H7N9 Avian Influenza Emergency Management in China -Temperature and Live Poultry Markets Analysis with Responding Policy Study -

An Chen,YueHua Li,Fei Chi,Zhengquan Yuan 위기관리 이론과 실천 2014 Journal of Safety and Crisis Management Vol.4 No.1

Influenza A virus subtype H7N9 has received great attention since the first human case was reported at the beginning of this year. The viral characteristics have been quickly brought into research process. Here, the effect of temperature and live poultry market has been considered on the basis of analysis of existing data. As expected, both temperature and live poultry market has significant impact on the spread of this epidemic. Finally, the effect of government reactions and medical treatment on response was discussed. It indicated that sufficient and rapid reactions did not always lead to a perfect outcome which proved the influence of temperature and live poultry market potentially. Research highlights: The effect of temperature on H7N9 avian influenza is proved by analyzing the latitude and temperature of affected area. The effect of live poultry markets on H7N9 avian influenza is confirmed by analyzing the relationship between the number of live poultry markets in affected area and incidence of H7N9 human infection. The effect of government actions and medical treatment is studied and it turned out the result is not in accordance with actual efforts.

The Supply Chain Analysis of Hakka Restaurants Industry for Hakka Liutui Regions in Taiwan

Chen,Jui-Ling,Guu,Yuan-Kuang,Kuo,Shiunn-Der 한국문화관광학회 2010 문화관광연구 Vol.12 No.2

Analytical Hierarchy Process (AHP) was applied to weight the 6 major and 18 secondary attributes from the data of interviews. The objectives were to find out the weaknesses of business development of the Liutui Hakka restaurants and food industry via competition analysis of the business supply chain. These findings would be used as references for suggesting a “Blue Ocean Strategy” to the future sustainable operation and an uncontested market of the Hakka restaurants and food industry in the Liutui area. The research showed that the top three priorities of the 6 major attributes were quality, customer service and marketing (equally weighted), and flexibility. The most important secondary attribute under the major attribute quality was product safety and wholesomeness. These findings would be provided to the business holders and governments as bases for making development policies and strategies for future sustainable Hakka restaurants and food industry.

Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study

Diem Ngoc Hong Tran,I-Hsuan Hwang,Fun-Jou Chen,Yuan-Pu Tseng,Ching-Mao Chang,Shih-Jen Tsai,Jen-Lin Yang,Ta-Peng Wu,Chung-Hua Hsu,Fang-Pey Chen,Yen-Ying Kung 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.3

Background: Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression. Thus, this study aimed to examine the core prescription pattern of Chinese herbal medicine (CHM) among patients with DD in Taiwan as a reference for related research and clinical applications. Methods: All patients, who had been diagnosed with major depressive disorder or minor depression or dysthymia without any other baseline diseases and had at least one CHM outpatient clinical visit from 2002 to 2011, were extracted from three randomly sampled cohorts, namely the 2000, 2005 and 2010 cohorts of the National Health Insurance Research Database (NHIRD) of Taiwan. The collected data was analyzed to explore the patterns of herbal products. Results: There were 197,146 patients with a diagnosis of DD and of these 1806 subjects had only a diagnosis of DD and utilized CHM. The most common formula was Gan-Mai-Da-Zao-Tang (12.19%), while Suan-Zao-Ren (3.99%) was the most commonly prescribed single herb. The core pattern of prescriptions consisted of a combination of Gan-Mai-Da-Zao-Tang, Jia-Wei-Xiao-Yao-San, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang, He-Huan-Pi, Yuan-Zhi and Shi-Chang-Pu. Conclusions: This study describes the CHM core prescription pattern used to treat patients in Taiwan with DD and it is a potential candidate for study in future pharmacological or clinical trials targeting DD.

An integrate information technology model during earthquake dynamics

Chen, Chen-Yuan,Chen, Ying-Hsiu,Yu, Shang-En,Chen, Yi-Wen,Li, Chien-Chung Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.5

Applying Information Technology (IT) in practical engineering has become one of the most important issues in the past few decades, especially on internal solitary wave, intelligent robot interaction, artificial intelligence, fuzzy Lyapunov, tension leg platform (TLP), consumer and service quality. Other than affecting the traditional teaching mode or increasing the inter-relation with users, IT can also be connected with the current society by collecting the latest information from the internet. It is apparently a fashion-catching-up technology. Therefore, the learning of how to use IT facilities is becoming one of engineers' skills nowadays. In addition to studying how well engineers learn to operate IT facilities and apply them into teaching, how engineers' general capacity of information effects the results of learning IT are also discussed. This research introduces the "Combined TAM and TPB mode," to understand the situation of engineers using IT facilities.

An integrate information technology model during earthquake dynamics

Chen-Yuan Chen,Ying-Hsiu Chen,Shang-En Yu,Yi-Wen Chen,Chien-Chung Li 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.5

Applying Information Technology (IT) in practical engineering has become one of the most important issues in the past few decades, especially on internal solitary wave, intelligent robot interaction, artificial intelligence, fuzzy Lyapunov, tension leg platform (TLP), consumer and service quality. Other than affecting the traditional teaching mode or increasing the inter-relation with users, IT can also be connected with the current society by collecting the latest information from the internet. It is apparently a fashion-catching-up technology. Therefore, the learning of how to use IT facilities is becoming one of engineers’ skills nowadays. In addition to studying how well engineers learn to operate IT facilities and apply them into teaching, how engineers’ general capacity of information effects the results of learning IT are also discussed. This research introduces the “Combined TAM and TPB mode,” to understand the situation of engineers using IT facilities.

