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The BRAHMS Experiment at the Relativistic Heavy Ion Collider
Y. K. Lee,I. G. Bearden,D. Beavis,C. Besliu,Y. Blyakhman,J. Brzychczyk,B. Budick,H. Bggild,C. Chasman,C. H. Christensen,P. Christiansen,J. Cibor,R. Debbe,E. Enger,J. J. Gaardhje,K. Grotowski,K. Hagel 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.I
The BRAHMS probes the hot and dense nuclear matter at the RHIC which has reached its design energy of psNN = 200 GeV for Au + Au collisions. The BRAHMS uses magnetic spectrometers for hadrons covering a large phase space 0 < y < 4 with good particle identification and momentum resolution. A comprehensive investigation of multiplicity distributions of emitted charged particles is carried out. Ratios of yields of antiparticles to particles are also measured as a function of rapidity. Rapidity dependent net-proton yield indicates that substantial transparency has been achieved in these collisions. Transverse momentum spectra of charged hadrons are measured up to 5 GeV/c which indicates a significant medium eect when compared to nucleon + nucleon reference spectra.
Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function
Parsa, Afshin,Fuchsberger, Christian,Kö,ttgen, Anna,O’Seaghdha, Conall M.,Pattaro, Cristian,de Andrade, Mariza,Chasman, Daniel I.,Teumer, Alexander,Endlich, Karlhans,Olden, Matthias,Chen, Ming-Hue American Society of Nephrology 2013 Journal of the American Society of Nephrology Vol.24 No.12
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, Tanya M.,Musunuru, Kiran,Smith, Albert V.,Edmondson, Andrew C.,Stylianou, Ioannis M.,Koseki, Masahiro,Pirruccello, James P.,Ripatti, Samuli,Chasman, Daniel I.,Willer, Cristen J.,Johansen, C Nature Publishing Group, a division of Macmillan P 2010 Nature Vol.466 No.7307
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P??<??5?????10<SUP>??8</SUP>), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes??GALNT2, PPP1R3B and TTC39B??with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
Larrainzar, Estí,baliz,Riely, Brendan K.,Kim, Sang Cheol,Carrasquilla-Garcia, Noelia,Yu, Hee-Ju,Hwang, Hyun-Ju,Oh, Mijin,Kim, Goon Bo,Surendrarao, Anandkumar K.,Chasman, Deborah,Siahpirani, Alir American Society of Plant Biologists 2015 Plant Physiology Vol.169 No.1
<P><I>Transcriptional reprogramming is regulated by Nod factor-induced ethylene signaling.</I></P><P>The legume-rhizobium symbiosis is initiated through the activation of the Nodulation (Nod) factor-signaling cascade, leading to a rapid reprogramming of host cell developmental pathways. In this work, we combine transcriptome sequencing with molecular genetics and network analysis to quantify and categorize the transcriptional changes occurring in roots of <I>Medicago truncatula</I> from minutes to days after inoculation with <I>Sinorhizobium medicae</I>. To identify the nature of the inductive and regulatory cues, we employed mutants with absent or decreased Nod factor sensitivities (i.e. <I>Nodulation factor perception</I> and <I>Lysine motif domain-containing receptor-like kinase3</I>, respectively) and an ethylene (ET)-insensitive, Nod factor-hypersensitive mutant (<I>sickle</I>). This unique data set encompasses nine time points, allowing observation of the symbiotic regulation of diverse biological processes with high temporal resolution. Among the many outputs of the study is the early Nod factor-induced, ET-regulated expression of ET signaling and biosynthesis genes. Coupled with the observation of massive transcriptional derepression in the ET-insensitive background, these results suggest that Nod factor signaling activates ET production to attenuate its own signal. Promoter:β-glucuronidase fusions report ET biosynthesis both in root hairs responding to rhizobium as well as in meristematic tissue during nodule organogenesis and growth, indicating that ET signaling functions at multiple developmental stages during symbiosis. In addition, we identified thousands of novel candidate genes undergoing Nod factor-dependent, ET-regulated expression. We leveraged the power of this large data set to model Nod factor- and ET-regulated signaling networks using MERLIN, a regulatory network inference algorithm. These analyses predict key nodes regulating the biological process impacted by Nod factor perception. We have made these results available to the research community through a searchable online resource.</P>