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A case of hair foreign body in the sole of a pediatric patient
( Hae Jeong Youn ),( Min Seok Hur ),( Hye In Cheon ),( Song Hee Han ),( Byung Gon Choi ),( Min Jung Kim ),( Nam Kyung Roh ),( Soo Young Kim ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Patients occasionally present with a hair strand penetrating into a body part after they fail to remove the vertically or obliquely imbedded short hair. However, a long hair strand invading into the skin in a curved shape, parallel to the epidermis, is much more uncommon. The stratum corneum (SC), the outermost skin layer, is stacked up with corneocytes, which act as a physical barrier. Palms and soles have thicker stratum granulosum and SC. However, infant skin has thinner epidermis, and the SC with smaller corneocytes up to the second year of life may be susceptible to foreign body invasion. We report a case in which a 2-year-old boy presented to us with an unusually shaped long hair that had penetrated into the epidermis of the sole. This case provided an opportunity to consider the skin structure and skin development in an infant, whose skin is more vulnerable to foreign body intrusion.
( Hae Jeong Youn ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Dihydrotestosterone (DHT) induces androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. We previously demonstrated how changes in the microRNA (miRNA) expression profile influenced DHT-mediated cell death, cell cycle arrest, cell viability, the generation of reactive oxygen species (ROS), and senescence. Protective effects against DHT have not, however, been elucidated at the genome level. Objectives: We wanted to show that epigallocatechin gallate (EGCG), a major component of green tea, protects DHT-induced cell death by regulating the cellular miRNA expression profile. Methods: We used an miRNA microarray to identify miRNA expression levels in human dermal papilla cells DPCs). We investigated whether the miRNA expression influenced the protective effects of EGCG against DHT-induced cell death, growth arrest, intracellular ROS levels, and senescence. Results: EGCG protected against the effects of DHT by altering the miRNA expression profile in human DPCs. In addition, EGCG attenuated DHT-mediated cell death and growth arrest and decreased intracellular ROS levels and senescence. A bioinformatics analysis elucidated the relationship between the altered miRNA expression and EGCG-mediated protective effects against DHT. Conclusion: Overall, our results suggest that EGCG ameliorates the negative effects of DHT by altering the miRNA expression profile in human DPCs.
The Role of Spleen Volume in Predicting Portal Hyper-tension in Patients with Cirrhosis
( Hae Won Yoo ),( Sang Gyune Kim ),( Young Seok Kim ),( Jeongju Yoo ),( Jae Woo Park ),( Yong Seok Lim ),( Jae Myeong Lee ),( Gab Jin Cheon ),( Jae Young Jang ),( Young Don Kim ),( Soung Won Jeong ),( 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: It is already well known that the size of the spleen increases as liver cirrhosis aggravates. However, there is few studies for establishing the correlation between portal hypertension and spleen volume (SV). In this study, we aimed to see the relationship between the splenic volume and hepatic venous wedge pressure (HVPG) and to find what determine the portal pressure. Methods: From May 2007 to February 2018, 337 cirrhotic patients who measured SV and HVPG simultaneously were included. SV was measured based on the ellipsoid volume calculation formula by measuring length, height, and width. Other clinical and biochemical factors which may contribute to increase portal pressure were also collected. Results: Mean HVPG was 14.2 ± 5.3 and Child-pugh class A, B, and C patients were 34%, 40%, and 16%, respectively. A significant positive correlation was noted between splenic volume and HVPG levels (r=0.127, P=0.019). Below 16mmHg of HVPG, the stronger correlation was noted between them (r=0.202, P=0.003) but this relation was not observed above 16mmHg of HVPG. We divided HVPG into various stages of portal hypertension(HVPG<5, 5≤HVPG<10, 10≤HVPG<16, HVPG≥16). The average spleen volume of each group tended to increase with increasing HVPG value. Mean splenic volume for each group was 320.74cm3, 464.78 cm3, 501.06 cm3, 525.94 cm3 respectively. But there was no significant difference in the mean spleen volume between the groups., HVPG was correlated with presence of ascites (P=0.038) as well as SV (P=0.043) after adjusted by MELD, Na, albumin, platelet count. Conclusions: The spleen volume tended to increase with increasing HVPG and this association was stronger when HVPG was below 16 mmHg. More studies with larger numbers are needed to predict the portal pressure non-invasively.
