were measured; this chest-wall dose was used as the standard for the analysis of this study, while the level of significance was set at P < 0.05. The measurement of the chest-wall dose with no bolus is 1.6 % to 10.3 % higher, and the differences of the minimum average and the maximum average of the five measurement points are −13.8 and −1.9, respectively (P < 0.05); however, when the bolus was used, the dosage was measured as 3.7 % to 9.2 % lower, and the differences of the minimum average and the maximum average are 7.4 and 9.0, −1.2 and 17.4, and 8.1 and 19.8 for 3 mm, 5 mm, and 10 mm, respectively (P < 0.05). As the thickness of the bolus is increased, the differences of the average surface dose are further increased. There are a variety of factors that affect the surface dose on the chest wall during post-mastectomy radiation therapy, for which verification is required; in particular, a consideration of the appropriate thickness and the number of uses when a bolus is used, and which has the greatest effect on the surface dose on the chest wall, is considered necessary.

Protective Effect of (-)-Epigallocatechin Gallate on Nitric Oxide-Induced Apoptosis in Alveolar Epithelial Cells

Cheon-Woong Choi,Jee-Hong Yoo,Sung-Eun Kim,Yun-Hee Sung,Jin-Hee Seo,Mal-Soon Shin,Dong-Hee Kim,Chang-Ju Kim 대한스트레스학회 2011 스트레스硏究 Vol.19 No.1

폐는 질소종류에 다양하게 반응한다. 폐 상피세포는 nitric oxide synthase (NOS)에 의해 L-아르기닌으로부터 합성된 유리기 무기물 가스인 산화질소에 민감하게 반응한다. 산화질소(nitric oxide)는 많은 생물학적 과정의 매개체이지만, 과도한 출현은 다양한 세포 유형의 세포사멸을 일으키기도 한다. 녹차의 주성분이며, 가장 풍부하게 들어있는 (-)-epigallocatechin-3-gallate (ECGC)는 최근에 세포사멸 경로를 조절하는 것으로 알려졌다. EGCG는 항산화, 항염증, 보호기전, 항세포사멸 효과를 보여주고 있다. 이에 본 연구에서는 인간 폐 상피세포에서 EGCG가 sodium nitroprusside (SNP)로 유도된 세포사멸에 대한 보호효과를 연구하였다. 인간의 폐포 유형 II L-132 세포를 가지고, EGCG의 항세포사멸을 확인하기 위해 MTT assay, DAPL staining, TUNEL assay, DNA fragmentation assay, Western blotting으로 분석하였다. 본 실험의 결과 SNP는 인간의 폐 상피 세포인 L-132에서 세포사멸의 형태학적 변화를 유발하였고, 세포사멸 전단계인 Bax 단백질의 발현을 증가시켰으며, caspase-3의 활성을 증가시켰다. 그러나 EGCE를 처치한 세포에서는 Bax 단백질의 발현을 감소하였고, 반 세포사멸 단백질인 Bcl-2의 발현은 현저하게 증가하여 caspase-3의 활성을 억제하는 결과를 확인하였다. 따라서 본 연구 결과 EGCG는 폐 상피 세포인 L-132에서 SNP로 유도된 세포사멸에 대한 보호 효과를 나타냄을 확인할 수 있었다. The lung is exposed to various stimulants, such as reactive nitrogen species. Alveolar epithelial cells are sensitive to nitric oxide (NO), which is a free radical inorganic gas synthesized from L-arginine by nitric oxide synthase (NOS). NO mediates many biological processes, but excessive NO exposure induces apoptosis in various cell types. (-)-Epigallocatechin-3-gallate (EGCG) has recently been shown to modulate apoptotic pathways. EGCG is the most abundant and most active ingredient of green tea. EGCG has been shown to have anti-carcinogenic, anti-oxidant, anti-inflammatory, neuroprotective, and anti-apoptotic effects. In the present study, we investigated whether EGCG exhibits a protective effect against apoptosis induced by the NO donor sodium nitroprusside (SNP) in human lung epithelial cells. To confirm the anti-apoptotic properties of EGCG, a 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 4,6-diamidino-2-phenylindole (DAPI) staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay, DNA fragmentation assay, and Western blotting were performed using human alveolar type II L-132 cells. The present results show that SNP induced apoptotic morphological changes, increased the expression levels of the pro-apoptotic protein Bax and enhanced the enzymatic activity of caspase-3 in L-132 human lung epithelial cells. However, EGCG treatment remarkably increased the expression of the anti-apoptotic protein Bcl-2, decreased the expression of Bax, and suppressed the enzymatic activity of caspase-3. The results of the present study revealed that EGCG exerts a protective effect against SNP-induced apoptosis in L-132 human lung epithelial cells. (Korean J Str Res 2011;19:69∼77)