The Energy Efficiency of China’s Regional Construction Industry Based on the Three-stage DEA Model and the DEA-DA Model

Yuan Chen,Bingsheng Liu,Yinghua Shen,Xueqing Wang 대한토목학회 2016 KSCE Journal of Civil Engineering Vol.20 No.1

China’s construction industry has constantly been confronted with the problems, such as high resource consumption, serious pollution and low energy efficiency. Thus, improving the energy efficiency of the construction industry and reducing its energy consumption can not only promote the sustainable development of the socio-economy and eco-economy, but also enhance the overall development level of the construction industry. In the context, the objectives are to put forward a set of systematic methodologies for measuring the energy efficiency of the regional construction industry and analyzing its change trends. First, the energy efficiency index system of the construction industry and its influencing factors are constructed through the literature review. Second, two research methods (the three-stage Data Envelopment Analysis (DEA) model and the Data Envelopment Analysis-Discriminant Analysis (DEA-DA) model) are applied to analyze the energy efficiency in 30 provinces of China and the change trends from 2003 to 2011. The results indicate that after eliminating the influence of the environment factors and random errors, the energy efficiency values of the construction industry in most of the provinces were improved. The mean of China’s energy efficiency of the construction industry in each year was approximately 0.92. Except Shandong with the lowest values, the mean of the other provinces was over 0.8, which reflected that the energy management and utilization levels in the construction industry were relative mature. However, the energy efficiency in most of provinces fluctuated constantly during these nine years, with the peak in 2004 and a downward trend in the overall efficiency after 2004. From the regional aspect, the energy efficiency of the construction industry in the eastern, central and western regions decreased successively; as the development level of the local economy had less significant effects on the energy efficiency, the gaps among the three regions were not obvious.

2,5-Hexanedione induces apoptosis via a mitochondriamediated pathway in PC12 cells

Yuan Qi,Shuang-yue Li,Feng-yuan Piao,Zhe-min Wang,Ruo-lin Chen,Shuang Liu,Jing-shun Shen 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1

2,5-Hexanedione (HD) is the main active metabolite of n-hexane and mediates the neurotoxicity of the parent compound. Studies suggested that apoptosis involved in HD neurotoxicity. However, the mechanism of HD-induced neuronal apoptosis remains unknown. To explore its underlying mechanism, we treated PC12 cells with 5, 10 and 20 mM HD for 24 h, respectively. We found that HD induced apoptotic death in PC12 cells in a dose-dependent manner. Moreover, HD down-regulated Bcl-2 expression, up-regulated Bax expression and Bax/Bcl-2 ratio, promoted the disruption of mitochondrial transmembrane potential, induced the release of cytochrome c from mitochondria, and increased the activity of caspase-3 in PC12 cells, which were all the key regulators of intrinsic apoptotic pathway. These results indicate that HD induces apoptosis via a mitochondria- mediated pathway in PC12 cells.

Gamma-aminobutyric acid production by strains of Escherichia coli using glycerol as a sole carbon source

Chen Yuan HOU,Taek Jin KANG 한국생물공학회 2017 한국생물공학회 학술대회 Vol.2017 No.10

The Site-Directed A184S Mutation in the HTH Domain of the Global Regulator IrrE Enhances Deinococcus radiodurans R1 Tolerance to UV Radiation and MMC Shock

( Chen Zhang ),( Zhengfu Zhou ),( Wei Zhang ),( Zhen Chen ),( Yuan Song ),( Wei Lu ),( Min Lin ),( Ming Chen ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.12

IrrE is a highly conserved global regulator in the Deinococcus genus and contributes to survival from high doses of UV radiation, ionizing radiation, and desiccation. Drad-IrrE and Dgob-IrrE from Deinococcus radiodurans and Deinococcus gobiensis I-0 each share 66% sequence identity. However, Dgob-IrrE showed a stronger protection phenotype against UV radiation than Drad-IrrE in the D. radiodurans irrE-deletion mutant (ΔirrE), which may be due to amino acid residues differences around the DNA-binding HTH domain. Site-directed mutagenesis was used to generate a Drad-IrrE A184S single mutant, which has been characterized and compared with the ΔirrE mutant complemented strain with Drad-irrE, designated ΔirrE-E. The effects of the A184S mutation following UV radiation and mitomycin C (MMC) shock were determined. The A184S mutant displayed significantly increased resistance to UV radiation and MMC shock. The corresponding A184 site in Dgob-IrrE was inversely mutated, generating the S131A mutant, which exhibited a loss of resistance against UV radiation, MMC shock, and desiccation. qPCR analysis revealed that critical genes in the DNA repair system, such as recA, pprA, uvrA, and ddrB, were remarkably induced after UV radiation and MMC shock in the ΔirrE-IE and A184S mutants. These data suggested that A184S improves the ability against UV radiation and MMC shock, providing new insights into the modification of IrrE. We speculated that the serine residue may determine the efficiency of DNA binding, leading to the increased expression of IrrE-dependent genes important for protection against DNA damage.

Voltage Source Inverter Drive Using Error-compensated Pulse Width Modulation

Chen, Keng-Yuan,Hu, Jwu-Sheng,Lin, Jau-Nan The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1

An error-compensated pulse width modulator (ECPWM) is proposed to improve the baseband harmonic performance and the switching loss of voltage source inverters (VSIs). Selecting between harmonic distortion and switching loss is a design tradeoff in the conventional space vector pulse width modulation. In this work, an accumulated difference in produced and desired phase voltages is considered to adjust the reference signal. This mechanism can compensate for the voltage error in the previous carrier period. With error compensation every half-carrier period, the proposed ECPWM allows one-half reduction in carrier frequency without scarifying baseband harmonic distortion. The proposed modulator is applied to a three-phase VSI with R-L load and a motor-speed-control system for experiments. The measured efficiency and operating temperature of switches confirm the effectiveness of the proposed scheme.