( Hae Won Yoo ),( Young Seok Kim ),( Sang Gyune Kim ),( Jeongju Yoo ),( Jae Woo Park ),( Yong Seok Lim ),( Gab Jin Cheon ),( Jae Young Jang ),( Young Don Kim ),( Soung Won Jeong ),( Sae Hwan Lee ),( B 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The Baveno VI guidelines proposed that esophagogastroduodendoscopy(EGD) for screening esophageal varices(EV) can be avoided if liver stiffness(LS) measured by transient elastography(TE) is less than 20 kPa and platelet count is greater than 150,000 cells/μL. However while validation of TE is well proven, 2D-SWE has not been sufficiently validated for EV prediction. The aim of this study is to predict the presence of EV by non-invasive tools combined with 2D-SWE and to compare the diagnostic capabilities with TE. Methods: Between January 2015 and October 2017, 258 patients with compensated advanced chronic liver disease(cACLD) who underwent 2D-SWE and EGD consecutively were enrolled. The AUROC was calculated to evaluate the accuracy of the prediction for the presence of EV using 2D-SWE, model combining 2D-SWE and platelet count(PC), liver stiffness to spleen/platelet score (LSPS) score and platelet-spleen ratio (PSR) score. 177 patients who underwent simultaneous TE examination were on the subgroup analysis was done. Results: The mean age was 56.8±10.7 years and most common etiology was chronic hepatitis B (45.0%). 83.1% of patients were in Child class A. Prevalence of all-size varices was 41.1%. 2D-SWE alone has good ability to discriminate varices (AUROCs : 0.750, 95% CI, 0.690 to 0.809). Model combining 2D-SWE with platelet count and LSPS using 2D-SWE has better discriminative ability for varices and AUROCs were 0.793 (95% CI, 0.738 to 0.848) and 0.813 (95% CI, 0.760 to 0.865) respectively. For 177 patients who performed TE and 2D-SWE simultaneously, there was no difference in predictive abilities when other factors such as albumin, bilirubin, ALT, Platelet count, hemoglobin, spleen diameter were adjusted in multivariate analysis. Conclusions: 2D-SWE combined with platelet count and LSPS seemed to be useful to predict EV. In addition, 2D-SWE has similar diagnostic performance with TE for predicting presence of EV.
치아우식증 유발 세균에 대한 CPC 함유 구강청정제의 항균효과
조원호 ( Won-ho Cho ),조자원 ( Ja-won Cho ),유현준 ( Hyun-jun Yoo ),신경훈 ( Kyong-hoon Shin ),신기해 ( Gi-hae Shin ),전열매 ( Yeol-mae Jeon ),이종천 ( Jong-cheon Lee ) 대한예방치과·구강보건학회 2021 大韓口腔保健學會誌 Vol.45 No.2
Objectives: The purpose of this study was to evaluate and report the antibacterial efficacy in relation to oral disease-causing bacteria using a mouthwash containing 0.05% CPC in an in vitro test. Methods: The sterilization test and susceptibility assay of mouthwash containing 0.05% CPC were investigated against Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus; Streptococcus sanguinis as oral bacteria related to dental caries; Enterococcus faecalis as apical periodontitis-related bacteria; and Actinomyces israelii, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Prevotella nigrescence, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Filifactor alocis as periodontal disease-related bacteria. Results: In the sterilization test, most of the bacteria had more than 99.99% sterilizing power for all samples but compared to other bacteria, the sterilizing power of these samples was not successful for L. acidophilus and E. faecalis bacteria. When comparing the sterilization power between the samples, sample 3 (0.05% CPC+20% ethanol) was the strongest. Conclusions: In the antimicrobial activity test, sample 3 inhibited growth at the lowest concentration overall.
