Practice and reflection of principals’ transformative curriculum leadership in a Taiwan KIST school

Huan‐Kan Tseng,Chuan‐Chung Hsieh,Robin Jung‐Cheng Chen 한국교육개발원 2021 KEDI Journal of Educational Policy Vol.18 No.2

This study adopts the framework of transformative curriculum leadership theory, focused on one privatized school, the KIST (KIPP Inspired Schools in Taiwan) school, as a case study. The authors mainly utilize interview methods to explore the practices of principals’ transformative curriculum leadership in the KIST school, and find that the case of school principal leadership successfully integrates the interactions from the school autonomy, the local educational authority, and the private foundation into a driving force to develop a new educational model. Such results not only restructure the subjectivity of school education, but also effectively provide the reference framework for policy correction and solutions to the contemporary problems of rural education.

Prediction of the Duration to Next Admission for an Acute Affective Episode in Patients with Bipolar I Disorder

Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.

Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking.

Chen, Huan,Jackson, David,Kim, Jae-Yean Landes Bioscience 2014 Plant signaling & behavior Vol.9 No.3

<P>Maize knotted (KN1) homeodomain (HD) protein is a well-known mobile transcription factor crucial for stem cell maintenance. Recent studies have revealed that the trihelical HD of knotted1-like homeobox (KNOX) proteins is necessary and sufficient for selective cell-to-cell trafficking. Also, the efficient trafficking ability for HD is likely to be acquired during the evolution of early nonvascular land plants. Here, using the point-mutated HD of KN1 and shoot meristemless (STM) in the trichome rescue system, together with molecular structure modeling, we have found the evolutionarily conserved amino acid residues, such as arginine in helix α1 and leucine in helix α3, which are essential for intercellular trafficking. Our studies provided important clues for the 3-dimensional protein structure required for cell-to-cell movement of non-cell-autonomous transcription factors.</P>

Green Tea Consumption May Be Associated with Cardiovascular Disease Risk and Nonalcoholic Fatty Liver Disease in Type 2 Diabetics: A Cross-Sectional Study in Southeast China

Huan-Huan Yang,Hui Zhou,Wan-Zhan Zhu,Cai-Long Chen,Guo-Chong Chen,Lu-Gang Yu,Li-qiang Qin 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.10

Dietary factors play a crucial role in the management of type 2 diabetes mellitus (T2DM) by reducing cardiovascular disease (CVD) risk. Therefore, we aimed to examine the associations between habitual green tea consumption and risk factors of CVD among T2DM patients. A total of 1013 patients with T2DM were included in a community-based cross-sectional study. Data on dietary habits, including tea consumption, were collected using a food frequency questionnaire. A multivariable logistic regression model was used to analyze the associations. In men, as compared with nongreen tea drinkers, odds ratios (ORs) (95% confidence interval [CI]) of nonalcoholic fatty liver disease (NAFLD) were 2.06 (95% CI, 1.20–3.55) for those with green tea consumption of once per day and 2.45 (95% CI, 1.31–4.58) for more than or equal to twice per day (P-trend = .004); ORs (95% CI) of general obesity were 2.19 (95% CI, 1.02–4.68) and 2.70 (95% CI, 1.18–6.21), respectively (P-trend = .021); whereas no such association was found in women. Sensitivity analysis according to self-awareness of their T2DM status revealed that the positive association between green tea consumption and general obesity was not reliable. Higher intake of green tea was still positively associated with NAFLD, but it only persisted in participants aged ≥52 years or the lower dietary quality subgroup in further analyses. Our findings suggest that tea consumption was associated with an increased risk of NAFLD among male T2DM patients aged 52 years or older, and those with lower dietary quality, which needs to be confirmed in future prospective studies.

現代漢語應答語“知道了”硏究

CHEN HUAN CHANG 한국중국언어문화연구회 2021 한중언어문화연구 Vol.- No.61

本文分析了现代汉语应答语“知道了”的话语功能。在使用“知道了”应答时,需考虑话者与听者之间的关系。它适用于长辈对晚辈,上司对下属,偶尔也适用于平辈之间的应答,但不适用于下属对上司,晚辈对长辈的应答。另外,它既可表示一种单纯的应答功能,也可表示“听者已经充分了解事实,无需话者进行过多说明”的含义,同时也还具有话语终结功能。说话人对对方所谈论的话题,不想做过多的讨论,强制性终结话题,或者转换话题。而韩语的“알겠습니다”和“알았어요”也同样表达了多种话语功能。汉语的“知道了”和韩语的“알겠습니다”两者之间并非对应关系。韩国语的“알겠습니다”表达的是一种尊重的态度,会按照对方的要求或者指示去行动的恭敬表达方式。韩语的“알았어요”的意思更接近于汉语的“知道了”,两者都具有终结话语功能。因此,韩国学生在学习汉语时,应避免将“알겠습니다”对应成“知道了”,以免造成语言上的误会而有失礼仪。

