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Effect of hydrothermal time on the structure and property of graphene oxide membrane
Tran Van Khai,Pham Thuy Trang,Le Ngoc Long,Le Van Thang,Tran Duc Chau,Vuong Vinh Dat,Mai Thanh Phong 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.4
Two dimensional graphene oxide (GO) has potential application in membrane separation owing to its unique structure andphysicochemical properties. In this study, the reduced graphene oxide (rGO) was synthesized from GO via hydrothermaltreatment at 160 oC for 1, 2, 3 and 4 h, and the rGO membranes were prepared on cellulose nitrate supporting membranesby vacuum filtration. The structural change and chemical composition of GO were investigated using X-ray diffraction (XRD),Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM),atomic force microscopy (AFM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS) andcontact angle measurements. The result shows that uniformly intact rGO membranes with good hydrophobicity could beachieved by adjusting the reduction degree of GO through changing the hydrothermal reaction time. The huge improvementof the hydrophobic property of rGO could be attributed to the removal of the most the hydrophilic oxygen-containingfunctional groups on the surface of GO. Additionally, the structure, chemical composition, and d-spacing of the GO can alsobe controlled by adjusting the reduction time. This method holds great potential because it can be prepared in large quantitiesat low cost, and suitable for applications in membrane technologies.
Chemical Constituents of Acanthus ilicifolius L. and Effect on Osteoblastic MC3T3E1 Cells
Phan Van Kiem,Tran Thu Huong,Eun Mi Choi,김영호,Tran Hong Quang,Le Thi Hong Nhung,Nguyen Xuan Cuong,Chau Van Minh 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside(2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-β-glucopyranoside (5), (-)-lyoniresinol (6), and α-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by pectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 (30 μM) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.
Chemical Constituents of Acanthus ilicifolius L. and Effect on Osteoblastic MC3T3E1 Cells
Kiem, Phan Van,Quang, Tran Hong,Huong, Tran Thu,Nhung, Le Thi Hong,Cuong, Nguyen Xuan,Minh, Chau Van,Choi, Eun-Mi,Kim, Young-Ho 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-$\beta$-glucopyranoside (5), (-)-lyoniresinol (6), and $\alpha$-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 ($30\;{\mu}M$) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.
Tran Hong Quang,Seok Bean Song,Bui Thi Thuy Luyen,Nguyen Phuong Thao,BUIHUU TAI,Nguyen Xuan Nhiem,Phan Van Kiem,Chau Van Minh,Nguyen Thi Thanh Ngan,김영호 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC50 values ranging from 6.2 to 9.1 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with EC50 values ranging from 4.1-12.7 μM. Compounds 4 and 5 exhibited PPARα, PPARγ, and PPARβ(δ) transactivational activities in a dose-dependent manner, with EC50 values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 μM, respectively.
Tran, Phuong Thao,Dat, Nguyen Tien,Dang, Nguyen Hai,Van Cuong, Pham,Lee, Suhyun,Hwangbo, Cheol,Van Minh, Chau,Lee, Jeong-Hyung Elsevier 2019 Phytomedicine Vol.55 No.-
<P><B>ABSTARCT</B></P> <P><B>Background</B></P> <P>Many bone-related diseases such as osteoporosis and rheumatoid arthritis are commonly associated with excessive activity of the osteoclast. Ganomycin I (GMI), a meroterpenoid isolated from Vietnamese mushroom <I>Ganoderma lucidum</I>, possesses a variety of beneficial effects on human health. However, its impact and underlying mechanism on osteoclastogenesis remain unclear. In the present study, we investigated the effect of GMI on RANKL-induced osteoclast formation in mouse BMMs and RAW264.7 cells.</P> <P><B>Methods</B></P> <P>BMMs or RAW264.7 cells were treated with GMI followed by an evaluation of cell viability, RANKL-induced osteoclast differentiation, actin-ring formation, and resorption pits activity. Effects of GMI on RANKL-induced phosphorylation of MAPKs as well as the expression levels of NFATc1 and c-Fos were evaluated by Western blot analysis. Expression levels of osteoclast marker genes were evaluated by Western blot analysis and reverse transcription-qPCR.</P> <P><B>Results</B></P> <P>GMI significantly inhibited RANKL-induced osteoclast differentiation by decreasing the number of osteoclasts, osteoclast actin–ring formation, and bone resorption in a dose-dependent manner without affecting cell viability. At molecular level, GMI inhibited the RANKL-induced phosphorylation of ERK, JNK, and p38 MAPKs, as well as the expression levels of c-Fos and NFATc1, which are known to be crucial transcription factors for osteoclast formation. In addition, GMI decreased expression levels of osteoclastogenesis specific marker genes including c-Src, CtsK, TRAP, MMP-9, OSCAR, and DC-STAMP in RANKL-stimulated BMMs.</P> <P><B>Conclusion</B></P> <P>Our findings suggest that GMI can attenuate osteoclast formation by suppressing RANKL-mediated MAPKs and NFATc1 signaling pathways and the anti-osteoclastogenic activity of GMI may extend our understanding of molecular mechanisms underlying biological activities and pharmacological use of <I>G. lucidum</I> as a traditional anti-osteoporotic medicine.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>