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원저(原著) : 간 질환자의 C형 간염항체 및 B형 간염항원 양성율
조창호 ( Chaog-ho Cho ),김창일 ( Chang-it Kim ),박경희 ( Kyung-hee Park ) 대한임상병리사협회 1994 임상수혈검사학회 발표자료집 Vol.1 No.1
In order to elucidate the prevalence of anti-HCV and HBsAg in liver disease patients, we examined anti-HCV and HBV markers in 359 samples from blood donors and 563 samples from liver disease patients using ELA method. The prevalence of anti-HCV in liver disease patients(12.1 %) was significantly higher than that(1.l %) of blood donors(P<0.05). Among blood donors the prevalence of anti-HCV in male(1.5 %) was not significantly higher than that(0.0%) in female. but in liver disease patients, male(14.1 %) was significantly higher than that(6.2%) in female. The positive rate of anti-HCV was significantly increased with age in liver disease patients(P<0.05), but in blood donors was not significantly. Anti-HCV was detected in 48.9 %(23/47) of hepatoma, 9.3 %(17/183) of liver cirrhosis, 8.4 %(28/333) of other chronic hepatitis. Relative risk for HBsAg was 6.98(95 % CI:4.11-11.86) in hepatoma(P<0.05). 3.60(95 % CI:2.86-4.53) in liver cirrhosis, 2.56(95 % CI: 2.10-2.88) in other chronic hepatitis. For anti-HCV, the relative risk in hepatoma was 13.45(95 % CI:8.91-20.32), in liver cirrhosis was 2.54(95 % CI:1.72-3.76), in other chronic hepatitis was 1.89(95 % CI: 1.44-2.49). These findings provide strong evidence that HCV infection is significantly correlated with hepatoma, and may even playa more important role than the hepatitis B virus.
국내 자생 포플러나무에 의한 디젤오염토양 정화특성 연구
장순웅,Chaog Soon-Woong 한국지하수토양환경학회 2006 지하수토양환경 Vol.11 No.5
본 연구에서는 국내에 자생하는 포플러나무중 양황철을 대상으로 토양칼럼에서의 디젤(TPH) 제거 특성 및 식물체에 미치는 독성효과를 평가하였다. 포플러 삽목은 2달간 생장시킨 후 본 실험에 이용되었으며, 다양한 디젤농도(0, 200, 500, 1000, 2000 mg/kg)를 대상으로 60여 일간 진행되었다. 양황철에 의한 디젤 제거 실험에서 낮은 디젤농도에서는 효과적인 처리가 관찰된 반면, 농도가 증가할수록 처리효율은 급격하게 감소하였다. 또한 뿌리생장이 활발한 토양칼럼 하부에서의 처리효율이 상대적으로 높았다. 그리고 양황철 생장과 증산량을 비교하여 디젤의 양황철에 미치는 독성효과의 여부를 검토하였다. 실험기간동안 양황철의 황백화 현상, 뿌리생장 저하, 증산량 감소 현상 등이 관찰 되었다. 또한 토양칼럼 깊이별 측정한 미생물 활성도 결과는 뿌리 생장이 많은 토양 칼럼 하부와 영양염류 및 디젤 분해미생물을 추가로 주입해준 경우가 높았다. 이러한 식물의 정화효과는 근권에 있는 토양미생물에 유용한 뿌리 분비물을 지속적으로 제공함으로써 미생물의 활발한 번식 및 분해활동이 더욱 촉진되는 것으로 보인다. In this study, uptake and toxicity of disel (TPH) by poplar specie, $P.\;nigra{\times}P.\;maximowiczii$ were assessed in laboratory soil column experiments. Poplar cuttings were grown for 2 months and exposed to various concentration (0, 200, 500, 1000, 2000 mg/kg) of disel for a period of 60 days. For disel removal experiments, disel was effectively removed in the range of lower concentration. but, the removal rate of disel was rapidly decreased as increasing initial disel concentrations. For the this reason, toxicity effetcs were evaluated by measuring in poplar cutting mass variation and monitoring transpiration. Exposure on higher disel concentration resulted in decrease of biomass and transpiration accompanied by chlorosis and abscission, indicating toxic effect of disel on the poplar tree. And also, we have observed that both removal efficiency of disel and the microbial activity were higher at the bottom of the soil column. It was suggested that the plant formed the root zone at contaminated soil, stimulated microbial activity by plant root exudates, and played an important role in enhanced biodegradation of disel.
최완재(Wanjae Choi),류현일(Hyunil Ryu),고슬미니(Seulmini Goh),주조가(Chaoge Zhou),권순조(Soonjo Kwon),전태준(Tae-Joon Jeon),김선민(Sun Min Kim) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12
Local anesthetics convert into cations in the body and bind to specific receptors in the sodium ion channel in the cell membrane to prevent the inflow of sodium ions and prevent cell membrane potential changes. This results in no neuronal transmission of the cells. Local anesthetics have been used to treat pain after surgery or through postoperative pain. However, local anesthetics can cause fatal side effects to prevent neurotransmission. It also changes heart rate, stimulates the central nervous system to give a sense of helplessness or delay breathing. The toxicity of these local anesthetics does not only affect the membrane protein, but also has a direct effect on the biomembrane. Toxicity studies applied to membrane proteins have been carried out so far, but toxicity studies applied to biomembranes have not progressed much. SEM photographs of the cells confirmed that the cells have an effect on the biomembrane and IC50 confirmed the cytotoxicity of lidocaine and tetracaine. Artificial cell membrane were prepared with a black lipid bilayer incorporating gramicidin and polydiacetylene (PDA), and the effects of local anesthetics on the biomembrane were quantitatively measured. These measurements can be used to measure the biomembrane toxicity of other local anesthetics and new local anesthetic agents.