$L^{\infty}$-CONVERGENCE OF MIXED FINITE ELEMENT METHOD FOR LAPLACIAN OPERATOR

Chen, Huan-Zhen,Jiang, Zi-Wen 한국전산응용수학회 2000 Journal of applied mathematics & informatics Vol.7 No.1

In this paper two so-called regularized Green's functions are introduced to derive the optimal maximum norm error estimates for the unknown function and the adjoint vector-valued function for mixed finite element methods of Laplacian operator. One contribution of the paper is a demonstration of how the boundedness of $L^1$-norm estimate for the second Green's function ${\lambda}_2$ and the optimal maximum norm error estimate for the adjoint vector-valued function are proved. These results are seemed to be to be new in the literature of the mixed finite element methods.

Impact of selected fungi from an artificial diet on the growth and development of Drosophila suzukii (Diptera: Drosophilidae)

Huan-Huan Gao,Nan Xu,Hao Chen,Qian Liu,Qian-Yun Pu,Dong-Yun Qin,Yi-Fan Zhai,Yi Yu 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.1

Drosophila suzukii (Diptera: Drosophilidae) is one of the very few Drosophila species which are able to lay eggs and feed on healthy ripening fruit. Adults and larvae are all able to obtain the nutrition in the decaying food, which will generate many microorganisms. However, the relationship between D. suzukii and microorganism is poorly understood. In this study, 13 species of fungi were identified in an artificial diet fed by D. suzukii. Short-term and continuously life table experiments were conducted to determine the impact of three of these fungus species including Geotrichum candidum, Talaromyces minioluteus and Actinomucor elegans on the growth and development of Drosophila suzukii. Results revealed that, compared to the control, G. candidum, T.minioluteus and A. elegans increased the mortality of D. suzukii adults in the short time, while extended the developmental time of pupal D. suzukii by 18.00%, 16.22% and 26.44%, respectively in the life table experiment. T. minioluteus reduced the total longevity of D. suzukii by 15.52%, while A. elegans enhanced the total longevity by 25.96%. G. candidum and A. elegans increased the fecundity bymore than two folds. T. minioluteus elongated the mean generation time (T) by 31.34%, whereas G. candidum shortened it by 15.26% but increased the net reproductive rate (R0) by 217.76%, intrinsic rate of increase (r) by 88.89% and finite rate of increase (λ) by 9.17%. It was concluded that G. candidumand A. elegans significantly had the beneficial effect on the growth and reproduction of D. suzukii, however, T. minioluteus had the negative effect on D. suzukii. Our results could provide a new integrated pest management strategy for D. suzukii which would be discussed in this study.

Lactoferrin Alleviates the Progression of Atherosclerosis in ApoE−/− Mice Fed with High-Fat/Cholesterol Diet Through Cholesterol Homeostasis

Chen-Jie Ling,Qing-Qing Min,Jin-Rong Yang,Zheng Zhang,Huan-Huan Yang,Jia-Ying Xu,Li-qiang Qin 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.10

Lactoferrin (LF) is a multifunctional glycoprotein and has beneficial effects on the regulation of lipid metabolism. However, whether LF supplementation alleviates the development of atherosclerosis (AS) remains unclear. In the present study, all of 48 male Apolipoprotein E−/− mice were fed with high-fat diet with 1.25% added cholesterol and divided to four treatment groups with either distilled water (HFCD), LF solutions at 2 mg/mL (low LF), 10 mg/mL (middle LF or MLF), or 20 mg/mL (high LF or HLF) for 12 weeks. Oral glucose tolerance tests (OGTT) were performed at weeks 0, 4, 8, and 12. At the end of the experiment, lipids in serum, liver, and feces were determined. The livers, whole aortas, and aortic sinuses were pathologically examined. The protein expression of factors related to cholesterol synthesis, absorption, and excretion were detected through western blot. No significant difference in body weight, food intake, and OGTT was observed among the four groups. Compared with the HFCD group, the MLF and HLF groups had significantly decreased serum and hepatic cholesterol levels and significantly increased fecal cholesterol contents. LF alleviated the hepatic steatosis and lipid droplet, especially in the MLF group. LF also significantly decreased the average lesion areas in the whole aorta, especially in the MLF group. On the other hand, LF downregulated hepatic protein expression of HMG-CoA reductase (the rate-limiting enzyme in cholesterol synthesis) and upregulated cholesterol 7-alpha hydroxylase (the rate-limiting enzyme in bile acid synthesis from cholesterol). LF also downregulated the intestinal expression of Niemann-Pick C1-like 1 protein, which is known to bind to a critical mediator of cholesterol absorption. In conclusion, LF supplementation alleviates the AS in mice on HFCD likely by reducing the synthesis and absorption of cholesterol and increasing cholesterol excretion.