경피폐세침흡인생검시 기흉의 발생빈도와 위험인자

최천웅 ( Cheon Woong Choi ),유지홍 ( Jee Hong Yoo ),진현정 ( Hyoun Jung Chin ),박명재 ( Myoung Jae Park ),강홍모 ( Hong Mo Kang ) 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.56 No.6

Evolution of plant-insect interactions: from fossils to phylogeny

Jae-Cheon Sohn,Sei-Woong Choi 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04

Plant-feeding insects are a ubiquitous feature of terrestrial life. It follows that understanding the evolution of insect herbivory and its diversity is fundamental to understanding the evolution of terrestrial ecosystems. During my Ph. D. study, I found phylogenetic conservatism in the feeding mode (internal vs. external feeding) of Yponomeutoidea, one of the primitive lepidopteran superfamilies, as well as in their diet breadth and in the growth form and taxonomic affinities of host plants they used. In spite of their importance in terrestrial ecosystems, the evolutionary history of Lepidoptera has been poorly known. This mostly is attributable to their poor fossil record. My Ph. D. study provided better understanding to the lepidopteran fossils. Fossils are an essential resource in divergence time estimation using molecular clock methods. Once reliably resolved, dating data can be used in tracing the evolutionary history of Lepidoptera/plant associations. I introduce my works to take such advantages from fossils and phylogenetic studies.

Earliest dipteran leaf mine from Late Cretaceous: implication of insect feeding damage fossils on climate change studies

Jae-Cheon Sohn,Nathan A. Jud,Sei-Woong Choi,Conrad Labandeira 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10

We describe an early angiosperm and a leaf mine ichnofossil from the Lower Cretaceous Potomac Group of Virginia, USA. The descriptions are based on a fossil leaf that was first reported in 1895 but identified as a fragment of a fossil fern. Leaf architectural features and sedimentological context indicate that this leaf was produced by an herbaceous eudicot angiosperm, possibly associated with Ranunculales. The leaf mine is a full depth linear-blotch mine with frass, a trace of puparium inside the blotch mine section, and feeding/oviposition-related puncture marks. The features of the mine are most consistent with those produced by agromyzid flies. This fossil extends the record of agromyzid flies by about 40 million years ago. This fossil provides evidence that agromyzid flies or their ancestors were feeding on herbaceous basal eudicots similar to modern herbaceous ranunculids during the Early Cretaceous, prior to the appearance and diversification of asterids. Our finding contradicts the previous hypotheses on the dipteran radiations associated with the past environmental changes. Insect feeding damages remained in fossilized leaves are currently considered as an important source for climate change studies. We review progresses in the study of the insect feeding trace fossils and their usefulness for monitoring environmental changes.

수수 × 수수 교잡종의 수확시기가 원형 곤포사일리지의 품질에 미치는 영향

최기춘(Ki Choon Choi),정민웅(Min-Woong Jung),김원호(Won Ho Kim),김천만(Cheon Man Kim),윤세형(Sei Hyung Yoon),최은민(Eun Min Choi),김종근(Jong Geun Kim),이상문(Sang Moon Lee),최종만(Jong Man Choi),김혁기(Hyuck Gi Kim),임영철(Young Chu 한국초지조사료학회 2011 한국초지조사료학회지 Vol.31 No.2