늑막액에서 Cholesterol 측정의 진단적 의의에 관한 연구
이원돈(Won Don Lee),김옥란(Ok Ran Kim),이재용(Jae Young Lee),성천모(Chun Mo Sung),배혜상(Hae Sang Bae),서승천(Seung Cheon Seo),최병휘(Byung Hue Choi),허성호(Sung Ho Hue) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A The cholesterol of pleural fluids was measured in 30 patients various diseases with pleural effusion to investigate the utility of differential diagnosis of exudates from transudates. Six cases were pleural transudates and 24 cases were pleural exudates as by classified predefined criteria. The results were as follows: 1) Mean protein level in group 1 (transudates) was l.9±0.8 g/dl and 4.8±0.9 g/dl in group 2 (exudates). Mean pleural fluid to serum ratio in group 1 was 0.30±0.11 and 0.80±0.48 in group 2. 2) Mean LDH level was 40X29 IU in group 1 and 325+271 IU in group 2. Mean pleural fluid to serum ratio was 0.20±0.11 in group 1 and 2.01±1.90 in group 2. 3) Mean cholesterol level was 37±14 mg/dl in group 1 and 97±42 mg/dl in group 2. Mean pleural fluid to serum ratio was 0.18±0.06 in group 1 and 0.71±0.32 in group 2. 4) A protein level of 3.0 g/dl, LDH level of 200 IU, cholesterol level of 60 mg/dl and their pleural fluid to serum ratios of 0.5, 0.6 and 0.3 respectively were used as dividing lines separating transudates from exudates, and 0% was misclassified in group 1. Misclassified effusions in group 2 for each single parameter were: protein 0%, protein ratio 4%, LDH 29%, LDH ratio 20%, cholesterol 20%, cholesterol ratio 0%, and Light criteria 4%. We found the use of cholesterol level to be superior to the measurement of LDH level and inferior to protein level. The ratio of pleural fluid to serum cholesterol markedly improved the result. On the basis of the above results, it is suggested that pleural fluid cholesterol is a useful index in differentiating exudative from transudative pleural effusions.
소화기 ; 진행성 위암 환자에서 1차 요법으로 FOLFOX-4 병합화학 약물치료의 효과와 안정성
이천우 ( Cheon Woo Lee ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ),문원 ( Won Moon ),김형훈 ( Hyung Hun Kim ),이혜원 ( Hae Won Lee ),구기환 ( Ki Hwan Ku ),김부경 ( Bu Kyung Kim ) 대한내과학회 2012 대한내과학회지 Vol.82 No.1
This study examined the efficacy and safety of oxaliplatin-5-fluorouracil-Leucovorin (FOLFOX-4) combination chemotherapy as first-Line treatment in patients with advanced gastric cancer. This retrospective study enrolled 35 patients diagnosed with pathologically proven surgically unresectable gastric cancer who received FOLFOX-4 combination chemotherapy between August 2006 and February 2009, using medical records. The administered dose of oxaliplatin was 85 mg/㎡ for 2 hrs and Leucovorin 200 mg/㎡ for 2 hrs on day 1, 5-fluorouracil 400 mg/㎡ as a bolus and 5-fluorouracil 600 mg/㎡ for 22 hrs on days 1 and 2, every 2 weeks. The response was assessed every three cycles. Toxicity was evaluated for every course of chemotherapy according to the NCI toxicity criteria ver. 2.0. The median patient age was 61 (range 27-77) years. The median overall survival was 8.50 (6.23-10.90) months and the median time to progression was 4.50 (0.38-9.75) months. With FOLFOX-4, there was no complete remission and 19 partial responses, for a response rate of 54.3%. Over 298 cycles, anemia worse than NCI toxicity grade 3 occurred in 1.3%, Leukopenia in 1.6%, neutropenia in 9%, and thrombocytopenia in 3.2%. Grade 1-2 neuropathy occurred in 14.7% of the cycles. Neutropenic fever occurred in two cycles and the regimen was changed because of side effects in one FOLFOX-4 has a very high response rate with mild toxicity in patients with advanced gastric cancer as a first-Line treatment. (Korean J Med 2012;82:37-44)