Thyroid-Associated Orbitopathy: Evaluating Microstructural Changes of Extraocular Muscles and Optic Nerves Using Readout-Segmented Echo-Planar Imaging-Based Diffusion Tensor Imaging

Huan-Huan Chen,Hao Hu,Wen Chen,Dai Cui,Xiao-Quan Xu,Fei-Yun Wu,Tao Yang 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.3

Objective: We aimed to investigate the ability of readout-segmented echo-planar imaging (rs-EPI)-based diffusion tensor imaging (DTI) in assessing the microstructural change of extraocular muscles (EOMs) and optic nerves in patients with thyroidassociated orbitopathy (TAO) as well as in evaluating disease activity. Materials and Methods: We enrolled 35 TAO patients and 22 healthy controls (HCs) who underwent pre-treatment rs-EPIbased DTI. Mean, axial, and radial diffusivity (MD, AD, and RD) and fractional anisotropy (FA) of the medial and lateral EOMs and optic nerve for each orbit were calculated and compared between TAO and HC groups and between active and inactive TAO groups. Factors such as age, sex, disease duration, mediation, and smoking history between groups were also compared. Logistic regression analysis was used to evaluate the predictive value of significant variables for disease activity. Results: Disease duration was significantly shorter in active TAOs than in inactive ones (p < 0.001). TAO patients showed significantly lower FA and higher MD, AD, and RD than HCs for both medial and lateral EOMs (p < 0.001), but not the AD value of lateral EOMs (p = 0.619). Active patients had significantly higher FA, MD, and AD than inactive patients for medial EOMs (p < 0.005), whereas only FA differed significantly in the lateral EOMs (p = 0.018). The MD, AD, and RD of optic nerves were significantly lower in TAO patients than HCs (p < 0.05), except for FA (p = 0.129). Multivariate analysis showed that the MD of medial EOMs and disease duration were significant predictors for disease activity. The combination of these two parameters showed optimal diagnostic efficiency for disease activity (area under the curve, 0.855; sensitivity, 68.4%; specificity, 96.9%). Conclusion: rs-EPI-based DTI is promising in assessing microstructural changes of EOMs and optic nerves and can help to indicate the disease activity of TAO, especially through the MD of medial EOMs.

現代漢語“有VP”的三個特殊句式

CHEN HUAN CHANG 중국어문학회 2022 中國語文學誌 Vol.- No.78

This study analyzed three special phrases of ‘有VP’ in modern Chinese. These are ‘有VP’, which forms sentences independently, ‘有VP’ for habitual meaning, and ‘有VP’ to express anti-actual assumptions. First, in the answer to the question, all the subject and VP components in front of the ‘有VP’ structure can be deleted, and only ‘有’ can form a sentence independently. This means that ‘有’ still retains the practical meaning of ‘being' to some extent and is not grammatically used as a aspect mark. Second, ‘有VP’ generally expresses an event that has already occurred in the past, but it can also indicate habitual behavior, so it also functions as a habitual marker. Considering that it is usually an auxiliary verb, an adverb, or an end-of-sentence investigation that indicates habit in Chinese, the possibility that ‘有’ is an auxiliary verb. Third, ‘有VP’ can refer to the anti-realistic assumption, which is an upward additive anti-factual thought, with a kind of ‘regret’, It can represent the function of the modality. Therefore, the property of ‘有’ is highly likely to be a multifunctional word formed by adding various grammatical functions while still retaining the meaning of the ‘being’. 本文主要对“有VP”的三个特殊句式“独立成句的‘有VP’,表达惯常义的‘有VP’以及表达反事实假设的‘有VP‘进行了分析。首先,在应答句中,‘有VP’句式前面的主语成分,以及VP成分都可以删除,只保留“有”独立成句。从这点可以看出现代汉语里“有”还某种程度保留着实际语义,还不能看成是一个体标记。第二,从‘有VP’除了能够表示一次性的已然事件以外,还能够表达惯常义,从“有”的出现位置来看,存在着“助动词”和“副词”两种可能。第三,‘有VP‘可以表示反事实假设,当‘有VP’用于假设句中,‘有VP’是一种上行式的,加法式的反事实思维,表达了话者的情感,这些情感可能是“遗憾”、“惋惜”、“不满”、甚至“责备”,这是一种情态体现。通过这些,本文推断“有VP”中“有”的性质有可能是表示存在意义的助动词,但是该助动词汉语里的“着”,“了”,”过”单纯表示语义意义的助动词不同。“有”是“有”在保留“存在”本义的同时,增加了一些语法功能,从而成为了多功能词。将“有”看成表达体意义功能词,或者看成“体标记”的主张,从现阶段来看,还值得商榷。