본 연구는 수확시기가 수수×수수 교잡종 원형 곤포사일리지의 품질에 미치는 영향을 구명하기 위하여 천안에 위치한 국립축산과학원 자원개발부에서 수행되었다. 수수 × 수수 교잡종 SS405를 이용하여 숙기별 2회 (출수기 및 완숙기)에 걸쳐 수확을 하여 사일리지로 조제하였다. 숙기가 진행됨에 따라 수수 × 수수 교잡종원형 곤포사일리지의 조단백질은 증가하는 경향을 보였으나 NDF 및 ADF 함량 그리고 TDN 함량은 비슷한 수준을 유지하였다. 그리고 숙기별 in vitro 건물소화율도 비슷하였다. 숙기별 사일리지의 pH는 3.8~4.4을 유지하였으며, 출수기의 pH는 완숙기의 보다 높았다. 수수 × 수수 교잡종 원형 곤포사일리지의 수확시기가 늦어짐에 따라 젖산 함량은 증가하였으나 초산 함량은 감소하였다 (P<0.05). 그리고 출수기의 원형 곤포사일리지의 초산 함량은 트랜치 사일리지보다 증가되었다 (P<0.05). 완숙기에서는 제조방법에 따라 젖산과 초산 함량은 큰 차이를 보이지 않았다. 이상의 결과를 종합하여 볼 때 양질의 수수 × 수수 교잡종 원형곤포 사일리지 조제를 위해서는 출수기와 완숙기 사이에 수확하여 사일리지를 만드는 것이 사일리지 발효를 향상시킬 수 있다. This study was performed to investigate the effects of harvest stage of sorghum × sorghum hybrid (SSH) on nutritive values and quality of round baled SSH silage manufactured with SSH grown in paddy land of Department of Animal Resources Development, National Institute of Animal Science, RDA. SSH “SS405” was harvested at two different growth stages (heading and ripen stage) and ensiled at each harvest stages. Crude protein content of round baled SSH silage increased with delayed harvest maturity, but contents of ADF (acid detergent fiber), NDF (neutral detergent fiber), TDN (total digestible nutrient) and in vitro dry matter digestibility (IVDMD) was not changed. The pH in round baled SSH silage ranged from 3.8 to 4.4 at two different harvest stages, and pH in heading stage was higher than that of ripen stage. The content of lactic acid of round baled SSH silage increased with delayed harvest maturity (P<0.05), but the content of acetic acid decreased (P<0.05). The contents of lactic acid and acetic acid in ripen stage were not influenced by manufacture method of silage. The content of acetic acid in round baled SSH silage of heading stage increased as compared to that of trench SSH silage (P<0.05). Therefore, this study suggest that round baled SSH silage manufactured in both heading and ripen stage can improve the silage fermentation.

The Occurrence of a Winter Geometrid Moth, Sebastosema bubonaria Warren, in Korea (Lepidoptera: Geometridae)

Choi, Sei-Woong,Sohn, Jae-Cheon 한국곤충학회 2003 Entomological Research Vol.33 No.4

One species of ennomine genus Sebastosema Warren, S. bubonaria Warren, is first recorded from Korea. Description of adult and illustration of male genitalia are provided. Based on the previous and the present works, there are 23 winter geometrid moths in Korea.

First Report of Five Noctuid Species (Lepidoptera: Noctuidae) from Korea

Jae Cheon Sohn,Laszlo Ronkay,Sei Woong Choi 한국응용곤충학회 2005 Journal of Asia-Pacific Entomology Vol.8 No.2

Five species of Noctuidae, Adrapsa simplex (Butler), Hydrillodes lentalis Guene, Xylena nihonica Hne, Rhynchaglaea scitula (Butler), and Lophoptera squammigera Guene, are reported for the first time in Korea. Two genera, Adrapsa and Lophoptera, are newly recorded from the Korean fauna. Adults and genitalia of each species are illustrated and their biological and distributional notes are briefly described.

Three Species of Acrolepiopsis (Lepidoptera, Glyphipterigidae, Acrolepiinae) New to Korea

Jae-Cheon Sohn,Sung-Soo Kim,Sei-Woong Choi 한국동물분류학회 2018 Animal Systematics, Evolution and Diversity Vol.34 No.4

Three species of Acrolepiopsis: A. issikiella (Moriuti, 1961), A. japonica Gaedike, 1982, and A. postomacula (Matsumura, 1931), are recorded from Korea for the first time. Acrolepiopsis issikiella is characterized by having the white costal strigulae and a large dorsal patch on the forewing. Acrolepidopsis japonica is the smallest congener in Korea. Acrolepiopsis postomacula is the only Korean species of Acrolepiinae associated with Hosta. Distributions and larval biology of the three species are summarized. Two species, A. issikiella and A. japonica, are potential pest species of yam-cultivating farms in Korea. Superficial and genital features of the species, if available, are illustrated.

Systematic study of Korean Epipleminae (Lepidoptera: Uraniidae): latest discoveries and updates

Jae-Cheon Sohn,Sung-Soo Kim,Sei-Woong Choi 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10

Epipleminae is the most species-rich lineage within Uraniidae and can be characterized by its unusual resting posture.Since Leech (1897) first reported two species, Epiplema moza (Butler, 1878) and Gathynia fasciaria Leech, 1897, therehave been 5 genera and 9 species of Epipleminae recorded from Korea (Sohn & Yen, 2005). We reported three speciesof Epipleminae new to Korea: Dysaethria meridiana (Inoue, 1982), Phazaca theclata (Guenee, 1857), and Europlemaleleji Sinev, 2016. Taxonomic status of Europlema leleji Sinev is revised. A revised checklist of the Korean Epipleminaeis provided.